Ctbp1 Rat Gene (C-terminal binding protein 1)

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Keyword

Gene:
Ctbp1 ( Rattus norvegicus )
C-terminal binding protein 1
Description: transcriptional co-repressor protein that may function in development, cell cycle regulation and cellular transformation; regulates tubulation of Golgi structures upon treatment with brefeldin A; interacts wth GTP, beta gamma subunits of G-proteins and viral EBNA3A protein
Synonyms: 50-kDaBFA-inducedADP-ribosylatedsubstrate; BARS-50; brefeldin A-ADP-riboslyated substrate; MGC93318; 50-kDa BFA-induced ADP-ribosylated substrate; BARS; CtBP3/BARS;  (details...)
ArrayIDs: 6294482; 5950810; 1370029_at; 5839519; 6566685; 5915936; AF067795_at; 6134320; AF067795_g_at; A_42_P477073; 6035659; 6067334; 6717156; 5855165; 5861222; 6214934; A_44_P427838; 5909435; GE1149778; GE20579; 5846377; 5891392; A_43_P11974; 6123411; 6521088; 6050175;  (details...)
Gene Type: protein-coding

Additional Data

Homologs
Homo sapiens: CTBP1     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Ctbp1     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Ctbp1 genome assembly 3.1 14 83025214 - 83052726
Rat Celera Assembly 14 76371216 - 76398073
RGSC genome assembly v3.4 14 83022822 - 83050339
Cytogenetic 14 q21
Mus musculus Ctbp1 Mouse genome assembly build 36.1 5 33590372 - 33617618
Cytogenetic 5 5 B1
Homo sapiens CTBP1 human genome assembly 4 1195117 - 1232621
Human genome assembly build 36.2 4 1195228 - 1232908
Cytogenetic 4 p16

View comparative maps:      NCBI MapViewer

Genome
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Annotation
Molecular Function

Gene Ontology

transcription factor activity,  NAD or NADH binding,  protein homodimerization activity ... (details...)
Biological Process

Note Reference

negatively controls tubulation of Golgi structures after treatment with brefeldin A 69822

acts as a transcriptional co-repressor 1298829

may function in development, cell cycle regulation and cellular transformation 1298829

Gene Ontology

oxidation reduction,  negative regulation of transcription from RNA polymerase II promoter,  Golgi organization ... (details...)
Cellular Component

Note Reference

protein is found in cytosol and may be associated with Golgi apparatus 69822

Gene Ontology

transcription factor complex,  nucleus,  cytoplasm ... (details...)
Expression

Note Reference

expressed in brain 69822

Protein

Note Reference

protein is ADP-ribosylated after exposure of cells to brefeldin A 69822

Physical interaction

Note Reference

interacts with a bipartite motif located in the C- terminus of viral EBNA3A protein 1298829

binds GTP and interacts with beta gamma subunit comples of G proteins 1298827

External Links
Databases
DATABASE ID SOURCE
PROSITE: D_2_HYOXYACID_DH_1 IPI
PROSITE: D_2_HYOXYACID_DH_3 IPI
UNIPARC: UPI0000402743 IPI
UNIPARC: UPI0000128638 IPI
UNIPARC: UPI000021EFED IPI
KEGG Report: rno:29382 ENTREZGENE
HomoloGene Group ID: 1015 ENTREZGENE
Germonline: 2441
Pfam: 2-Hacid_dh IPI
Pfam: 2-Hacid_dh_C IPI
KEGG Pathway: 05200 ENTREZGENE
KEGG Pathway: 05220 ENTREZGENE
KEGG Pathway: 04330 ENTREZGENE
KEGG Pathway: 04310 ENTREZGENE
InterPro: NAD(P)-bd_dom. IPI
InterPro: D-isomer_2_OHA_DH_NAD-bd. IPI
InterPro: D-isomer_2_OHA_DH. IPI
IPI: IPI00780254 IPI
IPI: IPI00948592 IPI
IPI: IPI00392657 IPI
Ensembl Protein: ENSRNOP00000035064 IPI
Ensembl Protein: ENSRNOP00000062945 IPI
Ensembl Protein: ENSRNOP00000054738 IPI
Gene3D-CATH: NAD(P)-bd IPI
Entrez Gene: Ctbp1 ENTREZGENE
IMAGE_CLONE: IMAGE:7108845 IMAGE-MGC_LOAD
MGC_CLONE: MGC:93318 IMAGE-MGC_LOAD
TIGR: TC205585
UniProt: CTBP1_RAT IPI
UniProt: Q6AZ26_RAT IPI
Ensembl Genes: ENSRNOG00000005428 IPI
Superfamily-SCOP: NAD(P)-bd IPI
Sequences
Nucleotide: XM_001063046 Get FASTA Search GEO Profiles
Nucleotide: CH473963 Get FASTA Search GEO Profiles
Nucleotide: AF067795 Get FASTA Search GEO Profiles
Nucleotide: BC078778 Get FASTA Search GEO Profiles
Nucleotide: NM_019201 Get FASTA Search GEO Profiles
Nucleotide: XM_001062979 Get FASTA Search GEO Profiles
Nucleotide: XM_001063097 Get FASTA Search GEO Profiles
(View all 7 Nucleotide Accessions)
Protein: EDM00131 Get FASTA
Protein: XP_001063046 Get FASTA
Protein: XP_001062979 Get FASTA
Protein: XP_001063097 Get FASTA
Protein: NP_062074 Get FASTA
Protein: AAC79427 Get FASTA
Protein: AAH78778 Get FASTA
Protein: Q9Z2F5 Get FASTA
Protein: Q6AZ26 Get FASTA
(View all 9 Protein Accessions)
Clusters
UniGene: 3946

References
Curated References
12 references in RGD related to Ctbp1

Other References
11 other references at PubMed related to Ctbp1

Database Information
RGD ID 2441
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

10-JUN-02: Ctbp1 C-terminal binding protein 1 APPROVED Name updated 70584