Smad1 (SMAD family member 1) - Rat Genome Database

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Gene: Smad1 (SMAD family member 1) Rattus norvegicus
Analyze
Symbol: Smad1
Name: SMAD family member 1
RGD ID: 3030
Description: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; SMAD binding activity; and enzyme binding activity. Involved in several processes, including BMP signaling pathway; cardiac muscle hypertrophy in response to stress; and positive regulation of dendrite morphogenesis. Predicted to be located in cytoplasm and nuclear inner membrane. Predicted to be part of heteromeric SMAD protein complex and homomeric SMAD protein complex. Predicted to be active in chromatin and male germ cell nucleus. Used to study pulmonary hypertension. Biomarker of glomerulonephritis; male infertility; nephrotic syndrome; and pulmonary hypertension. Orthologous to human SMAD1 (SMAD family member 1); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MAD (mothers against decapentaplegic Drosophila) homolog 1; MAD (mothers against decapentaplegic, Drosophila) homolog 1; MAD homolog 1; MAD homolog 1 (Drosophila); MAD homolog1 (mothers against decapentaplegic Drosophila); MAD homolog1 (mothers against decapentaplegic, Drosophila); Madh1; mothers against decapentaplegic homolog 1; mothers against DPP homolog 1; SMAD 1; SMAD, mothers against DPP homolog 1; SMAD, mothers against DPP homolog 1 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81945,417,430 - 45,477,962 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1945,417,433 - 45,477,957 (+)EnsemblGRCr8
mRatBN7.21928,513,130 - 28,573,665 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1928,513,131 - 28,573,651 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1935,369,097 - 35,429,185 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01936,023,176 - 36,083,272 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01938,258,468 - 38,318,560 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01932,182,942 - 32,248,694 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1932,188,267 - 32,248,684 (+)Ensemblrn6Rnor6.0
Rnor_5.01943,079,695 - 43,145,300 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41930,348,886 - 30,409,345 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1928,023,055 - 28,083,575 (+)NCBICelera
RGSC_v3.11930,353,711 - 30,414,170 (+)NCBI
Cytogenetic Map19q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxypsoralen  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
aucubin  (ISO)
azadirachtin A  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cytochalasin D  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
diclofenac  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
galangin  (ISO)
gentamycin  (EXP)
glycerol 2-phosphate  (ISO)
glyphosate  (ISO)
hexadecanoic acid  (ISO)
imperatorin  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
monocrotaline  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (ISO)
nicotine  (ISO)
nonanoic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
picrotoxin  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rolipram  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sirtinol  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
streptozocin  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure morphogenesis  (IBA)
anti-Mullerian hormone receptor signaling pathway  (IEA,ISO)
BMP signaling pathway  (IBA,IEA,IMP,ISO,ISS)
bone development  (ISO)
cardiac muscle cell proliferation  (ISO)
cardiac muscle hypertrophy in response to stress  (IMP)
cartilage development  (ISO)
cell differentiation  (IBA)
DNA-templated transcription  (IEA,ISO)
embryonic pattern specification  (ISS)
gamete generation  (ISO)
hindbrain development  (ISO)
homeostatic process  (ISO)
inflammatory response  (IEA,ISO)
intracellular iron ion homeostasis  (IEA,ISO)
kidney development  (IEP)
MAPK cascade  (IMP,ISO)
mesodermal cell fate commitment  (ISO)
midbrain development  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of muscle cell apoptotic process  (IEP)
ossification  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
osteoblast fate commitment  (ISO)
positive regulation of cartilage development  (ISO)
positive regulation of cell differentiation  (IDA)
positive regulation of dendrite morphogenesis  (IEP)
positive regulation of gene expression  (ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of sprouting angiogenesis  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
protein phosphorylation  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to xenobiotic stimulus  (IDA)
SMAD protein signal transduction  (IBA,IEA,ISO)
stem cell differentiation  (IEA,ISO)
transforming growth factor beta receptor signaling pathway  (IBA,IEA,ISO)
ureteric bud development  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Signaling by bone morphogenetic proteins and Smad1 modulates the postnatal differentiation of cerebellar cells. Angley C, etal., J Neurosci 2003 Jan 1;23(1):260-8.
2. Statins Decrease Expression of the Pro-Inflammatory Neuropeptides CGRP and Substance P in Sensory Neurons. Bucelli RC, etal., J Pharmacol Exp Ther. 2007 Dec 13;.
3. Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins. Chen Y, etal., Proc Natl Acad Sci U S A 1996 Nov 12;93(23):12992-7.
4. Bone morphogenetic protein 4 mediates bile duct ligation induced liver fibrosis through activation of Smad1 and ERK1/2 in rat hepatic stellate cells. Fan J, etal., J Cell Physiol. 2006 May;207(2):499-505.
5. The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways. Fukada T, etal., PLoS One. 2008;3(11):e3642. doi: 10.1371/journal.pone.0003642. Epub 2008 Nov 5.
6. Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. Fuller ML, etal., Ann Neurol. 2007 Sep;62(3):288-300.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathway. Izumi M, etal., J Biol Chem. 2001 Aug 17;276(33):31133-41. Epub 2001 Jun 14.
10. Cross-talk between bone morphogenetic protein 2 and leukemia inhibitory factor through ERK 1/2 and Smad1 in protection against doxorubicin-induced injury of cardiomyocytes. Izumi M, etal., J Mol Cell Cardiol. 2006 Feb;40(2):224-33. Epub 2006 Jan 19.
11. Extracellular signal-regulated kinases regulate dendritic growth in rat sympathetic neurons. Kim IJ, etal., J Neurosci. 2004 Mar 31;24(13):3304-12.
12. Chinese herbal formula Qilong-Lishui granule improves puromycin aminonucleoside-induced renal injury through regulation of bone morphogenetic proteins. Li P, etal., Nephrology (Carlton). 2007 Oct;12(5):466-73.
13. [Expression of Smad1 and Smad5 in the testis of infertile rats with kidney-yang deficiency] Ma J, etal., Zhonghua Nan Ke Xue. 2005 Jan;11(1):17-21.
14. Alteration of transforming growth factor-beta signaling system expression in adult rat germ cells with a chronic apoptotic cell death process after fetal androgen disruption. Maire M, etal., Endocrinology. 2005 Dec;146(12):5135-43. Epub 2005 Sep 15.
15. Smad1 protects cardiomyocytes from ischemia-reperfusion injury. Masaki M, etal., Circulation. 2005 May 31;111(21):2752-9. Epub 2005 May 23.
16. Expression of Smad1 is directly associated with mesangial matrix expansion in rat diabetic nephropathy. Matsubara T, etal., Lab Invest. 2006 Apr;86(4):357-68.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. Morty RE, etal., Arterioscler Thromb Vasc Biol. 2007 May;27(5):1072-8. Epub 2007 Mar 8.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Altered expression of Smad family members in injured motor neurons of rat. Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney. Oxburgh L and Robertson EJ, Mech Dev. 2002 Mar;112(1-2):207-11.
23. Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk. Paez-Pereda M, etal., Proc Natl Acad Sci U S A 2003 Feb 4;100(3):1034-9.
24. Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Pangas SA, etal., Mol Cell Biol. 2008 Jan;28(1):248-57. Epub 2007 Oct 29.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
27. Smad signaling in the rat model of monocrotaline pulmonary hypertension. Ramos MF, etal., Toxicol Pathol. 2008 Feb;36(2):311-20. doi: 10.1177/0192623307311402. Epub 2008 Mar 26.
28. GOA pipeline RGD automated data pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Shahid M, etal., Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H984-94. doi: 10.1152/ajpheart.00879.2015. Epub 2016 Feb 12.
31. Increased Smad1 expression and transcriptional activity enhances trans-differentiation of hepatic stellate cells. Shen H, etal., J Cell Physiol. 2007 Sep;212(3):764-70.
32. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
33. Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Takahashi H, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L450-8. Epub 2005 Dec 16.
34. Activation of STAT3/Smad1 is a key signaling pathway for progression to glomerulosclerosis in experimental glomerulonephritis. Takahashi T, etal., J Biol Chem. 2005 Feb 25;280(8):7100-6. Epub 2004 Dec 9.
35. Cross-talk between bone morphogenetic protein and transforming growth factor-beta signaling is essential for exendin-4-induced insulin-positive differentiation of AR42J cells. Yew KH, etal., J Biol Chem. 2005 Sep 16;280(37):32209-17. Epub 2005 Jul 14.
36. TGF-beta, BMPS, and their signal transducing mediators, Smads, in rat fracture healing. Yu Y, etal., J Biomed Mater Res 2002 Jun 5;60(3):392-7.
37. Cloning and expression of a rat Smad1: regulation by TGFbeta and modulation by the Ras/MEK pathway. Yue J, etal., J Cell Physiol 1999 Mar;178(3):387-96.
Additional References at PubMed
PMID:8653785   PMID:9111321   PMID:9389648   PMID:9436979   PMID:11160896   PMID:11779505   PMID:12151307   PMID:12270938   PMID:12647004   PMID:12874272   PMID:14633973   PMID:14656760  
PMID:15150273   PMID:15198985   PMID:15231748   PMID:15557274   PMID:15647271   PMID:15899870   PMID:16556916   PMID:16604073   PMID:16767106   PMID:16801560   PMID:17350578   PMID:17530186  
PMID:18184649   PMID:18285555   PMID:18548003   PMID:18622394   PMID:18692037   PMID:18776146   PMID:18842318   PMID:18997172   PMID:19103752   PMID:19224984   PMID:19251704   PMID:19252488  
PMID:19664780   PMID:19793887   PMID:19796622   PMID:19834880   PMID:20147459   PMID:20522807   PMID:20843790   PMID:20926379   PMID:21145505   PMID:21515935   PMID:21724602   PMID:21737358  
PMID:21804025   PMID:21986617   PMID:22051847   PMID:22500633   PMID:23169531   PMID:23610558   PMID:24042587   PMID:24047927   PMID:24211589   PMID:25010525   PMID:25100727   PMID:26352281  
PMID:26687945   PMID:27035233   PMID:27618520   PMID:28457943   PMID:29328402   PMID:30729278   PMID:30894415   PMID:38063098  


Genomics

Comparative Map Data
Smad1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81945,417,430 - 45,477,962 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1945,417,433 - 45,477,957 (+)EnsemblGRCr8
mRatBN7.21928,513,130 - 28,573,665 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1928,513,131 - 28,573,651 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1935,369,097 - 35,429,185 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01936,023,176 - 36,083,272 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01938,258,468 - 38,318,560 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01932,182,942 - 32,248,694 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1932,188,267 - 32,248,684 (+)Ensemblrn6Rnor6.0
Rnor_5.01943,079,695 - 43,145,300 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41930,348,886 - 30,409,345 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1928,023,055 - 28,083,575 (+)NCBICelera
RGSC_v3.11930,353,711 - 30,414,170 (+)NCBI
Cytogenetic Map19q11NCBI
SMAD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384145,480,770 - 145,559,176 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4145,480,769 - 145,559,176 (+)Ensemblhg38GRCh38
GRCh374146,402,458 - 146,480,328 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364146,622,401 - 146,699,778 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344146,760,555 - 146,837,928NCBI
Celera4143,730,483 - 143,807,862 (+)NCBICelera
Cytogenetic Map4q31.21NCBI
HuRef4142,134,622 - 142,210,284 (+)NCBIHuRef
CHM1_14146,379,527 - 146,456,909 (+)NCBICHM1_1
T2T-CHM13v2.04148,798,276 - 148,874,991 (+)NCBIT2T-CHM13v2.0
Smad1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39880,065,024 - 80,126,057 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl880,065,024 - 80,126,147 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38879,338,395 - 79,399,428 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl879,338,395 - 79,399,518 (-)Ensemblmm10GRCm38
MGSCv37881,862,294 - 81,923,367 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36882,234,467 - 82,295,540 (-)NCBIMGSCv36mm8
Celera883,615,361 - 83,676,406 (-)NCBICelera
Cytogenetic Map8C1NCBI
cM Map837.56NCBI
Smad1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554281,361,085 - 1,429,948 (+)Ensembl
ChiLan1.0NW_0049554281,357,398 - 1,429,521 (+)NCBIChiLan1.0ChiLan1.0
SMAD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23143,354,683 - 143,433,135 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14143,753,819 - 143,798,089 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04137,822,269 - 137,899,700 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14149,481,819 - 149,558,135 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4149,481,836 - 149,558,135 (+)EnsemblpanPan2panpan1.1
SMAD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11544,093,491 - 44,171,177 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1544,095,497 - 44,170,098 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1544,485,533 - 44,563,273 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01544,761,101 - 44,839,209 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1544,763,658 - 44,839,222 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11544,034,585 - 44,112,489 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01544,121,557 - 44,199,409 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01544,386,546 - 44,464,496 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Smad1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530146,145,177 - 46,219,936 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365353,582,489 - 3,657,063 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365353,582,512 - 3,626,312 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl882,908,527 - 82,968,994 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1882,907,557 - 82,987,909 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SMAD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1792,047,273 - 92,123,451 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl792,079,914 - 92,123,429 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603771,693,446 - 71,769,726 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248534,444,876 - 4,502,496 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248534,415,816 - 4,503,317 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Smad1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11720,704,883 - 20,766,033 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Smad1
334 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:609
Count of miRNA genes:269
Interacting mature miRNAs:327
Transcripts:ENSRNOT00000025079
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)194172060949971820Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)193009938347207961Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat

Markers in Region
Smad1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21928,539,696 - 28,540,047 (+)MAPPERmRatBN7.2
Rnor_6.01932,214,728 - 32,215,078NCBIRnor6.0
Rnor_5.01943,111,482 - 43,111,832UniSTSRnor5.0
RGSC_v3.41930,375,339 - 30,375,689UniSTSRGSC3.4
Celera1928,049,630 - 28,049,980UniSTS
Cytogenetic Map19q11UniSTS
RH138429  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21928,573,037 - 28,573,176 (+)MAPPERmRatBN7.2
Rnor_6.01932,248,067 - 32,248,205NCBIRnor6.0
Rnor_5.01943,144,673 - 43,144,811UniSTSRnor5.0
RGSC_v3.41930,408,731 - 30,408,869UniSTSRGSC3.4
Celera1928,082,961 - 28,083,099UniSTS
RH 3.4 Map31328.1UniSTS
Cytogenetic Map19q11UniSTS
RH130435  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21928,573,220 - 28,573,440 (+)MAPPERmRatBN7.2
Rnor_6.01932,248,250 - 32,248,469NCBIRnor6.0
Rnor_5.01943,144,856 - 43,145,075UniSTSRnor5.0
RGSC_v3.41930,408,914 - 30,409,133UniSTSRGSC3.4
Celera1928,083,144 - 28,083,363UniSTS
RH 3.4 Map19184.5UniSTS
Cytogenetic Map19q11UniSTS
RH94757  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21928,539,521 - 28,539,681 (+)MAPPERmRatBN7.2
Rnor_6.01932,214,553 - 32,214,712NCBIRnor6.0
Rnor_5.01943,111,307 - 43,111,466UniSTSRnor5.0
RGSC_v3.41930,375,164 - 30,375,323UniSTSRGSC3.4
Celera1928,049,455 - 28,049,614UniSTS
Cytogenetic Map19q11UniSTS
RH142930  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21928,569,488 - 28,569,719 (+)MAPPERmRatBN7.2
Rnor_6.01932,244,518 - 32,244,748NCBIRnor6.0
Rnor_5.01943,141,124 - 43,141,354UniSTSRnor5.0
RGSC_v3.41930,405,182 - 30,405,412UniSTSRGSC3.4
Celera1928,079,412 - 28,079,642UniSTS
RH 3.4 Map19212.5UniSTS
Cytogenetic Map19q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025079   ⟹   ENSRNOP00000025079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1945,417,433 - 45,477,957 (+)Ensembl
mRatBN7.2 Ensembl1928,513,131 - 28,573,651 (+)Ensembl
Rnor_6.0 Ensembl1932,188,267 - 32,248,684 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104934   ⟹   ENSRNOP00000083295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1945,417,462 - 45,477,957 (+)Ensembl
mRatBN7.2 Ensembl1928,513,131 - 28,573,651 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136882   ⟹   ENSRNOP00000102689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1945,417,462 - 45,477,957 (+)Ensembl
RefSeq Acc Id: NM_013130   ⟹   NP_037262
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81945,417,542 - 45,477,949 (+)NCBI
mRatBN7.21928,513,240 - 28,573,652 (+)NCBI
Rnor_6.01932,188,275 - 32,248,681 (+)NCBI
Rnor_5.01943,079,695 - 43,145,300 (+)NCBI
RGSC_v3.41930,348,886 - 30,409,345 (+)RGD
Celera1928,023,055 - 28,083,575 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255394   ⟹   XP_006255456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81945,417,430 - 45,477,962 (+)NCBI
mRatBN7.21928,513,131 - 28,573,665 (+)NCBI
Rnor_6.01932,188,174 - 32,248,694 (+)NCBI
Rnor_5.01943,079,695 - 43,145,300 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255395   ⟹   XP_006255457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81945,440,333 - 45,477,962 (+)NCBI
mRatBN7.21928,536,679 - 28,573,665 (+)NCBI
Rnor_6.01932,208,202 - 32,248,694 (+)NCBI
Rnor_5.01943,079,695 - 43,145,300 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255397   ⟹   XP_006255459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81945,417,430 - 45,477,962 (+)NCBI
mRatBN7.21928,513,221 - 28,573,658 (+)NCBI
Rnor_6.01932,188,174 - 32,248,694 (+)NCBI
Rnor_5.01943,079,695 - 43,145,300 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063277823   ⟹   XP_063133893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81945,425,838 - 45,477,962 (+)NCBI
RefSeq Acc Id: XM_063277824   ⟹   XP_063133894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81945,440,382 - 45,477,962 (+)NCBI
RefSeq Acc Id: XM_063277825   ⟹   XP_063133895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81945,417,885 - 45,477,962 (+)NCBI
RefSeq Acc Id: NP_037262   ⟸   NM_013130
- UniProtKB: A6IYI3 (UniProtKB/TrEMBL),   Q6P7A6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255456   ⟸   XM_006255394
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JSQ6 (UniProtKB/TrEMBL),   Q6P7A6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255459   ⟸   XM_006255397
- Peptide Label: isoform X2
- UniProtKB: Q6P7A6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255457   ⟸   XM_006255395
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JSQ6 (UniProtKB/TrEMBL),   Q6P7A6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025079   ⟸   ENSRNOT00000025079
Ensembl Acc Id: ENSRNOP00000083295   ⟸   ENSRNOT00000104934
RefSeq Acc Id: XP_063133895   ⟸   XM_063277825
- Peptide Label: isoform X3
- UniProtKB: A6IYI3 (UniProtKB/TrEMBL),   Q6P7A6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133893   ⟸   XM_063277823
- Peptide Label: isoform X3
- UniProtKB: A6IYI3 (UniProtKB/TrEMBL),   Q6P7A6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133894   ⟸   XM_063277824
- Peptide Label: isoform X3
- UniProtKB: A6IYI3 (UniProtKB/TrEMBL),   Q6P7A6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102689   ⟸   ENSRNOT00000136882
Protein Domains
MH1   MH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97588-F1-model_v2 AlphaFold P97588 1-468 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701052
Promoter ID:EPDNEW_R11575
Type:multiple initiation site
Name:Smad1_1
Description:SMAD family member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01932,188,256 - 32,188,316EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3030 AgrOrtholog
BioCyc Gene G2FUF-5948 BioCyc
Ensembl Genes ENSRNOG00000018483 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000025079 ENTREZGENE
  ENSRNOT00000136882 ENTREZGENE
Gene3D-CATH 2.60.200.10 UniProtKB/Swiss-Prot
  3.90.520.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599977 IMAGE-MGC_LOAD
InterPro Dwarfin UniProtKB/Swiss-Prot
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot
  MAD_homology_MH1 UniProtKB/Swiss-Prot
  SMAD-like_dom_sf UniProtKB/Swiss-Prot
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot
  SMAD_MH1_sf UniProtKB/Swiss-Prot
KEGG Report rno:25671 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72530 IMAGE-MGC_LOAD
NCBI Gene 25671 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1 UniProtKB/Swiss-Prot
  PTHR13703 UniProtKB/Swiss-Prot
Pfam MH1 UniProtKB/Swiss-Prot
  MH2 UniProtKB/Swiss-Prot
PhenoGen Smad1 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot
  MH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018483 RatGTEx
SMART DWA UniProtKB/Swiss-Prot
  DWB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot
  SSF56366 UniProtKB/Swiss-Prot
UniProt A0A0G2JSQ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G8R6_RAT UniProtKB/TrEMBL
  A0ABK0L233_RAT UniProtKB/TrEMBL
  A6IYI3 ENTREZGENE, UniProtKB/TrEMBL
  P97588 ENTREZGENE
  Q6P7A6 ENTREZGENE, UniProtKB/TrEMBL
  SMAD1_RAT UniProtKB/Swiss-Prot
UniProt Secondary O70520 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Smad1  SMAD family member 1  Smad1  MAD homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Smad1  MAD homolog 1 (Drosophila)      Name updated 1299863 APPROVED
2005-01-20 Smad1  SMAD, mothers against DPP homolog 1 (Drosophila)  Madh1  MAD homolog 1 (Drosophila)  Symbol and Name updated 1299863 APPROVED
2002-06-10 Madh1  MAD homolog 1 (Drosophila)      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cytoplasm and translocated to nucleus after activation by BMP4 631793
gene_process involved in regulating postnatal cerebellar differentiation 631793