FLG (filaggrin) - Rat Genome Database

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Gene: FLG (filaggrin) Canis lupus familiaris
Analyze
Symbol: FLG
Name: filaggrin
RGD ID: 12202256
Description: ENCODES a protein that exhibits keratin filament binding (ortholog); structural constituent of skin epidermis (ortholog); INVOLVED IN epidermal cell differentiation (ortholog); epidermis development (ortholog); establishment of skin barrier (ortholog); ASSOCIATED WITH atopic dermatitis (ortholog); atopic dermatitis 2 (ortholog); cerebellar hypoplasia (ortholog); FOUND IN cornified envelope (ortholog); cytoplasmic ribonucleoprotein granule (ortholog); keratohyalin granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11761,217,915 - 61,233,068 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1760,662,290 - 60,679,224 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01762,238,036 - 62,255,220 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11761,075,602 - 61,083,175 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01761,151,018 - 61,170,965 (-)NCBIUNSW_CanFamBas_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:23331676   PMID:23398596   PMID:23432387   PMID:23668858  


Genomics

Comparative Map Data
FLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11761,217,915 - 61,233,068 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1760,662,290 - 60,679,224 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01762,238,036 - 62,255,220 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11761,075,602 - 61,083,175 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01761,151,018 - 61,170,965 (-)NCBIUNSW_CanFamBas_1.0
FLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381152,302,165 - 152,325,239 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1152,302,165 - 152,325,239 (-)EnsemblGRCh38hg38GRCh38
GRCh371152,274,641 - 152,297,715 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361150,541,275 - 150,564,303 (-)NCBINCBI36Build 36hg18NCBI36
Celera1125,386,606 - 125,408,667 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1123,649,333 - 123,671,391 (-)NCBIHuRef
CHM1_11153,670,002 - 153,693,030 (-)NCBICHM1_1
T2T-CHM13v2.01151,437,741 - 151,461,789 (-)NCBIT2T-CHM13v2.0
Flg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39393,180,853 - 93,200,996 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl393,180,830 - 93,200,993 (+)EnsemblGRCm39 Ensembl
GRCm38393,273,546 - 93,293,689 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl393,273,523 - 93,293,686 (+)EnsemblGRCm38mm10GRCm38
MGSCv37393,089,108 - 93,097,615 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36393,367,872 - 93,379,097 (+)NCBIMGSCv36mm8
Celera393,804,333 - 93,822,603 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.16NCBI
Flg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82181,583,801 - 181,596,464 (+)NCBIGRCr8
mRatBN7.22178,884,793 - 178,912,986 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2186,449,517 - 186,478,945 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02184,429,834 - 184,448,291 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02179,092,619 - 179,122,045 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02193,565,401 - 193,574,297 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02211,289,344 - 211,294,588 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42186,307,359 - 186,311,549 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12186,259,903 - 186,260,929 (+)NCBI
Celera2171,386,515 - 171,395,603 (-)NCBICelera
Cytogenetic Map2q34NCBI
FLG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2197,536,576 - 97,547,401 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,286,770 - 97,298,567 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01127,634,416 - 127,649,659 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11131,276,648 - 131,285,336 (-)NCBIpanpan1.1PanPan1.1panPan2

Variants

.
Variants in FLG
242 total Variants

Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_022405017   ⟹   XP_022260725
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11761,217,915 - 61,233,068 (-)NCBI
Dog10K_Boxer_Tasha1760,662,290 - 60,679,224 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038423227   ⟹   XP_038279155
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01762,238,036 - 62,255,220 (-)NCBI
RefSeq Acc Id: XM_038499877   ⟹   XP_038355805
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11761,075,602 - 61,083,175 (-)NCBI
RefSeq Acc Id: XM_038626512   ⟹   XP_038482440
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01761,151,018 - 61,170,965 (-)NCBI
Protein Sequences
Protein RefSeqs XP_022260725 (Get FASTA)   NCBI Sequence Viewer  
  XP_038279155 (Get FASTA)   NCBI Sequence Viewer  
  XP_038355805 (Get FASTA)   NCBI Sequence Viewer  
  XP_038482440 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00845035844
  ENSCAFP00845035844.1
Reference Protein Sequences
RefSeq Acc Id: XP_022260725   ⟸   XM_022405017
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_038355805   ⟸   XM_038499877
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038482440   ⟸   XM_038626512
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038279155   ⟸   XM_038423227
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PW84 (UniProtKB/TrEMBL)
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00845025895 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845045679 ENTREZGENE
  ENSCAFT00845045679.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Filaggrin UniProtKB/TrEMBL
  S-100_dom UniProtKB/TrEMBL
  S100/CaBP7/8-like_CS UniProtKB/TrEMBL
  S100_Ca-bd_sub UniProtKB/TrEMBL
NCBI Gene FLG ENTREZGENE
PANTHER FILAGGRIN UniProtKB/TrEMBL
  FILAGGRIN-RELATED UniProtKB/TrEMBL
Pfam Filaggrin UniProtKB/TrEMBL
  S_100 UniProtKB/TrEMBL
PRINTS FILAGGRIN UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  S100_CABP UniProtKB/TrEMBL
SMART S_100 UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A8I3PW84 ENTREZGENE, UniProtKB/TrEMBL