Pfkl (phosphofructokinase, liver type) - Rat Genome Database

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Gene: Pfkl (phosphofructokinase, liver type) Rattus norvegicus
Analyze
Symbol: Pfkl
Name: phosphofructokinase, liver type
RGD ID: 3311
Description: Enables several functions, including 6-phosphofructokinase activity; anion binding activity; and identical protein binding activity. Involved in fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; and glycolytic process. Predicted to be located in cytosol. Predicted to be part of 6-phosphofructokinase complex. Predicted to be active in membrane. Orthologous to human PFKL (phosphofructokinase, liver type); PARTICIPATES IN glycolysis pathway; glycolysis/gluconeogenesis pathway; fructose and mannose metabolic pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 6-phosphofructokinase type B; 6-phosphofructokinase, liver type; ATP-dependent 6-phosphofructokinase, liver type; ATP-PFK; PFK-B; PFK-L; phosphofructo-1-kinase isozyme B; phosphofructokinase 1; phosphofructokinase, liver; phosphofructokinase, liver, B-type; phosphohexokinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,663,907 - 10,685,967 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2010,663,955 - 10,685,966 (+)EnsemblGRCr8
mRatBN7.22010,664,285 - 10,686,324 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,664,272 - 10,686,315 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2011,363,758 - 11,385,830 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,724,657 - 10,746,730 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,196,584 - 11,218,579 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,393,860 - 11,415,889 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,393,877 - 11,415,882 (+)Ensemblrn6Rnor6.0
Rnor_5.02013,563,748 - 13,585,941 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42011,009,359 - 11,032,511 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2012,170,125 - 12,192,155 (+)NCBICelera
RGSC_v3.12011,009,585 - 11,032,737 (+)NCBI
RH 3.4 Map20140.5RGD
Cytogenetic Map20p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aluminium phosphide  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
diclofenac  (ISO)
Diosbulbin B  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
flumequine  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
fructose  (EXP)
gentamycin  (EXP)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nitrates  (ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
Pf-06840003  (ISO)
phenylephrine  (EXP)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
protosappanin A  (ISO)
ranitidine  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
6-phosphofructokinase complex  (IBA,IEA,ISO)
cytoplasm  (IEA)
cytosol  (IEA,ISO)
membrane  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa Zn(2+)-binding protein (parathymosin). Brand IA and Heinickel A, J Biol Chem. 1991 Nov 5;266(31):20984-9.
2. Inactivation of phosphofructokinase by glucagon in rat hepatocytes. Castano JG, etal., J Biol Chem. 1979 Jul 10;254(13):5576-9.
3. Quantification of liver and kidney phosphofructokinase by radioimmunoassay in fed, starved and alloxan-diabetic rats. Donofrio JC, etal., Biochem J. 1984 Dec 1;224(2):541-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Critical switch of the metabolic fluxes by phosphofructo-2-kinase:fructose-2,6-bisphosphatase. A kinetic model. Goldstein BN and Maevsky AA, FEBS Lett 2002 Dec 18;532(3):295-9.
7. Relationships between concentration of hepatic intermediary metabolites and induction of the key glycolytic enzymes in vivo. Gunn JM and Taylor CB, Biochem J. 1973 Nov;136(3):455-65.
8. Rat-liver-type phosphofructokinase mRNA. Structure, tissue distribution and regulation. Hotta K, etal., Eur J Biochem 1991 Dec 5;202(2):293-8.
9. Stimulation of glycolysis and accumulation of a stimulator of phosphofructokinase in hepatocytes incubated with vasopressin. Hue L, etal., Biochem J. 1981 Mar 15;194(3):1023-6.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Control in vivo of rat liver phosphofructokinase by glucagon and nutritional changes. Nieto A and Castano JG, Biochem J. 1980 Mar 15;186(3):953-7.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. PROPERTIES OF PHOSPHOFRUCTOKINASE FROM RAT LIVER AND THEIR RELATION TO THE CONTROL OF GLYCOLYSIS AND GLUCONEOGENESIS. UNDERWOOD AH and NEWSHOLME EA, Biochem J. 1965 Jun;95:868-75.
22. Isoenzymes of phosphofructokinase in the rat. Demonstration of the three non-identical subunits by biochemical, immunochemical and kinetic studies. Vora S, etal., Biochem J. 1985 Jul 15;229(2):333-41.
23. Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate. Wimhurst JM and Manchester KL, Biochem J. 1973 May;134(1):143-56.
Additional References at PubMed
PMID:2521854   PMID:2960695   PMID:6227635   PMID:6444532   PMID:6444721   PMID:6451249   PMID:7825568   PMID:8172601   PMID:8780720   PMID:9287040   PMID:16780588   PMID:19056867  
PMID:19199708   PMID:19946888   PMID:20458337   PMID:22871113   PMID:22923583   PMID:23376485   PMID:25416956   PMID:30053369  


Genomics

Comparative Map Data
Pfkl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,663,907 - 10,685,967 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2010,663,955 - 10,685,966 (+)EnsemblGRCr8
mRatBN7.22010,664,285 - 10,686,324 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,664,272 - 10,686,315 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2011,363,758 - 11,385,830 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,724,657 - 10,746,730 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,196,584 - 11,218,579 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,393,860 - 11,415,889 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,393,877 - 11,415,882 (+)Ensemblrn6Rnor6.0
Rnor_5.02013,563,748 - 13,585,941 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42011,009,359 - 11,032,511 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2012,170,125 - 12,192,155 (+)NCBICelera
RGSC_v3.12011,009,585 - 11,032,737 (+)NCBI
RH 3.4 Map20140.5RGD
Cytogenetic Map20p12NCBI
PFKL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,300,053 - 44,327,373 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2144,300,017 - 44,327,377 (+)Ensemblhg38GRCh38
GRCh372145,719,936 - 45,747,256 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,544,358 - 44,571,689 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342144,544,357 - 44,571,684NCBI
Celera2130,825,177 - 30,852,489 (+)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2131,062,995 - 31,117,561 (+)NCBIHuRef
CHM1_12145,280,766 - 45,308,102 (+)NCBICHM1_1
T2T-CHM13v2.02142,654,110 - 42,681,430 (+)NCBIT2T-CHM13v2.0
Pfkl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391077,822,781 - 77,845,641 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1077,822,781 - 77,845,917 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381077,986,947 - 78,009,807 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1077,986,947 - 78,010,083 (-)Ensemblmm10GRCm38
MGSCv371077,449,692 - 77,472,541 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361077,390,400 - 77,412,878 (-)NCBIMGSCv36mm8
Celera1079,025,947 - 79,048,797 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Pfkl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,131,022 - 41,145,394 (-)Ensembl
ChiLan1.0NW_00495540741,131,022 - 41,145,392 (-)NCBIChiLan1.0ChiLan1.0
PFKL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22240,307,925 - 40,334,593 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12135,158,060 - 35,184,538 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02130,557,576 - 30,584,231 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12143,857,293 - 43,878,380 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2143,857,052 - 43,878,380 (+)EnsemblpanPan2panpan1.1
PFKL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13138,153,638 - 38,178,741 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3138,156,451 - 38,178,507 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3137,313,615 - 37,335,899 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03137,703,738 - 37,726,021 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3137,703,734 - 37,726,017 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13137,570,896 - 37,593,253 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03137,551,678 - 37,573,926 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03138,049,651 - 38,071,966 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pfkl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497137,350,253 - 37,373,807 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650093,854 - 117,653 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650094,016 - 117,598 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFKL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13207,167,281 - 207,191,671 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113207,167,287 - 207,191,688 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213217,047,266 - 217,071,450 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PFKL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,035,409 - 88,063,376 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,035,347 - 88,063,442 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605416,150,512 - 16,178,473 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfkl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474529,823,317 - 29,842,881 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474529,826,202 - 29,842,859 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pfkl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1181,278,332 - 1,300,763 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pfkl
313 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:56
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000001625
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20904109911115921Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
RH94598  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22010,686,160 - 10,686,250 (+)MAPPERmRatBN7.2
Rnor_6.02011,415,726 - 11,415,815NCBIRnor6.0
Rnor_5.02013,585,778 - 13,585,867UniSTSRnor5.0
RGSC_v3.42011,032,357 - 11,032,446UniSTSRGSC3.4
Celera2012,192,001 - 12,192,090UniSTS
RH 3.4 Map20140.5UniSTS
Cytogenetic Map20p12UniSTS
RH130425  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82010,685,680 - 10,685,884 (+)Marker Load Pipeline
mRatBN7.22010,686,036 - 10,686,240 (+)MAPPERmRatBN7.2
Rnor_6.02011,415,603 - 11,415,805NCBIRnor6.0
Rnor_5.02013,585,655 - 13,585,857UniSTSRnor5.0
RGSC_v3.42011,032,233 - 11,032,436UniSTSRGSC3.4
Celera2012,191,876 - 12,192,080UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001625   ⟹   ENSRNOP00000001625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2010,663,958 - 10,685,966 (+)Ensembl
mRatBN7.2 Ensembl2010,664,272 - 10,686,315 (+)Ensembl
Rnor_6.0 Ensembl2011,393,877 - 11,415,882 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000147989   ⟹   ENSRNOP00000100786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2010,663,955 - 10,685,966 (+)Ensembl
RefSeq Acc Id: NM_013190   ⟹   NP_037322
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,663,965 - 10,685,958 (+)NCBI
mRatBN7.22010,664,318 - 10,686,315 (+)NCBI
Rnor_6.02011,393,887 - 11,415,880 (+)NCBI
Rnor_5.02013,563,748 - 13,585,941 (+)NCBI
RGSC_v3.42011,009,359 - 11,032,511 (+)RGD
Celera2012,170,125 - 12,192,155 (+)RGD
Sequence:
RefSeq Acc Id: XM_008772798   ⟹   XP_008771020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,663,907 - 10,685,967 (+)NCBI
mRatBN7.22010,664,286 - 10,686,324 (+)NCBI
Rnor_6.02011,393,860 - 11,415,889 (+)NCBI
Sequence:
RefSeq Acc Id: NP_037322   ⟸   NM_013190
- UniProtKB: P30835 (UniProtKB/Swiss-Prot),   Q6P783 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771020   ⟸   XM_008772798
- Peptide Label: isoform X1
- UniProtKB: Q6P783 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001625   ⟸   ENSRNOT00000001625
Ensembl Acc Id: ENSRNOP00000100786   ⟸   ENSRNOT00000147989
Protein Domains
Phosphofructokinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30835-F1-model_v2 AlphaFold P30835 1-780 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701491
Promoter ID:EPDNEW_R12014
Type:initiation region
Name:Pfkl_1
Description:phosphofructokinase, liver type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02011,393,886 - 11,393,946EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3311 AgrOrtholog
BioCyc Gene G2FUF-4273 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
BioCyc Pathway Image ANAGLYCOLYSIS-PWY BioCyc
Ensembl Genes ENSRNOG00000001214 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001625 ENTREZGENE
  ENSRNOT00000001625.6 UniProtKB/Swiss-Prot
  ENSRNOT00000147989 ENTREZGENE
Gene3D-CATH 3.40.50.450 UniProtKB/Swiss-Prot
  3.40.50.460 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598160 IMAGE-MGC_LOAD
InterPro 6-Pfructokinase_euk UniProtKB/Swiss-Prot
  ATP_PFK UniProtKB/Swiss-Prot
  PFK_vert-type UniProtKB/Swiss-Prot
  Phosphofructokinase_CS UniProtKB/Swiss-Prot
  Phosphofructokinase_dom UniProtKB/Swiss-Prot
  PKF_sf UniProtKB/Swiss-Prot
KEGG Report rno:25741 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72281 IMAGE-MGC_LOAD
NCBI Gene 25741 ENTREZGENE
PANTHER ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, LIVER TYPE UniProtKB/Swiss-Prot
  PHOSPHOFRUCTOKINASE UniProtKB/Swiss-Prot
Pfam PFK UniProtKB/Swiss-Prot
PhenoGen Pfkl PhenoGen
PIRSF ATP_PFK_euk UniProtKB/Swiss-Prot
PRINTS PHFRCTKINASE UniProtKB/Swiss-Prot
PROSITE PHOSPHOFRUCTOKINASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001214 RatGTEx
Superfamily-SCOP SSF53784 UniProtKB/Swiss-Prot
TIGR TC228648
UniProt A0ABK0KZS4_RAT UniProtKB/TrEMBL
  A6JK50_RAT UniProtKB/TrEMBL
  A6JK51_RAT UniProtKB/TrEMBL
  A6JK52_RAT UniProtKB/TrEMBL
  P30835 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6P783 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Pfkl  phosphofructokinase, liver type  Pfkl  phosphofructokinase, liver  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Pfkl  phosphofructokinase, liver  Pfkl  phosphofructokinase, liver, B-type  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pfkl  Phosphofructokinase, liver, B-type      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains homodimer with each of its subunits contains an N-terminal kinase domain and a C-terminal bisphosphatase domain 633699
gene_regulation regulated by cyclic AMP-dependent protein kinase (cAMP-PK) 633699