Mst1 (macrophage stimulating 1) - Rat Genome Database

Name: Mst1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Mst1 (macrophage stimulating 1) Rattus norvegicus

Analyze

Symbol:

Mst1

Name:

macrophage stimulating 1

RGD ID:

3114

Description:

Enables enzyme binding activity and histone kinase activity. Involved in several processes, including cellular response to hypoxia; cellular response to type II interferon; and flagellated sperm motility. Predicted to be located in vacuole. Predicted to be active in extracellular space. Orthologous to several human genes including MST1 (macrophage stimulating 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

D8h3f15s2; E2F transcription factor 2; E2F2; hepatocyte growth factor-like protein; Macrophage stimulating 1 (hepatocyte growth factor-like)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MST1 (macrophage stimulating 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mst1 (macrophage stimulating 1 (hepatocyte growth factor-like))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mst1 (macrophage stimulating 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MST1 (macrophage stimulating 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MST1 (macrophage stimulating 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mst1 (macrophage stimulating 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MST1 (macrophage stimulating 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MST1 (macrophage stimulating 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mst1 (macrophage stimulating 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MST1L (macrophage stimulating 1 like (pseudogene))	HGNC	Panther, PhylomeDB
Alliance orthologs ³
Homo sapiens (human):	MST1 (macrophage stimulating 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mst1 (macrophage stimulating 1 (hepatocyte growth factor-like))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MST1L (macrophage stimulating 1 like (pseudogene))	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	mst1 (macrophage stimulating 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mst1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	117,646,485 - 117,652,016 (+)	NCBI		GRCr8
mRatBN7.2	8	108,767,886 - 108,773,425 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	108,768,839 - 108,773,416 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	114,395,059 - 114,399,629 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	112,594,383 - 112,598,953 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	110,437,023 - 110,441,594 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	116,857,716 - 116,862,286 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	116,857,684 - 116,862,423 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	116,211,755 - 116,216,379 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	113,348,203 - 113,352,773 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	113,367,657 - 113,372,228 (+)	NCBI
Celera	8	108,073,056 - 108,077,626 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 1 (ISO)

Breast Neoplasms (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Crohn's disease (ISO)

developmental and epileptic encephalopathy (ISO)

early infantile epileptic encephalopathy (ISO)

genetic disease (ISO)

Neoplasm Metastasis (ISO)

sclerosing cholangitis (ISO)

ulcerative colitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-naphthylamine (ISO)

2-palmitoylglycerol (ISO)

4,4'-diaminodiphenylmethane (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

butanal (ISO)

cadmium atom (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpromazine (ISO)

chlorpyrifos (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dioxygen (ISO)

disulfiram (ISO)

entinostat (ISO)

ethanol (ISO)

furan (EXP)

L-ascorbic acid (ISO)

lipopolysaccharide (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (EXP)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

nicotine (ISO)

nitrofen (EXP)

O-methyleugenol (ISO)

paracetamol (ISO)

paraquat (EXP)

perfluorooctanoic acid (EXP)

prothioconazole (ISO)

quercetin (ISO)

raloxifene (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sulforaphane (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tributylstannane (EXP)

trichloroethene (EXP)

valproic acid (ISO)

vinclozolin (ISO)

zinc sulfate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to hypoxia (IEP)

cellular response to type II interferon (IEP)

chromatin remodeling (IEA)

embryo implantation (ISO)

flagellated sperm motility (IEP)

mammary duct terminal end bud growth (ISO)

mammary gland development (ISO)

negative regulation of epithelial cell apoptotic process (ISO)

negative regulation of gluconeogenesis (ISO)

positive regulation of apoptotic process (IMP)

positive regulation of gene expression (ISO)

positive regulation of mammary gland epithelial cell proliferation (ISO)

protein modification process (IMP)

proteolysis (IEA)

regulation of macrophage chemotaxis (ISO)

regulation of receptor signaling pathway via JAK-STAT (IBA,ISO)

spermatogenesis (IEP)

Cellular Component

extracellular space (IBA,ISO)

vacuole (ISO)

Molecular Function

endopeptidase activity (IBA)

enzyme binding (IPI)

histone kinase activity (IDA)

protein binding (ISO)

receptor tyrosine kinase binding (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	Molecular cloning of rat macrophage-stimulating protein and its involvement in the male reproductive system.	Ohshiro K, etal., Biochem Biophys Res Commun 1996 Oct 3;227(1):273-80.
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Protein-L-isoaspartate (D-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1.	Yan G, etal., Int J Cardiol. 2013 Oct 9;168(4):3291-9. doi: 10.1016/j.ijcard.2013.04.045. Epub 2013 May 3.
10.	Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling.	Yun HJ, etal., EMBO J. 2011 May 13;30(12):2465-76. doi: 10.1038/emboj.2011.152.

Additional References at PubMed

PMID:7508914	PMID:12477932	PMID:12606483	PMID:15961701	PMID:17102628	PMID:17409315	PMID:18986304	PMID:19221179	PMID:19720831	PMID:20921231	PMID:22087277	PMID:23376485
PMID:23527007	PMID:25049204	PMID:25277788	PMID:26464622	PMID:30048231	PMID:32240614	PMID:33568044	PMID:34217161	PMID:38265688

Genomics

Comparative Map Data

Mst1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	117,646,485 - 117,652,016 (+)	NCBI		GRCr8
mRatBN7.2	8	108,767,886 - 108,773,425 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	108,768,839 - 108,773,416 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	114,395,059 - 114,399,629 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	112,594,383 - 112,598,953 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	110,437,023 - 110,441,594 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	116,857,716 - 116,862,286 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	116,857,684 - 116,862,423 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	116,211,755 - 116,216,379 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	113,348,203 - 113,352,773 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	113,367,657 - 113,372,228 (+)	NCBI
Celera	8	108,073,056 - 108,077,626 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

MST1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	49,683,947 - 49,689,474 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	49,683,947 - 49,689,501 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	49,721,380 - 49,726,907 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	49,696,391 - 49,701,099 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	49,696,391 - 49,701,099	NCBI
Celera	3	49,686,072 - 49,690,887 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	49,780,360 - 49,785,175 (-)	NCBI		HuRef
CHM1_1	3	49,673,436 - 49,678,251 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	49,713,231 - 49,718,759 (-)	NCBI		T2T-CHM13v2.0

Mst1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	107,957,607 - 107,962,226 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	107,957,635 - 107,962,202 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	108,080,409 - 108,085,027 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	108,080,436 - 108,085,003 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	107,982,767 - 107,987,358 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	107,938,552 - 107,943,099 (+)	NCBI		MGSCv36	mm8
Celera	9	107,690,205 - 107,694,796 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI
cM Map	9	59.07	NCBI

Mst1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	1,590,755 - 1,595,148 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	1,590,685 - 1,595,655 (-)	NCBI	ChiLan1.0	ChiLan1.0

MST1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	49,670,785 - 49,676,364 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	49,675,558 - 49,681,137 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	49,616,339 - 49,621,749 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	50,855,283 - 50,856,052 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

MST1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	39,582,237 - 39,586,958 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	39,582,282 - 39,586,908 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	39,503,160 - 39,507,883 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	39,939,767 - 39,944,483 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	39,938,823 - 39,944,461 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	39,306,836 - 39,311,565 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	39,710,205 - 39,714,921 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	39,990,036 - 39,994,752 (+)	NCBI		UU_Cfam_GSD_1.0

Mst1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	64,538,735 - 64,545,696 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	1,299,300 - 1,303,959 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	1,298,853 - 1,306,088 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MST1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	32,214,937 - 32,219,902 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	32,214,934 - 32,220,045 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	35,394,134 - 35,399,843 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MST1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	11,078,662 - 11,083,885 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	11,074,114 - 11,083,368 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	155,916,564 - 155,921,896 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mst1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	3,610,241 - 3,617,530 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	3,612,467 - 3,617,257 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mst1
11 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	47
Count of miRNA genes:	45
Interacting mature miRNAs:	45
Transcripts:	ENSRNOT00000026711
Prediction methods:	Microtar, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat
631217	Activ1	Activity QTL 1	15.9		voluntary movement trait (VT:0003491)	number of photobeam interruptions in an experimental apparatus (CMO:0001517)	8	102370617	108923645	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			43	35	2	35					5	10
Low	1	22	14	6	17	6	8	11	8	14	19	1	8
Below cutoff	2	19							36	19	16

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_024352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080801	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC089796	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X95096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000026711 ⟹ ENSRNOP00000026711

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	108,768,839 - 108,773,416 (+)	Ensembl
Rnor_6.0 Ensembl	8	116,857,684 - 116,862,423 (+)	Ensembl

RefSeq Acc Id:

NM_024352 ⟹ NP_077328

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,647,442 - 117,652,012 (+)	NCBI
mRatBN7.2	8	108,768,843 - 108,773,413 (+)	NCBI
Rnor_6.0	8	116,857,716 - 116,862,286 (+)	NCBI
Rnor_5.0	8	116,211,755 - 116,216,379 (+)	NCBI
RGSC_v3.4	8	113,348,203 - 113,352,773 (+)	RGD
Celera	8	108,073,056 - 108,077,626 (+)	RGD

Sequence:

show sequence

CAGCTTAGGAGAATGGGGTGGCTCCCACTACTGCTGCTTCTGGCACAGTGTTCAAGGGCTCTTG
GGCAGCGCTCACCGCTGAATGACTTCCAGCTGCTTCGGGGCACAGAGTTAAGGAACCTGCTACA
TCCAGTGGTGCCAGGGCCATGGCAGGAGGATGTGGCAGATGCCGAGGAGTGTGCTAGACGCTGT
GGGCCCCTTCTGGACTGCCGAGCCTTCCACTACAATATGAGCAGCCATGGTTGCCAGCTACTAC
CGTGGACTCAGCACTCTCTGCGTGCACAGCTACACCATTCTAGCCTGTGCGATCTCTTCCAGAA
GAAAGACTATGTACGGACCTGCATTATGGACAATGGGGCCAGCTACCGGGGCACTGTGGCCAGG
ACAGCTGATGGCTTGCCCTGCCAAGCCTGGAGCCGCAGGTTCCCCAATGACCACAAGTACACGC
CCACACCGAAGAATGGCCTGGAAGAGAACTTCTGTCGGAACCCTGATGGGGACCCCAGAGGTCC
CTGGTGCTACACGACAAACCGCAGCGTGCGTTTCCAGAGCTGCGGCATCAAATCATGCAGGGAG
GCGGTTTGTGTTTGGTGCAACGGCGAGGATTACCGTGGCGAGGTAGACGTTACAGAATCGGGAC
GGGAGTGTCAACGCTGGGACCTGCAGCACCCACACTCGCACCCTTTCCACCCTGAAAAGTTCCC
AGACAAAGCTCTGAAAGACAACTATTGCCGTAATCCGGATGCATCTGAGCGCCCCTGGTGCTAC
ACCACGGACCCGAATGTTGAGCGAGAGTTCTGTGACCTGCCCAGTTGCGGGCCCAACCTGCCAC
CGACCACCAAAGGATCCAAGTCACAACAGCGCAACAAGGTCAAGGCTTCGAACTGCTTCCGCGG
AAAAGGTGAAGACTATCGAGGCACAACCAATACCACCTCTGCGGGTGTGCCCTGCCAGCGCTGG
GATGCGCAGAATCCGCACCAGCACCGCTTTGTGCCGGAGAAATATGCTTGCAAGGACCTTCGTG
AGAATTTCTGCCGGAATCCTGATGGCTCCGAGGCGCCTTGGTGCTTCACATCTCGACCTGGTTT
GCGTGTGGCCTTTTGCTACCAGATCCCACGCTGCACAGAAGAAGTGGTGCCAGAGGGCTGCTAC
CATGGCTCAGGTGAACAGTATCGTGGCTCAGTCAGCAAGACACGCAAGGGCGTTCAGTGCCAGC
ACTGGTCCTCAGAGACACCACATAAGCCACAATTCACACCCACCTCAGCACCACATGCAGGCTT
GGAGGCAAACTTTTGCCGGAATCCGGATGGAGATAGCCATGGGCCCTGGTGTTATACTTTGGAC
CCAGAGACCCTGTTTGACTACTGTGCCCTAAAACGCTGTGATGATGACCAGCCACCATCCATCT
TGGACCCCCCAGTCCAGGTGCAGTTTGAAAAGTGTGGCAAGAGAGTTGACCAGAGTAATAGACT
TCGTGTGGTGGGGGGTCATCCTGGGAACTCACCGTGGACAGTCAGCTTGCGGAATCGACAGGGC
CAGCATTTCTGTGGGGGTTCCCTAGTGAAGGAGCAGTGGGTACTGACCGCCCGGCAATGCATCT
GGTCATGCCATGATCCTCTCACAGGATATGAGGTATGGTTGGGTACAATTAACCAGAACCCACA
GCCTGGAGAAGCAAACCTGCAGAGGGTCTCAGTGGCCAAGACAGTGTGCGGACCTGCAGGCTCC
CAACTTGTTCTGCTCAAGCTGGAGAGACCTGTGATCCTGAACCATCACGTGGCCAGGATTTGCC
TACCTCCTGAACAGTATGTGGTACCTCCAGGGACCAACTGCGAGATCGCTGGCTGGGGTGAATC
CAAAGGTACAAGCAATAGCACAGTCCTTCATGTGGCCAAAATGAAGGTCATCTCCAGTCAGGAA
TGTAATGTGAAGTACCGGAGACGAGTACAAGAGAGTGAGATATGCACCGAGGGGTTGCTGGCCC
CTACGGGCGCTTGTGAGGGTGACTACGGGGGCCCACTTGCCTGCTATACCCATGACTGCTGGGT
CCTACAGGGACTTATCATCCCGAACAGAGTGTGTGCACGGCCTCGCTGGCCAGCTATCTTCACA
CGTGTGTCTGTGTTTGTGGACTGGATTAACAAGGTCGTGCAGCTGGAGTAGGCCTGCTTTCGAT
CTCTTAGAGATGACAAGGCTGCTTATCAAACTAAAGCAAACTTTTC

hide sequence

RefSeq Acc Id:

XM_039080801 ⟹ XP_038936729

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,646,929 - 117,652,016 (+)	NCBI
mRatBN7.2	8	108,768,326 - 108,773,425 (+)	NCBI

RefSeq Acc Id:

XM_039080802 ⟹ XP_038936730

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,646,485 - 117,652,016 (+)	NCBI
mRatBN7.2	8	108,767,886 - 108,773,425 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_077328	(Get FASTA)	NCBI Sequence Viewer
	XP_038936729	(Get FASTA)	NCBI Sequence Viewer
	XP_038936730	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89796	(Get FASTA)	NCBI Sequence Viewer
	CAA64473	(Get FASTA)	NCBI Sequence Viewer
	EDL77193	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026711
	ENSRNOP00000026711.5

RefSeq Acc Id:	NP_077328 ⟸ NM_024352
- Peptide Label:	precursor
- UniProtKB:	P70521 (UniProtKB/TrEMBL), Q5EBC6 (UniProtKB/TrEMBL), F7FMS0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGWLPLLLLLAQCSRALGQRSPLNDFQLLRGTELRNLLHPVVPGPWQEDVADAEECARRCGPLL DCRAFHYNMSSHGCQLLPWTQHSLRAQLHHSSLCDLFQKKDYVRTCIMDNGASYRGTVARTADG LPCQAWSRRFPNDHKYTPTPKNGLEENFCRNPDGDPRGPWCYTTNRSVRFQSCGIKSCREAVCV WCNGEDYRGEVDVTESGRECQRWDLQHPHSHPFHPEKFPDKALKDNYCRNPDASERPWCYTTDP NVEREFCDLPSCGPNLPPTTKGSKSQQRNKVKASNCFRGKGEDYRGTTNTTSAGVPCQRWDAQN PHQHRFVPEKYACKDLRENFCRNPDGSEAPWCFTSRPGLRVAFCYQIPRCTEEVVPEGCYHGSG EQYRGSVSKTRKGVQCQHWSSETPHKPQFTPTSAPHAGLEANFCRNPDGDSHGPWCYTLDPETL FDYCALKRCDDDQPPSILDPPVQVQFEKCGKRVDQSNRLRVVGGHPGNSPWTVSLRNRQGQHFC GGSLVKEQWVLTARQCIWSCHDPLTGYEVWLGTINQNPQPGEANLQRVSVAKTVCGPAGSQLVL LKLERPVILNHHVARICLPPEQYVVPPGTNCEIAGWGESKGTSNSTVLHVAKMKVISSQECNVK YRRRVQESEICTEGLLAPTGACEGDYGGPLACYTHDCWVLQGLIIPNRVCARPRWPAIFTRVSV FVDWINKVVQLE hide sequence

RefSeq Acc Id:

ENSRNOP00000026711 ⟸ ENSRNOT00000026711

RefSeq Acc Id:	XP_038936730 ⟸ XM_039080802
- Peptide Label:	isoform X2
- UniProtKB:	F7FMS0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038936729 ⟸ XM_039080801
- Peptide Label:	isoform X1
- UniProtKB:	F7FMS0 (UniProtKB/TrEMBL)

Protein Domains

Apple Kringle Peptidase S1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F7FMS0-F1-model_v2	AlphaFold	F7FMS0	1-739	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696289

Promoter ID:

EPDNEW_R6814

Type:

multiple initiation site

Name:

Mst1_1

Description:

macrophage stimulating 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	116,857,703 - 116,857,763	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3114	AgrOrtholog
BioCyc Gene	G2FUF-29158	BioCyc
Ensembl Genes	ENSRNOG00000019680	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000026711	ENTREZGENE
	ENSRNOT00000026711.8	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
	2.40.20.10	UniProtKB/TrEMBL
	Hepatocyte Growth Factor	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7322260	IMAGE-MGC_LOAD
InterPro	HGF_MST1	UniProtKB/TrEMBL
	Kringle	UniProtKB/TrEMBL
	Kringle-like	UniProtKB/TrEMBL
	Kringle_CS	UniProtKB/TrEMBL
	Kringle_sf	UniProtKB/TrEMBL
	MSP_HGFL	UniProtKB/TrEMBL
	Pan_app	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1_S6	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Ser/Cys_Pept_Trypsin-like	UniProtKB/TrEMBL
KEGG Report	rno:24566	UniProtKB/TrEMBL
MGC_CLONE	MGC:108677	IMAGE-MGC_LOAD
NCBI Gene	24566	ENTREZGENE
PANTHER	HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN-RELATED	UniProtKB/TrEMBL
	PLASMINOGEN-RELATED	UniProtKB/TrEMBL
Pfam	Kringle	UniProtKB/TrEMBL
	PAN_1	UniProtKB/TrEMBL
	Trypsin	UniProtKB/TrEMBL
PhenoGen	Mst1	PhenoGen
PIRSF	HGF_MST1	UniProtKB/TrEMBL
	MSP_HGFL	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
	KRINGLE	UniProtKB/TrEMBL
PROSITE	KRINGLE_1	UniProtKB/TrEMBL
	KRINGLE_2	UniProtKB/TrEMBL
	PAN	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019680	RatGTEx
SMART	PAN_AP	UniProtKB/TrEMBL
	SM00130	UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	Hairpin loop containing domain-like	UniProtKB/TrEMBL
	Kringle-like	UniProtKB/TrEMBL
	Pept_Ser_Cys	UniProtKB/TrEMBL
UniProt	F7FMS0	ENTREZGENE, UniProtKB/TrEMBL
	P70521	ENTREZGENE, UniProtKB/TrEMBL
	Q5EBC6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-03-04	Mst1	macrophage stimulating 1	Mst1	Macrophage stimulating 1 (hepatocyte growth factor-like)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Mst1	Macrophage stimulating 1 (hepatocyte growth factor-like)			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA expressed in spermatogonia and spermatocytes in the testis and the epithelium lining the lumen of the epididymis	633226
gene_product	member of the hepatocyte growth factor family	633226

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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