RGD Reference Report - Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo. - Rat Genome Database

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Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.

Authors: Ivanova, D  Dirks, A  Montenegro-Venegas, C  Schone, C  Altrock, WD  Marini, C  Frischknecht, R  Schanze, D  Zenker, M  Gundelfinger, ED  Fejtova, A 
Citation: Ivanova D, etal., EMBO J. 2015 Apr 15;34(8):1056-77. doi: 10.15252/embj.201488796. Epub 2015 Feb 4.
RGD ID: 11079187
Pubmed: PMID:25652077   (View Abstract at PubMed)
PMCID: PMC4406652   (View Article at PubMed Central)
DOI: DOI:10.15252/embj.201488796   (Journal Full-text)

Persistent experience-driven adaptation of brain function is associated with alterations in gene expression patterns, resulting in structural and functional neuronal remodeling. How synaptic activity-in particular presynaptic performance-is coupled to gene expression in nucleus remains incompletely understood. Here, we report on a role of CtBP1, a transcriptional co-repressor enriched in presynapses and nuclei, in the activity-driven reconfiguration of gene expression in neurons. We demonstrate that presynaptic and nuclear pools of CtBP1 are interconnected and that both synaptic retention and shuttling of CtBP1 between cytoplasm and nucleus are co-regulated by neuronal activity. Finally, we show that CtBP1 is targeted and/or anchored to presynapses by direct interaction with the active zone scaffolding proteins Bassoon and Piccolo. This association is regulated by neuronal activity via modulation of cellular NAD/NADH levels and restrains the size of the CtBP1 pool available for nuclear import, thus contributing to the control of activity-dependent gene expression. Our combined results reveal a mechanism for coupling activity-induced molecular rearrangements in the presynapse with reconfiguration of neuronal gene expression.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
presynapse to nucleus signaling pathway involved_inIDA 11079187PMID:25652077SynGO 
presynapse to nucleus signaling pathway involved_inIMP 11079187PMID:25652077SynGO 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
glutamatergic synapse is_active_inIDA 11079187PMID:25652077SynGO 
glutamatergic synapse is_active_inIMP 11079187PMID:25652077SynGO 
nucleus located_inIDA 11079187PMID:25652077SynGO 
presynapse located_inIDA 11079187PMID:25652077SynGO 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding enablesIPIUniProtKB:O8877811079187PMID:25652077ParkinsonsUK-UCL 
protein binding enablesIPIUniProtKB:Q9JKS611079187PMID:25652077ParkinsonsUK-UCL 
transcription corepressor binding enablesIPIUniProtKB:Q9Z2F511079187; 11079187PMID:25652077ParkinsonsUK-UCL 

Objects Annotated

Genes (Rattus norvegicus)
Bsn  (bassoon (presynaptic cytomatrix protein))
Ctbp1  (C-terminal binding protein 1)
Pclo  (piccolo (presynaptic cytomatrix protein))


Additional Information