RGD Reference Report - Prohibitin, an antiproliferative protein, is localized to mitochondria. - Rat Genome Database

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Prohibitin, an antiproliferative protein, is localized to mitochondria.

Authors: Ikonen, E  Fiedler, K  Parton, RG  Simons, K 
Citation: Ikonen E, etal., FEBS Lett. 1995 Jan 30;358(3):273-7.
RGD ID: 1601307
Pubmed: PMID:7843414   (View Abstract at PubMed)

Prohibitin is a ubiquitously expressed protein with antiproliferative properties. When rat prohibitin tagged with a carboxy-terminal c-Myc epitope was expressed in baby hamster kidney cells the protein was targeted to mitochondria. In immunofluorescence microscopy prohibitin colocalized with a mitochondrial marker E3. Immunoelectron microscopy revealed that prohibitin was associated with the periphery of mitochondria. The amino-terminus of prohibitin shares characteristics of the known mitochondrial import signals, and positioning of the tag at the N-terminus causes accumulation of the protein in the cytoplasm. These findings help to direct functional studies on prohibitin and suggest that a mitochondrial protein may act as a tumor suppressor.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
mitochondrial outer membrane  IDA 1601307 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Phb1  (prohibitin 1)


Additional Information