Edn2 (endothelin 2) - Rat Genome Database

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Gene: Edn2 (endothelin 2) Rattus norvegicus
Analyze
Symbol: Edn2
Name: endothelin 2
RGD ID: 2533
Description: Predicted to enable endothelin B receptor binding activity and hormone activity. Involved in several processes, including ovarian follicle rupture; phospholipase C-activating G protein-coupled receptor signaling pathway; and regulation of hormone secretion. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human EDN2 (endothelin 2); PARTICIPATES IN endothelin signaling pathway; INTERACTS WITH ammonium chloride; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Endothelin isopeptide 2; endothelin-2; ET-2; Et2; PPET2; preproendothelin-2; RNEDN2S01; vasoactive intestinal contractor; VIC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Bp7  
Candidate Gene For: Bp7
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85139,036,576 - 139,042,074 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5139,036,492 - 139,043,070 (+)EnsemblGRCr8
mRatBN7.25133,751,316 - 133,756,814 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5133,751,217 - 133,756,814 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5136,479,131 - 136,484,624 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05138,235,562 - 138,241,057 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05138,256,179 - 138,261,668 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05139,098,472 - 139,106,396 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5139,100,898 - 139,105,792 (+)Ensemblrn6Rnor6.0
Rnor_5.05142,891,221 - 142,896,115 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45140,742,686 - 140,747,580 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5132,309,615 - 132,315,113 (+)NCBICelera
RGSC_v3.15140,747,827 - 140,753,399 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
aspartame  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
BQ 123  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) chloride  (ISO)
corticosterone  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
L-citrulline  (ISO)
lead diacetate  (ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
naphthalene  (ISO)
nickel dichloride  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tricetin  (ISO)
trichloroethene  (EXP)
Tungsten carbide  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function
endothelin B receptor binding  (IBA,IEA,ISO)
hormone activity  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2. Bloch KD, etal., Genomics 1991 May;10(1):236-42.
2. Association between diastolic blood pressure and variants of the endothelin-1 and endothelin-2 genes. Brown MJ, etal., J Cardiovasc Pharmacol. 2000;35(4 Suppl 2):S41-43.
3. Endothelin release during ischaemia and reperfusion of isolated perfused rat hearts. Brunner F, etal., J Mol Cell Cardiol. 1992 Nov;24(11):1291-305.
4. Broadly altered gene expression in blood leukocytes in essential hypertension is absent during treatment. Chon H, etal., Hypertension. 2004 May;43(5):947-51. Epub 2004 Mar 8.
5. Regional and maturation-associated expression of endothelin 2 in rat gastrointestinal tract. de la Monte SM, etal., J Histochem Cytochem. 1995 Feb;43(2):203-9.
6. Structure and organization of the rat endothelin-2 gene. Deng AY Mamm Genome 1997 Feb;8(2):157.
7. Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. Deng AY, etal., J Clin Invest 1994 Jun;93(6):2701-9
8. The effect of endothelin-1, endothelin-2 and endothelin-3 in early cerulein-induced acute pancreatitis in rats. Dlugosz JW, etal., Rocz Akad Med Bialymst. 2004;49:85-92.
9. Inhibition by phosphoramidon of the regional haemodynamic effects of proendothelin-2 and -3 in conscious rats. Gardiner SM, etal., Br J Pharmacol. 1992 Oct;107(2):584-90.
10. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Potent constrictor actions of endothelin-1, endothelin-2, and endothelin-3 in rat isolated portal vein. Guimaraes CL, etal., Hypertension. 1992 Feb;19(2 Suppl):II79-86.
14. Myocardial expression of endothelin-2 is altered reciprocally to that of endothelin-1 during ischemia of cardiomyocytes in vitro and during heart failure in vivo. Kakinuma Y, etal., Life Sci. 1999;65(16):1671-83.
15. Endothelin activation of an inwardly rectifying K+ current in atrial cells. Kim D Circ Res. 1991 Jul;69(1):250-5.
16. Endothelin-2 in ovarian follicle rupture. Ko C, etal., Endocrinology. 2006 Apr;147(4):1770-9. Epub 2006 Jan 12.
17. Serum level of endothelin-1 and -2 in pregnancies complicated by EPH gestosis. Leszczynska-Gorzelak B, etal., Gynecol Obstet Invest. 1997;43(1):37-40.
18. Comparison of the cardiovascular and neural activity of endothelin-1, -2, -3 and respective proendothelins: effects of phosphoramidon and thiorphan. Mattera GG, etal., Br J Pharmacol. 1993 Sep;110(1):331-7.
19. Endothelins stimulate deoxyribonucleic acid synthesis and cell proliferation in rat adrenal zona glomerulosa, acting through an endothelin A receptor coupled with protein kinase C- and tyrosine kinase-dependent signaling pathways. Mazzocchi G, etal., Endocrinology. 1997 Jun;138(6):2333-7.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Inhibitory and facilitatory presynaptic effects of endothelin on sympathetic cotransmission in the rat isolated tail artery. Mutafova-Yambolieva VN and Westfall DP, Br J Pharmacol. 1998 Jan;123(1):136-42.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Contractile responses of smooth muscle cells differentiated from rat neural stem cells. Oishi K, etal., J Physiol. 2002 Apr 1;540(Pt 1):139-52.
24. Contractile responses and myosin phosphorylation in reconstituted fibers of smooth muscle cells from the rat cerebral artery. Oishi K, etal., Jpn J Pharmacol. 2002 Sep;90(1):36-50.
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. Differential effects of ET-1, ET-2, and ET-3 on pancreatic microcirculation, tissue integrity, and inflammation. Plusczyk T, etal., Dig Dis Sci. 2001 Jun;46(6):1343-51.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. [Plasma concentrations of endothelin-1 and endothelin-2 in patients with pulmonary hypertension] Salomon P, etal., Pol Merkuriusz Lek. 1999 Sep;7(39):111-3.
31. Comparison of the pituitary effects of the mammalian endothelins: vasoactive intestinal contractor (endothelin-beta, rat endothelin-2) is a potent inhibitor of prolactin secretion. Samson WK and Skala KD, Endocrinology. 1992 May;130(5):2964-70.
32. Endothelin-mediated calcium signaling in preglomerular smooth muscle cells. Schroeder AC, etal., Hypertension. 2000 Jan;35(1 Pt 2):280-6.
33. Quantitative association between a newly identified molecular variant in the endothelin-2 gene and human essential hypertension. Sharma P, etal., J Hypertens. 1999 Sep;17(9):1281-7.
34. Endothelins induce Fos expression in neurons and glia in organotypic cultures of rat cerebellum. Sullivan AM and Morton AJ, J Neurochem. 1996 Oct;67(4):1409-18.
35. Plasma endothelin in patients with acute aortic disease. Wagner A, etal., Resuscitation. 2002 Apr;53(1):71-6.
36. Contribution of endogenous endothelin to the extension of myocardial infarct size in rats. Watanabe T, etal., Circ Res. 1991 Aug;69(2):370-7.
Additional References at PubMed
PMID:1713452   PMID:1917960   PMID:2649896   PMID:2768235   PMID:8982507   PMID:9422810   PMID:9492062   PMID:9696419   PMID:12207323   PMID:15691296   PMID:15948191   PMID:20450830  
PMID:22406300   PMID:22874467   PMID:22972036   PMID:23676500   PMID:23941276   PMID:25613530  


Genomics

Comparative Map Data
Edn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85139,036,576 - 139,042,074 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5139,036,492 - 139,043,070 (+)EnsemblGRCr8
mRatBN7.25133,751,316 - 133,756,814 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5133,751,217 - 133,756,814 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5136,479,131 - 136,484,624 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05138,235,562 - 138,241,057 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05138,256,179 - 138,261,668 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05139,098,472 - 139,106,396 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5139,100,898 - 139,105,792 (+)Ensemblrn6Rnor6.0
Rnor_5.05142,891,221 - 142,896,115 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45140,742,686 - 140,747,580 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5132,309,615 - 132,315,113 (+)NCBICelera
RGSC_v3.15140,747,827 - 140,753,399 (+)NCBI
Cytogenetic Map5q36NCBI
EDN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38141,478,775 - 41,484,683 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl141,478,774 - 41,484,686 (-)Ensemblhg38GRCh38
GRCh37141,944,446 - 41,950,354 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36141,717,033 - 41,722,884 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34141,613,539 - 41,619,390NCBI
Celera140,227,695 - 40,233,596 (-)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef140,062,640 - 40,068,539 (-)NCBIHuRef
CHM1_1142,060,834 - 42,066,733 (-)NCBICHM1_1
T2T-CHM13v2.0141,348,976 - 41,370,636 (-)NCBIT2T-CHM13v2.0
Edn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394120,018,403 - 120,024,557 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4120,018,403 - 120,024,557 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384120,161,206 - 120,167,360 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4120,161,206 - 120,167,360 (+)Ensemblmm10GRCm38
MGSCv374119,834,029 - 119,839,965 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364119,659,068 - 119,664,996 (+)NCBIMGSCv36mm8
Celera4118,876,990 - 118,882,911 (+)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map455.77NCBI
Edn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555371,228,070 - 1,233,797 (-)Ensembl
ChiLan1.0NW_0049555371,228,062 - 1,233,784 (-)NCBIChiLan1.0ChiLan1.0
EDN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21185,326,860 - 185,334,257 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11184,468,920 - 184,476,318 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0140,777,582 - 40,783,410 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1142,092,811 - 42,098,721 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl142,092,811 - 42,098,721 (-)EnsemblpanPan2panpan1.1
EDN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1151,647,966 - 1,654,272 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl151,648,077 - 1,654,272 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha151,906,346 - 1,911,819 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0151,736,878 - 1,742,351 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl151,736,155 - 1,742,351 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1151,643,415 - 1,648,886 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0151,703,305 - 1,708,777 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0151,718,751 - 1,724,224 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Edn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505857,236,189 - 57,239,728 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647423,060,905 - 23,064,566 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647423,061,219 - 23,064,525 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6169,744,568 - 169,758,283 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16169,751,956 - 169,758,011 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
EDN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12091,425,979 - 91,432,609 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2091,426,747 - 91,431,973 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603325,447,580 - 25,453,538 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Edn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624892870,259 - 877,387 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624892861,976 - 879,044 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Edn2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1136,818,685 - 36,824,371 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Edn2
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:82
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000012569
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133308734140009902Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5Mco19  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5 RGD
D5Mit19  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85139,037,822 - 139,038,027 (+)Marker Load Pipeline
mRatBN7.25133,752,562 - 133,752,767 (+)MAPPERmRatBN7.2
Rnor_6.05139,102,145 - 139,102,349NCBIRnor6.0
Rnor_5.05142,892,468 - 142,892,672UniSTSRnor5.0
RGSC_v3.45140,743,932 - 140,744,137RGDRGSC3.4
RGSC_v3.45140,743,933 - 140,744,137UniSTSRGSC3.4
Celera5132,310,862 - 132,311,066UniSTS
RGSC_v3.15140,749,159 - 140,749,363RGD
RH 3.4 Map5875.2RGD
RH 3.4 Map5875.2UniSTS
RH 2.0 Map5877.1RGD
Cytogenetic Map5q36UniSTS
D5Rat55  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25133,752,611 - 133,752,762 (+)MAPPERmRatBN7.2
Rnor_6.05139,102,194 - 139,102,344NCBIRnor6.0
Rnor_5.05142,892,517 - 142,892,667UniSTSRnor5.0
RGSC_v3.45140,743,808 - 140,744,258RGDRGSC3.4
RGSC_v3.45140,743,982 - 140,744,132UniSTSRGSC3.4
Celera5132,310,911 - 132,311,061UniSTS
RGSC_v3.15140,749,208 - 140,749,358RGD
RH 3.4 Map5875.0RGD
RH 3.4 Map5875.0UniSTS
RH 2.0 Map5873.5RGD
FHH x ACI Map570.92RGD
Cytogenetic Map5q36UniSTS
D5Rat86  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85139,034,670 - 139,034,903 (+)Marker Load Pipeline
mRatBN7.25133,749,410 - 133,749,643 (+)MAPPERmRatBN7.2
Rnor_6.05139,098,997 - 139,099,229NCBIRnor6.0
Rnor_5.05142,889,320 - 142,889,552UniSTSRnor5.0
RGSC_v3.45140,740,721 - 140,741,152RGDRGSC3.4
RGSC_v3.45140,740,781 - 140,741,013UniSTSRGSC3.4
Celera5132,307,710 - 132,307,942UniSTS
RGSC_v3.15140,746,007 - 140,746,239RGD
RH 3.4 Map5867.2RGD
RH 3.4 Map5867.2UniSTS
RH 2.0 Map5874.1RGD
SHRSP x BN Map571.7299RGD
FHH x ACI Map570.92RGD
Cytogenetic Map5q36UniSTS
RH142434  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85139,035,865 - 139,036,080 (+)Marker Load Pipeline
mRatBN7.25133,750,605 - 133,750,820 (+)MAPPERmRatBN7.2
Rnor_6.05139,100,192 - 139,100,406NCBIRnor6.0
Rnor_5.05142,890,515 - 142,890,729UniSTSRnor5.0
RGSC_v3.45140,741,976 - 140,742,190UniSTSRGSC3.4
Celera5132,308,905 - 132,309,119UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
16 9 42 30 23 29 11 7 11 6 109 64 6 19 12 41 18

Sequence


Ensembl Acc Id: ENSRNOT00000012569   ⟹   ENSRNOP00000012569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5139,036,492 - 139,043,070 (+)Ensembl
mRatBN7.2 Ensembl5133,751,217 - 133,756,814 (+)Ensembl
Rnor_6.0 Ensembl5139,100,898 - 139,105,792 (+)Ensembl
RefSeq Acc Id: NM_012549   ⟹   NP_036681
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85139,036,576 - 139,042,074 (+)NCBI
mRatBN7.25133,751,316 - 133,756,814 (+)NCBI
Rnor_6.05139,100,898 - 139,106,396 (+)NCBI
Rnor_5.05142,891,221 - 142,896,115 (+)NCBI
RGSC_v3.45140,742,686 - 140,747,580 (+)RGD
Celera5132,309,615 - 132,315,113 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_036681 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB39213 (Get FASTA)   NCBI Sequence Viewer  
  EDL80332 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012569
GenBank Protein P23943 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036681   ⟸   NM_012549
- Peptide Label: precursor
- UniProtKB: P23943 (UniProtKB/Swiss-Prot),   G3V771 (UniProtKB/TrEMBL),   A6IRY1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012569   ⟸   ENSRNOT00000012569
Protein Domains
Endothelin-like toxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23943-F1-model_v2 AlphaFold P23943 1-176 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693988
Promoter ID:EPDNEW_R4512
Type:single initiation site
Name:Edn2_1
Description:endothelin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05139,100,818 - 139,100,878EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2533 AgrOrtholog
BioCyc Gene G2FUF-40073 BioCyc
Ensembl Genes ENSRNOG00000009390 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000012569 ENTREZGENE
InterPro Endothelin UniProtKB/Swiss-Prot
  Endothelin_toxin_CS UniProtKB/Swiss-Prot
  Endothln-like_toxin UniProtKB/Swiss-Prot
NCBI Gene 24324 ENTREZGENE
PANTHER PTHR13874 UniProtKB/Swiss-Prot
  PTHR13874:SF9 UniProtKB/Swiss-Prot
Pfam Endothelin UniProtKB/Swiss-Prot
PhenoGen Edn2 PhenoGen
PRINTS ENDOTHELIN UniProtKB/Swiss-Prot
PROSITE ENDOTHELIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009390 RatGTEx
SMART END UniProtKB/Swiss-Prot
UniProt A6IRY1 ENTREZGENE, UniProtKB/TrEMBL
  EDN2_RAT UniProtKB/Swiss-Prot
  G3V771 ENTREZGENE, UniProtKB/TrEMBL
  P23943 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Edn2  Endothelin isopeptide 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in pituitary and medulla oblongata 734466