Epor (erythropoietin receptor) - Rat Genome Database

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Gene: Epor (erythropoietin receptor) Rattus norvegicus
Analyze
Symbol: Epor
Name: erythropoietin receptor
RGD ID: 2560
Description: Enables erythropoietin receptor activity. Involved in several processes, including cellular response to kainic acid; negative regulation of nitric oxide biosynthetic process; and positive regulation of ERK1 and ERK2 cascade. Located in external side of plasma membrane. Used to study high grade glioma. Biomarker of several diseases, including brain ischemia; cholangiocarcinoma; end stage renal disease; eye disease (multiple); and hepatic encephalopathy. Human ortholog(s) of this gene implicated in anemia; familial erythrocytosis 1; high grade glioma; polycythemia; and systemic lupus erythematosus. Orthologous to human EPOR (erythropoietin receptor); PARTICIPATES IN erythropoietin signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: EPO-R; MGC108723
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,765,738 - 28,770,371 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,765,746 - 28,770,322 (-)EnsemblGRCr8
mRatBN7.2820,489,678 - 20,494,257 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,489,678 - 20,494,257 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx824,519,099 - 24,523,676 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,816,236 - 22,820,813 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,719,272 - 20,723,848 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,969,737 - 22,974,468 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,969,745 - 22,974,321 (-)Ensemblrn6Rnor6.0
Rnor_5.0823,024,521 - 23,029,191 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4821,061,310 - 21,065,886 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,880,243 - 21,884,819 (-)NCBICelera
RGSC_v3.1821,061,309 - 21,065,886 (-)NCBI
Cytogenetic Map8q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acids  (ISO)
arsenous acid  (ISO)
bafilomycin A1  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
BQ 123  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP)
formaldehyde  (ISO)
gefitinib  (ISO)
genistein  (ISO)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
kainic acid  (EXP,ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
melatonin  (EXP)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenylhydrazine  (ISO)
phosphane  (EXP)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
streptozocin  (EXP)
tamoxifen  (ISO)
tetraphene  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
uranium atom  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
wortmannin  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The effect of erythropoietin on interleukin-1beta mediated increase in nitric oxide synthesis in vascular smooth muscle cells. Akimoto T, etal., J Hypertens. 1999 Sep;17(9):1249-56.
2. Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene. Arcasoy MO, etal., Blood. 1997 Jun 15;89(12):4628-35.
3. A novel mutation in the erythropoietin receptor gene is associated with familial erythrocytosis. Arcasoy MO, etal., Blood. 2002 Apr 15;99(8):3066-9.
4. Functional significance of erythropoietin receptor expression in breast cancer. Arcasoy MO, etal., Lab Invest. 2002 Jul;82(7):911-8.
5. Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairment. Assaraf MI, etal., J Neuropathol Exp Neurol. 2007 May;66(5):389-98.
6. Selective expression of mRNA coding for the truncated form of erythropoietin receptor in hematopoietic cells and its decrease in patients with polycythemia vera. Chiba S, etal., Blood. 1997 Jul 1;90(1):97-104.
7. Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis. de la Chapelle A, etal., Proc Natl Acad Sci U S A. 1993 May 15;90(10):4495-9.
8. Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene. Divoky V, etal., Proc Natl Acad Sci U S A 2001 Jan 30;98(3):986-91.
9. Up-regulated endogenous erythropoietin/erythropoietin receptor system and exogenous erythropoietin rescue retinal ganglion cells after chronic ocular hypertension. Fu QL, etal., Cell Mol Neurobiol. 2008 Feb;28(2):317-29. Epub 2007 Jun 7.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Erythropoietin and erythropoietin receptor expression after experimental spinal cord injury encourages therapy by exogenous erythropoietin. Grasso G, etal., Neurosurgery. 2005 Apr;56(4):821-7; discussion 821-7.
13. Autoantibodies to erythropoietin receptor in patients with immune-mediated diseases: relationship to anaemia with erythroid hypoplasia. Hara A, etal., Br J Haematol. 2013 Jan;160(2):244-50. doi: 10.1111/bjh.12105. Epub 2012 Nov 15.
14. Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor. Hellewell SC, etal., J Neuroinflammation. 2013 Dec 18;10:156. doi: 10.1186/1742-2094-10-156.
15. Down-Regulation of Cardiac Erythropoietin Receptor and its Downstream Activated Signal Transducer Phospho-STAT-5 in a Rat Model of Chronic Kidney Disease. Hertzberg-Bigelman E, etal., Isr Med Assoc J. 2016 Jun;18(6):326-30.
16. The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection. Hu MC, etal., Kidney Int. 2013 Sep;84(3):468-81. doi: 10.1038/ki.2013.149. Epub 2013 May 1.
17. Hypertension induced by erythropoietin has a correlation with truncated erythropoietin receptor mRNA in endothelial progenitor cells of hemodialysis patients. Ioka T, etal., Clin Pharmacol Ther. 2009 Aug;86(2):154-9. doi: 10.1038/clpt.2009.74. Epub 2009 May 20.
18. The erythropoietin receptor gene is not linked with the polycythemia phenotype in a family with autosomal dominant primary polycythemia. Kralovics R, etal., Proc Assoc Am Physicians. 1997 Nov;109(6):580-5.
19. Protective effects of erythropoietin on myocardial infarction in rats: the role of AMP-activated protein kinase signaling pathway. Li XJ, etal., Am J Med Sci. 2011 Aug;342(2):153-9. doi: 10.1097/MAJ.0b013e318210041d.
20. Recombinant human erythropoietin administration protects cortical neurons from traumatic brain injury in rats. Liao ZB, etal., Eur J Neurol. 2008 Feb;15(2):140-9. Epub 2007 Dec 18.
21. [Influence of HIF- 2α on the expression of GATA- 1 in bone marrow CD71(+) cell of high altitude polycythemia rat model]. Liu F, etal., Zhonghua Xue Ye Xue Za Zhi. 2016 Aug 14;37(8):696-701. doi: 10.3760/cma.j.issn.0253-2727.2016.08.013.
22. Erythropoietin pretreatment exerts anti-inflammatory effects in hepatic ischemia/reperfusion-injured rats via suppression of the TLR2/NF-κB pathway. Liu QS, etal., Transplant Proc. 2015 Mar;47(2):283-9. doi: 10.1016/j.transproceed.2014.10.045.
23. Both megakaryocytopoiesis and erythropoiesis are induced in mice infected with a retrovirus expressing an oncogenic erythropoietin receptor. Longmore GD, etal., Blood. 1993 Oct 15;82(8):2386-95.
24. Anti-erythropoietin receptor antibodies in systemic lupus erythematosus patients with anemia. Luo XY, etal., Lupus. 2013 Feb;22(2):121-7. doi: 10.1177/0961203312463980. Epub 2012 Oct 18.
25. Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells. Masuda S, etal., J Biol Chem 1993 May 25;268(15):11208-16.
26. Recovery of motor spontaneous activity after intranasal delivery of human recombinant erythropoietin in a focal brain hypoxia model induced by CoCl2 in rats. Merelli A, etal., Neurotox Res. 2011 Aug;20(2):182-92. doi: 10.1007/s12640-010-9233-8. Epub 2010 Nov 30.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Characterization of the erythropoietin/erythropoietin receptor axis in a rat model of liver damage and cholangiocarcinoma development. Moriconi F, etal., Histochem Cell Biol. 2013 Mar;139(3):473-85. doi: 10.1007/s00418-012-1037-x. Epub 2012 Oct 4.
29. Impaired erythropoiesis in transgenic mice overexpressing a truncated erythropoietin receptor. Nakamura Y, etal., Exp Hematol. 1998 Nov;26(12):1105-10.
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
32. A new agonist of the erythropoietin receptor, Epobis, induces neurite outgrowth and promotes neuronal survival. Pankratova S, etal., J Neurochem. 2012 Jun;121(6):915-23. doi: 10.1111/j.1471-4159.2012.07751.x. Epub 2012 Apr 24.
33. Targeting the erythropoietin receptor on glioma cells reduces tumour growth. Peres EA, etal., Exp Cell Res. 2011 Oct 1;317(16):2321-32. doi: 10.1016/j.yexcr.2011.06.011. Epub 2011 Jun 30.
34. EPO receptor gain-of-function causes hereditary polycythemia, alters CD34 cell differentiation and increases circulating endothelial precursors. Perrotta S, etal., PLoS One. 2010 Aug 5;5(8):e12015. doi: 10.1371/journal.pone.0012015.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
37. GOA pipeline RGD automated data pipeline
38. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Erythropoietin enhances immunostimulatory properties of immature dendritic cells. Rocchetta F, etal., Clin Exp Immunol. 2011 Aug;165(2):202-10. doi: 10.1111/j.1365-2249.2011.04417.x. Epub 2011 Jun 7.
41. Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. Ruscher K, etal., J Neurosci 2002 Dec 1;22(23):10291-301.
42. Erythropoietin receptor expression is concordant with erythropoietin but not with common beta chain expression in the rat brain throughout the life span. Sanchez PE, etal., J Comp Neurol. 2009 Jun 1;514(4):403-14.
43. Changes in CNS cells in hyperammonemic portal hypertensive rats. Tallis S, etal., J Neurochem. 2014 Feb;128(3):431-44. doi: 10.1111/jnc.12458. Epub 2013 Oct 24.
44. [Effects of hyperoxia on erythropoietin receptor expression in lung development of neonatal rats]. Wang XL, etal., Zhonghua Er Ke Za Zhi. 2011 May;49(5):361-6.
45. Permanent focal cerebral ischemia activates erythropoietin receptor in the neonatal rat brain. Wen TC, etal., Neurosci Lett. 2004 Jan 30;355(3):165-8.
46. Expression pattern of erythropoietin and erythropoietin receptor in experimental model of retinal detachment. Xie Z, etal., Curr Eye Res. 2007 Sep;32(9):757-64.
47. The intron 5-inserted form of rat erythropoietin receptor is expressed as a membrane-bound form. Yamaji R, etal., Biochim Biophys Acta 1998 Jun 22;1403(2):169-78.
48. VEGFA activates erythropoietin receptor and enhances VEGFR2-mediated pathological angiogenesis. Yang Z, etal., Am J Pathol. 2014 Apr;184(4):1230-9. doi: 10.1016/j.ajpath.2013.12.023. Epub 2014 Mar 12.
49. Neuroprotective effects of erythropoietin posttreatment against kainate-induced excitotoxicity in mixed spinal cultures. Yoo JY, etal., J Neurosci Res. 2009 Jan;87(1):150-63. doi: 10.1002/jnr.21832.
50. Erythropoietin attenuates oxidative stress and apoptosis in Schwann cells isolated from streptozotocin-induced diabetic rats. Yu T, etal., J Pharm Pharmacol. 2014 Aug;66(8):1150-60. doi: 10.1111/jphp.12244. Epub 2014 Mar 27.
51. [Expression of erythropoietin and its receptor in the brain of newborn rats suffering from fetal distress]. Zhang ZM, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2011 Nov;13(11):912-6.
Additional References at PubMed
PMID:2163696   PMID:9029168   PMID:11493922   PMID:11807041   PMID:12477932   PMID:12930840   PMID:15050726   PMID:15059965   PMID:15470751   PMID:15812815   PMID:16116438   PMID:17300687  
PMID:19218878   PMID:19536483   PMID:21058338   PMID:22495316   PMID:23821361   PMID:27959434   PMID:28359933   PMID:35917324  


Genomics

Comparative Map Data
Epor
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,765,738 - 28,770,371 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,765,746 - 28,770,322 (-)EnsemblGRCr8
mRatBN7.2820,489,678 - 20,494,257 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,489,678 - 20,494,257 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx824,519,099 - 24,523,676 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,816,236 - 22,820,813 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,719,272 - 20,723,848 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,969,737 - 22,974,468 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,969,745 - 22,974,321 (-)Ensemblrn6Rnor6.0
Rnor_5.0823,024,521 - 23,029,191 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4821,061,310 - 21,065,886 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,880,243 - 21,884,819 (-)NCBICelera
RGSC_v3.1821,061,309 - 21,065,886 (-)NCBI
Cytogenetic Map8q13NCBI
EPOR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,377,207 - 11,384,314 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,377,207 - 11,384,343 (-)Ensemblhg38GRCh38
GRCh371911,487,883 - 11,494,990 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,349,475 - 11,356,019 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341911,349,474 - 11,356,019NCBI
Celera1911,382,748 - 11,389,885 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1911,063,851 - 11,070,988 (-)NCBIHuRef
CHM1_11911,488,891 - 11,496,028 (-)NCBICHM1_1
T2T-CHM13v2.01911,504,177 - 11,511,284 (-)NCBIT2T-CHM13v2.0
Epor
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,870,193 - 21,874,915 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,870,193 - 21,874,802 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38921,958,897 - 21,963,576 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,958,897 - 21,963,506 (-)Ensemblmm10GRCm38
MGSCv37921,763,343 - 21,768,020 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36921,709,306 - 21,713,878 (-)NCBIMGSCv36mm8
Celera919,228,327 - 19,233,004 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.93NCBI
Epor
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,293,540 - 2,298,715 (-)Ensembl
ChiLan1.0NW_0049554952,293,587 - 2,299,302 (-)NCBIChiLan1.0ChiLan1.0
EPOR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22016,291,699 - 16,298,323 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11915,290,664 - 15,297,285 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,925,148 - 10,931,955 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11911,635,248 - 11,642,383 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,635,248 - 11,642,383 (-)EnsemblpanPan2panpan1.1
EPOR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,945,777 - 49,950,856 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,945,777 - 49,950,856 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2049,816,892 - 49,821,971 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02050,463,402 - 50,469,165 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,464,086 - 50,469,165 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,674,383 - 49,679,467 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,100,740 - 50,105,821 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,343,701 - 50,348,780 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Epor
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,880,801 - 208,886,331 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,468,634 - 1,473,880 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,468,391 - 1,473,880 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPOR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl270,063,519 - 70,068,821 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1270,063,601 - 70,068,821 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2270,426,996 - 70,432,219 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPOR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,313,382 - 10,320,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl610,313,775 - 10,320,066 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660749,573,409 - 9,580,946 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epor
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,181,957 - 3,187,231 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248283,181,772 - 3,187,242 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Epor
23 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:121
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000017369
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
PMC150206P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,489,827 - 20,490,586 (+)MAPPERmRatBN7.2
Rnor_6.0822,969,895 - 22,970,653NCBIRnor6.0
Rnor_5.0823,024,679 - 23,025,437UniSTSRnor5.0
RGSC_v3.4821,061,460 - 21,062,218UniSTSRGSC3.4
Celera821,880,393 - 21,881,151UniSTS
Cytogenetic Map8q13UniSTS
RH141265  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,489,769 - 20,491,421 (+)MAPPERmRatBN7.2
Rnor_6.0822,969,837 - 22,971,487NCBIRnor6.0
Rnor_5.0823,024,621 - 23,026,271UniSTSRnor5.0
RGSC_v3.4821,061,402 - 21,063,052UniSTSRGSC3.4
Celera821,880,335 - 21,881,985UniSTS
Cytogenetic Map8q13UniSTS
PMC150350P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,489,973 - 20,490,573 (+)MAPPERmRatBN7.2
Rnor_6.0822,970,041 - 22,970,640NCBIRnor6.0
Rnor_5.0823,024,825 - 23,025,424UniSTSRnor5.0
RGSC_v3.4821,061,606 - 21,062,205UniSTSRGSC3.4
Celera821,880,539 - 21,881,138UniSTS
Cytogenetic Map8q13UniSTS
UniSTS:259513  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8828,768,592 - 28,769,148 (+)Marker Load Pipeline
mRatBN7.2820,492,525 - 20,493,082 (+)MAPPERmRatBN7.2
Rnor_6.0822,972,592 - 22,973,147NCBIRnor6.0
Rnor_5.0823,027,376 - 23,027,931UniSTSRnor5.0
RGSC_v3.4821,064,157 - 21,064,712UniSTSRGSC3.4
Celera821,883,090 - 21,883,645UniSTS
Cytogenetic Map8q13UniSTS
UniSTS:496753  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,490,049 - 20,490,451 (+)MAPPERmRatBN7.2
Rnor_6.0822,970,117 - 22,970,518NCBIRnor6.0
Rnor_5.0823,024,901 - 23,025,302UniSTSRnor5.0
RGSC_v3.4821,061,682 - 21,062,083UniSTSRGSC3.4
Celera821,880,615 - 21,881,016UniSTS
Cytogenetic Map8q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 161 91 90 59 92 59 6 347 191 11 140 73 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017369   ⟹   ENSRNOP00000017369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,765,746 - 28,770,322 (-)Ensembl
mRatBN7.2 Ensembl820,489,678 - 20,494,257 (-)Ensembl
Rnor_6.0 Ensembl822,969,745 - 22,974,321 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115997   ⟹   ENSRNOP00000085239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl820,489,678 - 20,494,175 (-)Ensembl
RefSeq Acc Id: NM_017002   ⟹   NP_058698
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,765,746 - 28,770,322 (-)NCBI
mRatBN7.2820,489,678 - 20,494,257 (-)NCBI
Rnor_6.0822,969,745 - 22,974,321 (-)NCBI
Rnor_5.0823,024,521 - 23,029,191 (-)NCBI
RGSC_v3.4821,061,310 - 21,065,886 (-)RGD
Celera821,880,243 - 21,884,819 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264889   ⟹   XP_063120959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,765,738 - 28,770,371 (-)NCBI
RefSeq Acc Id: XM_063264890   ⟹   XP_063120960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,765,738 - 28,769,983 (-)NCBI
RefSeq Acc Id: XM_063264891   ⟹   XP_063120961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,765,738 - 28,768,717 (-)NCBI
RefSeq Acc Id: XR_010053927
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,766,469 - 28,770,371 (-)NCBI
RefSeq Acc Id: XR_010053928
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,766,469 - 28,770,371 (-)NCBI
RefSeq Acc Id: NP_058698   ⟸   NM_017002
- Peptide Label: precursor
- UniProtKB: Q07303 (UniProtKB/Swiss-Prot),   Q5FVS4 (UniProtKB/TrEMBL),   A6JNW6 (UniProtKB/TrEMBL),   F7EQZ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017369   ⟸   ENSRNOT00000017369
Ensembl Acc Id: ENSRNOP00000085239   ⟸   ENSRNOT00000115997
RefSeq Acc Id: XP_063120959   ⟸   XM_063264889
- Peptide Label: isoform X1
- UniProtKB: Q07303 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063120960   ⟸   XM_063264890
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GCI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120961   ⟸   XM_063264891
- Peptide Label: isoform X3
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07303-F1-model_v2 AlphaFold Q07303 1-507 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2560 AgrOrtholog
BioCyc Gene G2FUF-31399 BioCyc
Ensembl Genes ENSRNOG00000012619 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017369 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7375416 IMAGE-MGC_LOAD
InterPro Erythropoietin_rcpt UniProtKB/Swiss-Prot
  FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Growth/epo_recpt_lig-bind UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Long_hematopoietin_rcpt_CS UniProtKB/Swiss-Prot
MGC_CLONE MGC:108723 IMAGE-MGC_LOAD
NCBI Gene 24336 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot
  PTHR23037:SF28 UniProtKB/Swiss-Prot
Pfam EpoR_lig-bind UniProtKB/Swiss-Prot
  fn3 UniProtKB/Swiss-Prot
PhenoGen Epor PhenoGen
PIRSF EPO_receptor UniProtKB/Swiss-Prot
PROSITE FN3 UniProtKB/Swiss-Prot
  HEMATOPO_REC_L_F1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012619 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot
UniProt A0A8I6GCI9 ENTREZGENE
  A6JNW6 ENTREZGENE, UniProtKB/TrEMBL
  EPOR_RAT UniProtKB/Swiss-Prot
  F7EQZ7 ENTREZGENE, UniProtKB/TrEMBL
  O35545_RAT UniProtKB/TrEMBL
  Q07303 ENTREZGENE
  Q5FVS4 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Epor  Erythropoietin receptor      Symbol and Name status set to approved 70586 APPROVED