JAG1 (jagged canonical Notch ligand 1) - Rat Genome Database

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Pathways
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Gene: JAG1 (jagged canonical Notch ligand 1) Pan paniscus
Analyze
Symbol: JAG1
Name: jagged canonical Notch ligand 1
RGD ID: 11807023
Description: ENCODES a protein that exhibits receptor ligand activity (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); animal organ regeneration (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Alagille syndrome pathway; altered Notch signaling pathway involving the main players; Notch signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Alagille syndrome (ortholog); ALAGILLE SYNDROME 1 (ortholog); FOUND IN adherens junction (inferred); apical part of cell (inferred); apical plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: jagged 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22111,508,727 - 11,544,727 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12011,505,265 - 11,541,556 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02010,582,234 - 10,618,507 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12010,582,094 - 10,618,383 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2010,582,094 - 10,618,383 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IEA,ISO)
animal organ regeneration  (ISO)
aorta morphogenesis  (IEA)
blood vessel remodeling  (IEA,ISO)
camera-type eye development  (IEA,ISO)
cardiac neural crest cell development involved in outflow tract morphogenesis  (IEA)
cardiac right ventricle morphogenesis  (IEA)
cardiac septum morphogenesis  (IEA)
cell communication  (IEA)
ciliary body morphogenesis  (IEA,ISO)
developmental process  (IEA)
distal tubule development  (IEA)
endocardial cushion cell development  (IEA)
inhibition of neuroepithelial cell differentiation  (IEA,ISO)
inner ear auditory receptor cell differentiation  (IEA,ISO)
inner ear development  (IEA)
loop of Henle development  (IEA)
morphogenesis of an epithelial sheet  (IEA,ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell migration  (IEA)
negative regulation of cell-cell adhesion  (IEA)
negative regulation of cell-matrix adhesion  (IEA)
negative regulation of endothelial cell differentiation  (IEA)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of neuron differentiation  (IEA,ISO)
negative regulation of Notch signaling pathway  (IEA)
negative regulation of stem cell differentiation  (IEA)
nephron development  (IEA)
neuroendocrine cell differentiation  (IEA,ISO)
neuron differentiation  (IEA,ISO)
neuronal stem cell population maintenance  (IEA)
Notch signaling pathway  (IEA,ISO)
podocyte development  (IEA)
positive regulation of cardiac epithelial to mesenchymal transition  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of myeloid cell differentiation  (IEA,ISO)
positive regulation of Notch signaling pathway  (IEA)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
pulmonary artery morphogenesis  (IEA)
pulmonary valve morphogenesis  (IEA)
regulation of cell population proliferation  (ISO)
regulation of epithelial cell proliferation  (IEA,ISO)
regulation of reproductive process  (IEA)
response to muramyl dipeptide  (IEA)
T cell mediated immunity  (IEA)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
JAG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22111,508,727 - 11,544,727 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12011,505,265 - 11,541,556 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02010,582,234 - 10,618,507 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12010,582,094 - 10,618,383 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2010,582,094 - 10,618,383 (-)Ensemblpanpan1.1panPan2
JAG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382010,637,684 - 10,673,999 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2010,637,684 - 10,673,999 (-)EnsemblGRCh38hg38GRCh38
GRCh372010,618,332 - 10,654,647 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362010,566,334 - 10,602,590 (-)NCBINCBI36Build 36hg18NCBI36
Build 342010,566,333 - 10,602,590NCBI
Celera2010,688,304 - 10,724,650 (-)NCBICelera
Cytogenetic Map20p12.2NCBI
HuRef2010,569,771 - 10,606,135 (-)NCBIHuRef
CHM1_12010,618,904 - 10,655,234 (-)NCBICHM1_1
T2T-CHM13v2.02010,680,698 - 10,717,017 (-)NCBIT2T-CHM13v2.0
Jag1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392136,923,371 - 136,958,440 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2136,923,376 - 136,958,564 (-)EnsemblGRCm39 Ensembl
GRCm382137,081,451 - 137,116,520 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2137,081,456 - 137,116,644 (-)EnsemblGRCm38mm10GRCm38
MGSCv372136,907,194 - 136,942,067 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362136,772,899 - 136,807,772 (-)NCBIMGSCv36mm8
Celera2138,273,274 - 138,308,181 (-)NCBICelera
Cytogenetic Map2F3NCBI
cM Map267.73NCBI
Jag1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83144,859,453 - 144,894,883 (-)NCBIGRCr8
mRatBN7.23124,406,783 - 124,442,220 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3124,406,794 - 124,442,209 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3128,293,948 - 128,329,348 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03136,870,930 - 136,906,325 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03134,556,899 - 134,592,326 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03130,079,361 - 130,114,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3130,079,361 - 130,114,770 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03136,558,688 - 136,594,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43125,181,063 - 125,216,481 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13125,086,635 - 125,122,054 (-)NCBI
Celera3123,126,087 - 123,161,497 (-)NCBICelera
Cytogenetic Map3q36NCBI
Jag1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541520,490,414 - 20,527,917 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541520,490,414 - 20,526,068 (-)NCBIChiLan1.0ChiLan1.0
JAG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12411,656,926 - 11,693,146 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2411,657,416 - 11,692,199 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2411,476,448 - 11,510,591 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02412,068,191 - 12,103,901 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2412,068,190 - 12,103,063 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12411,675,811 - 11,709,929 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02411,775,152 - 11,810,791 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02412,117,643 - 12,153,536 (+)NCBIUU_Cfam_GSD_1.0
Jag1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640160,426,337 - 160,462,907 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364858,857,669 - 8,895,315 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364858,857,688 - 8,894,270 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JAG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1719,591,259 - 19,629,641 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11719,591,248 - 19,629,659 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21722,066,099 - 22,104,519 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JAG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,484,699 - 27,521,108 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,484,760 - 27,522,504 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607117,075,556 - 17,111,911 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jag1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474111,647,463 - 11,683,488 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474111,647,723 - 11,683,137 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000045430   ⟹   ENSPPAP00000022619
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2010,582,094 - 10,618,383 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000045465   ⟹   ENSPPAP00000022654
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2010,583,906 - 10,617,869 (-)Ensembl
RefSeq Acc Id: XM_003810571   ⟹   XP_003810619
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22111,508,727 - 11,544,727 (-)NCBI
NHGRI_mPanPan12011,505,265 - 11,541,556 (-)NCBI
Mhudiblu_PPA_v02010,582,236 - 10,618,507 (-)NCBI
PanPan1.12010,582,094 - 10,618,383 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003810619 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000022619
  ENSPPAP00000022619.1
  ENSPPAP00000022654.1
Reference Protein Sequences
RefSeq Acc Id: XP_003810619   ⟸   XM_003810571
- UniProtKB: A0A2R9AZ83 (UniProtKB/TrEMBL),   A0A2R9AZB5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000022654   ⟸   ENSPPAT00000045465
RefSeq Acc Id: ENSPPAP00000022619   ⟸   ENSPPAT00000045430
Protein Domains
DSL   EGF-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034400 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000045430.1 UniProtKB/TrEMBL
  ENSPPAT00000045465.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.25.140 UniProtKB/TrEMBL
  2.60.40.3510 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro DSL UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Jagged/Serrate UniProtKB/TrEMBL
  Notch_ligand_N UniProtKB/TrEMBL
  VWF_dom UniProtKB/TrEMBL
KEGG Report pps:100984049 UniProtKB/TrEMBL
NCBI Gene JAG1 ENTREZGENE
PANTHER EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  JAGGED CANONICAL NOTCH LIGAND 2 UniProtKB/TrEMBL
  NEUROGENIC LOCUS PROTEIN DELTA UniProtKB/TrEMBL
  NOTCH LIGAND FAMILY MEMBER UniProtKB/TrEMBL
Pfam DL-JAG_EGF-like UniProtKB/TrEMBL
  DSL UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  MNNL UniProtKB/TrEMBL
PRINTS EGFBLOOD UniProtKB/TrEMBL
  JAGGEDFAMILY UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  DSL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
SMART DSL UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
  VWC_out UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  FnI-like domain UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A2R9AZ83 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AZB5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-08 JAG1  jagged canonical Notch ligand 1    jagged 1  Symbol and/or name change 5135510 APPROVED