RGD Reference Report - Molecular genetics of meningiomas. - Rat Genome Database

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Molecular genetics of meningiomas.

Authors: Ragel, BT  Jensen, RL 
Citation: Ragel BT and Jensen RL, Neurosurg Focus. 2005 Nov 15;19(5):E9.
RGD ID: 1624321
Pubmed: PMID:16398473   (View Abstract at PubMed)

In this article the authors provide a brief description of the current understanding of meningioma genetics. Chromosome 22 abnormalities, especially in the Neurofibromatosis Type 2 (NF2) gene, have been associated with meningioma development. Loss of heterozygosity of chromosome 22 occurs in approximately 60% of meningiomas; however, loss of NF2 gene function occurs in only one third of these lesions. This discrepancy supports the theory that a second tumor suppressor gene exists on chromosome 22, and the authors introduce several possible gene candidates, including BAM22, LARGE, INI1, and MN1 genes. Deletions of 1p have also been shown to correlate with meningioma progression. The genetic similarities and differences among sporadic, NF2-associated, pediatric, and radiation-induced meningiomas are discussed, with the observation that the nonsporadic meningiomas have a higher incidence of multiple chromosomal abnormalities at presentation. Ultimately, a better understanding of the molecular pathways of meningioma tumorigenesis will lead to new, successful treatments.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MN1Humanmeningioma  TAS  RGD 
Mn1Ratmeningioma  ISOMN1 (Homo sapiens) RGD 
Mn1Mousemeningioma  ISOMN1 (Homo sapiens) RGD 
NF2Humanmeningioma  TAS  RGD 
Nf2Ratmeningioma  ISONF2 (Homo sapiens) RGD 
Nf2Mousemeningioma  ISONF2 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mn1  (MN1 proto-oncogene, transcriptional regulator)
Nf2  (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor)

Genes (Mus musculus)
Mn1  (meningioma 1)
Nf2  (neurofibromin 2)

Genes (Homo sapiens)
MN1  (MN1 proto-oncogene, transcriptional regulator)
NF2  (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor)


Additional Information