Nup153 (nucleoporin 153) - Rat Genome Database

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Gene: Nup153 (nucleoporin 153) Rattus norvegicus
Analyze
Symbol: Nup153
Name: nucleoporin 153
RGD ID: 3216
Description: Enables several functions, including nuclear localization sequence binding activity; small GTPase binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including amyloid fibril formation; negative regulation of RNA export from nucleus; and nucleocytoplasmic transport. Located in annulate lamellae and nucleus. Part of nuclear pore nuclear basket. Orthologous to human NUP153 (nucleoporin 153); PARTICIPATES IN mRNA nuclear export pathway; RNA transport pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 153 kDa nucleoporin; Nuclear pore complex protein; nuclear pore complex protein Nup153; nucleoporin 153kD; nucleoporin Nup153; NUCZINK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81718,178,434 - 18,231,109 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1718,178,456 - 18,231,109 (+)EnsemblGRCr8
mRatBN7.21717,972,217 - 18,024,876 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1717,972,217 - 18,024,876 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1717,858,346 - 17,910,897 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01719,462,206 - 19,514,765 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01717,785,461 - 17,838,024 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01718,358,712 - 18,411,368 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1718,358,712 - 18,411,368 (+)Ensemblrn6Rnor6.0
Rnor_5.01719,523,818 - 19,576,545 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41724,031,666 - 24,084,210 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1717,680,974 - 17,733,501 (+)NCBICelera
RGSC_v3.11724,034,506 - 24,086,843 (+)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
choline  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diethyl maleate  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nefazodone  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenytoin  (EXP)
phorone  (EXP)
pirinixic acid  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
annulate lamellae  (IDA)
membrane  (IEA,ISO)
nuclear envelope  (IEA,ISO)
nuclear inclusion body  (IDA,IEA,ISO)
nuclear membrane  (IDA,IEA,ISO,ISS)
nuclear periphery  (IDA,IEA,ISO,ISS)
nuclear pore  (IBA,IDA,IEA,ISO,ISS)
nuclear pore nuclear basket  (IDA,IEA,ISO)
nucleoplasmic side of nuclear pore  (IDA)
nucleus  (IEA)
protein-containing complex  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import. Ben-Efraim I and Gerace L, J Cell Biol. 2001 Jan 22;152(2):411-7.
2. Sequential recruitment of NPC proteins to the nuclear periphery at the end of mitosis. Bodoor K, etal., J Cell Sci. 1999 Jul;112 ( Pt 13):2253-64.
3. Regulation of mRNA trafficking by nuclear pore complexes. Bonnet A and Palancade B, Genes (Basel). 2014 Sep 2;5(3):767-91. doi: 10.3390/genes5030767.
4. A biochemical and immunological comparison of nuclear and cytoplasmic pore complexes. Ewald A, etal., J Cell Sci. 1996 Jul;109 ( Pt 7):1813-24.
5. Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. Frosst P, etal., J Cell Biol. 2002 Feb 18;156(4):617-30. Epub 2002 Feb 11.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. Hawryluk-Gara LA, etal., Mol Biol Cell. 2005 May;16(5):2382-94. Epub 2005 Feb 9.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Crystallographic and biochemical analysis of the Ran-binding zinc finger domain. Partridge JR and Schwartz TU, J Mol Biol. 2009 Aug 14;391(2):375-89. Epub 2009 Jun 6.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Radu A, etal., Proc Natl Acad Sci U S A 1995 Feb 28;92(5):1769-73.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. The crystal structure of the Ran-Nup153ZnF2 complex: a general Ran docking site at the nuclear pore complex. Schrader N, etal., Structure. 2008 Jul;16(7):1116-25. doi: 10.1016/j.str.2008.03.014.
18. Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr. Shah S, etal., J Cell Biol. 1998 Apr 6;141(1):31-49.
19. A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm. Sukegawa J and Blobel G, Cell 1993 Jan 15;72(1):29-38.
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:12802065   PMID:15229283   PMID:20407419   PMID:22253824   PMID:23238392   PMID:26051542  


Genomics

Comparative Map Data
Nup153
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81718,178,434 - 18,231,109 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1718,178,456 - 18,231,109 (+)EnsemblGRCr8
mRatBN7.21717,972,217 - 18,024,876 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1717,972,217 - 18,024,876 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1717,858,346 - 17,910,897 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01719,462,206 - 19,514,765 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01717,785,461 - 17,838,024 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01718,358,712 - 18,411,368 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1718,358,712 - 18,411,368 (+)Ensemblrn6Rnor6.0
Rnor_5.01719,523,818 - 19,576,545 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41724,031,666 - 24,084,210 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1717,680,974 - 17,733,501 (+)NCBICelera
RGSC_v3.11724,034,506 - 24,086,843 (+)NCBI
Cytogenetic Map17p14NCBI
NUP153
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38617,615,037 - 17,706,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl617,614,707 - 17,706,935 (-)Ensemblhg38GRCh38
GRCh37617,615,268 - 17,707,156 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36617,723,248 - 17,814,797 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34617,723,247 - 17,814,797NCBI
Celera618,853,298 - 18,944,916 (-)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef617,559,859 - 17,651,999 (-)NCBIHuRef
CHM1_1617,617,771 - 17,709,603 (-)NCBICHM1_1
T2T-CHM13v2.0617,487,223 - 17,579,176 (-)NCBIT2T-CHM13v2.0
Nup153
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391346,833,369 - 46,890,682 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1346,833,381 - 46,881,416 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381346,679,902 - 46,727,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1346,679,905 - 46,727,940 (-)Ensemblmm10GRCm38
MGSCv371346,775,271 - 46,823,218 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361346,691,073 - 46,738,559 (-)NCBIMGSCv36mm8
Celera1347,763,419 - 47,811,332 (-)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1324.3NCBI
Nup153
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554838,388,066 - 8,455,965 (+)Ensembl
ChiLan1.0NW_0049554838,377,253 - 8,457,018 (+)NCBIChiLan1.0ChiLan1.0
NUP153
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2532,280,305 - 32,372,958 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1628,265,350 - 28,357,856 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0617,468,826 - 17,561,064 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1617,826,769 - 17,918,060 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl617,826,769 - 17,917,992 (-)EnsemblpanPan2panpan1.1
NUP153
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13516,517,992 - 16,598,472 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3516,519,109 - 16,589,537 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3516,468,185 - 16,540,246 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03516,624,199 - 16,708,905 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3516,624,201 - 16,696,283 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13516,438,735 - 16,523,130 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03516,492,051 - 16,576,640 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03517,825,780 - 17,910,231 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nup153
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049468,133,301 - 8,201,435 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365523,530,559 - 3,577,177 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365523,529,506 - 3,588,830 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUP153
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl713,393,547 - 13,466,504 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1713,393,542 - 13,466,577 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2714,095,848 - 14,184,559 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUP153
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11754,426,383 - 54,518,986 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1754,426,289 - 54,519,249 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604417,820,600 - 17,921,055 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nup153
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247568,889,992 - 8,959,115 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247568,890,010 - 8,959,704 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nup153
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11465,657,637 - 65,709,976 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nup153
333 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:571
Count of miRNA genes:269
Interacting mature miRNAs:336
Transcripts:ENSRNOT00000001979
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920650523859062Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920650523859062Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171553702528637951Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920650523859062Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat

Markers in Region
C88147  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21718,024,710 - 18,024,823 (+)MAPPERmRatBN7.2
Rnor_6.01718,411,203 - 18,411,315NCBIRnor6.0
Rnor_5.01719,523,871 - 19,523,983UniSTSRnor5.0
RGSC_v3.41724,084,045 - 24,084,157UniSTSRGSC3.4
Celera1717,733,336 - 17,733,448UniSTS
Cytogenetic Map17p13UniSTS
RH127428  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21718,024,549 - 18,024,739 (+)MAPPERmRatBN7.2
Rnor_6.01718,411,042 - 18,411,231NCBIRnor6.0
Rnor_5.01719,523,955 - 19,524,144UniSTSRnor5.0
RGSC_v3.41724,083,884 - 24,084,073UniSTSRGSC3.4
Celera1717,733,175 - 17,733,364UniSTS
RH 3.4 Map17198.2UniSTS
Cytogenetic Map17p13UniSTS
RH141746  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21718,023,772 - 18,023,966 (+)MAPPERmRatBN7.2
Rnor_6.01718,410,265 - 18,410,458NCBIRnor6.0
Rnor_5.01719,524,728 - 19,524,921UniSTSRnor5.0
RGSC_v3.41724,083,107 - 24,083,300UniSTSRGSC3.4
Celera1717,732,398 - 17,732,591UniSTS
RH 3.4 Map17217.7UniSTS
Cytogenetic Map17p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001979   ⟹   ENSRNOP00000001979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1718,178,456 - 18,231,109 (+)Ensembl
mRatBN7.2 Ensembl1717,972,217 - 18,024,876 (+)Ensembl
Rnor_6.0 Ensembl1718,358,712 - 18,411,368 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115610   ⟹   ENSRNOP00000076690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1718,178,803 - 18,229,865 (+)Ensembl
mRatBN7.2 Ensembl1717,972,217 - 18,023,633 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116856   ⟹   ENSRNOP00000097503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1718,178,456 - 18,231,109 (+)Ensembl
mRatBN7.2 Ensembl1717,972,217 - 18,024,876 (+)Ensembl
RefSeq Acc Id: NM_001100470   ⟹   NP_001093940
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81718,178,456 - 18,231,109 (+)NCBI
mRatBN7.21717,972,217 - 18,024,876 (+)NCBI
Rnor_6.01718,358,712 - 18,411,368 (+)NCBI
Rnor_5.01719,523,818 - 19,576,545 (-)NCBI
RGSC_v3.41724,031,666 - 24,084,210 (+)RGD
Celera1717,680,974 - 17,733,501 (+)RGD
Sequence:
RefSeq Acc Id: XM_017600457   ⟹   XP_017455946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81718,178,434 - 18,230,903 (+)NCBI
mRatBN7.21717,972,260 - 18,024,876 (+)NCBI
Rnor_6.01718,358,884 - 18,411,368 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001093940 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455946 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH84700 (Get FASTA)   NCBI Sequence Viewer  
  EDL98160 (Get FASTA)   NCBI Sequence Viewer  
  EDL98161 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001979
  ENSRNOP00000076690
GenBank Protein P49791 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001093940   ⟸   NM_001100470
- UniProtKB: P49791 (UniProtKB/Swiss-Prot),   G3V662 (UniProtKB/TrEMBL),   A6J711 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455946   ⟸   XM_017600457
- Peptide Label: isoform X1
- UniProtKB: P49791 (UniProtKB/Swiss-Prot),   A0A8I6B5V4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001979   ⟸   ENSRNOT00000001979
Ensembl Acc Id: ENSRNOP00000076690   ⟸   ENSRNOT00000115610
Ensembl Acc Id: ENSRNOP00000097503   ⟸   ENSRNOT00000116856
Protein Domains
RanBP2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49791-F1-model_v2 AlphaFold P49791 1-1468 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700368
Promoter ID:EPDNEW_R10891
Type:initiation region
Name:Nup153_1
Description:nucleoporin 153
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01718,358,743 - 18,358,803EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3216 AgrOrtholog
BioCyc Gene G2FUF-9895 BioCyc
Ensembl Genes ENSRNOG00000001456 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000001979 ENTREZGENE
  ENSRNOT00000115610 ENTREZGENE
Gene3D-CATH Zinc finger, RanBP2-type UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132834 IMAGE-MGC_LOAD
InterPro Nucleoporin UniProtKB/Swiss-Prot
  Nup153_N UniProtKB/Swiss-Prot
  Retro-transposon_transp_CS UniProtKB/Swiss-Prot
  Znf_RanBP2 UniProtKB/Swiss-Prot
  Znf_RanBP2_sf UniProtKB/Swiss-Prot
MGC_CLONE MGC:105890 IMAGE-MGC_LOAD
NCBI Gene 25281 ENTREZGENE
PANTHER NUCLEAR PORE COMPLEX PROTEIN NUP153 UniProtKB/Swiss-Prot
  PTHR23193 UniProtKB/Swiss-Prot
Pfam Nup153 UniProtKB/Swiss-Prot
  Nup_retrotrp_bd UniProtKB/Swiss-Prot
  zf-RanBP UniProtKB/Swiss-Prot
PhenoGen Nup153 PhenoGen
PROSITE ZF_RANBP2_1 UniProtKB/Swiss-Prot
  ZF_RANBP2_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001456 RatGTEx
SMART ZnF_RBZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF90209 UniProtKB/Swiss-Prot
UniProt A0A8I5YBF7_RAT UniProtKB/TrEMBL
  A0A8I6B5V4 ENTREZGENE, UniProtKB/TrEMBL
  A6J710_RAT UniProtKB/TrEMBL
  A6J711 ENTREZGENE, UniProtKB/TrEMBL
  G3V662 ENTREZGENE, UniProtKB/TrEMBL
  NU153_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5XFX2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Nup153  nucleoporin 153    nucleoporin 153kD  Name updated 1299863 APPROVED
2002-11-06 Nup153  nucleoporin 153kD    Nuclear pore complex protein  Name updated 625702 APPROVED
2002-06-10 Nup153  Nuclear pore complex protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to nucleoplasmic side of the nuclear pore complex 729043
gene_domains contains a repetitive degenerate pentapeptide motif and a novel 4-fold repeat of a Cys2-Cys2-type zinc finger motif 729043
gene_function binds DNA in a zinc-dependent fashion 729043