Ctsc (cathepsin C) - Rat Genome Database

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Gene: Ctsc (cathepsin C) Rattus norvegicus
Analyze
Symbol: Ctsc
Name: cathepsin C
RGD ID: 2445
Description: Enables several functions, including chloride ion binding activity; identical protein binding activity; and protein-folding chaperone binding activity. Involved in positive regulation of proteolysis involved in protein catabolic process. Located in lysosome. Biomarker of brain ischemia; hypertension; and obesity. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (cathepsin C); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CATC; Cathepsin C (dipeptidyl peptidase I); cathepsin J; dipeptidyl peptidase 1; dipeptidyl peptidase I; dipeptidyl transferase; dipeptidyl-peptidase 1; dipeptidyl-peptidase I; DPP-I; DPPI
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81151,440,860 - 151,472,430 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1151,441,032 - 151,474,082 (+)EnsemblGRCr8
mRatBN7.21142,028,386 - 142,059,841 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1142,028,392 - 142,060,387 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1149,985,662 - 150,017,065 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01157,162,100 - 157,193,503 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01150,036,027 - 150,067,428 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01151,918,514 - 151,949,979 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,918,571 - 151,949,983 (+)Ensemblrn6Rnor6.0
Rnor_5.01158,231,534 - 158,263,124 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41144,629,802 - 144,661,183 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1140,327,884 - 140,359,275 (+)NCBICelera
RGSC_v3.11144,708,207 - 144,739,589 (+)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aconitine  (EXP)
acrylamide  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
choline  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
Evodiamine  (ISO)
fenofibrate  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrazine  (ISO)
ibuprofen  (EXP,ISO)
ifosfamide  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirimiphos-methyl  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sotorasib  (ISO)
stattic  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toosendanin  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
XL147  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
extracellular space  (IBA)
lysosome  (IBA,IDA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Gene expression in rats with Barrett's esophagus and esophageal adenocarcinoma induced by gastroduodenoesophageal reflux. Cheng P, etal., World J Gastroenterol. 2005 Sep 7;11(33):5117-22.
2. Increased muscle proteolysis after local trauma mainly reflects macrophage-associated lysosomal proteolysis. Farges MC, etal., Am J Physiol Endocrinol Metab 2002 Feb;282(2):E326-35.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Mutations of the cathepsin C gene are responsible for Papillon-Lefevre syndrome. Hart TC, etal., J Med Genet. 1999 Dec;36(12):881-7.
6. Cathepsin C propeptide interacts with intestinal alkaline phosphatase and heat shock cognate protein 70 in human Caco-2 cells. Hirasaka K, etal., J Physiol Sci. 2008 Apr;58(2):105-11. doi: 10.2170/physiolsci.RP013007. Epub 2008 Mar 1.
7. Molecular cloning of cDNA for rat cathepsin C. Cathepsin C, a cysteine proteinase with an extremely long propeptide. Ishidoh K, etal., J Biol Chem 1991 Sep 5;266(25):16312-7.
8. Dipeptide vinyl sulfones suitable for intracellular inhibition of dipeptidyl peptidase I. Korver GE, etal., Int Immunopharmacol. 2001 Jan;1(1):21-32.
9. Active recombinant rat dipeptidyl aminopeptidase I (cathepsin C) produced using the baculovirus expression system. Lauritzen C, etal., Protein Expr Purif. 1998 Dec;14(3):434-42.
10. Genomics of the periinfarction cortex after focal cerebral ischemia. Lu A, etal., J Cereb Blood Flow Metab. 2003 Jul;23(7):786-810.
11. Synthesis, transport and processing of cathepsin C in Morris hepatoma 7777 cells and rat hepatocytes. Mainferme F, etal., Eur J Biochem. 1985 Nov 15;153(1):211-6.
12. Hydrolase activities increase in the rat aorta with growth and aging but not in liver and kidney. Markle RA Proc Soc Exp Biol Med. 1986 Nov;183(2):169-76.
13. Proteolytic enzymes in ordinary, hyperacute, monocytic and passive transfer forms of experimental allergic encephalomyelitis. Marks N, etal., Brain Res. 1977 Mar 4;123(1):147-57.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Processing and transport of the precursor of cathepsin C during its transfer into lysosomes. Muno D, etal., Arch Biochem Biophys. 1993 Oct;306(1):103-10.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domain. Olsen JG, etal., FEBS Lett. 2001 Oct 12;506(3):201-6.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Importance of the propeptide in the biosynthetic maturation of rat cathepsin C. Santilman V, etal., Eur J Cell Biol 2002 Dec;81(12):654-63.
23. Mutation analysis of the cathepsin C gene in Indian families with Papillon-Lefevre syndrome. Selvaraju V, etal., BMC Med Genet 2003 Jul 12;4(1):5.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. [Effect of neonatal nutrition on the enzyme activity of liver lysosomes, adipocytes and thrombocytes in young and old rats] Vasil'ev AV, etal., Vopr Pitan. 1986 Mar-Apr;(2):43-7.
26. Hydrolase activities in the rat aorta. I. Effects of diabetes mellitus and insulin treatment. Wolinsky H, etal., Circ Res. 1978 Jun;42(6):821-31.
27. Hydrolase activities in the rat aorta. II. Effects of hypertension alone and in combination with diabetes mellitus. Wolinsky H, etal., Circ Res. 1978 Jun;42(6):831-9.
Additional References at PubMed
PMID:1515062   PMID:1740150   PMID:8811434   PMID:16502470   PMID:19056867   PMID:19199708   PMID:19946888   PMID:20435891   PMID:23376485   PMID:23533145   PMID:26884336   PMID:28251676  
PMID:28665049   PMID:32302668   PMID:34828301  


Genomics

Comparative Map Data
Ctsc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81151,440,860 - 151,472,430 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1151,441,032 - 151,474,082 (+)EnsemblGRCr8
mRatBN7.21142,028,386 - 142,059,841 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1142,028,392 - 142,060,387 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1149,985,662 - 150,017,065 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01157,162,100 - 157,193,503 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01150,036,027 - 150,067,428 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01151,918,514 - 151,949,979 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,918,571 - 151,949,983 (+)Ensemblrn6Rnor6.0
Rnor_5.01158,231,534 - 158,263,124 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41144,629,802 - 144,661,183 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1140,327,884 - 140,359,275 (+)NCBICelera
RGSC_v3.11144,708,207 - 144,739,589 (+)NCBI
Cytogenetic Map1q32NCBI
CTSC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381188,293,592 - 88,337,736 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1188,265,069 - 88,359,684 (-)Ensemblhg38GRCh38
GRCh371188,026,760 - 88,070,904 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361187,666,408 - 87,710,586 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341187,698,901 - 87,710,586NCBI
Celera1186,561,173 - 86,605,363 (+)NCBICelera
Cytogenetic Map11q14.2NCBI
HuRef1184,265,651 - 84,309,838 (-)NCBIHuRef
CHM1_11187,909,527 - 87,953,700 (-)NCBICHM1_1
T2T-CHM13v2.01188,212,614 - 88,256,755 (-)NCBIT2T-CHM13v2.0
Ctsc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39787,927,233 - 87,960,083 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl787,927,293 - 87,960,096 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38788,278,024 - 88,315,861 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl788,278,085 - 88,310,888 (+)Ensemblmm10GRCm38
MGSCv37795,426,603 - 95,459,385 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36788,153,327 - 88,186,080 (+)NCBIMGSCv36mm8
Celera785,627,464 - 85,661,039 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map749.11NCBI
Ctsc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554145,062,355 - 5,092,154 (+)Ensembl
ChiLan1.0NW_0049554145,062,355 - 5,092,631 (+)NCBIChiLan1.0ChiLan1.0
CTSC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2989,168,583 - 89,213,037 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11190,209,107 - 90,254,688 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01183,299,827 - 83,345,383 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,890,010 - 86,933,847 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,890,010 - 86,933,847 (-)EnsemblpanPan2panpan1.1
CTSC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12111,659,296 - 11,692,957 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2111,659,292 - 11,692,816 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2111,517,038 - 11,552,914 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02111,838,431 - 11,874,146 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2111,838,429 - 11,876,897 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12111,627,285 - 11,662,982 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02111,697,940 - 11,733,812 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02111,752,070 - 11,787,980 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ctsc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494774,101,638 - 74,140,957 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367361,201,343 - 1,240,311 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl921,722,036 - 21,761,516 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1921,726,628 - 21,761,796 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2924,081,771 - 24,116,596 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1179,426,556 - 79,468,464 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl179,426,549 - 79,468,340 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604346,251,030 - 46,291,563 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248451,783,918 - 1,815,981 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248451,783,807 - 1,816,471 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ctsc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12112,974,483 - 113,006,535 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ctsc
228 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:366
Count of miRNA genes:212
Interacting mature miRNAs:252
Transcripts:ENSRNOT00000022342
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132889797152403053Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1142582180153680016Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429152404087Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
RH140897  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21142,060,161 - 142,060,354 (+)MAPPERmRatBN7.2
Rnor_6.01151,950,300 - 151,950,492NCBIRnor6.0
Rnor_5.01158,263,445 - 158,263,637UniSTSRnor5.0
RGSC_v3.41144,661,504 - 144,661,696UniSTSRGSC3.4
Celera1140,359,596 - 140,359,788UniSTS
RH 3.4 Map11115.5UniSTS
Cytogenetic Map1q32UniSTS
RH127861  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21142,039,595 - 142,039,775 (+)MAPPERmRatBN7.2
Rnor_6.01151,929,734 - 151,929,913NCBIRnor6.0
Rnor_5.01158,242,670 - 158,242,849UniSTSRnor5.0
RGSC_v3.41144,640,938 - 144,641,117UniSTSRGSC3.4
Celera1140,339,020 - 140,339,199UniSTS
RH 3.4 Map11115.5UniSTS
Cytogenetic Map1q32UniSTS
BF389062  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21142,051,346 - 142,051,511 (+)MAPPERmRatBN7.2
Rnor_6.01151,941,485 - 151,941,649NCBIRnor6.0
Rnor_5.01158,254,421 - 158,254,585UniSTSRnor5.0
RGSC_v3.41144,652,689 - 144,652,853UniSTSRGSC3.4
Celera1140,350,781 - 140,350,945UniSTS
RH 3.4 Map11115.1UniSTS
Cytogenetic Map1q32UniSTS
AA800884  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21142,041,144 - 142,041,234 (+)MAPPERmRatBN7.2
Rnor_6.01151,931,283 - 151,931,372NCBIRnor6.0
Rnor_5.01158,244,219 - 158,244,308UniSTSRnor5.0
RGSC_v3.41144,642,487 - 144,642,576UniSTSRGSC3.4
Celera1140,340,579 - 140,340,668UniSTS
RH 3.4 Map11123.1UniSTS
Cytogenetic Map1q32UniSTS


Related Rat Strains
The following Strains have been annotated to Ctsc
FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022342   ⟹   ENSRNOP00000022342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1151,441,032 - 151,474,082 (+)Ensembl
mRatBN7.2 Ensembl1142,028,392 - 142,060,387 (+)Ensembl
Rnor_6.0 Ensembl1151,918,571 - 151,949,983 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097085   ⟹   ENSRNOP00000085136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1142,028,392 - 142,037,751 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108529   ⟹   ENSRNOP00000084170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1142,028,392 - 142,036,904 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000132158   ⟹   ENSRNOP00000099158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1151,441,032 - 151,452,718 (+)Ensembl
RefSeq Acc Id: NM_017097   ⟹   NP_058793
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81151,441,049 - 151,472,430 (+)NCBI
mRatBN7.21142,028,460 - 142,059,841 (+)NCBI
Rnor_6.01151,918,598 - 151,949,979 (+)NCBI
Rnor_5.01158,231,534 - 158,263,124 (+)NCBI
RGSC_v3.41144,629,802 - 144,661,183 (+)RGD
Celera1140,327,884 - 140,359,275 (+)RGD
Sequence:
RefSeq Acc Id: XM_008759637   ⟹   XP_008757859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81151,440,860 - 151,452,725 (+)NCBI
mRatBN7.21142,028,386 - 142,041,540 (+)NCBI
Rnor_6.01151,918,514 - 151,932,554 (+)NCBI
Sequence:
RefSeq Acc Id: NP_058793   ⟸   NM_017097
- Peptide Label: precursor
- UniProtKB: P80068 (UniProtKB/Swiss-Prot),   P80067 (UniProtKB/Swiss-Prot),   A6I5Z1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757859   ⟸   XM_008759637
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZG1 (UniProtKB/TrEMBL),   A6I5Z3 (UniProtKB/TrEMBL),   A0A8I6A0Q1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022342   ⟸   ENSRNOT00000022342
Ensembl Acc Id: ENSRNOP00000084170   ⟸   ENSRNOT00000108529
Ensembl Acc Id: ENSRNOP00000085136   ⟸   ENSRNOT00000097085
Ensembl Acc Id: ENSRNOP00000099158   ⟸   ENSRNOT00000132158
Protein Domains
Cathepsin C exclusion   Peptidase C1A papain C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P80067-F1-model_v2 AlphaFold P80067 1-462 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690178
Promoter ID:EPDNEW_R703
Type:initiation region
Name:Ctsc_1
Description:cathepsin C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01151,918,581 - 151,918,641EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2445 AgrOrtholog
BioCyc Gene G2FUF-58577 BioCyc
Ensembl Genes ENSRNOG00000016496 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022342 ENTREZGENE
  ENSRNOT00000022342.6 UniProtKB/Swiss-Prot
  ENSRNOT00000132158 ENTREZGENE
Gene3D-CATH 2.40.128.80 UniProtKB/Swiss-Prot
  Cysteine proteinases UniProtKB/Swiss-Prot
InterPro CatC UniProtKB/Swiss-Prot
  CathepsinC_exc UniProtKB/Swiss-Prot
  CathepsinC_exc_dom_sf UniProtKB/Swiss-Prot
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Pept_asp_AS UniProtKB/Swiss-Prot
  Pept_cys_AS UniProtKB/Swiss-Prot
  Pept_his_AS UniProtKB/Swiss-Prot
  Peptidase_C1A UniProtKB/Swiss-Prot
  Peptidase_C1A_C UniProtKB/Swiss-Prot
KEGG Report rno:25423 UniProtKB/Swiss-Prot
NCBI Gene 25423 ENTREZGENE
PANTHER CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/Swiss-Prot
Pfam CathepsinC_exc UniProtKB/Swiss-Prot
  Peptidase_C1 UniProtKB/Swiss-Prot
PhenoGen Ctsc PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016496 RatGTEx
SMART Pept_C1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot
  SSF75001 UniProtKB/Swiss-Prot
TIGR TC217945
UniProt A0A8I5ZZG1 ENTREZGENE
  A0A8I6A0Q1 ENTREZGENE
  A0ABK0L8F4_RAT UniProtKB/TrEMBL
  A6I5Z1 ENTREZGENE, UniProtKB/TrEMBL
  A6I5Z2_RAT UniProtKB/TrEMBL
  A6I5Z3 ENTREZGENE, UniProtKB/TrEMBL
  CATC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P80068 ENTREZGENE
UniProt Secondary P80068 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Ctsc  cathepsin C    Cathepsin C (dipeptidyl peptidase I)  Name updated 625702 APPROVED
2002-06-10 Ctsc  Cathepsin C (dipeptidyl peptidase I)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog is associated with Papillon-Lefevre syndrome 728224