Nf2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor) - Rat Genome Database

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Gene: Nf2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor) Rattus norvegicus
Analyze
Symbol: Nf2
Name: NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
RGD ID: 3169
Description: Enables beta-catenin binding activity; integrin binding activity; and protein domain specific binding activity. Involved in negative regulation of cell growth. Located in perinuclear region of cytoplasm. Part of protein-containing complex. Biomarker of epilepsy. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); malignant pleural mesothelioma; meningioma (multiple); neurilemmoma; and vestibular schwannomatosis. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amitrole; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: merlin; moesin-ezrin-radixin-like protein; neurofibromatosis 2; neurofibromin 2; neurofibromin 2 (merlin); neurofibromin-2; schwannomin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,850,894 - 83,934,263 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1483,850,894 - 83,934,151 (-)EnsemblGRCr8
mRatBN7.21479,627,399 - 79,710,709 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,627,399 - 79,710,667 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1484,057,988 - 84,141,291 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01485,298,058 - 85,381,369 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,747,732 - 81,831,027 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,996,905 - 85,088,547 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,996,905 - 85,088,523 (-)Ensemblrn6Rnor6.0
Rnor_5.01485,673,149 - 85,766,360 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41485,415,142 - 85,508,807 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1478,532,232 - 78,615,355 (-)NCBICelera
RGSC_v3.11485,436,559 - 85,527,546 (-)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
acrolein  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphotericin B  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
benzophenanthridine  (ISO)
bisphenol A  (EXP)
cadmium dichloride  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
Evodiamine  (ISO)
folic acid  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
Muraglitazar  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
ozone  (ISO)
paracetamol  (ISO)
selenium atom  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
thiram  (ISO)
tipifarnib  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tungsten  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO)
brain development  (ISO)
cell-cell junction organization  (ISO)
ectoderm development  (ISO)
hippo signaling  (IEA,ISO)
hippocampus development  (ISO)
lens fiber cell differentiation  (IEA,ISO)
mesoderm formation  (ISO)
negative regulation of cell growth  (IDA)
negative regulation of cell growth involved in contact inhibition  (IEA,ISO)
negative regulation of cell population proliferation  (IBA,IEA,ISO)
negative regulation of cell-cell adhesion  (IEA,ISO)
negative regulation of MAPK cascade  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (IEA,ISO)
odontogenesis of dentin-containing tooth  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of early endosome to late endosome transport  (IBA)
positive regulation of protein localization to early endosome  (IBA)
positive regulation of stress fiber assembly  (IEA,ISO)
regulation of apoptotic process  (IEA,ISO,ISS)
regulation of cell cycle  (IEA,ISO,ISS)
regulation of cell population proliferation  (ISO)
regulation of cell shape  (IBA)
regulation of gliogenesis  (IBA,ISO)
regulation of hippo signaling  (IBA,IEA,ISO)
regulation of neural precursor cell proliferation  (ISO)
regulation of neurogenesis  (ISO)
regulation of organelle assembly  (IBA)
regulation of protein localization to nucleus  (ISO)
regulation of protein stability  (ISO)
regulation of stem cell proliferation  (ISO)
Schwann cell proliferation  (IEA,ISO)

Cellular Component
adherens junction  (IBA,IEA,ISO)
apical part of cell  (IBA,IEA,ISO)
apical plasma membrane  (IEA)
cell body  (IEA,ISO)
cell projection  (IEA)
cell tip  (IEA)
cleavage furrow  (IEA,ISO)
cortical actin cytoskeleton  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytoskeleton  (IEA,ISO)
cytosol  (IEA,ISO)
early endosome  (IEA,ISO)
filopodium  (IBA,IEA,ISO)
lamellipodium  (IEA,ISO)
microvillus membrane  (IEA)
neuron projection  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
perinuclear region of cytoplasm  (IDA,IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
protein-containing complex  (IDA)
ruffle  (IEA,ISO)
T-tubule  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A mouse model recapitulating molecular features of human mesothelioma. Altomare DA, etal., Cancer Res. 2005 Sep 15;65(18):8090-5. doi: 10.1158/0008-5472.CAN-05-2312.
2. Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice. Badhai J, etal., J Exp Med. 2020 Jun 1;217(6). pii: 151644. doi: 10.1084/jem.20191257.
3. Lipid raft localization of ErbB2 in vestibular schwannoma and schwann cells. Brown KD and Hansen MR, Otol Neurotol. 2008 Jan;29(1):79-85.
4. Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations. Bueno R, etal., Nat Genet. 2016 Apr;48(4):407-16. doi: 10.1038/ng.3520. Epub 2016 Feb 29.
5. A mosaic pattern of INI1/SMARCB1 protein expression distinguishes Schwannomatosis and NF2-associated peripheral schwannomas from solitary peripheral schwannomas and NF2-associated vestibular schwannomas. Caltabiano R, etal., Childs Nerv Syst. 2017 Jun;33(6):933-940. doi: 10.1007/s00381-017-3340-2. Epub 2017 Apr 1.
6. Loss of NF2/Merlin expression in advanced sporadic colorectal cancer. Cačev T, etal., Cell Oncol (Dordr). 2014 Feb;37(1):69-77. doi: 10.1007/s13402-013-0164-2. Epub 2013 Dec 10.
7. Merlin, the product of NF2 gene, is associated with aromatase expression and estrogen formation in human liver tissues and liver cancer cells. Cocciadiferro L, etal., J Steroid Biochem Mol Biol. 2017 Sep;172:222-230. doi: 10.1016/j.jsbmb.2016.05.023. Epub 2016 Jun 8.
8. Allelic loss of 14q and 22q, NF2 mutation, and genetic instability occur independently of c-kit mutation in gastrointestinal stromal tumor. Fukasawa T, etal., Jpn J Cancer Res. 2000 Dec;91(12):1241-9. doi: 10.1111/j.1349-7006.2000.tb00910.x.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system. Gronholm M, etal., Mol Cell Neurosci. 2005 Apr;28(4):683-93.
12. Expression of the neurofibromatosis 2 (NF2) gene isoforms during rat embryonic development. Gutmann DH, etal., Hum Mol Genet 1995 Mar;4(3):471-8.
13. [Expression of Merlin protein in non-small cell lung carcinoma and the clinical significance]. Hu J, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Jun;36(6):565-9. doi: 10.3969/j.issn.1672-7347.2011.06.015.
14. Characterization of the rat neurofibromatosis 2 gene and its involvement in asbestos-induced mesothelioma. Kleymenova EV, etal., Mol Carcinog 1997 Jan;18(1):54-60.
15. p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis. Laine H, etal., J Neurosci. 2007 Feb 7;27(6):1434-44.
16. Targeted next-generation sequencing for differential diagnosis of neurofibromatosis type 2, schwannomatosis, and meningiomatosis. Louvrier C, etal., Neuro Oncol. 2018 Jun 18;20(7):917-929. doi: 10.1093/neuonc/noy009.
17. A splicing variant of Merlin promotes metastasis in hepatocellular carcinoma. Luo ZL, etal., Nat Commun. 2015 Oct 7;6:8457. doi: 10.1038/ncomms9457.
18. Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy. Matthaei M, etal., Invest Ophthalmol Vis Sci. 2012 Sep 28;53(10):6718-27.
19. Low Merlin expression and high Survivin labeling index are indicators for poor prognosis in patients with malignant pleural mesothelioma. Meerang M, etal., Mol Oncol. 2016 Oct;10(8):1255-65. doi: 10.1016/j.molonc.2016.06.005. Epub 2016 Jun 25.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma. Morris ZS and McClatchey AI, Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9767-72. Epub 2009 Jun 1.
22. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Morrison H, etal., Genes Dev. 2001 Apr 15;15(8):968-80.
23. Predominant occurrence of somatic mutations of the NF2 gene in meningiomas and schwannomas. Mérel P, etal., Genes Chromosomes Cancer. 1995 Jul;13(3):211-6. doi: 10.1002/gcc.2870130311.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Merlin, the neurofibromatosis type 2 gene product, and beta1 integrin associate in isolated and differentiating Schwann cells. Obremski VJ, etal., J Neurobiol. 1998 Dec;37(4):487-501.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Molecular genetics of meningiomas. Ragel BT and Jensen RL, Neurosurg Focus. 2005 Nov 15;19(5):E9.
28. Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells. Rangwala R, etal., J Biol Chem. 2005 Mar 25;280(12):11790-7. Epub 2005 Jan 19.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. The prognostic significance of BAP1, NF2, and CDKN2A in malignant peritoneal mesothelioma. Singhi AD, etal., Mod Pathol. 2016 Jan;29(1):14-24. doi: 10.1038/modpathol.2015.121. Epub 2015 Oct 23.
33. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Wang Q, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Jan;37(1):115-7.
34. Involvement of p21 (waf1) in merlin deficient sporadic vestibular schwannomas. Wu H, etal., Neuroscience. 2010 Sep 29;170(1):149-55. doi: 10.1016/j.neuroscience.2010.06.051. Epub 2010 Jul 1.
35. A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions. Yi C, etal., Cancer Cell. 2011 Apr 12;19(4):527-40. doi: 10.1016/j.ccr.2011.02.017.
36. Molecular alterations of the NF2 gene in hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Zhang N, etal., Oncol Rep. 2017 Dec;38(6):3650-3658. doi: 10.3892/or.2017.6055. Epub 2017 Oct 24.
Additional References at PubMed
PMID:8547603   PMID:8889548   PMID:9171370   PMID:9537418   PMID:9553042   PMID:9563848   PMID:9631655   PMID:10401006   PMID:10861283   PMID:10887156   PMID:12118253   PMID:12444102  
PMID:12695331   PMID:14580336   PMID:14991710   PMID:15133494   PMID:15467741   PMID:15598747   PMID:16405865   PMID:16571745   PMID:16885985   PMID:17210637   PMID:17353411   PMID:17891137  
PMID:19946888   PMID:20159598   PMID:20178741   PMID:20181838   PMID:21167305   PMID:21182951   PMID:23863479   PMID:25433207   PMID:29709009   PMID:38185389  


Genomics

Comparative Map Data
Nf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,850,894 - 83,934,263 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1483,850,894 - 83,934,151 (-)EnsemblGRCr8
mRatBN7.21479,627,399 - 79,710,709 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,627,399 - 79,710,667 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1484,057,988 - 84,141,291 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01485,298,058 - 85,381,369 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,747,732 - 81,831,027 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,996,905 - 85,088,547 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,996,905 - 85,088,523 (-)Ensemblrn6Rnor6.0
Rnor_5.01485,673,149 - 85,766,360 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41485,415,142 - 85,508,807 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1478,532,232 - 78,615,355 (-)NCBICelera
RGSC_v3.11485,436,559 - 85,527,546 (-)NCBI
Cytogenetic Map14q21NCBI
NF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382229,603,556 - 29,698,600 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2229,603,546 - 29,698,598 (+)Ensemblhg38GRCh38
GRCh372229,999,545 - 30,094,589 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,329,565 - 28,424,587 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342228,324,118 - 28,419,137NCBI
Celera2213,799,281 - 13,894,313 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2212,962,966 - 13,057,866 (+)NCBIHuRef
CHM1_12229,958,840 - 30,053,867 (+)NCBICHM1_1
T2T-CHM13v2.02230,066,918 - 30,161,963 (+)NCBIT2T-CHM13v2.0
Nf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,715,845 - 4,799,544 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,715,845 - 4,799,536 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38114,757,639 - 4,849,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,765,845 - 4,849,536 (-)Ensemblmm10GRCm38
MGSCv37114,665,851 - 4,749,530 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36114,667,997 - 4,749,553 (-)NCBIMGSCv36mm8
Celera115,266,247 - 5,349,954 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.0NCBI
Nf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554553,862,347 - 3,951,891 (+)Ensembl
ChiLan1.0NW_0049554553,862,804 - 3,950,669 (+)NCBIChiLan1.0ChiLan1.0
NF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22339,576,173 - 39,669,929 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12242,277,420 - 42,371,228 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02210,648,022 - 10,738,167 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12228,454,119 - 28,544,013 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2228,454,119 - 28,544,013 (+)EnsemblpanPan2panpan1.1
NF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,816,869 - 22,896,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,816,551 - 22,894,196 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2622,688,278 - 22,767,181 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02623,190,481 - 23,269,695 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2623,190,429 - 23,269,692 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12622,900,555 - 22,979,936 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02623,163,349 - 23,242,535 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,223,162 - 23,302,265 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,250,596 - 112,334,448 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366573,536,141 - 3,623,821 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366573,536,212 - 3,622,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,653,900 - 46,731,999 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11446,653,869 - 46,726,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,688,078 - 49,760,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11912,474,479 - 12,572,144 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1912,474,468 - 12,572,250 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045113,569,107 - 113,665,600 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247475,923,834 - 6,011,939 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247475,923,827 - 6,011,276 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nf2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11173,743,707 - 73,826,394 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nf2
1090 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:412
Count of miRNA genes:216
Interacting mature miRNAs:265
Transcripts:ENSRNOT00000010690
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat

Markers in Region
RH130158  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21479,627,425 - 79,627,636 (+)MAPPERmRatBN7.2
Rnor_6.01484,996,932 - 84,997,142NCBIRnor6.0
Rnor_5.01485,673,176 - 85,673,386UniSTSRnor5.0
RGSC_v3.41485,415,169 - 85,415,379UniSTSRGSC3.4
Celera1478,532,259 - 78,532,469UniSTS
RH 3.4 Map14555.1UniSTS
Cytogenetic Map14q21UniSTS
RH134074  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21479,664,298 - 79,664,478 (+)MAPPERmRatBN7.2
Rnor_6.01485,042,171 - 85,042,350NCBIRnor6.0
Rnor_5.01485,719,978 - 85,720,157UniSTSRnor5.0
RGSC_v3.41485,453,237 - 85,453,416UniSTSRGSC3.4
Celera1478,569,038 - 78,569,217UniSTS
RH 3.4 Map14551.79UniSTS
Cytogenetic Map14q21UniSTS
RH94846  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81483,866,726 - 83,866,879 (+)Marker Load Pipeline
mRatBN7.21479,643,232 - 79,643,385 (+)MAPPERmRatBN7.2
Rnor_6.01485,012,815 - 85,012,967NCBIRnor6.0
Rnor_5.01485,689,059 - 85,689,211UniSTSRnor5.0
RGSC_v3.41485,431,087 - 85,431,239UniSTSRGSC3.4
Celera1478,548,060 - 78,548,212UniSTS
Cytogenetic Map14q21UniSTS
RH94847  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21479,643,222 - 79,643,375 (+)MAPPERmRatBN7.2
Rnor_6.01485,012,805 - 85,012,957NCBIRnor6.0
Rnor_5.01485,689,049 - 85,689,201UniSTSRnor5.0
RGSC_v3.41485,431,077 - 85,431,229UniSTSRGSC3.4
Celera1478,548,050 - 78,548,202UniSTS
Cytogenetic Map14q21UniSTS
BF399446  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81483,908,113 - 83,908,320 (+)Marker Load Pipeline
mRatBN7.21479,684,625 - 79,684,832 (+)MAPPERmRatBN7.2
Rnor_6.01485,062,486 - 85,062,692NCBIRnor6.0
Rnor_5.01485,740,263 - 85,740,469UniSTSRnor5.0
RGSC_v3.41485,482,723 - 85,482,929UniSTSRGSC3.4
Celera1478,589,312 - 78,589,518UniSTS
RH 3.4 Map14552.39UniSTS
Cytogenetic Map14q21UniSTS
GDB:373416  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21479,645,804 - 79,645,922 (+)MAPPERmRatBN7.2
Rnor_6.01485,024,417 - 85,024,534NCBIRnor6.0
Rnor_5.01485,702,224 - 85,702,341UniSTSRnor5.0
RGSC_v3.41485,433,893 - 85,434,010UniSTSRGSC3.4
Celera1478,550,428 - 78,550,545UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA955327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF558742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP499772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ201846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA511825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB578019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB787451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB814077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK364860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO387057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO573762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR467414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U17266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U61772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010690   ⟹   ENSRNOP00000010690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1483,850,894 - 83,934,151 (-)Ensembl
mRatBN7.2 Ensembl1479,627,399 - 79,710,667 (-)Ensembl
Rnor_6.0 Ensembl1484,996,905 - 85,088,523 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105938   ⟹   ENSRNOP00000087785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1483,852,145 - 83,934,151 (-)Ensembl
mRatBN7.2 Ensembl1479,627,417 - 79,710,666 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115516   ⟹   ENSRNOP00000089056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1483,866,702 - 83,934,151 (-)Ensembl
mRatBN7.2 Ensembl1479,642,208 - 79,710,667 (-)Ensembl
RefSeq Acc Id: NM_013193   ⟹   NP_037325
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81483,850,894 - 83,934,151 (-)NCBI
mRatBN7.21479,627,399 - 79,710,667 (-)NCBI
Rnor_6.01484,996,905 - 85,088,523 (-)NCBI
Rnor_5.01485,673,149 - 85,766,360 (-)NCBI
RGSC_v3.41485,415,142 - 85,508,807 (-)RGD
Celera1478,532,232 - 78,615,355 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251188   ⟹   XP_006251250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81483,850,900 - 83,934,263 (-)NCBI
mRatBN7.21479,627,400 - 79,710,709 (-)NCBI
Rnor_6.01484,996,907 - 85,088,545 (-)NCBI
Rnor_5.01485,673,149 - 85,766,360 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272882   ⟹   XP_063128952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81483,850,900 - 83,934,260 (-)NCBI
RefSeq Acc Id: XM_063272883   ⟹   XP_063128953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81483,850,900 - 83,934,260 (-)NCBI
RefSeq Acc Id: XM_063272884   ⟹   XP_063128954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81483,850,900 - 83,934,260 (-)NCBI
RefSeq Acc Id: XM_063272885   ⟹   XP_063128955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81483,869,291 - 83,934,260 (-)NCBI
RefSeq Acc Id: NP_037325   ⟸   NM_013193
- UniProtKB: Q63648 (UniProtKB/Swiss-Prot),   G3V717 (UniProtKB/TrEMBL),   A6IKI1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251250   ⟸   XM_006251188
- Peptide Label: isoform X3
- UniProtKB: Q63648 (UniProtKB/Swiss-Prot),   A0A8I6A8G0 (UniProtKB/TrEMBL),   A6IKH9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010690   ⟸   ENSRNOT00000010690
Ensembl Acc Id: ENSRNOP00000087785   ⟸   ENSRNOT00000105938
Ensembl Acc Id: ENSRNOP00000089056   ⟸   ENSRNOT00000115516
RefSeq Acc Id: XP_063128952   ⟸   XM_063272882
- Peptide Label: isoform X1
- UniProtKB: Q63648 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063128953   ⟸   XM_063272883
- Peptide Label: isoform X2
- UniProtKB: Q63648 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063128954   ⟸   XM_063272884
- Peptide Label: isoform X2
- UniProtKB: Q63648 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063128955   ⟸   XM_063272885
- Peptide Label: isoform X4
- UniProtKB: Q63648 (UniProtKB/Swiss-Prot)
Protein Domains
Ezrin/radixin/moesin C-terminal   FERM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63648-F1-model_v2 AlphaFold Q63648 1-586 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699448
Promoter ID:EPDNEW_R9972
Type:initiation region
Name:Nf2_1
Description:neurofibromin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01485,088,565 - 85,088,625EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3169 AgrOrtholog
BioCyc Gene G2FUF-15168 BioCyc
Ensembl Genes ENSRNOG00000007948 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000010690 ENTREZGENE
  ENSRNOT00000105938 ENTREZGENE
Gene3D-CATH 1.20.5.450 UniProtKB/Swiss-Prot
  1.20.80.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  6.10.360.10 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
InterPro Band_41_domain UniProtKB/Swiss-Prot
  ERM UniProtKB/Swiss-Prot
  ERM_C_dom UniProtKB/Swiss-Prot
  ERM_FERM_C UniProtKB/Swiss-Prot
  ERM_helical UniProtKB/Swiss-Prot
  Ez/rad/moesin-like UniProtKB/Swiss-Prot
  FERM/acyl-CoA-bd_prot_sf UniProtKB/Swiss-Prot
  FERM_2 UniProtKB/Swiss-Prot
  FERM_central UniProtKB/Swiss-Prot
  FERM_CS UniProtKB/Swiss-Prot
  FERM_domain UniProtKB/Swiss-Prot
  FERM_N UniProtKB/Swiss-Prot
  FERM_PH-like_C UniProtKB/Swiss-Prot
  Moesin_tail_sf UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
KEGG Report rno:25744 UniProtKB/Swiss-Prot
NCBI Gene 25744 ENTREZGENE
PANTHER PTHR23281 UniProtKB/Swiss-Prot
Pfam ERM_C UniProtKB/Swiss-Prot
  ERM_helical UniProtKB/Swiss-Prot
  FERM_C UniProtKB/Swiss-Prot
  FERM_M UniProtKB/Swiss-Prot
  FERM_N UniProtKB/Swiss-Prot
PhenoGen Nf2 PhenoGen
PIRSF ERM UniProtKB/Swiss-Prot
PRINTS BAND41 UniProtKB/Swiss-Prot
  ERMFAMILY UniProtKB/Swiss-Prot
PROSITE FERM_1 UniProtKB/Swiss-Prot
  FERM_2 UniProtKB/Swiss-Prot
  FERM_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007948 RatGTEx
SMART B41 UniProtKB/Swiss-Prot
  FERM_C UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF47031 UniProtKB/Swiss-Prot
  SSF48678 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
UniProt A0A8I6A8G0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GHR3_RAT UniProtKB/TrEMBL
  A6IKH8_RAT UniProtKB/TrEMBL
  A6IKH9 ENTREZGENE, UniProtKB/TrEMBL
  A6IKI0_RAT UniProtKB/TrEMBL
  A6IKI1 ENTREZGENE, UniProtKB/TrEMBL
  G3V717 ENTREZGENE, UniProtKB/TrEMBL
  MERL_RAT UniProtKB/Swiss-Prot
  Q62723_RAT UniProtKB/TrEMBL
  Q63648 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-10-22 Nf2  NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor  Nf2  neurofibromin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-07-13 Nf2  neurofibromin 2  Nf2  neurofibromin 2 (merlin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Nf2  neurofibromin 2 (merlin)  Nf2  neurofibromatosis 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Nf2  neurofibromatosis 2    Neurofibromatosis 2  Name updated 625702 APPROVED
2002-06-10 Nf2  Neurofibromatosis 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript alternative splice isoform type 1 merlin is missing exon 16 sequence contained in type 2 merlin 633510