Igfbp4 (insulin-like growth factor binding protein 4) - Rat Genome Database

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Gene: Igfbp4 (insulin-like growth factor binding protein 4) Rattus norvegicus
Analyze
Symbol: Igfbp4
Name: insulin-like growth factor binding protein 4
RGD ID: 2875
Description: Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Predicted to act upstream of or within several processes, including positive regulation of signal transduction; regulation of glucose metabolic process; and type B pancreatic cell proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human IGFBP4 (insulin like growth factor binding protein 4); PARTICIPATES IN insulin-like growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IBP-4; IBP4; IGF-binding protein 4; IGF-BP4; IGFBP-4; insulin-like growth factor-binding protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SS.LEW-(D10Got112-Igfbp4)/Ayd   SS.LEW-(D10Rat24-Igfbp4)/Ayd   SS.LEW-(D10Rat27-Igfbp4)/Ayd  
QTLs:   Rends3   Kidm38   Bp346   Am11   Am10  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,491,471 - 84,503,487 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1084,485,775 - 84,503,473 (+)EnsemblGRCr8
mRatBN7.21083,995,253 - 84,007,272 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,989,591 - 84,007,225 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1088,939,170 - 88,951,179 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,437,283 - 88,449,292 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,829,446 - 83,841,461 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,950,555 - 86,962,563 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,950,557 - 86,962,578 (+)Ensemblrn6Rnor6.0
Rnor_5.01086,747,476 - 86,759,484 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41087,822,429 - 87,834,315 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1082,736,335 - 82,748,330 (+)NCBICelera
RGSC_v3.11087,836,798 - 87,848,684 (+)NCBI
RH 3.4 Map10860.1RGD
Cytogenetic Map10q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-Nitrobenzanthrone  (ISO)
3-nitropropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (EXP)
aluminium sulfate (anhydrous)  (ISO)
aluminium trifluoride  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bicalutamide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cumene  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glucose  (ISO)
graphene oxide  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
N(6)-methyladenosine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
parathion  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylephrine  (EXP)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
succimer  (ISO)
sulforaphane  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vitamin E  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of granulosa cell-derived insulin-like growth factor binding proteins (IGFBPs): role for protein kinase-C in the pre- and posttranslational modulation of IGFBP-4 and IGFBP-5. Chamoun D, etal., Biol Reprod 2002 Sep;67(3):1003-12.
2. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
3. Interleukin-6 stimulates hepatic insulin-like growth factor binding protein-4 messenger ribonucleic acid and protein. Fernandez-Celemin L and Thissen JP, Endocrinology 2001 Jan;142(1):241-8.
4. Structure of the rat insulin-like growth factor binding protein-4 gene. Gao L, etal., Biochem Biophys Res Commun 1993 Feb 15;190(3):1053-9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
8. Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes. Landau D, etal., Endocrinology. 1995 May;136(5):1835-42. doi: 10.1210/endo.136.5.7536658.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7510770   PMID:7679139   PMID:11068878   PMID:12162998   PMID:12477932   PMID:14983400   PMID:15204833   PMID:16339387   PMID:16675541   PMID:20938897   PMID:21846294   PMID:23639626  
PMID:24006456   PMID:24175938   PMID:28595186   PMID:34906040   PMID:36868516   PMID:39244846  


Genomics

Comparative Map Data
Igfbp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,491,471 - 84,503,487 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1084,485,775 - 84,503,473 (+)EnsemblGRCr8
mRatBN7.21083,995,253 - 84,007,272 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,989,591 - 84,007,225 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1088,939,170 - 88,951,179 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,437,283 - 88,449,292 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,829,446 - 83,841,461 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,950,555 - 86,962,563 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,950,557 - 86,962,578 (+)Ensemblrn6Rnor6.0
Rnor_5.01086,747,476 - 86,759,484 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41087,822,429 - 87,834,315 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1082,736,335 - 82,748,330 (+)NCBICelera
RGSC_v3.11087,836,798 - 87,848,684 (+)NCBI
RH 3.4 Map10860.1RGD
Cytogenetic Map10q31NCBI
IGFBP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,443,450 - 40,457,725 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,443,446 - 40,457,727 (+)Ensemblhg38GRCh38
GRCh371738,599,702 - 38,613,977 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,853,202 - 35,867,508 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341735,853,248 - 35,867,457NCBI
Celera1735,259,825 - 35,274,137 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1734,392,540 - 34,406,855 (+)NCBIHuRef
CHM1_11738,834,974 - 38,849,254 (+)NCBICHM1_1
T2T-CHM13v2.01741,306,951 - 41,321,232 (+)NCBIT2T-CHM13v2.0
Igfbp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,930,820 - 98,943,481 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,932,070 - 98,945,218 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381199,040,005 - 99,052,655 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1199,041,244 - 99,054,392 (+)Ensemblmm10GRCm38
MGSCv371198,902,574 - 98,913,960 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361198,857,350 - 98,868,736 (+)NCBIMGSCv36mm8
Celera11108,707,143 - 108,718,579 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.92NCBI
Igfbp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545115,027,184 - 15,029,830 (+)NCBIChiLan1.0ChiLan1.0
IGFBP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,496,732 - 24,512,370 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,391,701 - 26,405,953 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01716,830,994 - 16,845,339 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,055,544 - 17,060,712 (-)NCBIPanPan1.1PanPan1.1panPan2
IGFBP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,168,241 - 22,182,272 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,126,470 - 22,182,518 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha921,642,296 - 21,654,538 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0922,962,295 - 22,974,991 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl922,962,298 - 22,975,086 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,736,648 - 21,748,885 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0921,995,532 - 22,007,775 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,120,045 - 22,132,291 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Igfbp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,580,785 - 21,592,658 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,482,431 - 15,494,436 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,482,483 - 15,494,402 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1221,965,502 - 21,980,945 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11221,966,524 - 21,980,043 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,276,126 - 22,289,602 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IGFBP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11665,722,216 - 65,737,380 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1665,723,361 - 65,737,072 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607736,607,867 - 36,623,001 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfbp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247952,844,526 - 2,851,942 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247952,843,759 - 2,851,796 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Igfbp4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1955,389,719 - 55,402,152 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Igfbp4
198 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:155
Count of miRNA genes:98
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000014153
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107870758585720738Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313384503487Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH140035  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81084,489,838 - 84,490,294 (+)Marker Load Pipeline
mRatBN7.21083,993,619 - 83,994,075 (+)MAPPERmRatBN7.2
Rnor_6.01086,948,923 - 86,949,378NCBIRnor6.0
Rnor_5.01086,745,844 - 86,746,299UniSTSRnor5.0
RGSC_v3.41087,820,797 - 87,821,252UniSTSRGSC3.4
Celera1082,734,703 - 82,735,158UniSTS
RH 3.4 Map10860.1UniSTS
Cytogenetic Map10q31UniSTS


Related Rat Strains
The following Strains have been annotated to Igfbp4
SS.LEW-(D10Got112-Igfbp4)/Ayd     SS.LEW-(D10Rat24-Igfbp4)/Ayd     SS.LEW-(D10Rat27-Igfbp4)/Ayd    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
17 12 76 170 91 90 59 110 59 6 406 223 15 146 99 122 31 22 22

Sequence


Ensembl Acc Id: ENSRNOT00000014153   ⟹   ENSRNOP00000014153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1084,485,775 - 84,503,446 (+)Ensembl
mRatBN7.2 Ensembl1083,989,591 - 84,007,225 (+)Ensembl
Rnor_6.0 Ensembl1086,950,557 - 86,962,578 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106145   ⟹   ENSRNOP00000093833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1084,497,784 - 84,503,473 (+)Ensembl
mRatBN7.2 Ensembl1084,001,567 - 84,007,225 (+)Ensembl
RefSeq Acc Id: NM_001004274   ⟹   NP_001004274
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81084,491,471 - 84,503,487 (+)NCBI
mRatBN7.21083,995,253 - 84,007,272 (+)NCBI
Rnor_6.01086,950,555 - 86,962,563 (+)NCBI
Rnor_5.01086,747,476 - 86,759,484 (+)NCBI
RGSC_v3.41087,822,429 - 87,834,315 (+)RGD
Celera1082,736,335 - 82,748,330 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001004274 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98750 (Get FASTA)   NCBI Sequence Viewer  
  AAN87106 (Get FASTA)   NCBI Sequence Viewer  
  AAT96376 (Get FASTA)   NCBI Sequence Viewer  
  EDM05968 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014153
  ENSRNOP00000014153.5
GenBank Protein P21744 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001004274   ⟸   NM_001004274
- Peptide Label: precursor
- UniProtKB: Q68J74 (UniProtKB/Swiss-Prot),   P21744 (UniProtKB/Swiss-Prot),   A6HIW3 (UniProtKB/TrEMBL),   A6HIW4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014153   ⟸   ENSRNOT00000014153
Ensembl Acc Id: ENSRNOP00000093833   ⟸   ENSRNOT00000106145
Protein Domains
IGFBP N-terminal   Thyroglobulin type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21744-F1-model_v2 AlphaFold P21744 1-254 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697675
Promoter ID:EPDNEW_R8200
Type:single initiation site
Name:Igfbp4_1
Description:insulin-like growth factor binding protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01086,950,547 - 86,950,607EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2875 AgrOrtholog
BioCyc Gene G2FUF-23327 BioCyc
Ensembl Genes ENSRNOG00000010635 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014153 ENTREZGENE
  ENSRNOT00000014153.8 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.40.20 UniProtKB/Swiss-Prot
  4.10.800.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7368649 IMAGE-MGC_LOAD
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  IGFBP-4 UniProtKB/Swiss-Prot
  IGFBP-like UniProtKB/Swiss-Prot
  IGFBP_1-6_chordata UniProtKB/Swiss-Prot
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot
KEGG Report rno:360622 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112770 IMAGE-MGC_LOAD
NCBI Gene Igfbp4 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN UniProtKB/Swiss-Prot
  PTHR11551:SF7 UniProtKB/Swiss-Prot
Pfam IGFBP UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
PhenoGen Igfbp4 PhenoGen
PRINTS IGFBPFAMILY UniProtKB/Swiss-Prot
  IGFBPFAMILY4 UniProtKB/Swiss-Prot
PROSITE IGFBP_N_1 UniProtKB/Swiss-Prot
  IGFBP_N_2 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010635 RatGTEx
SMART SM00121 UniProtKB/Swiss-Prot
  SM00211 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot
  SSF57610 UniProtKB/Swiss-Prot
UniProt A0A8I6GKG6_RAT UniProtKB/TrEMBL
  A6HIW3 ENTREZGENE, UniProtKB/TrEMBL
  A6HIW4 ENTREZGENE, UniProtKB/TrEMBL
  IBP4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q68J74 ENTREZGENE
UniProt Secondary Q68J74 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Igfbp4  insulin-like growth factor binding protein 4    insulin-like growth factor-binding protein 4  Name updated 1299863 APPROVED
2002-06-10 Igfbp4  insulin-like growth factor-binding protein 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in all tissues; highest expression in liver 61527
gene_function binding to IGF alters the interaction of IGFs with their cell surface receptors 61527
gene_other gene contains a TATA box and a CAAT box, as well as three cAMP responsive elements, three AP-1 binding sites and one progesterone receptor binding site 729004
gene_process prolongs the half-life of IGFs and either inhibits or stimulates the growth promoting effects of IGFs on cell culture 61527