Gdnf (glial cell derived neurotrophic factor) - Rat Genome Database

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Gene: Gdnf (glial cell derived neurotrophic factor) Rattus norvegicus
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Symbol: Gdnf
Name: glial cell derived neurotrophic factor
RGD ID: 2677
Description: Enables protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including negative regulation of apoptotic process; regulation of cytokine production; and regulation of morphogenesis of an epithelium. Located in extracellular space. Part of receptor complex. Used to study alcohol dependence; alcohol use disorder; brain disease (multiple); and hyperprolactinemia. Biomarker of several diseases, including alcohol use disorder; amphetamine abuse; irritable bowel syndrome; middle cerebral artery infarction; and neuropathy (multiple). Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; Parkinsonism; anxiety disorder; depressive disorder; and heroin dependence. Orthologous to human GDNF (glial cell derived neurotrophic factor); INTERACTS WITH (+)-pilocarpine; (R)-salsolinol; (S)-AMPA.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: astrocyte-derived trophic factor; ATF; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; glial cell line-derived neurotrophic factor; GNDF
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Gdil1 Gdil2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8258,621,327 - 58,647,242 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl258,621,327 - 58,647,240 (+)EnsemblGRCr8
mRatBN7.2256,894,022 - 56,919,935 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl256,895,010 - 56,917,209 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx263,981,903 - 64,007,772 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0262,069,964 - 62,095,814 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0257,071,144 - 57,096,990 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0256,884,181 - 56,912,964 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl256,887,987 - 56,910,238 (+)Ensemblrn6Rnor6.0
Rnor_5.0276,896,991 - 76,922,471 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4257,399,312 - 57,424,030 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera252,510,468 - 52,532,694 (+)NCBICelera
RGSC_v3.1257,327,544 - 57,352,263 (+)NCBI
Cytogenetic Map2q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
alcohol dependence  (IDA,IMP,ISO)
alcohol use disorder  (IDA,IEP,ISO)
alcohol withdrawal syndrome  (IDA)
alcohol-associated liver disease  (ISO)
Alcoholic Intoxication  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (IEP,ISO)
amyotrophic lateral sclerosis  (ISO)
Anorectal Malformations  (IEP)
anxiety disorder  (ISO)
Binge Drinking  (IEP,IMP)
Brain Injuries  (IEP)
Cerebral Hemorrhage  (IMP)
Churg-Strauss syndrome  (ISO)
Cocaine-Related Disorders  (ISO)
congenital central hypoventilation syndrome  (ISO)
Constipation  (IEP)
depressive disorder  (ISO)
Drug-Induced Dyskinesia  (ISO)
Ependymomas  (ISO)
epilepsy  (ISO)
Fetal Growth Retardation  (IEP)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
Guillain-Barre syndrome  (ISO)
hereditary sensory neuropathy  (ISO)
heroin dependence  (ISO)
Herpes Simplex Encephalitis  (ISO)
high grade glioma  (ISO)
Hirschsprung's disease  (ISO,ISS)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
hyperprolactinemia  (IMP)
Intervertebral Disc Disease  (ISO)
irritable bowel syndrome  (IEP)
Kennedy's disease  (ISO)
middle cerebral artery infarction  (IDA,IEP,IMP)
morphine withdrawal syndrome  (IEP)
multiple system atrophy  (ISO)
neurodegenerative disease  (ISO)
Neurologic Manifestations  (ISO)
neuromuscular disease  (IEP)
nicotine dependence  (IEP,ISO)
obsessive-compulsive disorder  (IEP)
oligodendroglioma  (ISO)
Optic Nerve Injuries  (IEP)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (IDA,IEP,ISO)
pheochromocytoma  (ISO)
polyarteritis nodosa  (ISO)
Postoperative Cognitive Dysfunction  (IDA,IEP,ISO)
retinal degeneration  (ISO)
sciatic neuropathy  (IEP)
secondary Parkinson disease  (ISO)
Sjogren's syndrome  (ISO)
Spinal Cord Injuries  (IEP,ISO)
status epilepticus  (ISO)
temporal lobe epilepsy  (IDA)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(R)-salsolinol  (EXP)
(S)-AMPA  (EXP)
(S)-amphetamine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
13,14-dihydro-Delta(12)-prostaglandin J2  (EXP)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-arachidonoylglycerol  (ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
actinomycin D  (EXP)
adenosine  (ISO)
aflatoxin B1  (EXP,ISO)
agathisflavone  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-D-galactose  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
apigenin  (EXP)
apomorphine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromocriptine  (ISO)
bucladesine  (ISO)
busulfan  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cabergoline  (ISO)
cadmium dichloride  (ISO)
candesartan  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
cordycepin  (ISO)
cyanocob(III)alamin  (EXP)
cyclophosphamide  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dabigatran  (EXP)
DDE  (EXP)
dermatan sulfate  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
dopamine  (EXP,ISO)
dopaminechrome (enol form)  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
echinacoside  (ISO)
epoxiconazole  (EXP,ISO)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
excitatory amino acid agonist  (EXP)
fenvalerate  (EXP)
ferrostatin-1  (EXP)
fisetin  (EXP)
fluoranthene  (ISO)
fluoxetine  (EXP)
folpet  (ISO)
furan  (EXP)
galactose  (EXP)
genistein  (ISO)
geraniol  (ISO)
glyphosate  (EXP)
Harpagoside  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
L-ascorbic acid  (ISO)
lidocaine  (EXP)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
manganese(II) chloride  (ISO)
Mazindol  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxidopamine  (EXP,ISO)
paraquat  (ISO)
PD173074  (EXP)
pergolide  (ISO)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (ISO)
puerarin  (ISO)
pyrethrins  (EXP)
rasagiline  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
rutin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salvianolic acid B  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
SKF 38393  (ISO)
sodium arsenite  (ISO)
sodium benzoate  (ISO)
streptozocin  (EXP)
sulfasalazine  (ISO)
telmisartan  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
trichloroethene  (EXP)
triphenylstannane  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
vanoxerine dihydrochloride  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in ureteric bud morphogenesis  (ISO,ISS)
cell surface receptor protein tyrosine kinase signaling pathway  (IMP)
cellular response to dexamethasone stimulus  (IDA)
commissural neuron axon guidance  (ISO)
dorsal spinal cord development  (ISO)
embryonic organ development  (ISO)
enteric nervous system development  (ISO,ISS)
glial cell-derived neurotrophic factor receptor signaling pathway  (IBA,ISO,ISS)
male gonad development  (IEP)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (IDA,IEA,ISO)
metanephros development  (ISO,ISS)
midbrain development  (IEP)
mRNA stabilization  (ISO,ISS)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of glial cell apoptotic process  (IMP)
negative regulation of interleukin-1 beta production  (IMP)
negative regulation of neuron apoptotic process  (IEA,IMP,ISO,ISS)
negative regulation of tumor necrosis factor production  (IMP)
nervous system development  (ISO)
neural crest cell migration  (ISO,ISS)
neural crest cell migration involved in autonomic nervous system development  (ISO)
neuron differentiation  (IDA,IEA)
neuron projection development  (IBA,ISO,ISS)
organ induction  (ISO)
peripheral nervous system development  (ISO)
peristalsis  (ISO,ISS)
positive regulation of branching involved in ureteric bud morphogenesis  (IDA,IEA,IMP,ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of interleukin-10 production  (IMP)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO)
positive regulation of neuron differentiation  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
positive regulation of ureteric bud formation  (ISO,ISS)
postganglionic parasympathetic fiber development  (ISO,ISS)
postsynaptic membrane organization  (ISO)
regulation of cell differentiation  (IEA)
regulation of dopamine uptake involved in synaptic transmission  (ISO,ISS)
regulation of gene expression  (ISO)
regulation of morphogenesis of a branching structure  (ISO,ISS)
regulation of semaphorin-plexin signaling pathway  (ISO)
regulation of ureteric bud formation  (IDA)
retina development in camera-type eye  (IEP)
signal transduction  (IEA)
sympathetic nervous system development  (ISO,ISS)
system development  (IEA)
ureteric bud development  (ISO)
ureteric bud formation  (ISO)

Cellular Component
extracellular region  (IEA,ISO,ISS,TAS)
extracellular space  (IBA,IDA,IMP,ISO)
Golgi apparatus  (ISO)
receptor complex  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GDNF is a novel ethanol-responsive gene in the VTA: implications for the development and persistence of excessive drinking. Ahmadiantehrani S, etal., Addict Biol. 2014 Jul;19(4):623-33. doi: 10.1111/adb.12028. Epub 2013 Jan 9.
2. Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease. Airavaara M, etal., J Biol Chem. 2011 Dec 30;286(52):45093-102. Epub 2011 Nov 11.
3. Low functional programming of renal AT2R mediates the developmental origin of glomerulosclerosis in adult offspring induced by prenatal caffeine exposure. Ao Y, etal., Toxicol Appl Pharmacol. 2015 Sep 1;287(2):128-138. doi: 10.1016/j.taap.2015.05.007. Epub 2015 May 15.
4. Induction of GDNF mRNA expression by melatonin in rat C6 glioma cells. Armstrong KJ and Niles LP, Neuroreport 2002 Mar 25;13(4):473-5.
5. Gene expression patterns for GDNF and its receptors in the human putamen affected by Parkinson's disease: a real-time PCR study. Backman CM, etal., Mol Cell Endocrinol. 2006 Jun 27;252(1-2):160-6. Epub 2006 Apr 27.
6. Binge alcohol-induced alterations in BDNF and GDNF expression in central extended amygdala and pyriform cortex on infant rats. Balaszczuk V, etal., Int J Dev Neurosci. 2013 Aug;31(5):287-96. doi: 10.1016/j.ijdevneu.2013.04.002. Epub 2013 Apr 12.
7. Glial cell line-derived neurotrophic factor (GDNF) is an endogenous protector in the mesolimbic system against excessive alcohol consumption and relapse. Barak S, etal., Addict Biol. 2015 Jul;20(4):629-42. doi: 10.1111/adb.12152. Epub 2014 May 6.
8. Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption. Barak S, etal., Transl Psychiatry. 2011;1(12):e60-. doi: 10.1038/tp.2011.57.
9. [Effect of electroacupuncture on gastrointestinal motility in rats with slow transit constipation based on GDNF methylation modification]. Cao Y, etal., Zhen Ci Yan Jiu. 2022 Feb 25;47(2):141-7. doi: 10.13702/j.1000-0607.20210253.
10. Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin. Carmillo P, etal., Biochemistry. 2005 Feb 22;44(7):2545-54.
11. Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor. Carnicella S, etal., Biol Psychiatry. 2009 Jul 15;66(2):146-53. doi: 10.1016/j.biopsych.2008.12.022. Epub 2009 Feb 20.
12. Integrin alphav and NCAM mediate the effects of GDNF on DA neuron survival, outgrowth, DA turnover and motor activity in rats. Chao CC, etal., Neurobiol Aging 2003 Jan-Feb;24(1):105-16.
13. GDNF Schwann cells in hydrogel scaffolds promote regional axon regeneration, remyelination and functional improvement after spinal cord transection in rats. Chen BK, etal., J Tissue Eng Regen Med. 2018 Jan;12(1):e398-e407. doi: 10.1002/term.2431. Epub 2017 Jun 26.
14. Time-course of GDNF and its receptor expression after brain injury in the rat. Cheng Q, etal., Neurosci Lett. 2008 Jul 4;439(1):24-9. Epub 2008 May 1.
15. p-Hydroxybenzyl Alcohol Prevents Memory Deficits by Increasing Neurotrophic Factors and Decreasing Inflammatory Factors in a Mice Model of Alzheimer's Disease. Ding Y, etal., J Alzheimers Dis. 2019;67(3):1007-1019. doi: 10.3233/JAD-180910.
16. Serum glial cell line-derived neurotrophic factor levels and postoperative cognitive dysfunction after surgery for rheumatic heart disease. Duan X, etal., J Thorac Cardiovasc Surg. 2018 Mar;155(3):958-965.e1. doi: 10.1016/j.jtcvs.2017.07.073. Epub 2017 Aug 24.
17. X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding. Eigenbrot C and Gerber N, Nat Struct Biol. 1997 Jun;4(6):435-8.
18. Distinct structural elements in GDNF mediate binding to GFRalpha1 and activation of the GFRalpha1-c-Ret receptor complex. Eketjäll S, etal., EMBO J. 1999 Nov 1;18(21):5901-10.
19. The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. Esposito E, etal., J Neuroinflammation. 2012 Apr 10;9:66. doi: 10.1186/1742-2094-9-66.
20. Intranasal Administration of chitosan-Coated Nanostructured Lipid Carriers Loaded with GDNF Improves Behavioral and Histological Recovery in a Partial Lesion Model of Parkinson's Disease. Gartziandia O, etal., J Biomed Nanotechnol. 2016 Dec;12(12):2220-30. doi: 10.1166/jbn.2016.2313.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
23. Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. Grote D, etal., PLoS Genet. 2008 Dec;4(12):e1000316. doi: 10.1371/journal.pgen.1000316. Epub 2008 Dec 26.
24. Effect of Escitalopram on Serum GDNF and BDNF Levels and 5-HT Level of Brain Tissue of Obsessive-Compulsive Disorder Rats. Guo HR, etal., Cell Mol Neurobiol. 2020 Aug;40(6):991-997. doi: 10.1007/s10571-020-00788-4. Epub 2020 Jan 11.
25. Physical Exercise Promotes Beneficial Changes on Neurotrophic Factors in Mesolimbic Brain Areas After AMPH Relapse: Involvement of the Endogenous Opioid System. H Z R, etal., Neurotox Res. 2023 Dec;41(6):741-751. doi: 10.1007/s12640-023-00675-y. Epub 2023 Oct 31.
26. Inflammation-induced GDNF improves locomotor function after spinal cord injury. Hashimoto M, etal., Neuroreport 2005 Feb 8;16(2):99-102.
27. Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption. He DY, etal., J Neurosci. 2005 Jan 19;25(3):619-28. doi: 10.1523/JNEUROSCI.3959-04.2005.
28. BDNF and GDNF serum levels in alcohol-dependent patients during withdrawal. Heberlein A, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1060-4. doi: 10.1016/j.pnpbp.2010.05.025. Epub 2010 May 27.
29. Expression of glial cell line-derived neurotrophic factor family of growth factors in peripheral nerve injury in rats. Hoke A, etal., Neuroreport. 2000 Jun 5;11(8):1651-4.
30. Effect of exogenous glial cell-derived neurotrophic factor on development of the enteric nervous system in the rectal end of fetal rats with anorectal malformations. Huang Y and Zheng S, Pediatr Surg Int. 2013 Apr;29(4):375-9. doi: 10.1007/s00383-012-3251-y.
31. Infusion of mesenchymal stem cells overexpressing GDNF ameliorates renal function in nephrotoxic serum nephritis. Huang ZY, etal., Cell Biochem Funct. 2012 Mar;30(2):139-44. doi: 10.1002/cbf.1827. Epub 2011 Nov 22.
32. The effects of a polyphenol present in olive oil, oleuropein aglycone, in an experimental model of spinal cord injury in mice. Impellizzeri D, etal., Biochem Pharmacol. 2012 Feb 8.
33. Mildronate as a regulator of protein expression in a rat model of Parkinson's disease. Isajevs S, etal., Medicina (Kaunas). 2011;47(10):552-9.
34. Activation of cell-survival signal Akt by GDNF in normal rat brain. Jin G, etal., Brain Res 2002 Dec 27;958(2):429-33.
35. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Jing S, etal., Cell 1996 Jun 28;85(7):1113-24.
36. Production of the novel mesangial autocrine growth factors GDNF and IL-10 is regulated by the immunomodulator AS101. Kalechman Y, etal., J Am Soc Nephrol 2003 Mar;14(3):620-30.
37. p-Hydroxybenzyl alcohol prevents brain injury and behavioral impairment by activating Nrf2, PDI, and neurotrophic factor genes in a rat model of brain ischemia. Kam KY, etal., Mol Cells. 2011 Mar;31(3):209-15. doi: 10.1007/s10059-011-0028-4. Epub 2011 Jan 6.
38. GDNF released from encapsulated cells suppresses seizure activity in the epileptic hippocampus. Kanter-Schlifke I, etal., Exp Neurol. 2009 Apr;216(2):413-9. Epub 2009 Jan 7.
39. Glial cell line-derived neurotrophic factor (GDNF) as a novel candidate gene of anxiety. Kotyuk E, etal., PLoS One. 2013 Dec 6;8(12):e80613. doi: 10.1371/journal.pone.0080613. eCollection 2013.
40. BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity. Kramer F, etal., J Neurooncol. 2010 May;98(1):31-9. doi: 10.1007/s11060-009-0063-6. Epub 2009 Nov 25.
41. Regulation of GDNF and its receptor components GFR-alpha1, -alpha2 and Ret during development and in the mature retino-collicular pathway. Kretz A, etal., Brain Res. 2006 May 23;1090(1):1-14. Epub 2006 May 2.
42. An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease. Laganiere J, etal., J Neurosci. 2010 Dec 8;30(49):16469-74. doi: 10.1523/JNEUROSCI.2440-10.2010.
43. Human fetal brain-derived neural stem/progenitor cells grafted into the adult epileptic brain restrain seizures in rat models of temporal lobe epilepsy. Lee H, etal., PLoS One. 2014 Aug 8;9(8):e104092. doi: 10.1371/journal.pone.0104092. eCollection 2014.
44. Signaling of glial cell line-derived neurotrophic factor and its receptor GFRalpha1 induce Nurr1 and Pitx3 to promote survival of grafted midbrain-derived neural stem cells in a rat model of Parkinson disease. Lei Z, etal., J Neuropathol Exp Neurol. 2011 Sep;70(9):736-47.
45. Increased serum neurotrophin levels related to alcohol use disorder in a young population sample. Lhullier AC, etal., Alcohol Clin Exp Res. 2015 Jan;39(1):30-3. doi: 10.1111/acer.12592.
46. GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transection. Lindqvist N, etal., Exp Neurol. 2004 Jun;187(2):487-99.
47. Gene Expression Profiling of Rat Testis Development During the Early Post-Natal Stages. Liu T, etal., Reprod Domest Anim. 2011 Nov 24. doi: 10.1111/j.1439-0531.2011.01950.x.
48. Glial cell line-derived neurotrophic factor contributes to alcoholic-induced liver injury by regulating the NF-κB pathway. Liu X, etal., Alcohol Clin Exp Res. 2022 May;46(5):724-735. doi: 10.1111/acer.14815. Epub 2022 Apr 8.
49. Association of the GDNF gene with depression and heroin dependence, but not schizophrenia, in a Chinese population. Ma XC, etal., Psychiatry Res. 2013 Dec 30;210(3):1296-8. doi: 10.1016/j.psychres.2013.08.025. Epub 2013 Sep 7.
50. Alcohol consumption alters Gdnf promoter methylation and expression in rats. Maier HB, etal., J Psychiatr Res. 2020 Feb;121:1-9. doi: 10.1016/j.jpsychires.2019.10.020. Epub 2019 Oct 31.
51. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
52. Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis. Michos O, etal., Development. 2007 Jul;134(13):2397-405. Epub 2007 May 23.
53. Short-term ethanol exposure causes imbalanced neurotrophic factor allocation in the basal forebrain cholinergic system: a novel insight into understanding the initial processes of alcohol addiction. Miki T, etal., J Neural Transm (Vienna). 2014 Feb;121(2):201-10. doi: 10.1007/s00702-013-1085-y. Epub 2013 Sep 6.
54. Improvement of memory and learning by intracerebroventricular microinjection of T3 in rat model of ischemic brain stroke mediated by upregulation of BDNF and GDNF in CA1 hippocampal region. Mokhtari T, etal., Daru. 2017 Feb 15;25(1):4. doi: 10.1186/s40199-017-0169-x.
55. Glial cell line-derived neurotrophic factor gene therapy ameliorates chronic hyperprolactinemia in senile rats. Morel GR, etal., Neuroscience. 2010 May 19;167(3):946-53. doi: 10.1016/j.neuroscience.2010.02.053. Epub 2010 Feb 26.
56. Adenoviral vector carrying glial cell-derived neurotrophic factor for direct gene therapy in comparison with human umbilical cord blood cell-mediated therapy of spinal cord injury in rat. Mukhamedshina YO, etal., Spinal Cord. 2016 May;54(5):347-59. doi: 10.1038/sc.2015.161. Epub 2015 Sep 29.
57. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
58. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
59. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
60. Effect of moxibustion on the expression of GDNF and its receptor GFRα3 in the colon and spinal cord of rats with irritable bowel syndrome. Qi Q, etal., Acupunct Med. 2019 Aug;37(4):244-251. doi: 10.1136/acupmed-2017-011455. Epub 2019 Jun 12.
61. Effects of striatal transplantation of cells transfected with GDNF gene without pre- and pro-regions in mouse model of Parkinson's disease. Revishchin A, etal., BMC Neurosci. 2016 Jun 10;17(1):34. doi: 10.1186/s12868-016-0271-x.
62. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
63. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
64. Role of cytokine and neurotrophic factors in nicotine addiction in the conditioned place preference paradigm. Rosa MLP, etal., Neurosci Lett. 2021 Nov 1;764:136235. doi: 10.1016/j.neulet.2021.136235. Epub 2021 Sep 8.
65. Differential mRNA expression of neurotrophic factors GDNF, BDNF, and NT-3 in experimental herpes simplex virus encephalitis. Sellner J, etal., Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):267-71. Epub 2005 Apr 22.
66. Astrocytic endogenous glial cell derived neurotrophic factor production is enhanced by bone marrow stromal cell transplantation in the ischemic boundary zone after stroke in adult rats. Shen LH, etal., Glia. 2010 Jul;58(9):1074-81. doi: 10.1002/glia.20988.
67. Effects of dexamethasone exposure on rat metanephric development: in vitro and in vivo studies. Singh RR, etal., Am J Physiol Renal Physiol. 2007 Aug;293(2):F548-54. Epub 2007 May 30.
68. Triple-Gene Therapy for Stroke: A Proof-of-Concept in Vivo Study in Rats. Sokolov ME, etal., Front Pharmacol. 2018 Feb 15;9:111. doi: 10.3389/fphar.2018.00111. eCollection 2018.
69. Effect of Glycemic Disorders and Habits on the Concentration of Selected Neurotrophic Factors in Patients with Lumbosacral Intervertebral Disc Degeneration. Staszkiewicz R, etal., Curr Pharm Biotechnol. 2023 Sep 28. doi: 10.2174/0113892010262904230919073351.
70. GDNF protects enteric glia from apoptosis: evidence for an autocrine loop. Steinkamp M, etal., BMC Gastroenterol. 2012 Jan 17;12:6. doi: 10.1186/1471-230X-12-6.
71. Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson's disease. Sun M, etal., Brain Res. 2005 Aug 9;1052(2):119-29.
72. GDNF augments survival and differentiation of TH-positive neurons in neural progenitor cells. Sun ZH, etal., Cell Biol Int 2004;28(4):323-5.
73. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
74. Ethanol and nicotine interaction within the posterior ventral tegmental area in male and female alcohol-preferring rats: evidence of synergy and differential gene activation in the nucleus accumbens shell. Truitt WA, etal., Psychopharmacology (Berl). 2015 Feb;232(3):639-49. doi: 10.1007/s00213-014-3702-3. Epub 2014 Aug 26.
75. Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of alpha-synucleinopathy. Ubhi K, etal., Exp Neurol. 2012 Jan 16.
76. Inhibition of ERK/CREB signaling contributes to postoperative learning and memory dysfunction in neonatal rats. Wang H, etal., J Mol Med (Berl). 2023 Mar;101(3):265-278. doi: 10.1007/s00109-023-02285-9. Epub 2023 Jan 23.
77. Glial cell-derived neurotrophic factor alleviates sepsis-induced neuromuscular dysfunction by decreasing the expression of γ- and α7-nicotinic acetylcholine receptors in an experimental rat model of neuromyopathy. Wang X, etal., Biochem Biophys Res Commun. 2018 Feb 5;496(2):260-266. doi: 10.1016/j.bbrc.2018.01.020. Epub 2018 Jan 5.
78. Glial cell-derived neurotrophic factor decrease may mediate learning, memory and behavior impairments in rats after neonatal surgery. Xie Y, etal., Brain Res Bull. 2022 Jan;178:9-16. doi: 10.1016/j.brainresbull.2021.10.020. Epub 2021 Oct 30.
79. Expression of glial cell line-derived neurotrophic factor and GDNFR-alpha mRNAs in human peripheral neuropathies. Yamamoto M, etal., Brain Res. 1998 Nov 2;809(2):175-81.
80. Expression of GDNF and GDNFR-alpha mRNAs in muscles of patients with motor neuron diseases. Yamamoto M, etal., Neurochem Res. 1999 Jun;24(6):785-90.
81. Intrastriatal gene delivery of GDNF persistently attenuates methamphetamine self-administration and relapse in mice. Yan Y, etal., Int J Neuropsychopharmacol. 2013 Aug;16(7):1559-67. doi: 10.1017/S1461145712001575. Epub 2013 Feb 22.
82. Neuroprotective effects of bone marrow stem cells overexpressing glial cell line-derived neurotrophic factor on rats with intracerebral hemorrhage and neurons exposed to hypoxia/reoxygenation. Yang C, etal., Neurosurgery. 2011 Mar;68(3):691-704. doi: 10.1227/NEU.0b013e3182098a8a.
83. The relationship between overexpression of glial cell-derived neurotrophic factor and its RET receptor with progression and prognosis of human pancreatic cancer. Zeng Q, etal., J Int Med Res. 2008 Jul-Aug;36(4):656-64.
84. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Zhang J, etal., Anesthesiology. 2014 Oct;121(4):773-85. doi: 10.1097/ALN.0000000000000352.
85. Protective effects of tetrahydropalmatine against ketamine-induced learning and memory injury via antioxidative, anti-inflammatory and anti-apoptotic mechanisms in mice. Zhang Y, etal., Mol Med Rep. 2018 May;17(5):6873-6880. doi: 10.3892/mmr.2018.8700. Epub 2018 Mar 7.
86. Amantadine Alleviates Postoperative Cognitive Dysfunction Possibly by Preserving Neurotrophic Factor Expression and Dendritic Arborization in the Hippocampus of Old Rodents. Zhong J, etal., Front Aging Neurosci. 2020 Nov 26;12:605330. doi: 10.3389/fnagi.2020.605330. eCollection 2020.
87. Bone marrow mesenchymal stem cells upregulate PI3K/AKT pathway and down-regulate NF-κB pathway by secreting glial cell-derived neurotrophic factors to regulate microglial polarization and alleviate deafferentation pain in rats. Zhong Z, etal., Neurobiol Dis. 2020 Sep;143:104945. doi: 10.1016/j.nbd.2020.104945. Epub 2020 May 16.
88. [The expression of glial cell derived neurotrophic factor and its receptor GDNFR-alpha and GDNFR-beta mRNA in spinal cord, brainstem and frontal cortex during morphine withdrawal in rats] Zhou W, etal., Zhonghua Yi Xue Za Zhi 2000 Feb;80(2):135-9.
89. Re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood. Zipori D, etal., Sci Rep. 2017 May 30;7(1):2479. doi: 10.1038/s41598-017-02177-2.
90. Protein arginine methyltransferase 8 regulates ferroptosis and macrophage polarization in spinal cord injury via glial cell-derived neurotrophic factor. Zou Z, etal., CNS Neurosci Ther. 2023 Aug;29(8):2145-2161. doi: 10.1111/cns.14162. Epub 2023 Mar 13.
Additional References at PubMed
PMID:7696586   PMID:7867768   PMID:7895811   PMID:8493557   PMID:8657306   PMID:8657307   PMID:8657308   PMID:8988018   PMID:9192898   PMID:9811930   PMID:10322633   PMID:10921886  
PMID:11675876   PMID:11774071   PMID:12125080   PMID:12210384   PMID:12231225   PMID:12358785   PMID:12478607   PMID:12480187   PMID:12712323   PMID:12715924   PMID:12781994   PMID:12832519  
PMID:12832538   PMID:12837245   PMID:12876402   PMID:12957504   PMID:13678594   PMID:14552879   PMID:14552891   PMID:14552902   PMID:14596863   PMID:14598299   PMID:14608602   PMID:14708939  
PMID:14753442   PMID:15033464   PMID:15044553   PMID:15090036   PMID:15130495   PMID:15212950   PMID:15242795   PMID:15381279   PMID:15519246   PMID:15582775   PMID:15618882   PMID:15659589  
PMID:15691764   PMID:15812312   PMID:15905075   PMID:15935064   PMID:15964099   PMID:16086701   PMID:16524382   PMID:16569669   PMID:16584838   PMID:16643884   PMID:16672314   PMID:16766196  
PMID:16841166   PMID:16854632   PMID:16967504   PMID:17113937   PMID:17229286   PMID:17240430   PMID:17298301   PMID:17387333   PMID:17399854   PMID:17537792   PMID:17663984   PMID:17765347  
PMID:17880388   PMID:17888513   PMID:17920149   PMID:17967506   PMID:18003772   PMID:18038430   PMID:18095158   PMID:18194437   PMID:18293415   PMID:18363829   PMID:18465789   PMID:18520583  
PMID:18585464   PMID:18593521   PMID:18668157   PMID:18973572   PMID:19154763   PMID:19238724   PMID:19277011   PMID:19339709   PMID:19362079   PMID:19460370   PMID:19520066   PMID:19524560  
PMID:19530158   PMID:19558709   PMID:19709371   PMID:19741142   PMID:19845157   PMID:19925812   PMID:19944698   PMID:20079213   PMID:20175208   PMID:20305789   PMID:20625988   PMID:20626773  
PMID:20682772   PMID:20739562   PMID:21040239   PMID:21130871   PMID:21174801   PMID:21223624   PMID:21279379   PMID:21281623   PMID:21515689   PMID:21586298   PMID:21653894   PMID:21659885  
PMID:21699926   PMID:21828353   PMID:21871541   PMID:21994944   PMID:22230667   PMID:22266674   PMID:22281445   PMID:22282251   PMID:22575563   PMID:22579834   PMID:22672424   PMID:22704965  
PMID:22807215   PMID:22897442   PMID:22985671   PMID:22998873   PMID:23032401   PMID:23151666   PMID:23261589   PMID:23373701   PMID:23472740   PMID:23613711   PMID:23694790   PMID:23767459  
PMID:23934644   PMID:24312503   PMID:24619502   PMID:24632468   PMID:24706318   PMID:24878766   PMID:25201174   PMID:25220603   PMID:25301495   PMID:25423132   PMID:25572945   PMID:25655216  
PMID:25869129   PMID:25972459   PMID:26318480   PMID:26340267   PMID:26466815   PMID:26709397   PMID:26777664   PMID:26815249   PMID:27230884   PMID:27519646   PMID:28130107   PMID:28276446  
PMID:29018141   PMID:29088765   PMID:29712778   PMID:30541958   PMID:31112899   PMID:31720997   PMID:31819204   PMID:31922368   PMID:32214273   PMID:32470881   PMID:32539191   PMID:32567526  
PMID:33476055   PMID:33883060   PMID:34273501   PMID:34624416   PMID:35806000   PMID:35925441   PMID:37178997   PMID:38219812  


Genomics

Comparative Map Data
Gdnf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8258,621,327 - 58,647,242 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl258,621,327 - 58,647,240 (+)EnsemblGRCr8
mRatBN7.2256,894,022 - 56,919,935 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl256,895,010 - 56,917,209 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx263,981,903 - 64,007,772 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0262,069,964 - 62,095,814 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0257,071,144 - 57,096,990 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0256,884,181 - 56,912,964 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl256,887,987 - 56,910,238 (+)Ensemblrn6Rnor6.0
Rnor_5.0276,896,991 - 76,922,471 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4257,399,312 - 57,424,030 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera252,510,468 - 52,532,694 (+)NCBICelera
RGSC_v3.1257,327,544 - 57,352,263 (+)NCBI
Cytogenetic Map2q16NCBI
GDNF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38537,812,677 - 37,840,041 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl537,812,677 - 37,840,041 (-)Ensemblhg38GRCh38
GRCh37537,812,779 - 37,840,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36537,851,510 - 37,875,539 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34537,851,509 - 37,870,655NCBI
Celera537,699,155 - 37,726,173 (-)NCBICelera
Cytogenetic Map5p13.2NCBI
HuRef537,765,313 - 37,792,316 (-)NCBIHuRef
CHM1_1537,814,804 - 37,841,806 (-)NCBICHM1_1
T2T-CHM13v2.0538,061,739 - 38,089,107 (-)NCBIT2T-CHM13v2.0
Gdnf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39157,839,529 - 7,867,061 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl157,840,327 - 7,867,056 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38157,810,048 - 7,837,580 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl157,810,846 - 7,837,575 (+)Ensemblmm10GRCm38
MGSCv37157,761,011 - 7,787,575 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36157,758,226 - 7,784,790 (+)NCBIMGSCv36mm8
Celera157,656,819 - 7,683,345 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map153.8NCBI
Gdnf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542622,386,450 - 22,412,324 (-)Ensembl
ChiLan1.0NW_00495542622,386,613 - 22,412,324 (-)NCBIChiLan1.0ChiLan1.0
GDNF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2472,503,313 - 72,530,699 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1570,643,011 - 70,684,335 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0572,539,374 - 72,566,918 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1577,573,466 - 77,600,478 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl577,577,313 - 77,601,362 (+)EnsemblpanPan2panpan1.1
GDNF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1470,966,694 - 70,991,860 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl470,971,432 - 70,989,714 (+)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.0471,483,108 - 71,516,105 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl471,487,859 - 71,508,270 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1471,230,252 - 71,263,217 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0471,343,690 - 71,376,610 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0471,882,215 - 71,915,204 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gdnf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213227,058,585 - 227,083,871 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365184,288,154 - 4,310,753 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365184,291,391 - 4,310,752 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDNF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1622,936,604 - 22,966,536 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11622,936,602 - 22,965,929 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21624,176,604 - 24,179,641 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GDNF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1436,662,033 - 36,691,761 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl436,665,009 - 36,684,257 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607127,015,956 - 27,043,442 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gdnf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475917,263,969 - 17,287,723 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475917,263,570 - 17,290,046 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gdnf
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13172,670,582 - 172,692,700 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gdnf
201 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:34
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000041288
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25838820177302351Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
Gdnf  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.4257,423,774 - 57,424,011UniSTSRGSC3.4
RGSC_v3.4257,423,673 - 57,423,854UniSTSRGSC3.4
RGSC_v3.4257,423,677 - 57,424,014UniSTSRGSC3.4
Celera252,532,337 - 52,532,518UniSTS
Celera252,532,341 - 52,532,678UniSTS
Celera252,532,438 - 52,532,675UniSTS
GDNF_3150  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2256,916,745 - 56,917,221 (+)MAPPERmRatBN7.2
Rnor_6.0256,909,775 - 56,910,250NCBIRnor6.0
Rnor_5.0276,919,282 - 76,919,757UniSTSRnor5.0
RGSC_v3.4257,423,567 - 57,424,042UniSTSRGSC3.4
Celera252,532,231 - 52,532,706UniSTS
Cytogenetic Map2q16UniSTS
Gdnf  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0276,919,388 - 76,919,569UniSTSRnor5.0
RGSC_v3.4257,423,673 - 57,423,854UniSTSRGSC3.4
Celera252,532,337 - 52,532,518UniSTS
Cytogenetic Map2q16UniSTS
Gdnf  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0276,919,489 - 76,919,726UniSTSRnor5.0
RGSC_v3.4257,423,774 - 57,424,011UniSTSRGSC3.4
Celera252,532,438 - 52,532,675UniSTS
Cytogenetic Map2q16UniSTS
Gdnf  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0276,919,392 - 76,919,729UniSTSRnor5.0
RGSC_v3.4257,423,677 - 57,424,014UniSTSRGSC3.4
Celera252,532,341 - 52,532,678UniSTS
Cytogenetic Map2q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 9 48 129 70 70 45 21 45 6 220 97 11 109 58 92 25 10 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001401780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC141975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF205713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF205714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF205715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF497634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ011432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU068467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU068468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU068469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU068470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU068471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU068472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L15305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S75583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X92495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000041288   ⟹   ENSRNOP00000044012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl256,895,010 - 56,917,209 (+)Ensembl
Rnor_6.0 Ensembl256,887,987 - 56,910,238 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124638   ⟹   ENSRNOP00000110121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl258,623,817 - 58,647,240 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143194   ⟹   ENSRNOP00000107775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl258,621,327 - 58,647,240 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153536   ⟹   ENSRNOP00000110606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl258,625,447 - 58,647,240 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000160755   ⟹   ENSRNOP00000098957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl258,625,139 - 58,647,240 (+)Ensembl
RefSeq Acc Id: NM_001401780   ⟹   NP_001388709
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8258,621,327 - 58,647,240 (+)NCBI
mRatBN7.2256,894,022 - 56,919,935 (+)NCBI
RefSeq Acc Id: NM_019139   ⟹   NP_062012
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8258,621,327 - 58,647,240 (+)NCBI
mRatBN7.2256,894,022 - 56,919,935 (+)NCBI
Rnor_6.0256,887,987 - 56,910,238 (+)NCBI
Rnor_5.0276,896,991 - 76,922,471 (+)NCBI
RGSC_v3.4257,399,312 - 57,424,030 (+)RGD
Celera252,510,468 - 52,532,694 (+)RGD
Sequence:
RefSeq Acc Id: XM_008760756   ⟹   XP_008758978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8258,625,454 - 58,647,242 (+)NCBI
mRatBN7.2256,898,358 - 56,919,935 (+)NCBI
Rnor_6.0256,892,164 - 56,912,964 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008760757   ⟹   XP_008758979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8258,625,454 - 58,647,242 (+)NCBI
mRatBN7.2256,898,278 - 56,919,935 (+)NCBI
Rnor_6.0256,892,164 - 56,912,964 (+)NCBI
Sequence:
RefSeq Acc Id: NP_062012   ⟸   NM_019139
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9QXJ9 (UniProtKB/Swiss-Prot),   Q9QXJ8 (UniProtKB/Swiss-Prot),   Q9QXJ7 (UniProtKB/Swiss-Prot),   Q9QX95 (UniProtKB/Swiss-Prot),   Q9QX94 (UniProtKB/Swiss-Prot),   Q8R485 (UniProtKB/Swiss-Prot),   Q64063 (UniProtKB/Swiss-Prot),   Q64062 (UniProtKB/Swiss-Prot),   Q63214 (UniProtKB/Swiss-Prot),   Q07731 (UniProtKB/Swiss-Prot),   A7UGJ1 (UniProtKB/TrEMBL),   F8WFL7 (UniProtKB/TrEMBL),   A6KGH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758978   ⟸   XM_008760756
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008758979   ⟸   XM_008760757
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000044012   ⟸   ENSRNOT00000041288
RefSeq Acc Id: NP_001388709   ⟸   NM_001401780
- Peptide Label: isoform 2 precursor
- UniProtKB: A7UGI9 (UniProtKB/TrEMBL),   A7UGJ0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107775   ⟸   ENSRNOT00000143194
Ensembl Acc Id: ENSRNOP00000110606   ⟸   ENSRNOT00000153536
Ensembl Acc Id: ENSRNOP00000098957   ⟸   ENSRNOT00000160755
Ensembl Acc Id: ENSRNOP00000110121   ⟸   ENSRNOT00000124638
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07731-F1-model_v2 AlphaFold Q07731 1-211 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2677 AgrOrtholog
BioCyc Gene G2FUF-54131 BioCyc
Ensembl Genes ENSRNOG00000012819 Ensembl
  ENSRNOG00000083179 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000143194 ENTREZGENE
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  GDNF UniProtKB/Swiss-Prot
  GDNF_fam UniProtKB/Swiss-Prot
  GDNF_TGF-b-like UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
KEGG Report rno:25453 UniProtKB/Swiss-Prot
NCBI Gene 25453 ENTREZGENE
PANTHER PTHR12173 UniProtKB/Swiss-Prot
  PTHR12173:SF1 UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
PhenoGen Gdnf PhenoGen
PIRSF GDNF UniProtKB/Swiss-Prot
PROSITE TGF_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012819 RatGTEx
  ENSRNOG00000083179 RatGTEx
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
TIGR TC222344
UniProt A0ABK0LB82_RAT UniProtKB/TrEMBL
  A0ABK0LYZ4_RAT UniProtKB/TrEMBL
  A0ABK0M4C0_RAT UniProtKB/TrEMBL
  A0ABK0M5C9_RAT UniProtKB/TrEMBL
  A6KGH0 ENTREZGENE, UniProtKB/TrEMBL
  A6KGH1_RAT UniProtKB/TrEMBL
  A7UGI9 ENTREZGENE, UniProtKB/TrEMBL
  A7UGJ0 ENTREZGENE, UniProtKB/TrEMBL
  A7UGJ1 ENTREZGENE, UniProtKB/TrEMBL
  F8WFL7 ENTREZGENE
  GDNF_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63214 ENTREZGENE
  Q64062 ENTREZGENE
  Q64063 ENTREZGENE
  Q8R485 ENTREZGENE
  Q9QX94 ENTREZGENE
  Q9QX95 ENTREZGENE
  Q9QXJ7 ENTREZGENE
  Q9QXJ8 ENTREZGENE
  Q9QXJ9 ENTREZGENE
UniProt Secondary Q63214 UniProtKB/Swiss-Prot
  Q64062 UniProtKB/Swiss-Prot
  Q64063 UniProtKB/Swiss-Prot
  Q8R485 UniProtKB/Swiss-Prot
  Q9QX94 UniProtKB/Swiss-Prot
  Q9QX95 UniProtKB/Swiss-Prot
  Q9QXJ7 UniProtKB/Swiss-Prot
  Q9QXJ8 UniProtKB/Swiss-Prot
  Q9QXJ9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-17 Gdnf  glial cell derived neurotrophic factor  Gdnf  glial cell line derived neurotrophic factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gdnf  Glial cell line derived neutrophic factor      Symbol and Name status set to approved 70586 APPROVED