Flg (filaggrin) - Rat Genome Database

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Gene: Flg (filaggrin) Rattus norvegicus
Analyze
Symbol: Flg
Name: filaggrin
RGD ID: 2620
Description: Human ortholog(s) of this gene implicated in atopic dermatitis 2 and ichthyosis vulgaris. Orthologous to human FLG (filaggrin); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; acrylamide; ammonium chloride.
Type: protein-coding (Ensembl: pseudogene)
RefSeq Status: VALIDATED
Previously known as: Filaggrin (profilaggrin); LOC679174; Pflg; profilaggrin
RGD Orthologs
Human
Mouse
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82181,583,801 - 181,596,464 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2181,583,808 - 181,595,968 (+)EnsemblGRCr8
mRatBN7.22178,884,793 - 178,912,986 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2186,449,517 - 186,478,945 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02184,429,834 - 184,448,291 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02179,092,619 - 179,122,045 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02193,565,401 - 193,574,297 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02211,289,344 - 211,294,588 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42186,307,359 - 186,311,549 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2171,386,515 - 171,395,603 (-)NCBICelera
RGSC_v3.12186,259,903 - 186,260,929 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,5-trichlorophenol  (ISO)
2,4-D  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,6-dimethoxyphenol  (ISO)
4-Hydroxybenzophenone  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
ammonium chloride  (EXP)
antimonite  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-damascenone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcipotriol  (ISO)
calcitriol  (ISO)
clofibrate  (ISO)
cortisol  (ISO)
D-glucose  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
doxorubicin  (ISO)
folic acid  (ISO)
fructose  (ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
glucose  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
iron dichloride  (ISO)
isotretinoin  (ISO)
lucanthone  (ISO)
LY294002  (ISO)
methylparaben  (ISO)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(5-carboxy-2-ethylpentyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
NS-398  (ISO)
okadaic acid  (ISO)
oxybenzone  (ISO)
paracetamol  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluoropentanoic acid  (ISO)
phenacetin  (EXP)
phenylhydrazine  (EXP)
pirinixic acid  (ISO)
propylparaben  (ISO)
quercitrin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dodecyl sulfate  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
trans-urocanic acid  (ISO)
triclosan  (ISO)
triptonide  (ISO)
urocanic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Loss-of-function polymorphisms in the filaggrin gene are associated with an increased susceptibility to chronic irritant contact dermatitis: a case-control study. de Jongh CM, etal., Br J Dermatol. 2008 Sep;159(3):621-7. doi: 10.1111/j.1365-2133.2008.08730.x. Epub 2008 Jul 10.
2. A prospective study of filaggrin null mutations in keratoconus patients with or without atopic disorders. Droitcourt C, etal., Dermatology. 2011;222(4):336-41. doi: 10.1159/000328408. Epub 2011 Jun 23.
3. No Association of filaggrin copy number variation and atopic dermatitis risk in White and Black Americans. Fulton RL, etal., Exp Dermatol. 2022 Feb;31(2):233-236. doi: 10.1111/exd.14449. Epub 2021 Aug 21.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Filaggrin, an intermediate filament-associated protein: structural and functional implications from the sequence of a cDNA from rat. Haydock PV and Dale BA, DNA Cell Biol 1990 May;9(4):251-61.
6. Antisense profilaggrin RNA delays and decreases profilaggrin expression and alters in vitro differentiation of rat epidermal keratinocytes. Haydock PV, etal., J Invest Dermatol. 1993 Aug;101(2):118-26.
7. Association between P478S polymorphism of the filaggrin gene & atopic dermatitis. Kim SY, etal., Indian J Med Res. 2013 Dec;138(6):922-7.
8. Induction of selected lipid metabolic enzymes and differentiation-linked structural proteins by air exposure in fetal rat skin explants. Komuves LG, etal., J Invest Dermatol. 1999 Mar;112(3):303-9.
9. Ligands and activators of nuclear hormone receptors regulate epidermal differentiation during fetal rat skin development. Kömüves LG, etal., J Invest Dermatol. 1998 Sep;111(3):429-33. doi: 10.1046/j.1523-1747.1998.00296.x.
10. Filaggrin gene mutations and the distribution of filaggrin in oral mucosa of patients with oral lichen planus and healthy controls. Larsen KR, etal., J Eur Acad Dermatol Venereol. 2017 May;31(5):887-893. doi: 10.1111/jdv.14098. Epub 2017 Jan 9.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Association of Filaggrin loss-of-function-mutations with atopic dermatitis and asthma in the Early Treatment of the Atopic Child (ETAC) population. Muller S, etal., Pediatr Allergy Immunol. 2009 Jun;20(4):358-61. doi: 10.1111/j.1399-3038.2008.00808.x.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Functional analysis of the profilaggrin N-terminal peptide: identification of domains that regulate nuclear and cytoplasmic distribution. Pearton DJ, etal., J Invest Dermatol. 2002 Sep;119(3):661-9.
16. Independent regulation of two cytoplasmic processing stages of the intermediate filament-associated protein filaggrin and role of Ca2+ in the second stage. Resing KA, etal., J Biol Chem. 1993 Nov 25;268(33):25139-45.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma. Rogers AJ, etal., J Allergy Clin Immunol. 2007 Dec;120(6):1332-7. doi: 10.1016/j.jaci.2007.09.037.
21. Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment. Scott IR and Harding CR, Dev Biol. 1986 May;115(1):84-92. doi: 10.1016/0012-1606(86)90230-7.
22. Massively Parallel Sequencingof the Filaggrin Gene Reveals an Association Between FLG Loss-of-function Mutations and Leprosy. Shi W, etal., Acta Derm Venereol. 2020 Oct 21;100(17):adv00299. doi: 10.2340/00015555-3663.
23. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Smith FJ, etal., Nat Genet. 2006 Mar;38(3):337-42. Epub 2006 Jan 29.
24. Linkage between phosphorylated cystatin alpha and filaggrin by epidermal transglutaminase as a model of cornified envelope and inhibition of cathepsin L activity by cornified envelope and the conjugated cystatin alpha. Takahashi M, etal., FEBS Lett. 1994 Mar 7;340(3):173-6. doi: 10.1016/0014-5793(94)80131-2.
25. Filaggrin loss-of-function variants are associated with atopic dermatitis phenotypes in a diverse, early-life prospective cohort. Virolainen SJ, etal., JCI Insight. 2024 Apr 2;9(9):e178258. doi: 10.1172/jci.insight.178258.
26. Filaggrin polymorphism P478S, IgE level, and atopic phenotypes. Wang IJ, etal., Br J Dermatol. 2011 Apr;164(4):791-6. doi: 10.1111/j.1365-2133.2011.10212.x.
Additional References at PubMed
PMID:1429717   PMID:4557539   PMID:6170061   PMID:6174530   PMID:7543090   PMID:11572870   PMID:12850301   PMID:20376063   PMID:21464233   PMID:21630459   PMID:21744336   PMID:22366455  
PMID:23403047   PMID:24084074   PMID:33450132  


Genomics

Comparative Map Data
Flg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82181,583,801 - 181,596,464 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2181,583,808 - 181,595,968 (+)EnsemblGRCr8
mRatBN7.22178,884,793 - 178,912,986 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2186,449,517 - 186,478,945 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02184,429,834 - 184,448,291 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02179,092,619 - 179,122,045 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02193,565,401 - 193,574,297 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02211,289,344 - 211,294,588 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42186,307,359 - 186,311,549 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2171,386,515 - 171,395,603 (-)NCBICelera
RGSC_v3.12186,259,903 - 186,260,929 (+)NCBI
Cytogenetic Map2q34NCBI
FLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381152,302,165 - 152,325,239 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1152,302,165 - 152,325,239 (-)Ensemblhg38GRCh38
GRCh371152,274,641 - 152,297,715 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361150,541,275 - 150,564,303 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1125,386,606 - 125,408,667 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1123,649,333 - 123,671,391 (-)NCBIHuRef
CHM1_11153,670,002 - 153,693,030 (-)NCBICHM1_1
T2T-CHM13v2.01151,437,741 - 151,461,789 (-)NCBIT2T-CHM13v2.0
Flg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39393,180,853 - 93,200,996 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl393,180,830 - 93,200,993 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38393,273,546 - 93,293,689 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl393,273,523 - 93,293,686 (+)Ensemblmm10GRCm38
MGSCv37393,089,108 - 93,097,615 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36393,367,872 - 93,379,097 (+)NCBIMGSCv36mm8
Celera393,804,333 - 93,822,603 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.16NCBI
FLG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2197,536,576 - 97,547,401 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,286,770 - 97,298,567 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01127,634,416 - 127,649,659 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11131,276,648 - 131,285,336 (-)NCBIPanPan1.1PanPan1.1panPan2
FLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11761,217,915 - 61,233,068 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1760,662,290 - 60,679,224 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01762,238,036 - 62,255,220 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1762,238,628 - 62,255,215 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11761,075,602 - 61,083,175 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01761,151,018 - 61,170,965 (-)NCBIUNSW_CanFamBas_1.0
FLG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603810,884,513 - 10,889,562 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Flg
163 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
Flg  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22178,909,027 - 178,909,309 (+)MAPPERmRatBN7.2
mRatBN7.22178,891,975 - 178,892,257 (+)MAPPERmRatBN7.2
mRatBN7.22178,893,193 - 178,893,475 (+)MAPPERmRatBN7.2
mRatBN7.22178,899,283 - 178,899,565 (+)MAPPERmRatBN7.2
mRatBN7.22178,900,501 - 178,900,783 (+)MAPPERmRatBN7.2
mRatBN7.22178,904,155 - 178,904,437 (+)MAPPERmRatBN7.2
mRatBN7.22178,905,373 - 178,905,655 (+)MAPPERmRatBN7.2
mRatBN7.22178,906,591 - 178,906,873 (+)MAPPERmRatBN7.2
mRatBN7.22178,907,809 - 178,908,091 (+)MAPPERmRatBN7.2
mRatBN7.22178,890,757 - 178,891,039 (+)MAPPERmRatBN7.2
mRatBN7.22178,910,245 - 178,910,527 (+)MAPPERmRatBN7.2
mRatBN7.22178,911,463 - 178,911,745 (+)MAPPERmRatBN7.2
mRatBN7.22178,898,065 - 178,898,347 (+)MAPPERmRatBN7.2
mRatBN7.22178,896,847 - 178,897,129 (+)MAPPERmRatBN7.2
mRatBN7.22178,895,629 - 178,895,911 (+)MAPPERmRatBN7.2
mRatBN7.22178,894,411 - 178,894,693 (+)MAPPERmRatBN7.2
Rnor_6.02193,572,763 - 193,573,044NCBIRnor6.0
Rnor_5.02211,292,237 - 211,292,518UniSTSRnor5.0
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
mesenchyme
nervous system
reproductive system
sensory system
visual system
1 7 1 9 4 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000123009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2181,583,808 - 181,595,968 (+)Ensembl
RefSeq Acc Id: NM_001393766   ⟹   NP_001380695
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82181,583,801 - 181,596,464 (+)NCBI
mRatBN7.22178,884,793 - 178,912,986 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001380695 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41161 (Get FASTA)   NCBI Sequence Viewer  
  AAM54369 (Get FASTA)   NCBI Sequence Viewer  
  EDL87862 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001380695   ⟸   NM_001393766
Protein Domains
EF-hand

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2620 AgrOrtholog
BioCyc Gene G2FUF-52243 BioCyc
Ensembl Genes ENSRNOG00000071961 Ensembl
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Filaggrin UniProtKB/TrEMBL
  S-100_dom UniProtKB/TrEMBL
  S100-fused_Epidermal_Struct UniProtKB/TrEMBL
  S100/CaBP-9k_CS UniProtKB/TrEMBL
  S100_Ca-bd_sub UniProtKB/TrEMBL
NCBI Gene 24641 ENTREZGENE
PANTHER FILAGGRIN UniProtKB/TrEMBL
  FILAGGRIN-RELATED UniProtKB/TrEMBL
Pfam Filaggrin UniProtKB/TrEMBL
  S_100 UniProtKB/TrEMBL
PhenoGen Flg PhenoGen
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  S100_CABP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000071961 RatGTEx
SMART S_100 UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A6KMN2_RAT UniProtKB/TrEMBL
  Q8CIU0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Flg  filaggrin  LOC679174  similar to filaggrin  Data merged from RGD:1591824 737654 PROVISIONAL
2006-11-20 LOC679174  similar to filaggrin      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-11-06 Flg  filaggrin    Filaggrin (profilaggrin)  Name updated 625702 APPROVED
2002-06-10 Flg  Filaggrin (profilaggrin)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two repeats of 406 amino acid with a filaggrin domain in each repeat 632675
gene_expression expressed in fully cornified cells of the mammalian epidermis, mRNA highly expressed only in keratinizing epithelia 632675
gene_process responsible for epidermal differentiation 632675
gene_transcript cDNA is 2,314 bp long and has a 1,875 bp long coding region ending with an A-T rich 3' noncoding region 632675