Pc (pyruvate carboxylase) - Rat Genome Database

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Gene: Pc (pyruvate carboxylase) Rattus norvegicus
Analyze
Symbol: Pc
Name: pyruvate carboxylase
RGD ID: 3262
Description: Enables biotin binding activity and pyruvate carboxylase activity. Involved in gluconeogenesis and positive regulation of phospholipid biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase); PARTICIPATES IN gluconeogenesis pathway; alanine metabolic pathway; citric acid cycle pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PCB; Pcx; pyruvate carboxylase, mitochondrial; pyruvic carboxylase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81211,228,708 - 211,327,792 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1211,228,731 - 211,329,940 (+)EnsemblGRCr8
mRatBN7.21201,799,374 - 201,898,412 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,804,267 - 201,898,380 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1210,152,085 - 210,251,300 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01217,244,857 - 217,343,799 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,935,881 - 210,034,819 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,759,157 - 219,859,854 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,759,183 - 219,859,848 (+)Ensemblrn6Rnor6.0
Rnor_5.01226,626,831 - 226,726,350 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41207,112,853 - 207,212,737 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1199,343,224 - 199,439,273 (+)NCBICelera
RGSC_v3.11207,266,305 - 207,366,189 (+)NCBI
RH 3.4 Map11554.4RGD
Cytogenetic Map1q43NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-phenylbutyric acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzatropine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium atom  (EXP)
clofibrate  (EXP)
clomipramine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
duvoglustat  (ISO)
elemental selenium  (ISO)
entacapone  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furfural  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glycidyl methacrylate  (ISO)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP)
imipramine  (EXP)
indometacin  (EXP)
inulin  (ISO)
iodide salt  (EXP)
isoniazide  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ethionine  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP,ISO)
mifepristone  (EXP,ISO)
Muraglitazar  (EXP)
N-hexadecanoylsphingosine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
nobiletin  (ISO)
obeticholic acid  (ISO)
oleic acid  (EXP)
omeprazole  (EXP)
orotic acid  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP,ISO)
Propiverine  (EXP)
resveratrol  (ISO)
rimonabant  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenic acid  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
triadimefon  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
zearalenone  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
mitochondrial matrix  (IEA)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver. Ballard FJ and Hanson RW, Biochem J. 1967 Sep;104(3):866-71.
2. Amerindian pyruvate carboxylase deficiency is associated with two distinct missense mutations. Carbone MA, etal., Am J Hum Genet 1998 Jun;62(6):1312-9.
3. Intron retention and frameshift mutations result in severe pyruvate carboxylase deficiency in two male siblings. Carbone MA, etal., Hum Mutat. 2002 Jul;20(1):48-56.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Cloning, sequencing and expression of rat liver pyruvate carboxylase. Jitrapakdee S, etal., Biochem J 1996 Jun 1;316 ( Pt 2):631-7.
7. Structure, mechanism and regulation of pyruvate carboxylase. Jitrapakdee S, etal., Biochem J. 2008 Aug 1;413(3):369-87.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Regulation of pyruvate carboxylase activity by calcium in intact rat liver mitochondria. Kimmich GA and Rasmussen H, J Biol Chem. 1969 Jan 10;244(1):190-9.
10. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. The sequence of the rat pyruvate carboxylase-encoding cDNA. Lehn DA, etal., Gene 1995 Nov 20;165(2):331-2.
12. Enhanced rat beta-cell proliferation in 60% pancreatectomized islets by increased glucose metabolic flux through pyruvate carboxylase pathway. Liu YQ, etal., Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E471-8. Epub 2004 Oct 26.
13. beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats. Liu YQ, etal., J Biol Chem 2002 Oct 18;277(42):39163-8.
14. Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells. MacDonald MJ, etal., Arch Biochem Biophys. 2013 Apr 1;532(1):23-31. doi: 10.1016/j.abb.2013.01.002. Epub 2013 Jan 25.
15. cDNA cloning of human kidney pyruvate carboxylase. MacKay N, etal., Biochem Biophys Res Commun 1994 Jul 29;202(2):1009-14.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. Pharmacological biotin supplementation maintains biotin status and function in rats administered dietary carbamazepine. Rathman SC, etal., J Nutr. 2003 Sep;133(9):2857-62.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26. Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate. Wimhurst JM and Manchester KL, Biochem J. 1973 May;134(1):143-56.
Additional References at PubMed
PMID:3178228   PMID:8687459   PMID:12477932   PMID:12865426   PMID:14651853   PMID:16729965   PMID:16740637   PMID:16752176   PMID:17408383   PMID:18297087   PMID:18614015   PMID:18686030  
PMID:18697738   PMID:18769905   PMID:20001964   PMID:21700703   PMID:23861867   PMID:25054881   PMID:25931508   PMID:26316108   PMID:26767982   PMID:29476059   PMID:30053369   PMID:32357304  


Genomics

Comparative Map Data
Pc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81211,228,708 - 211,327,792 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1211,228,731 - 211,329,940 (+)EnsemblGRCr8
mRatBN7.21201,799,374 - 201,898,412 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,804,267 - 201,898,380 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1210,152,085 - 210,251,300 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01217,244,857 - 217,343,799 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,935,881 - 210,034,819 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,759,157 - 219,859,854 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,759,183 - 219,859,848 (+)Ensemblrn6Rnor6.0
Rnor_5.01226,626,831 - 226,726,350 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41207,112,853 - 207,212,737 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1199,343,224 - 199,439,273 (+)NCBICelera
RGSC_v3.11207,266,305 - 207,366,189 (+)NCBI
RH 3.4 Map11554.4RGD
Cytogenetic Map1q43NCBI
PC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381166,848,420 - 66,958,383 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1166,848,208 - 66,958,524 (-)Ensemblhg38GRCh38
GRCh371166,615,891 - 66,725,854 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,372,573 - 66,482,423 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341166,372,572 - 66,431,998NCBI
Celera1163,944,403 - 64,054,124 (-)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1162,944,043 - 63,053,644 (-)NCBIHuRef
CHM1_11166,499,596 - 66,607,614 (-)NCBICHM1_1
T2T-CHM13v2.01166,844,694 - 66,952,886 (-)NCBIT2T-CHM13v2.0
Pcx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,560,500 - 4,671,780 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,560,500 - 4,671,780 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38194,510,472 - 4,621,752 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,510,472 - 4,621,752 (+)Ensemblmm10GRCm38
MGSCv37194,510,472 - 4,621,752 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36194,594,346 - 4,621,698 (+)NCBIMGSCv36mm8
Celera194,381,239 - 4,492,934 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.07NCBI
Pc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542218,420,596 - 18,536,436 (+)Ensembl
ChiLan1.0NW_00495542218,421,100 - 18,536,591 (+)NCBIChiLan1.0ChiLan1.0
PC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,074,256 - 68,186,372 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,116,844 - 69,229,111 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,205,644 - 62,317,917 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11165,527,285 - 65,639,533 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1165,527,662 - 65,551,396 (-)EnsemblpanPan2panpan1.1
PC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,406,994 - 50,507,677 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,412,272 - 50,507,669 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1849,016,958 - 49,117,517 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01851,357,399 - 51,457,857 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1851,357,414 - 51,457,857 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11850,541,749 - 50,642,299 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01850,121,287 - 50,221,660 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,910,958 - 51,011,409 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049476,235,346 - 6,350,686 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,677,583 - 2,793,197 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,677,770 - 2,793,033 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl25,518,517 - 5,587,797 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.125,566,608 - 5,587,797 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.224,594,815 - 4,609,731 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2p17NCBI
PC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.117,310,738 - 7,418,357 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl17,357,246 - 7,417,998 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038104,598,850 - 104,705,939 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476719,480,522 - 19,614,051 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476719,481,158 - 19,601,036 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v123,044,145 - 3,142,564 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pc
436 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:128
Interacting mature miRNAs:151
Transcripts:ENSRNOT00000026316
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat

Markers in Region
D1Got187  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21201,818,238 - 201,818,406 (+)MAPPERmRatBN7.2
Rnor_6.01219,778,018 - 219,778,182NCBIRnor6.0
Celera1199,362,095 - 199,362,261UniSTS
RH 3.4 Map11554.5RGD
RH 3.4 Map11554.5UniSTS
RH 2.0 Map11134.4RGD
Cytogenetic Map1q42UniSTS
RH94624  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21201,898,189 - 201,898,375 (+)MAPPERmRatBN7.2
Rnor_6.01219,859,658 - 219,859,843NCBIRnor6.0
Rnor_5.01226,726,138 - 226,726,323UniSTSRnor5.0
RGSC_v3.41207,212,546 - 207,212,731UniSTSRGSC3.4
Celera1199,439,082 - 199,439,267UniSTS
RH 3.4 Map11554.4UniSTS
Cytogenetic Map1q42UniSTS
BI301314  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21201,845,141 - 201,845,307 (+)MAPPERmRatBN7.2
Rnor_6.01219,805,009 - 219,805,174NCBIRnor6.0
Rnor_5.01226,671,415 - 226,671,580UniSTSRnor5.0
RGSC_v3.41207,159,556 - 207,159,721UniSTSRGSC3.4
Celera1199,389,173 - 199,389,338UniSTS
RH 3.4 Map11555.9UniSTS
Cytogenetic Map1q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 90 59 6 354 190 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001439916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC119332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U32314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U36585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U54551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U54552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U54553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U54554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U54555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U81515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000026316   ⟹   ENSRNOP00000026316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1211,239,090 - 211,329,940 (+)Ensembl
mRatBN7.2 Ensembl1201,809,771 - 201,898,380 (+)Ensembl
Rnor_6.0 Ensembl1219,759,183 - 219,859,848 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082388   ⟹   ENSRNOP00000075317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1211,228,731 - 211,327,791 (+)Ensembl
mRatBN7.2 Ensembl1201,804,267 - 201,898,376 (+)Ensembl
Rnor_6.0 Ensembl1219,764,001 - 219,859,844 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087432   ⟹   ENSRNOP00000068757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1211,301,230 - 211,327,791 (+)Ensembl
mRatBN7.2 Ensembl1201,872,018 - 201,898,380 (+)Ensembl
Rnor_6.0 Ensembl1219,833,299 - 219,859,847 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106490   ⟹   ENSRNOP00000086416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1201,835,211 - 201,898,380 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119641   ⟹   ENSRNOP00000092227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1211,228,878 - 211,329,940 (+)Ensembl
mRatBN7.2 Ensembl1201,873,788 - 201,898,380 (+)Ensembl
RefSeq Acc Id: NM_012744   ⟹   NP_036876
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,228,868 - 211,327,792 (+)NCBI
mRatBN7.21201,799,448 - 201,898,381 (+)NCBI
Rnor_6.01219,759,183 - 219,859,849 (+)NCBI
Rnor_5.01226,626,831 - 226,726,350 (+)NCBI
RGSC_v3.41207,112,853 - 207,212,737 (+)RGD
Celera1199,343,224 - 199,439,273 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230691   ⟹   XP_006230753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,228,708 - 211,327,792 (+)NCBI
mRatBN7.21201,799,374 - 201,898,376 (+)NCBI
Rnor_6.01219,759,157 - 219,859,844 (+)NCBI
Rnor_5.01226,626,831 - 226,726,350 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230692   ⟹   XP_006230754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,301,497 - 211,327,792 (+)NCBI
mRatBN7.21201,872,078 - 201,898,412 (+)NCBI
Rnor_6.01219,833,584 - 219,859,854 (+)NCBI
Rnor_5.01226,626,831 - 226,726,350 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101401   ⟹   XP_038957329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,321,709 - 211,327,792 (+)NCBI
mRatBN7.21201,892,268 - 201,898,402 (+)NCBI
RefSeq Acc Id: XM_063281274   ⟹   XP_063137344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,301,528 - 211,327,792 (+)NCBI
RefSeq Acc Id: XM_063281278   ⟹   XP_063137348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,239,134 - 211,327,792 (+)NCBI
RefSeq Acc Id: XM_063281280   ⟹   XP_063137350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,301,521 - 211,327,792 (+)NCBI
RefSeq Acc Id: XM_063281286   ⟹   XP_063137356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,266,714 - 211,327,792 (+)NCBI
RefSeq Acc Id: NP_036876   ⟸   NM_012744
- Peptide Label: precursor
- UniProtKB: Q5RKM0 (UniProtKB/Swiss-Prot),   Q64555 (UniProtKB/Swiss-Prot),   P52873 (UniProtKB/Swiss-Prot),   A6HYX8 (UniProtKB/TrEMBL),   A0A8I6A5A2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230753   ⟸   XM_006230691
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QDW8 (UniProtKB/TrEMBL),   A0A8I6A5A2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230754   ⟸   XM_006230692
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSRNOP00000075317   ⟸   ENSRNOT00000082388
Ensembl Acc Id: ENSRNOP00000026316   ⟸   ENSRNOT00000026316
Ensembl Acc Id: ENSRNOP00000068757   ⟸   ENSRNOT00000087432
RefSeq Acc Id: XP_038957329   ⟸   XM_039101401
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000092227   ⟸   ENSRNOT00000119641
Ensembl Acc Id: ENSRNOP00000086416   ⟸   ENSRNOT00000106490
RefSeq Acc Id: XP_063137348   ⟸   XM_063281278
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QDW8 (UniProtKB/TrEMBL),   A0A8I6A5A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137356   ⟸   XM_063281286
- Peptide Label: isoform X4
- UniProtKB: Q64555 (UniProtKB/Swiss-Prot),   Q5RKM0 (UniProtKB/Swiss-Prot),   P52873 (UniProtKB/Swiss-Prot),   A6HYX8 (UniProtKB/TrEMBL),   A0A8I6A5A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137350   ⟸   XM_063281280
- Peptide Label: isoform X4
- UniProtKB: Q64555 (UniProtKB/Swiss-Prot),   Q5RKM0 (UniProtKB/Swiss-Prot),   P52873 (UniProtKB/Swiss-Prot),   A6HYX8 (UniProtKB/TrEMBL),   A0A8I6A5A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137344   ⟸   XM_063281274
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JTL5 (UniProtKB/TrEMBL)
Protein Domains
ATP-grasp   Biotin carboxylation   Biotinyl-binding   Lipoyl-binding   Pyruvate carboxyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52873-F1-model_v2 AlphaFold P52873 1-1178 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690626
Promoter ID:EPDNEW_R1150
Type:multiple initiation site
Name:Pc_1
Description:pyruvate carboxylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01219,759,190 - 219,759,250EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3262 AgrOrtholog
BioCyc Gene G2FUF-56750 BioCyc
BioCyc Pathway PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000019372 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026316 ENTREZGENE
  ENSRNOT00000082388 ENTREZGENE
  ENSRNOT00000087432 ENTREZGENE
  ENSRNOT00000119641 ENTREZGENE
Gene3D-CATH 2.40.50.100 UniProtKB/Swiss-Prot
  3.20.20.70 UniProtKB/Swiss-Prot
  3.30.1490.20 UniProtKB/Swiss-Prot
  3.40.50.20 UniProtKB/Swiss-Prot
  ATP-grasp fold, B domain UniProtKB/Swiss-Prot
  pyruvate carboxylase f1077a mutant domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109369 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/Swiss-Prot
  ATP-grasp UniProtKB/Swiss-Prot
  ATP_grasp_subdomain_1 UniProtKB/Swiss-Prot
  BC-like_N UniProtKB/Swiss-Prot
  Biotin_BS UniProtKB/Swiss-Prot
  Biotin_carboxylation_dom UniProtKB/Swiss-Prot
  Biotin_COase_C UniProtKB/Swiss-Prot
  Biotin_lipoyl UniProtKB/Swiss-Prot
  Carboxylase_cons_dom UniProtKB/Swiss-Prot
  CbamoylP_synth_lsu-like_ATP-bd UniProtKB/Swiss-Prot
  PCB-like UniProtKB/Swiss-Prot
  PreATP-grasp_dom_sf UniProtKB/Swiss-Prot
  PYR_CT UniProtKB/Swiss-Prot
  Pyruv_COase UniProtKB/Swiss-Prot
  Rudment_hybrid_motif UniProtKB/Swiss-Prot
  Single_hybrid_motif UniProtKB/Swiss-Prot
KEGG Report rno:25104 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93035 IMAGE-MGC_LOAD
NCBI Gene 25104 ENTREZGENE
PANTHER PYRUVATE CARBOXYLASE UniProtKB/Swiss-Prot
  PYRUVATE CARBOXYLASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam Biotin_carb_C UniProtKB/Swiss-Prot
  Biotin_carb_N UniProtKB/Swiss-Prot
  Biotin_lipoyl UniProtKB/Swiss-Prot
  CPSase_L_D2 UniProtKB/Swiss-Prot
  HMGL-like UniProtKB/Swiss-Prot
  PYC_OADA UniProtKB/Swiss-Prot
PhenoGen Pc PhenoGen
PIRSF Pyruv_carbox UniProtKB/Swiss-Prot
PROSITE ATP_GRASP UniProtKB/Swiss-Prot
  BIOTIN UniProtKB/Swiss-Prot
  BIOTINYL_LIPOYL UniProtKB/Swiss-Prot
  PS50979 UniProtKB/Swiss-Prot
  PYR_CT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019372 RatGTEx
SMART Biotin_carb_C UniProtKB/Swiss-Prot
Superfamily-SCOP Aldolase UniProtKB/Swiss-Prot
  Glutathione synthetase ATP-binding domain-like UniProtKB/Swiss-Prot
  post-HMGL domain-like UniProtKB/Swiss-Prot
  SSF51230 UniProtKB/Swiss-Prot
  SSF51246 UniProtKB/Swiss-Prot
  SSF52440 UniProtKB/Swiss-Prot
TIGR TC217253
UniProt A0A0G2JTL5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5A2 ENTREZGENE
  A0A8L2QDW8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2URL3_RAT UniProtKB/TrEMBL
  A6HYX8 ENTREZGENE, UniProtKB/TrEMBL
  P52873 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5RKM0 ENTREZGENE
  Q64555 ENTREZGENE
UniProt Secondary Q5RKM0 UniProtKB/Swiss-Prot
  Q64555 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-24 Pc  pyruvate carboxylase  Pcx  pyruvate carboxylase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Pcx  pyruvate carboxylase  Pc  Pyruvate carboxylase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pc  Pyruvate carboxylase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 1178 amino acids; 129.8 kDa 729499