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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2875
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igfbp4
Name: insulin-like growth factor binding protein 4
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igfbp4increases expressionISOIGFBP4 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of IGFBP4 proteinPMID:27430728
Igfbp4multiple interactionsISOIGFBP4 (Homo sapiens)6480464CTD[Arsenic Trioxide co-treated with Curcumin] results in increased expression of IGFBP4 protein; [Tretinoin co-treated with Arsenic Trioxide] results in decreased expression of IGFBP4 mRNAPMID:15894607 PMID:27430728
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