Pld1 (phospholipase D1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Pld1 (phospholipase D1) Rattus norvegicus
Analyze
Symbol: Pld1
Name: phospholipase D1
RGD ID: 3349
Description: Enables phospholipase D activity. Involved in phospholipid catabolic process; positive regulation of cell migration; and response to peptide hormone. Acts upstream of or within phosphatidic acid biosynthetic process. Located in Golgi cisterna; lamellipodium; and vesicle. Is active in synapse. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to human PLD1 (phospholipase D1); PARTICIPATES IN mTOR signaling pathway; ceramide signaling pathway; endocytosis pathway; INTERACTS WITH 1-octadec-9-enoylglycero-3-phosphate; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: choline phosphatase 1; Phoshpolipase D gene 1; Phoshpolipase D gene 1 probably with two splicing variants A and B; phosphatidylcholine-hydrolyzing phospholipase D1; phospholipase D gene 1; phospholipase D gene 1 probably with two splicing variants A and B; phospholipase D gene 1, probably with two splicing variants A and B; phospholipase D1, phosphatidylcholine-specific; PLD 1; Pld1a; Pld1b; Plda; Pldb; rPLD1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82112,777,820 - 112,975,857 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2112,777,951 - 112,976,245 (+)EnsemblGRCr8
mRatBN7.22110,849,205 - 111,047,304 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2110,893,608 - 111,047,692 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2117,548,080 - 117,700,325 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02115,660,662 - 115,812,852 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02110,374,318 - 110,526,587 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02113,651,967 - 113,849,403 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,652,348 - 113,849,403 (+)Ensemblrn6Rnor6.0
Rnor_5.02133,357,235 - 133,554,180 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42115,306,940 - 115,460,518 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2106,084,707 - 106,238,116 (+)NCBICelera
RGSC_v3.12115,251,901 - 115,405,480 (+)NCBI
Cytogenetic Map2q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-bisphospho-D-glyceric acid  (ISO)
2,3-bisphosphoglyceric acid  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-naphthylamine  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP)
caffeine  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
ganglioside GM1  (EXP)
genistein  (EXP)
glyphosate  (ISO)
Goe 6976  (EXP,ISO)
hexadecanoic acid  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indometacin  (EXP)
irinotecan  (EXP)
isoniazide  (ISO)
isoprenaline  (ISO)
Licochalcone B  (ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melanins  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury(1+)  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Muconic dialdehyde  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
oleic acid  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphatidic acid  (ISO)
pinostrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
pyrethrins  (EXP)
quercetin  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP)
rottlerin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sulforaphane  (ISO)
testosterone  (ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
topotecan  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Involvement of phospholipase D in the cAMP-regulated exocytosis of rat parotid acinar cells. Dohke Y, etal., Biochem Biophys Res Commun 2002 Dec 13;299(4):663-8.
2. Phospholipase D2 is localized to the rims of the Golgi apparatus in mammalian cells. Freyberg Z, etal., Mol Biol Cell. 2002 Nov;13(11):3930-42.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Simultaneous high expression of PLD1 and Sp1 predicts a poor prognosis for pancreatic ductal adenocarcinoma patients. Hu J, etal., Oncotarget. 2016 Nov 29;7(48):78557-78565. doi: 10.18632/oncotarget.12447.
6. Mechanisms of regulation of phospholipase D1 by protein kinase Calpha. Hu T and Exton JH, J Biol Chem 2003 Jan 24;278(4):2348-55.
7. A role for phospholipase D1 in neurotransmitter release. Humeau Y, etal., Proc Natl Acad Sci U S A 2001 Dec 18;98(26):15300-5.
8. Stability of phospholipase D in primary astrocytes. Jin S, etal., Biochem Biophys Res Commun 2002 Sep 27;297(3):545-51.
9. Differential expression of phospholipase D isozymes in the hippocampus following kainic acid-induced seizures. Kim SY, etal., J Neuropathol Exp Neurol. 2004 Aug;63(8):812-20.
10. Subcellular distribution and characterization of rat pancreatic phospholipase D isoforms. Laine J, etal., Pancreas. 2000 May;20(4):323-36.
11. Phospholipase D is essential for keratocyte-like migration of NBT-II cells. Nagasaki A, etal., Cell Struct Funct. 2008;33(1):27-33. Epub 2008 Mar 13.
12. Molecular cloning and chromosome mapping of rat phospholipase D genes, Pld1a, Pld1b and Pld2. Nakashima S, etal., Cytogenet Cell Genet 1997;79(1-2):109-13.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis. Panupinthu N, etal., J Cell Biol. 2008 Jun 2;181(5):859-71. doi: 10.1083/jcb.200708037.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells. Powner DJ, etal., Mol Biol Cell 2002 Apr;13(4):1252-62.
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Parathyroid hormone stimulates phosphatidylethanolamine hydrolysis by phospholipase D in osteoblastic cells. Singh AT, etal., Lipids. 2005 Nov;40(11):1135-40.
21. Differential mRNA expression of phospholipase D (PLD) isozymes during cAMP-induced differentiation in C6 glioma cells. Yoshimura S, etal., Biochem Biophys Res Commun 1996 Aug 14;225(2):494-9.
22. Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells. Zhong M, etal., Biochem Biophys Res Commun 2003 Mar 14;302(3):615-9.
Additional References at PubMed
PMID:9188501   PMID:9361006   PMID:9445394   PMID:11121416   PMID:11544318   PMID:11665609   PMID:11812783   PMID:12054584   PMID:12388770   PMID:12429840   PMID:12472177   PMID:12642902  
PMID:12876278   PMID:14660552   PMID:14718562   PMID:14744865   PMID:14769825   PMID:15087463   PMID:15187091   PMID:15199126   PMID:15210717   PMID:15475361   PMID:15601581   PMID:15616193  
PMID:15752728   PMID:15980073   PMID:16339153   PMID:16842757   PMID:17146759   PMID:17540765   PMID:17897319   PMID:18541525   PMID:18550821   PMID:19010519   PMID:19161391   PMID:19261846  
PMID:19741172   PMID:19794068   PMID:19946888   PMID:20965153   PMID:21525000   PMID:21916846   PMID:22544632   PMID:22674271   PMID:22797597   PMID:23932932   PMID:24269608   PMID:24728967  
PMID:24986006   PMID:25361009   PMID:28648601   PMID:28729535   PMID:30207376   PMID:31356881   PMID:32337269   PMID:34431424   PMID:36162649   PMID:38117597  


Genomics

Comparative Map Data
Pld1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82112,777,820 - 112,975,857 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2112,777,951 - 112,976,245 (+)EnsemblGRCr8
mRatBN7.22110,849,205 - 111,047,304 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2110,893,608 - 111,047,692 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2117,548,080 - 117,700,325 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02115,660,662 - 115,812,852 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02110,374,318 - 110,526,587 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02113,651,967 - 113,849,403 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,652,348 - 113,849,403 (+)Ensemblrn6Rnor6.0
Rnor_5.02133,357,235 - 133,554,180 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42115,306,940 - 115,460,518 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2106,084,707 - 106,238,116 (+)NCBICelera
RGSC_v3.12115,251,901 - 115,405,480 (+)NCBI
Cytogenetic Map2q24NCBI
PLD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383171,600,404 - 171,810,483 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3171,600,404 - 171,810,950 (-)Ensemblhg38GRCh38
GRCh373171,318,194 - 171,528,273 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363172,801,339 - 172,938,566 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343172,801,346 - 172,938,574NCBI
Celera3169,718,435 - 169,928,143 (-)NCBICelera
Cytogenetic Map3q26.31NCBI
HuRef3168,688,221 - 168,898,341 (-)NCBIHuRef
CHM1_13171,281,084 - 171,491,135 (-)NCBICHM1_1
T2T-CHM13v2.03174,384,521 - 174,594,617 (-)NCBIT2T-CHM13v2.0
Pld1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39327,992,636 - 28,187,388 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl327,992,844 - 28,187,511 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38327,938,459 - 28,133,362 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl327,938,695 - 28,133,362 (+)Ensemblmm10GRCm38
MGSCv37327,837,602 - 28,032,284 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36328,215,231 - 28,324,307 (+)NCBIMGSCv36mm8
Celera327,897,052 - 28,088,894 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map311.15NCBI
Pld1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554201,696,751 - 1,892,741 (-)Ensembl
ChiLan1.0NW_0049554201,697,716 - 1,892,741 (-)NCBIChiLan1.0ChiLan1.0
PLD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22169,481,152 - 169,693,135 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13169,482,578 - 169,696,377 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03168,606,342 - 168,816,383 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13176,790,736 - 176,999,974 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3176,790,753 - 176,961,033 (-)EnsemblpanPan2panpan1.1
PLD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13435,917,759 - 36,080,383 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3435,921,058 - 36,121,631 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3444,928,877 - 45,133,990 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03436,000,267 - 36,205,332 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3436,000,274 - 36,205,751 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13435,940,863 - 36,145,600 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03435,903,822 - 36,109,331 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03436,165,953 - 36,370,780 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pld1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602102,572,478 - 102,777,840 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936593930,637 - 1,046,821 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936593844,634 - 1,049,478 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13110,154,874 - 110,376,294 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113110,152,268 - 110,376,319 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213119,138,285 - 119,362,303 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11517,667,079 - 17,871,452 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1517,706,030 - 17,870,266 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606326,423,171 - 26,629,555 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pld1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473049,665,432 - 49,885,184 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473049,665,432 - 49,885,242 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pld1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13126,531,701 - 126,733,956 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pld1
1123 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:953
Count of miRNA genes:299
Interacting mature miRNAs:383
Transcripts:ENSRNOT00000039296, ENSRNOT00000039308
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat

Markers in Region
RH139663  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,046,730 - 111,046,946 (+)MAPPERmRatBN7.2
Rnor_6.02113,848,442 - 113,848,657NCBIRnor6.0
Rnor_5.02133,553,219 - 133,553,434UniSTSRnor5.0
RGSC_v3.42115,459,557 - 115,459,772UniSTSRGSC3.4
Celera2106,237,155 - 106,237,370UniSTS
RH 3.4 Map2703.0UniSTS
Cytogenetic Map2q23.3-q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000039296   ⟹   ENSRNOP00000034466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2112,822,196 - 112,975,892 (+)Ensembl
mRatBN7.2 Ensembl2110,893,608 - 111,047,339 (+)Ensembl
Rnor_6.0 Ensembl2113,652,348 - 113,849,038 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000039308   ⟹   ENSRNOP00000035045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2112,820,671 - 112,976,245 (+)Ensembl
mRatBN7.2 Ensembl2110,893,623 - 111,047,692 (+)Ensembl
Rnor_6.0 Ensembl2113,696,154 - 113,849,403 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091545   ⟹   ENSRNOP00000073521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2113,696,259 - 113,847,533 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000163953   ⟹   ENSRNOP00000106851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2112,777,951 - 112,975,789 (+)Ensembl
RefSeq Acc Id: NM_001399082   ⟹   NP_001386011
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82112,822,176 - 112,975,857 (+)NCBI
mRatBN7.22110,893,588 - 111,047,304 (+)NCBI
RefSeq Acc Id: NM_030992   ⟹   NP_112254
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82112,822,176 - 112,975,857 (+)NCBI
mRatBN7.22110,893,588 - 111,047,304 (+)NCBI
Rnor_6.02113,696,154 - 113,849,403 (+)NCBI
Rnor_5.02133,357,235 - 133,554,180 (+)NCBI
RGSC_v3.42115,306,940 - 115,460,518 (+)RGD
Celera2106,084,707 - 106,238,116 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232206   ⟹   XP_006232268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82112,777,820 - 112,975,793 (+)NCBI
mRatBN7.22110,849,205 - 111,047,304 (+)NCBI
Rnor_6.02113,651,967 - 113,849,015 (+)NCBI
Rnor_5.02133,357,235 - 133,554,180 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063281317   ⟹   XP_063137387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82112,777,822 - 112,975,793 (+)NCBI
RefSeq Acc Id: NP_112254   ⟸   NM_030992
- Peptide Label: isoform 2
- UniProtKB: D4A318 (UniProtKB/TrEMBL),   A6IHH9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232268   ⟸   XM_006232206
- Peptide Label: isoform X1
- UniProtKB: Q9QWJ6 (UniProtKB/Swiss-Prot),   P70497 (UniProtKB/Swiss-Prot),   P70496 (UniProtKB/Swiss-Prot),   O54765 (UniProtKB/Swiss-Prot),   O35856 (UniProtKB/Swiss-Prot),   O08959 (UniProtKB/Swiss-Prot),   F1LMG4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073521   ⟸   ENSRNOT00000091545
Ensembl Acc Id: ENSRNOP00000034466   ⟸   ENSRNOT00000039296
Ensembl Acc Id: ENSRNOP00000035045   ⟸   ENSRNOT00000039308
RefSeq Acc Id: NP_001386011   ⟸   NM_001399082
- Peptide Label: isoform 1
- UniProtKB: Q9QWJ6 (UniProtKB/Swiss-Prot),   P70497 (UniProtKB/Swiss-Prot),   P70496 (UniProtKB/Swiss-Prot),   O54765 (UniProtKB/Swiss-Prot),   O35856 (UniProtKB/Swiss-Prot),   O08959 (UniProtKB/Swiss-Prot),   F1LMG4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137387   ⟸   XM_063281317
- Peptide Label: isoform X2
- UniProtKB: A6IHH9 (UniProtKB/TrEMBL),   D4A318 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106851   ⟸   ENSRNOT00000163953
Protein Domains
PH   PLD phosphodiesterase   PX

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70496-F1-model_v2 AlphaFold P70496 1-1074 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691272
Promoter ID:EPDNEW_R1790
Type:initiation region
Name:Pld1_2
Description:phospholipase D1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1791  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02113,652,315 - 113,652,375EPDNEW
RGD ID:13691266
Promoter ID:EPDNEW_R1791
Type:initiation region
Name:Pld1_1
Description:phospholipase D1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1790  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02113,696,154 - 113,696,214EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3349 AgrOrtholog
BioCyc Gene G2FUF-53495 BioCyc
Ensembl Genes ENSRNOG00000028156 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000039296 ENTREZGENE
  ENSRNOT00000039308 ENTREZGENE
  ENSRNOT00000163953 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  3.30.1520.10 UniProtKB/Swiss-Prot
  Endonuclease Chain A UniProtKB/Swiss-Prot
InterPro PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  Phox UniProtKB/Swiss-Prot
  PLD-like_dom UniProtKB/Swiss-Prot
  PLipase_D/transphosphatidylase UniProtKB/Swiss-Prot
  PLipase_D_euk UniProtKB/Swiss-Prot
  PLipase_D_fam UniProtKB/Swiss-Prot
  PX_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25096 UniProtKB/Swiss-Prot
NCBI Gene 25096 ENTREZGENE
PANTHER PHOSPHOLIPASE D1 UniProtKB/Swiss-Prot
  PTHR18896 UniProtKB/Swiss-Prot
Pfam PF00169 UniProtKB/Swiss-Prot
  PF00787 UniProtKB/Swiss-Prot
  PLDc UniProtKB/Swiss-Prot
  PLDc_2 UniProtKB/Swiss-Prot
PhenoGen Pld1 PhenoGen
PIRSF Phospholipase_D_euk UniProtKB/Swiss-Prot
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot
  PLD UniProtKB/Swiss-Prot
  PS50195 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028156 RatGTEx
SMART PLDc UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
  SM00312 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  Phospholipase D/nuclease UniProtKB/Swiss-Prot
  SSF64268 UniProtKB/Swiss-Prot
UniProt A0ABK0L8Z9_RAT UniProtKB/TrEMBL
  A6IHH7_RAT UniProtKB/TrEMBL
  A6IHH9 ENTREZGENE, UniProtKB/TrEMBL
  A6IHI1_RAT UniProtKB/TrEMBL
  A6IHI3_RAT UniProtKB/TrEMBL
  A6IHI4_RAT UniProtKB/TrEMBL
  D4A318 ENTREZGENE, UniProtKB/TrEMBL
  F1LMG4 ENTREZGENE, UniProtKB/TrEMBL
  O08959 ENTREZGENE
  O35856 ENTREZGENE
  O54765 ENTREZGENE
  P70496 ENTREZGENE
  P70497 ENTREZGENE
  PLD1_RAT UniProtKB/Swiss-Prot
  Q9QWJ6 ENTREZGENE
UniProt Secondary O08959 UniProtKB/Swiss-Prot
  O35856 UniProtKB/Swiss-Prot
  O54765 UniProtKB/Swiss-Prot
  P70497 UniProtKB/Swiss-Prot
  Q9QWJ6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pld1  phospholipase D1  Pld1  phospholipase D1, phosphatidylcholine-specific  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-05-07 Pld1  phospholipase D1, phosphatidylcholine-specific  Pld1  phospholipase D1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pld1  Phoshpolipase D gene 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs inhibited by neomycin 628523
gene_expression expressed in neuron plasma membrane 70245
gene_function hydrolyzes phosphatidylcholine to produce choline and phosphatidic acid 70245
gene_function exhibits transphosphatidylation activity 628523
gene_physical_interaction binds PKC-alpha through the N terminus 729596
gene_process involved in cAMP-regulated exocytosis in rat parotid acinar cells 628523
gene_process may have a post-docking role in Ca2+ dependent exocytosis 628523
gene_product member of the phospholipase superfamily 628523
gene_regulation activated by small molecular mass GTP-binding proteins 628523
gene_transcript may have two splice variants, A and B 70245