Jag1 (jagged canonical Notch ligand 1) - Rat Genome Database

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Gene: Jag1 (jagged canonical Notch ligand 1) Rattus norvegicus
Analyze
Symbol: Jag1
Name: jagged canonical Notch ligand 1
RGD ID: 2937
Description: Enables Notch binding activity and receptor ligand activity. Involved in several processes, including animal organ regeneration; inner ear auditory receptor cell differentiation; and positive regulation of cardiac epithelial to mesenchymal transition. Predicted to be located in adherens junction and apical plasma membrane. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; Alagille syndrome pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: jagged 1; protein jagged-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83144,859,453 - 144,894,883 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3144,859,453 - 144,894,872 (-)EnsemblGRCr8
mRatBN7.23124,406,783 - 124,442,220 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3124,406,794 - 124,442,209 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3128,293,948 - 128,329,348 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03136,870,930 - 136,906,325 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03134,556,899 - 134,592,326 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03130,079,361 - 130,114,781 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3130,079,361 - 130,114,770 (-)Ensemblrn6Rnor6.0
Rnor_5.03136,558,688 - 136,594,108 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43125,181,063 - 125,216,481 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3123,126,087 - 123,161,497 (-)NCBICelera
RGSC_v3.13125,086,635 - 125,122,054 (-)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,4-benzoquinone  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
9-phenanthrol  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-naphthoflavone  (EXP)
alpha-pinene  (ISO)
alpha-Zearalanol  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (EXP)
celastrol  (ISO)
chloropicrin  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
DAPT  (ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emodin  (EXP)
endosulfan  (EXP)
Enterolactone  (ISO)
enzacamene  (EXP)
enzalutamide  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
Ethylenethiourea  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP)
formaldehyde  (ISO)
furan  (EXP)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycyrrhizinic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
HT-2 toxin  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
L-ascorbic acid  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mechlorethamine  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (ISO)
N(6)-dimethylallyladenine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
pinosylvin  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tebuconazole  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
Tiron  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-pinosylvin  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IEA)
animal organ morphogenesis  (ISO)
animal organ regeneration  (IEP)
aorta morphogenesis  (IEA,ISO)
blood vessel remodeling  (ISO)
camera-type eye development  (ISO)
cardiac neural crest cell development involved in outflow tract morphogenesis  (IEA,ISO)
cardiac right ventricle morphogenesis  (IEA,ISO)
cardiac septum morphogenesis  (IEA,ISO)
cell communication  (IEA)
cell differentiation  (IEA)
cell fate determination  (NAS)
ciliary body morphogenesis  (ISO)
distal tubule development  (IEA,ISO)
endocardial cushion cell development  (IEA,ISO)
inner ear auditory receptor cell differentiation  (IEA,IMP,ISO)
inner ear development  (IEA,ISO)
loop of Henle development  (IEA,ISO)
morphogenesis of an epithelial sheet  (ISO)
negative regulation of cell differentiation  (IDA,IEA,ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of cell-cell adhesion  (IEA,ISO)
negative regulation of cell-matrix adhesion  (IEA,ISO)
negative regulation of endothelial cell differentiation  (IEA,ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of stem cell differentiation  (IEA,ISO)
nephron development  (IEA,ISO,ISS)
neuronal stem cell population maintenance  (IEA,ISO)
Notch signaling pathway  (IDA,IEA,IMP,ISO)
podocyte development  (IEA,ISO,ISS)
positive regulation of cardiac epithelial to mesenchymal transition  (IGI)
positive regulation of cell differentiation  (IEA)
positive regulation of gene expression  (IGI)
positive regulation of macromolecule biosynthetic process  (IEA)
positive regulation of myeloid cell differentiation  (ISO)
positive regulation of Notch signaling pathway  (IEA,ISO,ISS)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
pulmonary artery morphogenesis  (IEA,ISO)
pulmonary valve morphogenesis  (IEA,ISO)
regeneration  (IEA)
regulation of cell population proliferation  (IEA,IMP,ISO)
regulation of gene expression  (IEA)
regulation of multicellular organismal process  (IEA)
response to muramyl dipeptide  (IEA,ISO)
system development  (IEA)
T cell mediated immunity  (IEA,ISO)
wound healing  (IEA,IEP)

Cellular Component
adherens junction  (IEA,ISO,ISS)
apical part of cell  (IEA,ISO)
apical plasma membrane  (IEA,ISO,ISS)
membrane  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans. Ban M, etal., J Neuroimmunol. 2006 Oct;179(1-2):108-16. Epub 2006 Aug 24.
2. Soluble Jagged-1 inhibits neointima formation by attenuating Notch-Herp2 signaling. Caolo V, etal., Arterioscler Thromb Vasc Biol. 2011 May;31(5):1059-65. Epub 2011 Feb 17.
3. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates. Chen AC, etal., J Biol Chem. 2010 Apr 9;285(15):11378-91. doi: 10.1074/jbc.M109.088815. Epub 2010 Feb 9.
4. The pattern of expression of Notch protein members in normal and pathological endometrium. Cobellis L, etal., J Anat. 2008 Aug 4.
5. Familial Tetralogy of Fallot caused by mutation in the jagged1 gene. Eldadah ZA, etal., Hum Mol Genet. 2001 Jan 15;10(2):163-9.
6. JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. Elyaman W, etal., J Immunol. 2007 Nov 1;179(9):5990-8.
7. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Differential effects of targeting Notch receptors in a mouse model of liver cancer. Huntzicker EG, etal., Hepatology. 2015 Mar;61(3):942-52. doi: 10.1002/hep.27566. Epub 2015 Jan 28.
10. Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands. Kakuda S and Haltiwanger RS, Dev Cell. 2017 Jan 23;40(2):193-201. doi: 10.1016/j.devcel.2016.12.013. Epub 2017 Jan 12.
11. Notch1, Jagged1, and HES5 are abundantly expressed in osteoarthritis. Karlsson C, etal., Cells Tissues Organs. 2008;188(3):287-98. Epub 2008 Mar 20.
12. Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells. Kijima M, etal., J Immunol. 2009 Mar 15;182(6):3566-72.
13. Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Kohler C, etal., Hepatology 2004 Apr;39(4):1056-65.
14. The expression profile of Jagged1 and Delta-like 4 in hepatocellular carcinoma. Kunanopparat A, etal., Asian Pac J Allergy Immunol. 2019 Jan 13. doi: 10.12932/AP-040818-0388.
15. Familial deafness, congenital heart defects, and posterior embryotoxon caused by cysteine substitution in the first epidermal-growth-factor-like domain of jagged 1. Le Caignec C, etal., Am J Hum Genet. 2002 Jul;71(1):180-6. Epub 2002 May 17.
16. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Li L, etal., Nat Genet. 1997 Jul;16(3):243-51.
17. Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Lindner V, etal., Am J Pathol. 2001 Sep;159(3):875-83. doi: 10.1016/S0002-9440(10)61763-4.
18. Jagged: a mammalian ligand that activates Notch1. Lindsell CE, etal., Cell 1995 Mar 24;80(6):909-17.
19. NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling. McBride KL, etal., Hum Mol Genet. 2008 Sep 15;17(18):2886-93. doi: 10.1093/hmg/ddn187. Epub 2008 Jun 30.
20. Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling. Meng H, etal., J Biol Chem. 2010 Jul 23;285(30):23047-55. doi: 10.1074/jbc.M110.144634. Epub 2010 May 14.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy. Miloudi K, etal., Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4538-4547. doi: 10.1073/pnas.1814711116. Epub 2019 Feb 20.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12. Oda T, etal., Genomics. 1997 Aug 1;43(3):376-9.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. Alagille syndrome and the Jagged1 gene. Piccoli DA and Spinner NB, Semin Liver Dis. 2001 Nov;21(4):525-34.
27. Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis. Piggott K, etal., Circulation. 2011 Jan 25;123(3):309-18. Epub 2011 Jan 10.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. Oxidative stress-induced apoptosis in two patients with Alagille syndrome. Radi E, etal., J Neurol Sci. 2011 Sep 15;308(1-2):49-56. Epub 2011 Jun 28.
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT. Riley MF, etal., Biochim Biophys Acta. 2011 Jan;1812(1):121-9. doi: 10.1016/j.bbadis.2010.10.002. Epub 2010 Oct 14.
35. Proteomics comparison of cerebrospinal fluid of relapsing remitting and primary progressive multiple sclerosis. Stoop MP, etal., PLoS One. 2010 Aug 27;5(8):e12442.
36. Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway. Su Y, etal., J Gastrointest Surg. 2006 Nov;10(9):1230-41; discussion 1242.
37. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
38. Notch4 and Jagged-1 induce microvessel differentiation of rat brain endothelial cells. Uyttendaele H, etal., Microvasc Res 2000 Sep;60(2):91-103.
39. Ozzy, a Jag1 vestibular mouse mutant, displays characteristics of Alagille syndrome. Vrijens K, etal., Neurobiol Dis. 2006 Oct;24(1):28-40. Epub 2006 Jul 26.
40. Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate. Wang SY, etal., Neuroscience. 2015 Aug 20;301:276-88. doi: 10.1016/j.neuroscience.2015.06.002. Epub 2015 Jun 8.
41. The expression levels of Notch-related signaling molecules in pulmonary microvascular endothelial cells in bleomycin-induced rat pulmonary fibrosis. Yin Q, etal., Physiol Res. 2017 May 4;66(2):305-315. doi: 10.33549/physiolres.933356. Epub 2016 Dec 16.
42. Notch signaling regulates the pattern of auditory hair cell differentiation in mammals. Zine A, etal., Development. 2000 Aug;127(15):3373-83.
Additional References at PubMed
PMID:8923452   PMID:8955070   PMID:9207787   PMID:9707552   PMID:10196361   PMID:10329626   PMID:10551863   PMID:10679295   PMID:10958687   PMID:11006133   PMID:11067884   PMID:11181574  
PMID:11427524   PMID:11861489   PMID:12107827   PMID:15060169   PMID:15064243   PMID:15574878   PMID:15821257   PMID:15845452   PMID:16000382   PMID:16378597   PMID:16413496   PMID:16495313  
PMID:16647886   PMID:17475842   PMID:17761753   PMID:18079106   PMID:18449946   PMID:18781453   PMID:19389353   PMID:19481073   PMID:19503073   PMID:19509466   PMID:19682396   PMID:20081190  
PMID:20437614   PMID:21156799   PMID:22465068   PMID:23046039   PMID:23086448   PMID:23232913   PMID:23331119   PMID:23595520   PMID:23676271   PMID:23775982   PMID:23806616   PMID:23980096  
PMID:24667410   PMID:24715457   PMID:24866722   PMID:24907271   PMID:25406395   PMID:25446530   PMID:25535084   PMID:25660475   PMID:26276215   PMID:28163178   PMID:28776666   PMID:30134210  
PMID:31585906   PMID:33049352   PMID:34269482   PMID:34755661  


Genomics

Comparative Map Data
Jag1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83144,859,453 - 144,894,883 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3144,859,453 - 144,894,872 (-)EnsemblGRCr8
mRatBN7.23124,406,783 - 124,442,220 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3124,406,794 - 124,442,209 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3128,293,948 - 128,329,348 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03136,870,930 - 136,906,325 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03134,556,899 - 134,592,326 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03130,079,361 - 130,114,781 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3130,079,361 - 130,114,770 (-)Ensemblrn6Rnor6.0
Rnor_5.03136,558,688 - 136,594,108 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43125,181,063 - 125,216,481 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3123,126,087 - 123,161,497 (-)NCBICelera
RGSC_v3.13125,086,635 - 125,122,054 (-)NCBI
Cytogenetic Map3q36NCBI
JAG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382010,637,684 - 10,673,999 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2010,637,684 - 10,674,396 (-)Ensemblhg38GRCh38
GRCh372010,618,332 - 10,654,647 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362010,566,334 - 10,602,590 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342010,566,333 - 10,602,590NCBI
Celera2010,688,304 - 10,724,650 (-)NCBICelera
Cytogenetic Map20p12.2NCBI
HuRef2010,569,771 - 10,606,135 (-)NCBIHuRef
CHM1_12010,618,904 - 10,655,234 (-)NCBICHM1_1
T2T-CHM13v2.02010,680,698 - 10,717,017 (-)NCBIT2T-CHM13v2.0
Jag1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392136,923,371 - 136,958,440 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2136,923,376 - 136,958,564 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382137,081,451 - 137,116,520 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2137,081,456 - 137,116,644 (-)Ensemblmm10GRCm38
MGSCv372136,907,194 - 136,942,067 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362136,772,899 - 136,807,772 (-)NCBIMGSCv36mm8
Celera2138,273,274 - 138,308,181 (-)NCBICelera
Cytogenetic Map2F3NCBI
cM Map267.73NCBI
Jag1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541520,490,414 - 20,527,917 (-)Ensembl
ChiLan1.0NW_00495541520,490,414 - 20,526,068 (-)NCBIChiLan1.0ChiLan1.0
JAG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22111,508,727 - 11,544,727 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12011,505,265 - 11,541,556 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02010,582,234 - 10,618,507 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12010,582,094 - 10,618,383 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2010,582,094 - 10,618,383 (-)EnsemblpanPan2panpan1.1
JAG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12411,656,926 - 11,693,146 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2411,657,416 - 11,692,199 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2411,476,448 - 11,510,591 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02412,068,191 - 12,103,901 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2412,068,190 - 12,103,063 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12411,675,811 - 11,709,929 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02411,775,152 - 11,810,791 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02412,117,643 - 12,153,536 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Jag1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640160,426,337 - 160,462,907 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364858,857,669 - 8,895,315 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364858,857,688 - 8,894,270 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JAG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1719,591,259 - 19,629,641 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11719,591,248 - 19,629,659 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21722,066,099 - 22,104,519 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JAG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,484,699 - 27,521,108 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,484,760 - 27,522,504 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607117,075,556 - 17,111,911 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jag1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474111,647,463 - 11,683,488 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474111,647,723 - 11,683,137 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Jag1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15116,665,740 - 116,701,378 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Jag1
131 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:824
Count of miRNA genes:304
Interacting mature miRNAs:416
Transcripts:ENSRNOT00000010638
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
BE116991  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23124,406,834 - 124,406,997 (+)MAPPERmRatBN7.2
Rnor_6.03130,079,402 - 130,079,564NCBIRnor6.0
Rnor_5.03136,558,729 - 136,558,891UniSTSRnor5.0
RGSC_v3.43125,181,104 - 125,181,266UniSTSRGSC3.4
Celera3123,126,128 - 123,126,290UniSTS
RH 3.4 Map31118.4UniSTS
Cytogenetic Map3q36UniSTS
UniSTS:465457  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23124,408,780 - 124,410,360 (+)MAPPERmRatBN7.2
Rnor_6.03130,081,348 - 130,082,927NCBIRnor6.0
Rnor_5.03136,560,675 - 136,562,254UniSTSRnor5.0
RGSC_v3.43125,183,050 - 125,184,629UniSTSRGSC3.4
Celera3123,128,068 - 123,129,647UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 82 59 6 346 182 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010638   ⟹   ENSRNOP00000010638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3144,859,453 - 144,894,872 (-)Ensembl
mRatBN7.2 Ensembl3124,406,794 - 124,442,209 (-)Ensembl
Rnor_6.0 Ensembl3130,079,361 - 130,114,770 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094546   ⟹   ENSRNOP00000097522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3144,859,453 - 144,894,872 (-)Ensembl
mRatBN7.2 Ensembl3124,406,794 - 124,442,209 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000158820   ⟹   ENSRNOP00000105256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3144,859,453 - 144,892,063 (-)Ensembl
RefSeq Acc Id: NM_019147   ⟹   NP_062020
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83144,859,453 - 144,894,883 (-)NCBI
mRatBN7.23124,406,783 - 124,442,220 (-)NCBI
Rnor_6.03130,079,361 - 130,114,781 (-)NCBI
Rnor_5.03136,558,688 - 136,594,108 (-)NCBI
RGSC_v3.43125,181,063 - 125,216,481 (-)RGD
Celera3123,126,087 - 123,161,497 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062020 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB06509 (Get FASTA)   NCBI Sequence Viewer  
  EDL80309 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010638
GenBank Protein Q63722 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062020   ⟸   NM_019147
- Peptide Label: precursor
- UniProtKB: Q63722 (UniProtKB/Swiss-Prot),   P70640 (UniProtKB/Swiss-Prot),   G3V710 (UniProtKB/TrEMBL),   A6HQK8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010638   ⟸   ENSRNOT00000010638
Ensembl Acc Id: ENSRNOP00000097522   ⟸   ENSRNOT00000094546
Ensembl Acc Id: ENSRNOP00000105256   ⟸   ENSRNOT00000158820
Protein Domains
DSL   EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63722-F1-model_v2 AlphaFold Q63722 1-1219 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2937 AgrOrtholog
BioCyc Gene G2FUF-47707 BioCyc
Ensembl Genes ENSRNOG00000007443 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000010638 ENTREZGENE
Gene3D-CATH 2.10.25.140 UniProtKB/Swiss-Prot
  2.60.40.3510 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro DSL UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_CS UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  JAG1_1/2_dom UniProtKB/Swiss-Prot
  Jagged/Serrate UniProtKB/Swiss-Prot
  Notch_ligand_N UniProtKB/Swiss-Prot
  VWF_dom UniProtKB/Swiss-Prot
KEGG Report rno:29146 UniProtKB/Swiss-Prot
NCBI Gene 29146 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2 UniProtKB/Swiss-Prot
  DELTA-LIKE PROTEIN UniProtKB/Swiss-Prot
Pfam DL-JAG_EGF-like UniProtKB/Swiss-Prot
  DSL UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  EGF_TEN UniProtKB/Swiss-Prot
  hEGF UniProtKB/Swiss-Prot
  JAG1 UniProtKB/Swiss-Prot
  MNNL UniProtKB/Swiss-Prot
PharmGKB JAG1 RGD
PhenoGen Jag1 PhenoGen
PRINTS EGFBLOOD UniProtKB/Swiss-Prot
  JAGGEDFAMILY UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  DSL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007443 RatGTEx
SMART DSL UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  VWC UniProtKB/Swiss-Prot
  VWC_out UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
TIGR TC208615
UniProt A0A8I6ASU4_RAT UniProtKB/TrEMBL
  A0ABK0LSR9_RAT UniProtKB/TrEMBL
  A6HQK8 ENTREZGENE, UniProtKB/TrEMBL
  G3V710 ENTREZGENE, UniProtKB/TrEMBL
  JAG1_RAT UniProtKB/Swiss-Prot
  P70640 ENTREZGENE
  Q63722 ENTREZGENE
UniProt Secondary P70640 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Jag1  jagged canonical Notch ligand 1  Jag1  jagged 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Jag1  jagged 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds with Notch and helps in keeping mammalian cells in an undifferentiated state 69863