Ctbp1 (C-terminal binding protein 1) - Rat Genome Database

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Gene: Ctbp1 (C-terminal binding protein 1) Rattus norvegicus
Analyze
Symbol: Ctbp1
Name: C-terminal binding protein 1
RGD ID: 2441
Description: Enables NAD binding activity; PDZ domain binding activity; and protein homodimerization activity. Involved in presynapse to nucleus signaling pathway. Located in cytoplasm and nucleus. Is active in glutamatergic synapse. Is extrinsic component of presynaptic endocytic zone membrane. Orthologous to human CTBP1 (C-terminal binding protein 1); PARTICIPATES IN Notch signaling pathway; chronic myeloid leukemia pathway; Wnt signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 50 kDa BFA-dependent ADP-ribosylation substrate; 50-kDa BFA-induced ADP-ribosylated substrate; 50-kDaBFA-inducedADP-ribosylatedsubstrate; BARS; BARS-50; brefeldin A-ADP-riboslyated substrate; C-terminal-binding protein 1; C-terminal-binding protein 3; C-terminus binding protein 3/brefeldin A (BFA) adenosine diphosphate-ribosylated substrate; ctBP3; CtBP3/BARS; MGC93318
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81481,679,956 - 81,707,331 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1481,679,765 - 81,707,554 (+)EnsemblGRCr8
mRatBN7.21477,455,580 - 77,482,821 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1477,455,696 - 77,482,821 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1481,897,623 - 81,924,823 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01483,138,172 - 83,165,372 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01479,583,490 - 79,610,690 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01482,762,109 - 82,789,350 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,762,190 - 82,789,319 (+)Ensemblrn6Rnor6.0
Rnor_5.01483,447,911 - 83,475,152 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41483,022,824 - 83,050,335 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1476,376,169 - 76,398,029 (+)NCBICelera
RGSC_v3.11483,025,214 - 83,052,726 (-)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
Allylamine  (EXP)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
elemental selenium  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
ionomycin  (ISO)
ivermectin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
niclosamide  (ISO)
nitrates  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
pyrrolidine dithiocarbamate  (ISO)
pyruvic acid  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of matrin 3. A 125-kilodalton protein of the nuclear matrix contains an extensive acidic domain. Belgrader P, etal., J Biol Chem 1991 May 25;266(15):9893-9.
2. CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Chinnadurai G Mol Cell 2002 Feb;9(2):213-24.
3. Evidence that the 50-kDa substrate of brefeldin A-dependent ADP-ribosylation binds GTP and is modulated by the G-protein beta gamma subunit complex. Di Girolamo M, etal., Proc Natl Acad Sci U S A 1995 Jul 18;92(15):7065-9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP). Hickabottom M, etal., J Biol Chem 2002 Dec 6;277(49):47197-204. Epub 2002 Oct 7.
7. CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles. Ivanova D, etal., Cell Rep. 2020 Feb 18;30(7):2444-2459.e7. doi: 10.1016/j.celrep.2020.01.079.
8. Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo. Ivanova D, etal., EMBO J. 2015 Apr 15;34(8):1056-77. doi: 10.15252/embj.201488796. Epub 2015 Feb 4.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. CtBP1/BARS Gly172-->Glu mutant structure: impairing NAD(H)-binding and dimerization. Nardini M, etal., Biochem Biophys Res Commun. 2009 Mar 27;381(1):70-4. doi: 10.1016/j.bbrc.2009.02.010. Epub 2009 Feb 10.
11. CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission. Nardini M, etal., EMBO J 2003 Jun 16;22(12):3122-30.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins. Quinlan KG, etal., Mol Cell Biol. 2006 Nov;26(21):8159-72. Epub 2006 Aug 28.
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Binding of neuronal nitric-oxide synthase (nNOS) to carboxyl-terminal-binding protein (CtBP) changes the localization of CtBP from the nucleus to the cytosol: a novel function for targeting by the PDZ domain of nNOS. Riefler GM and Firestein BL, J Biol Chem. 2001 Dec 21;276(51):48262-8. Epub 2001 Oct 5.
19. Molecular cloning and functional characterization of brefeldin A-ADP-ribosylated substrate. A novel protein involved in the maintenance of the Golgi structure. Spano S, etal., J Biol Chem 1999 Jun 18;274(25):17705-10.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12037320   PMID:14701752   PMID:15232108   PMID:16287852   PMID:16609867   PMID:16702210   PMID:17392792   PMID:18374649   PMID:18483224   PMID:19162039   PMID:21102443   PMID:21499258  
PMID:21988832   PMID:22301782   PMID:22745816   PMID:23859824   PMID:24722188   PMID:25416956   PMID:27107012   PMID:28408745   PMID:31340205   PMID:31515488  


Genomics

Comparative Map Data
Ctbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81481,679,956 - 81,707,331 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1481,679,765 - 81,707,554 (+)EnsemblGRCr8
mRatBN7.21477,455,580 - 77,482,821 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1477,455,696 - 77,482,821 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1481,897,623 - 81,924,823 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01483,138,172 - 83,165,372 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01479,583,490 - 79,610,690 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01482,762,109 - 82,789,350 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,762,190 - 82,789,319 (+)Ensemblrn6Rnor6.0
Rnor_5.01483,447,911 - 83,475,152 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41483,022,824 - 83,050,335 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1476,376,169 - 76,398,029 (+)NCBICelera
RGSC_v3.11483,025,214 - 83,052,726 (-)NCBI
Cytogenetic Map14q21NCBI
CTBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3841,211,445 - 1,250,355 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl41,211,434 - 1,250,333 (-)Ensemblhg38GRCh38
GRCh3741,205,233 - 1,244,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3641,195,228 - 1,232,908 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3441,195,117 - 1,232,621NCBI
Celera41,138,238 - 1,175,924 (-)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef41,173,813 - 1,211,667 (-)NCBIHuRef
CHM1_141,204,881 - 1,242,708 (-)NCBICHM1_1
T2T-CHM13v2.041,210,608 - 1,249,282 (-)NCBIT2T-CHM13v2.0
Ctbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39533,405,067 - 33,432,348 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl533,405,067 - 33,432,338 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38533,247,723 - 33,275,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,247,723 - 33,274,994 (-)Ensemblmm10GRCm38
MGSCv37533,590,372 - 33,617,618 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36533,564,580 - 33,591,826 (-)NCBIMGSCv36mm8
Celera530,726,910 - 30,746,219 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.52NCBI
Ctbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955514626,645 - 652,817 (-)Ensembl
ChiLan1.0NW_004955514630,168 - 652,817 (-)NCBIChiLan1.0ChiLan1.0
CTBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v231,542,985 - 1,581,765 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan141,509,137 - 1,547,666 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v041,354,806 - 1,393,244 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.141,238,982 - 1,275,536 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl41,238,984 - 1,266,822 (-)EnsemblpanPan2panpan1.1
CTBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1391,385,733 - 91,400,252 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl391,379,049 - 91,400,656 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha393,843,707 - 93,867,009 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0392,375,018 - 92,398,321 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl392,374,989 - 92,398,326 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1391,548,411 - 91,571,713 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0391,601,300 - 91,624,692 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0391,985,325 - 92,008,625 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ctbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528568,331,034 - 68,353,468 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647722,032,664 - 22,055,187 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647722,032,712 - 22,055,160 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8475,888 - 496,002 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18475,164 - 496,510 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CTBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12747,533,490 - 47,570,505 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2747,544,682 - 47,570,636 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660513,909,688 - 3,946,439 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475525,999,713 - 26,021,331 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475525,998,524 - 26,021,223 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ctbp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11171,565,492 - 71,593,052 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ctbp1
226 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:676
Count of miRNA genes:286
Interacting mature miRNAs:353
Transcripts:ENSRNOT00000057929, ENSRNOT00000065393
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
RH128943  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21477,482,626 - 77,482,820 (+)MAPPERmRatBN7.2
Rnor_6.01482,789,156 - 82,789,349NCBIRnor6.0
Rnor_5.01483,474,958 - 83,475,151UniSTSRnor5.0
RGSC_v3.41483,022,792 - 83,022,985UniSTSRGSC3.4
Celera1476,397,868 - 76,398,061UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF067795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000057929   ⟹   ENSRNOP00000054738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1481,680,065 - 81,707,347 (+)Ensembl
mRatBN7.2 Ensembl1477,455,696 - 77,482,286 (+)Ensembl
Rnor_6.0 Ensembl1482,762,190 - 82,788,736 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000065393   ⟹   ENSRNOP00000062945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1481,679,765 - 81,707,328 (+)Ensembl
mRatBN7.2 Ensembl1477,455,742 - 77,482,821 (+)Ensembl
Rnor_6.0 Ensembl1482,769,642 - 82,789,319 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112665   ⟹   ENSRNOP00000080240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1481,680,078 - 81,707,330 (+)Ensembl
mRatBN7.2 Ensembl1477,455,696 - 77,482,821 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119292   ⟹   ENSRNOP00000081185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1481,680,078 - 81,707,554 (+)Ensembl
mRatBN7.2 Ensembl1477,455,696 - 77,482,821 (+)Ensembl
RefSeq Acc Id: NM_019201   ⟹   NP_062074
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,680,096 - 81,707,298 (+)NCBI
mRatBN7.21477,455,586 - 77,482,788 (+)NCBI
Rnor_6.01482,762,115 - 82,789,317 (+)NCBI
Rnor_5.01483,447,911 - 83,475,152 (+)NCBI
RGSC_v3.41483,022,824 - 83,050,335 (-)RGD
Celera1476,376,169 - 76,398,029 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251225   ⟹   XP_006251287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,679,956 - 81,707,331 (+)NCBI
mRatBN7.21477,455,582 - 77,482,821 (+)NCBI
Rnor_6.01482,762,145 - 82,789,350 (+)NCBI
Rnor_5.01483,447,911 - 83,475,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006251226   ⟹   XP_006251288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,679,956 - 81,707,331 (+)NCBI
mRatBN7.21477,455,581 - 77,482,821 (+)NCBI
Rnor_6.01482,762,144 - 82,789,350 (+)NCBI
Rnor_5.01483,447,911 - 83,475,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006251227   ⟹   XP_006251289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,679,956 - 81,707,331 (+)NCBI
mRatBN7.21477,455,582 - 77,482,821 (+)NCBI
Rnor_6.01482,762,145 - 82,789,350 (+)NCBI
Rnor_5.01483,447,911 - 83,475,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006251228   ⟹   XP_006251290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,679,956 - 81,707,331 (+)NCBI
mRatBN7.21477,455,581 - 77,482,821 (+)NCBI
Rnor_6.01482,762,145 - 82,788,630 (+)NCBI
Rnor_5.01483,447,911 - 83,475,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599147   ⟹   XP_017454636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,680,403 - 81,707,331 (+)NCBI
mRatBN7.21477,455,975 - 77,482,821 (+)NCBI
Rnor_6.01482,762,450 - 82,789,350 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063272993   ⟹   XP_063129063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,682,301 - 81,707,331 (+)NCBI
RefSeq Acc Id: XM_063272994   ⟹   XP_063129064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,680,416 - 81,707,331 (+)NCBI
RefSeq Acc Id: XM_063272996   ⟹   XP_063129066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,682,340 - 81,707,331 (+)NCBI
RefSeq Acc Id: XM_063272997   ⟹   XP_063129067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,680,417 - 81,707,331 (+)NCBI
RefSeq Acc Id: XM_063272998   ⟹   XP_063129068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,680,416 - 81,707,331 (+)NCBI
RefSeq Acc Id: NP_062074   ⟸   NM_019201
- UniProtKB: Q9Z2F5 (UniProtKB/Swiss-Prot),   A6IK67 (UniProtKB/TrEMBL),   A0A8I5ZSG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251287   ⟸   XM_006251225
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UI20 (UniProtKB/TrEMBL),   A0A8I5ZSG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251289   ⟸   XM_006251227
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZSG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251288   ⟸   XM_006251226
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZSG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251290   ⟸   XM_006251228
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZSG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454636   ⟸   XM_017599147
- Peptide Label: isoform X3
- UniProtKB: Q9Z2F5 (UniProtKB/Swiss-Prot),   A6IK67 (UniProtKB/TrEMBL),   A0A8I5ZSG1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054738   ⟸   ENSRNOT00000057929
Ensembl Acc Id: ENSRNOP00000062945   ⟸   ENSRNOT00000065393
Ensembl Acc Id: ENSRNOP00000080240   ⟸   ENSRNOT00000112665
Ensembl Acc Id: ENSRNOP00000081185   ⟸   ENSRNOT00000119292
RefSeq Acc Id: XP_063129064   ⟸   XM_063272994
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZSG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129068   ⟸   XM_063272998
- Peptide Label: isoform X8
- UniProtKB: Q6AZ26 (UniProtKB/TrEMBL),   A0A8I5ZSG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129067   ⟸   XM_063272997
- Peptide Label: isoform X7
- UniProtKB: F7FG31 (UniProtKB/TrEMBL),   A0A8I5ZSG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129063   ⟸   XM_063272993
- Peptide Label: isoform X3
- UniProtKB: Q9Z2F5 (UniProtKB/Swiss-Prot),   A6IK67 (UniProtKB/TrEMBL),   A0A8I5ZSG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129066   ⟸   XM_063272996
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZSG1 (UniProtKB/TrEMBL)
Protein Domains
D-isomer specific 2-hydroxyacid dehydrogenase   D-isomer specific 2-hydroxyacid dehydrogenase NAD-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2F5-F1-model_v2 AlphaFold Q9Z2F5 1-430 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699418
Promoter ID:EPDNEW_R9938
Type:initiation region
Name:Ctbp1_1
Description:C-terminal binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01482,762,097 - 82,762,157EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2441 AgrOrtholog
BioCyc Gene G2FUF-15254 BioCyc
Ensembl Genes ENSRNOG00000005428 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000057929 ENTREZGENE
  ENSRNOT00000112665 ENTREZGENE
  ENSRNOT00000112665.1 UniProtKB/Swiss-Prot
  ENSRNOT00000119292 ENTREZGENE
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108845 IMAGE-MGC_LOAD
InterPro CtBP UniProtKB/Swiss-Prot
  CTBP_dehydrogenase UniProtKB/Swiss-Prot
  D-isomer_2_OHA_DH_cat_dom UniProtKB/Swiss-Prot
  D-isomer_DH_CS UniProtKB/Swiss-Prot
  D-isomer_DH_CS1 UniProtKB/Swiss-Prot
  D-isomer_DH_NAD-bd UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:29382 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93318 IMAGE-MGC_LOAD
NCBI Gene 29382 ENTREZGENE
PANTHER C-TERMINAL-BINDING PROTEIN UniProtKB/Swiss-Prot
  C-TERMINAL-BINDING PROTEIN 1 UniProtKB/Swiss-Prot
Pfam 2-Hacid_dh UniProtKB/Swiss-Prot
  2-Hacid_dh_C UniProtKB/Swiss-Prot
PhenoGen Ctbp1 PhenoGen
PROSITE D_2_HYDROXYACID_DH_1 UniProtKB/Swiss-Prot
  D_2_HYDROXYACID_DH_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005428 RatGTEx
Superfamily-SCOP Formate/glycerate dehydrogenase catalytic domain-like UniProtKB/Swiss-Prot
  SSF51735 UniProtKB/Swiss-Prot
TIGR TC205585
UniProt A0A0H2UI20 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZSG1 ENTREZGENE, UniProtKB/TrEMBL
  A6IK67 ENTREZGENE, UniProtKB/TrEMBL
  CTBP1_RAT UniProtKB/Swiss-Prot
  F7FG31 ENTREZGENE, UniProtKB/TrEMBL
  Q6AZ26 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z2F5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ctbp1  C-terminal binding protein 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization protein is found in cytosol and may be associated with Golgi apparatus 69822
gene_expression expressed in brain 69822
gene_physical_interaction interacts with a bipartite motif located in the C- terminus of viral EBNA3A protein 1298829
gene_physical_interaction binds GTP and interacts with beta gamma subunit comples of G proteins 1298827
gene_process negatively controls tubulation of Golgi structures after treatment with brefeldin A 69822
gene_process acts as a transcriptional co-repressor 1298829
gene_process may function in development, cell cycle regulation and cellular transformation 1298829
gene_protein protein is ADP-ribosylated after exposure of cells to brefeldin A 69822