RGD Reference Report - Expression of glial cell line-derived neurotrophic factor and GDNFR-alpha mRNAs in human peripheral neuropathies. - Rat Genome Database

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Expression of glial cell line-derived neurotrophic factor and GDNFR-alpha mRNAs in human peripheral neuropathies.

Authors: Yamamoto, M  Mitsuma, N  Ito, Y  Hattori, N  Nagamatsu, M  Li, M  Mitsuma, T  Sobue, G 
Citation: Yamamoto M, etal., Brain Res. 1998 Nov 2;809(2):175-81.
RGD ID: 6218983
Pubmed: PMID:9853108   (View Abstract at PubMed)

The steady-state mRNA levels of glial cell line-derived neurotrophic factor (GDNF), GDNFR-alpha and RET were examined in various human peripheral neuropathies to determine the relationship with myelinated fiber pathology, and T cell and macrophage invasions in the diseased nerves. GDNF and GDNFR-alpha mRNA levels were elevated to variable extent in the diseased nerves, although they were not specific to the type of diseases. The increase of GDNFR-alpha mRNA levels was correlated with the extent of the nerves with axonal pathology, and was proportional to the extent of invasion of the nerves by T cells and macrophages. The GDNF mRNA levels were not related to axonal, demyelinating pathology, or inflammatory cell invasions. RET mRNA expression was not detected in normal nor diseased nerves. The GDNF and GDNFR-alpha expression in the diseased human nerves is regulated by an underlying pathology-related process, and could play a role in peripheral nerve repair.

Objects Annotated

Genes (Rattus norvegicus)
Gdnf  (glial cell derived neurotrophic factor)
Gfra1  (GDNF family receptor alpha 1)

Genes (Mus musculus)
Gdnf  (glial cell line derived neurotrophic factor)
Gfra1  (glial cell line derived neurotrophic factor family receptor alpha 1)

Genes (Homo sapiens)
GDNF  (glial cell derived neurotrophic factor)
GFRA1  (GDNF family receptor alpha 1)


Additional Information