Phb1 (prohibitin 1) - Rat Genome Database

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Gene: Phb1 (prohibitin 1) Rattus norvegicus
Analyze
Symbol: Phb1
Name: prohibitin 1
RGD ID: 3322
Description: Predicted to enable several functions, including complement binding activity; histone deacetylase binding activity; and protein heterodimerization activity. Involved in several processes, including female gonad development; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of smooth muscle cell proliferation. Located in mitochondrial outer membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Is extrinsic component of presynaptic active zone membrane. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB1 (prohibitin 1); INTERACTS WITH (R)-adrenaline; 17alpha-ethynylestradiol; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Phb; prohibitin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Phb1-ps1   Phb1-ps21  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,102,043 - 81,114,815 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1081,102,028 - 81,116,233 (+)EnsemblGRCr8
mRatBN7.21080,605,268 - 80,618,043 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,605,251 - 80,618,042 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1085,553,897 - 85,566,665 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,051,939 - 85,064,707 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,444,228 - 80,456,976 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,476,107 - 83,488,878 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,476,107 - 83,488,878 (+)Ensemblrn6Rnor6.0
Rnor_5.01083,284,048 - 83,296,819 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1079,373,802 - 79,386,571 (+)NCBICelera
RGSC_v3.1199,127,730 - 9,128,666 (+)NCBI
Cytogenetic Map10q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (EXP)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
7,12-dimethyltetraphene  (EXP,IEP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
busulfan  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
choline  (EXP)
chromium trinitrate  (ISO)
chromium(6+)  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
DDE  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
diuron  (EXP)
dopamine  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
eurycomanone  (ISO)
finasteride  (EXP)
flavone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
genistein  (EXP)
geraniol  (EXP,ISO)
hyaluronic acid  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
inulin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (EXP)
lead(0)  (ISO)
leflunomide  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
LY294002  (EXP,ISO)
malathion  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
ochratoxin A  (EXP,ISO)
ozone  (EXP)
paracetamol  (ISO)
paraoxon  (ISO)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
PhIP  (EXP,IEP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
pyrogallol  (ISO)
quinomethionate  (ISO)
rotenone  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
streptozocin  (EXP)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
Tributyltin oxide  (ISO)
triciribine  (EXP)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
antiviral innate immune response  (ISO)
B cell activation  (IEA,ISO,ISS)
cellular response to interleukin-6  (ISO)
DNA biosynthetic process  (IEA,ISO)
epigenetic regulation of gene expression  (ISO)
host-mediated perturbation of viral RNA genome replication  (IEA,ISO)
mitochondrion organization  (IBA,ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (IMP,ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of gene expression  (IMP)
negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by competitive promoter binding  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
ovarian follicle atresia  (IEP)
ovarian follicle development  (IEP)
positive regulation of complement activation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immunoglobulin production  (IEA,ISO,ISS)
positive regulation of interleukin-17 production  (ISO,ISS)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO,ISS)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
progesterone receptor signaling pathway  (ISO)
protein stabilization  (ISO)
regulation of DNA-templated transcription  (ISO)
response to cytokine  (IEP)
response to ethanol  (IEP)
response to immobilization stress  (IEP)
response to peptide hormone  (IEP)
response to xenobiotic stimulus  (IEP)
RIG-I signaling pathway  (ISO)
symbiont entry into host cell  (IEA,ISO)
T-helper 17 type immune response  (ISO,ISS)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Regions of evolutionary conservation between the rat and human prohibitin-encoding genes. Altus MS, etal., Gene 1995 Jun 9;158(2):291-4.
2. Prohibitin gene is overexpressed but not mutated in rat bladder carcinomas and cell lines. Asamoto M and Cohen SM, Cancer Lett. 1994 Aug 15;83(1-2):201-7.
3. S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver. Bailey SM, etal., Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G857-67. Epub 2006 Jul 6.
4. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
5. Two-dimensional gel analysis of human endometrial proteins: characterization of proteins with increased expression in hyperplasia and adenocarcinoma. Byrjalsen I, etal., Mol Hum Reprod. 1999 Aug;5(8):748-56.
6. Prohibitin 3' untranslated region polymorphism and breast cancer risk. Campbell IG, etal., Cancer Epidemiol Biomarkers Prev. 2003 Nov;12(11 Pt 1):1273-4.
7. Regulatory effects of Prohibitin 1 on proliferation and apoptosis of pulmonary arterial smooth muscle cells in monocrotaline-induced PAH rats. Cao YY, etal., Life Sci. 2020 Jun 1;250:117548. doi: 10.1016/j.lfs.2020.117548. Epub 2020 Mar 12.
8. Apoptosis of rat granulosa cells after staurosporine and serum withdrawal is suppressed by adenovirus-directed overexpression of prohibitin. Chowdhury I, etal., Endocrinology. 2007 Jan;148(1):206-17. Epub 2006 Oct 12.
9. Gonadotropin-releasing hormone attenuates pregnancy-associated thymic involution and modulates the expression of antiproliferative gene product prohibitin. Dixit VD, etal., Endocrinology. 2003 Apr;144(4):1496-505.
10. Composition of the synaptic PSD-95 complex. Dosemeci A, etal., Mol Cell Proteomics. 2007 Oct;6(10):1749-60. doi: 10.1074/mcp.M700040-MCP200. Epub 2007 Jul 9.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Prohibitin suppresses renal interstitial fibroblasts proliferation and phenotypic change induced by transforming growth factor-beta1. Guo W, etal., Mol Cell Biochem. 2007 Jan;295(1-2):167-77. Epub 2006 Oct 17.
14. Prohibitin, an antiproliferative protein, is localized to mitochondria. Ikonen E, etal., FEBS Lett. 1995 Jan 30;358(3):273-7.
15. Single nucleotide polymorphism in prohibitin 39 untranslated region and breast-cancer susceptibility. Jupe ER, etal., Lancet. 2001 May 19;357(9268):1588-9.
16. Proteomic characterization of the effects of clofibrate on protein expression in rat liver. Leonard JF, etal., Proteomics. 2006 Mar;6(6):1915-33.
17. Proteomic analysis of mitochondrial proteins in cardiomyocytes from chronic stressed rat. Liu XH, etal., Proteomics. 2004 Oct;4(10):3167-76.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells. Nuell MJ, etal., Mol Cell Biol 1991 Mar;11(3):1372-81.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Proteomic identification of oxidized mitochondrial proteins following experimental traumatic brain injury. Opii WO, etal., J Neurotrauma. 2007 May;24(5):772-89.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer. Sato T, etal., Cancer Res. 1992 Mar 15;52(6):1643-6.
28. cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenzanthracene. Shan L, etal., Carcinogenesis. 2002 Oct;23(10):1561-8.
29. A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia. Smalla KH, etal., Mol Psychiatry. 2008 Sep;13(9):878-96. doi: 10.1038/mp.2008.60. Epub 2008 May 27.
30. The prohibitin 3' untranslated region polymorphism is not associated with risk of ovarian cancer. Spurdle AB, etal., Gynecol Oncol. 2003 Jul;90(1):145-9.
31. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
32. Prohibitin expression is decreased in the regenerating liver but not in chemically induced hepatic tumors in rats. Tanno S, etal., Jpn J Cancer Res. 1997 Dec;88(12):1155-64.
33. Regulation of prohibitin expression during follicular development and atresia in the mammalian ovary. Thompson WE, etal., Biol Reprod. 2004 Jul;71(1):282-90. Epub 2004 Mar 17.
34. The significance of prohibitin and c-Met/hepatocyte growth factor receptor in the progression of cervical adenocarcinoma. Tsai HW, etal., Hum Pathol. 2006 Feb;37(2):198-204. Epub 2005 Dec 20.
35. Prohibitin identified by proteomic analysis of prostate biopsies distinguishes hyperplasia and cancer. Ummanni R, etal., Cancer Lett. 2008 Mar 31;.
36. Prohibitin in the pathogenesis of transitional cell bladder cancer. Wu TF, etal., Anticancer Res. 2007 Mar-Apr;27(2):895-900.
Additional References at PubMed
PMID:11302691   PMID:11884367   PMID:12065415   PMID:12466959   PMID:12566959   PMID:12865426   PMID:14500729   PMID:14651853   PMID:15274632   PMID:15489334   PMID:16210410   PMID:16854843  
PMID:16964284   PMID:17008324   PMID:17070910   PMID:17324931   PMID:17597094   PMID:17634366   PMID:18480465   PMID:18487222   PMID:18614015   PMID:18958584   PMID:19906925   PMID:19946888  
PMID:20030709   PMID:20403401   PMID:20458337   PMID:20832420   PMID:20833797   PMID:20959514   PMID:21179762   PMID:21256116   PMID:21914039   PMID:22238093   PMID:22417827   PMID:22711522  
PMID:23254195   PMID:23376485   PMID:23921388   PMID:23992168   PMID:24096434   PMID:24185039   PMID:24204768   PMID:24625528   PMID:24732013   PMID:25031298   PMID:25463519   PMID:26048717  
PMID:26310625   PMID:26316108   PMID:26623724   PMID:27044659   PMID:27854077   PMID:28376086   PMID:29476059   PMID:29867124   PMID:30967257   PMID:34219469   PMID:35352799   PMID:36453777  


Genomics

Comparative Map Data
Phb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,102,043 - 81,114,815 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1081,102,028 - 81,116,233 (+)EnsemblGRCr8
mRatBN7.21080,605,268 - 80,618,043 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,605,251 - 80,618,042 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1085,553,897 - 85,566,665 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,051,939 - 85,064,707 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,444,228 - 80,456,976 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,476,107 - 83,488,878 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,476,107 - 83,488,878 (+)Ensemblrn6Rnor6.0
Rnor_5.01083,284,048 - 83,296,819 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1079,373,802 - 79,386,571 (+)NCBICelera
RGSC_v3.1199,127,730 - 9,128,666 (+)NCBI
Cytogenetic Map10q26NCBI
PHB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381749,404,052 - 49,414,882 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1749,404,009 - 49,414,905 (-)Ensemblhg38GRCh38
GRCh371747,481,414 - 47,492,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,836,419 - 44,847,241 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341744,836,418 - 44,847,241NCBI
Celera1743,936,440 - 43,947,262 (-)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1742,846,458 - 42,857,310 (-)NCBIHuRef
CHM1_11747,546,565 - 47,557,421 (-)NCBICHM1_1
T2T-CHM13v2.01750,267,083 - 50,277,908 (-)NCBIT2T-CHM13v2.0
Phb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,557,783 - 95,571,599 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1195,557,783 - 95,571,599 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381195,666,957 - 95,680,773 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,666,957 - 95,680,773 (+)Ensemblmm10GRCm38
MGSCv371195,528,271 - 95,542,087 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361195,483,105 - 95,496,855 (+)NCBIMGSCv36mm8
Celera11105,306,168 - 105,322,388 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Phb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545112,110,290 - 12,120,124 (+)Ensembl
ChiLan1.0NW_00495545112,110,290 - 12,119,870 (+)NCBIChiLan1.0ChiLan1.0
PHB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,752,626 - 15,762,789 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,718,717 - 17,728,876 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0178,189,555 - 8,200,491 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1178,175,912 - 8,186,790 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl178,175,968 - 8,186,790 (+)EnsemblpanPan2panpan1.1
PHB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,525,711 - 25,536,722 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,526,649 - 25,536,722 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha924,985,397 - 24,996,403 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0926,321,934 - 26,332,949 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,185,622 - 26,347,114 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,089,828 - 25,100,839 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,349,147 - 25,360,155 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0925,478,042 - 25,489,037 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Phb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560224,936,269 - 24,948,093 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649012,127,065 - 12,138,870 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649012,127,065 - 12,138,870 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,596,523 - 25,609,706 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11225,596,520 - 25,609,693 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,535,912 - 25,549,084 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PHB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11669,805,968 - 69,816,792 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1669,806,923 - 69,816,754 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607740,910,348 - 40,921,223 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247955,556,450 - 5,565,988 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247955,556,728 - 5,565,969 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Phb1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1958,714,369 - 58,727,259 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Phb1
145 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:367
Count of miRNA genes:197
Interacting mature miRNAs:227
Transcripts:ENSRNOT00000075733
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107870758585720738Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)107369533983061459Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)107369533983061459Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313384503487Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107395020983959619Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH127963  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19p13UniSTS
Cytogenetic MapXq14UniSTS
Cytogenetic MapXq21UniSTS
Cytogenetic Map6q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001430076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC072518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC097304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M61219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U17178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000075733   ⟹   ENSRNOP00000066502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1081,102,028 - 81,116,233 (+)Ensembl
mRatBN7.2 Ensembl1080,605,251 - 80,618,042 (+)Ensembl
Rnor_6.0 Ensembl1083,476,107 - 83,488,878 (+)Ensembl
RefSeq Acc Id: NM_031851   ⟹   NP_114039
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,102,043 - 81,114,815 (+)NCBI
mRatBN7.21080,605,268 - 80,618,042 (+)NCBI
Rnor_6.01083,476,107 - 83,488,878 (+)NCBI
Rnor_5.01083,284,048 - 83,296,819 (+)NCBI
Celera1079,373,802 - 79,386,571 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085263   ⟹   XP_038941191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,102,088 - 81,114,083 (+)NCBI
mRatBN7.21080,605,318 - 80,618,043 (+)NCBI
RefSeq Acc Id: XM_063268456   ⟹   XP_063124526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,102,072 - 81,114,083 (+)NCBI
RefSeq Acc Id: NP_114039   ⟸   NM_031851
- UniProtKB: Q4V8M6 (UniProtKB/Swiss-Prot),   P67779 (UniProtKB/Swiss-Prot),   A6HIA7 (UniProtKB/TrEMBL),   A6HHC9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066502   ⟸   ENSRNOT00000075733
RefSeq Acc Id: XP_038941191   ⟸   XM_039085263
- Peptide Label: isoform X1
- UniProtKB: P67779 (UniProtKB/Swiss-Prot),   Q4V8M6 (UniProtKB/Swiss-Prot),   A6HIA7 (UniProtKB/TrEMBL),   A6HHC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124526   ⟸   XM_063268456
- Peptide Label: isoform X1
Protein Domains
Band

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P67779-F1-model_v2 AlphaFold P67779 1-272 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697620
Promoter ID:EPDNEW_R8145
Type:multiple initiation site
Name:Phb_1
Description:prohibitin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01083,476,090 - 83,476,150EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3322 AgrOrtholog
BioCyc Gene G2FUF-23537 BioCyc
Ensembl Genes ENSRNOG00000046799 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000075733 ENTREZGENE
  ENSRNOT00000075733.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.479.30 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7105633 IMAGE-MGC_LOAD
  IMAGE:7441791 IMAGE-MGC_LOAD
InterPro Band_7 UniProtKB/Swiss-Prot
  Band_7/SPFH_dom_sf UniProtKB/Swiss-Prot
  Prohibitin UniProtKB/Swiss-Prot
KEGG Report rno:25344 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114298 IMAGE-MGC_LOAD
  MGC:91613 IMAGE-MGC_LOAD
NCBI Gene 25344 ENTREZGENE
PANTHER PROHIBITIN UniProtKB/Swiss-Prot
  PTHR23222 UniProtKB/Swiss-Prot
Pfam Band_7 UniProtKB/Swiss-Prot
PhenoGen Phb1 PhenoGen
PRINTS PROHIBITIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046799 RatGTEx
SMART PHB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF117892 UniProtKB/Swiss-Prot
UniProt A6HHC9 ENTREZGENE, UniProtKB/TrEMBL
  A6HIA7 ENTREZGENE, UniProtKB/TrEMBL
  P67779 ENTREZGENE, UniProtKB/Swiss-Prot
  Q4V8M6 ENTREZGENE
UniProt Secondary P24142 UniProtKB/Swiss-Prot
  Q4V8M6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-11-11 Phb1  prohibitin 1  Phb  prohibitin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Phb  Prohibitin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology has homology to the Drosophila Cc gene 729436