MRNA NUCLEAR EXPORT PATHWAY (PW:0001587)

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Description

Mature mRNA - the pre-mRNA that has been 5'capped, spliced and 3' polyadenylated, has to reach the cytoplasm in order to serve as the template for protein translation. Its directional transport through the nuclear pore complex (NPC) is a critical aspect of regulated gene expression. While the above steps/pathways have many times been described separately, it is now known that they are intimately intertwined. Transport is linked to transcription and to the processing events with which transcripti

Pathway Diagram:

Elsevier Inc. mature mRNA 4E-SE mRNA spliceosome pathway 5'-end pre-mRNA capping pathway 3'-end pre-mRNA processing pathway 4E-SE mRNA ---> cargo release Anp32a GDP Ran. GTP phytate Rangap1 Nxf1 Ranbp1 ---> Ran. Ranbp2 ---> Ran. Rangap1 ---> Ran. Anp32b ---- Xpo1 Anp32a ---- Xpo1 Nxf1 ---- TREX/THO complex Ddx19b Ranbp2 Ranbp1 ARE mRNA Gle1 Anp32b 3'-end pre-mRNA processing pathway ---> mature mRNA spliceosome pathway ---> mature mRNA ARE mRNA ---> cargo release Elavl1 Lrpprc ---- Xpo1 Nxf3 ---- Xpo1 5'-end pre-mRNA capping pathway ---> mature mRNA mRNA maturation pathway Xpo1 Nxf3 Ran ---- Xpo1 Ran Nxf1 ---- Nxt1 mature mRNA ---- Nxf3 4E-SE mRNA ---- Lrpprc Anp32b ---- ARE mRNA Anp32b ---- Elavl1 Anp32a ---- ARE mRNA ARE mRNA ---- Elavl1 Nxt1 mature mRNA ---- TREX/THO complex cargo release Lrpprc Eif4e Eif4e ---- Lrpprc mature mRNA ---> cargo release Gle1 --+> Ddx19b Nuclear Pore Complex TREX/THO complex Anp32a ---- Elavl1 NXF1-NXT1 export pathway CRM1 export pathway
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Genes in Pathway:

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mRNA nuclear export pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nup107 nucleoporin 107 JBrowse link 7 60,781,724 60,825,225 RGD:9743947
G Nup133 nucleoporin 133 JBrowse link 19 56,681,965 56,731,404 RGD:9743947
G Nup153 nucleoporin 153 JBrowse link 17 18,358,712 18,411,368 RGD:9743947
G Nup160 nucleoporin 160 JBrowse link 3 79,496,239 79,562,163 RGD:9743947
G Nup214 nucleoporin 214 JBrowse link 3
3
9,227,869
10,993,584
9,236,878
11,070,638
RGD:9743947
G Nup37 nucleoporin 37 JBrowse link 7 28,715,299 28,750,978 RGD:9743947
G Nup43 nucleoporin 43 JBrowse link 1 1,771,468 1,781,554 RGD:9743947
G Nup54 nucleoporin 54 JBrowse link 14 17,123,434 17,141,832 RGD:9743947
G Nup58 nucleoporin 58 JBrowse link 15 40,496,754 40,545,933 RGD:9743947
G Nup62 nucleoporin 62 JBrowse link 1 100,811,140 100,827,119 RGD:9743947
G Nup85 nucleoporin 85 JBrowse link 10 104,118,999 104,137,258 RGD:9743947
G Nup98 nucleoporin 98 JBrowse link 1 167,213,866 167,308,851 RGD:9743947
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component JBrowse link 4 145,686,186 145,699,577 RGD:9743947
G Seh1l SEH1-like nucleoporin JBrowse link 18 63,545,150 63,568,101 RGD:9743947
CRM1 export pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anp32a acidic nuclear phosphoprotein 32 family member A JBrowse link 8 67,295,578 67,333,075 RGD:9743967
G Anp32b acidic nuclear phosphoprotein 32 family member B JBrowse link 5 62,070,709 62,094,633 RGD:9743967
G Eif4e eukaryotic translation initiation factor 4E JBrowse link 2 243,819,616 243,853,987 RGD:9743967
G Elavl1 ELAV like RNA binding protein 1 JBrowse link 12 2,461,502 2,502,432 RGD:9743967
G Lrpprc leucine-rich pentatricopeptide repeat containing JBrowse link 6 7,984,043 8,066,874 RGD:9743967
G Nup98 nucleoporin 98 JBrowse link 1 167,213,866 167,308,851 RGD:9743967
G Nxf3 nuclear RNA export factor 3 JBrowse link X 106,562,957 106,587,487 RGD:9743967
G Ran RAN, member RAS oncogene family JBrowse link 12 31,319,556 31,324,105 RGD:9743967
G Ranbp1 RAN binding protein 1 JBrowse link 11 86,890,585 86,898,818 RGD:9743967
G Ranbp2 RAN binding protein 2 JBrowse link 20
20
28,027,054
28,365,538
28,076,664
28,375,676
RGD:9743967
G Rangap1 RAN GTPase activating protein 1 JBrowse link 7 122,939,266 122,967,178 RGD:9743967
G Xpo1 exportin 1 JBrowse link 14 108,007,421 108,049,088 RGD:9743967
NXF1-NXT1 export pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alyref Aly/REF export factor JBrowse link 10 109,768,593 109,774,639 RGD:9743960
G Ddx19b DEAD-box helicase 19B JBrowse link 19 43,217,199 43,246,196 RGD:9743967
G Ddx39b DExD-box helicase 39B JBrowse link 20 4,806,103 4,818,600 RGD:9743960
G Gle1 GLE1 RNA export mediator JBrowse link 3 8,498,098 8,530,218 RGD:9743967
G Nup214 nucleoporin 214 JBrowse link 3
3
9,227,869
10,993,584
9,236,878
11,070,638
RGD:9743967
G Nxf1 nuclear RNA export factor 1 JBrowse link 1 224,957,535 224,970,728 RGD:9743967
G Nxt1 nuclear transport factor 2-like export factor 1 JBrowse link 3 142,993,658 142,996,580 RGD:9743967
G Sarnp SAP domain containing ribonucleoprotein JBrowse link 7 3,246,220 3,300,467 RGD:9743960
G Thoc1 THO complex 1 JBrowse link 18 1,142,540 1,177,084 RGD:9743960
G Thoc2 THO complex 2 JBrowse link X 128,153,824 128,268,327 RGD:9743960
G Thoc5 THO complex 5 JBrowse link 14 85,138,219 85,171,729 RGD:9743960
G Thoc6 THO complex 6 JBrowse link 10 12,989,135 12,994,495 RGD:9743960
G Thoc7 THO complex 7 JBrowse link 15 12,569,235 12,584,101 RGD:9743960

Pathway Gene Annotations

Disease Annotations Associated with Genes in the mRNA nuclear export pathway
Pathway Annotations Associated with Genes in the mRNA nuclear export pathway

References Associated with the mRNA nuclear export pathway:

Ontology Path Diagram:

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