Prl3d1l1 (prolactin family 3, subfamily D, member 1 like 1) - Rat Genome Database

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Gene: Prl3d1l1 (prolactin family 3, subfamily D, member 1 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prl3d1l1 (Ensembl: Rpl-1)
Name: prolactin family 3, subfamily D, member 1 like 1 (Ensembl:chorionic somatomammotropin hormone 1)
RGD ID: 2427
Description: Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chorionic somatomammotropin hormone 1; Csh1; lactogen I; Pl-I; Pl-Im; Pl1; placental lactogen 1; placental lactogen 1-like; placental lactogen I; Placental lactogen-1; Prl3d1; prolactin family 3, subfamily D, member 1; prolactin-3D1; Rhco1; rPl-1; rPL-I
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81738,041,402 - 38,047,329 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1738,041,345 - 38,047,331 (-)EnsemblGRCr8
UTH_Rnor_SHR_Utx1737,703,388 - 37,709,319 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01739,307,406 - 39,313,339 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01737,651,296 - 37,657,253 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01739,777,255 - 39,782,877 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01741,684,099 - 41,689,719 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01744,715,911 - 44,721,879 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41744,427,291 - 44,433,204 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1737,336,214 - 37,342,145 (-)NCBICelera
RGSC_v3.11744,430,167 - 44,436,032 (-)NCBI
Cytogenetic Map17p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A cDNA encoding a new member of the rat placental lactogen family, PL-I mosaic (PL-Im). Hirosawa M, etal., Endocr J 1994 Aug;41(4):387-97.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Molecular cloning and expression of rat placental lactogen-Iv, a variant of rPL-I present in late pregnant rat placenta. Robertson MC, etal., Endocrinology 1991 Nov;129(5):2746-56.
Additional References at PubMed
PMID:2373051   PMID:16481593   PMID:16897344   PMID:17728251  


Genomics

Variants

.
Variants in Prl3d1l1
9 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:76
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000042298
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173219953449497050Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat


Expression

RNA-SEQ Expression

circulatory system
ectoderm
endocrine system
mesenchyme
mesoderm
nervous system
reproductive system
2 9 5 5 5 6 14

Sequence


Ensembl Acc Id: ENSRNOT00000042298   ⟹   ENSRNOP00000049253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1739,777,301 - 39,782,860 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000131042   ⟹   ENSRNOP00000108787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1738,041,345 - 38,047,331 (-)Ensembl
RefSeq Acc Id: NM_017363   ⟹   NP_059059
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81738,041,402 - 38,047,329 (-)NCBI
Rnor_6.01739,777,255 - 39,782,877 (-)NCBI
Rnor_5.01744,715,911 - 44,721,879 (-)NCBI
RGSC_v3.41744,427,291 - 44,433,204 (-)RGD
Celera1737,336,214 - 37,342,145 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_059059 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41506 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000108787
GenBank Protein P21702 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_059059   ⟸   NM_017363
- Peptide Label: precursor
- UniProtKB: A6J7T3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049253   ⟸   ENSRNOT00000042298
Ensembl Acc Id: ENSRNOP00000108787   ⟸   ENSRNOT00000131042

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21702-F1-model_v2 AlphaFold P21702 1-230 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSRNOG00000050920 Ensembl
  ENSRNOG00000074382 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000131042 ENTREZGENE
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  Somatotropin/Prolactin UniProtKB/Swiss-Prot
  Somatotropin_CS UniProtKB/Swiss-Prot
NCBI Gene 53950 ENTREZGENE
PANTHER GROWTH HORMONE D5-RELATED UniProtKB/Swiss-Prot
  SOMATOTROPIN,PROLACTIN UniProtKB/Swiss-Prot
Pfam Hormone_1 UniProtKB/Swiss-Prot
PhenoGen Prl3d1l1 PhenoGen
PRINTS SOMATOTROPIN UniProtKB/Swiss-Prot
PROSITE SOMATOTROPIN_1 UniProtKB/Swiss-Prot
  SOMATOTROPIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000050920 RatGTEx
  ENSRNOG00000074382 RatGTEx
Superfamily-SCOP 4-helical cytokines UniProtKB/Swiss-Prot
UniProt A0ABK0M170_RAT UniProtKB/TrEMBL
  A6J7T3 ENTREZGENE, UniProtKB/TrEMBL
  P21702 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-03-06 Prl3d1l1  prolactin family 3, subfamily D, member 1 like 1  Prl3d1  prolactin family 3, subfamily D, member 1  Name and Symbol changed 629549 APPROVED
2022-04-07 Prl3d1  prolactin family 3, subfamily D, member 1  Prl3d1  Prolactin family 3, subfamily D, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-04-07 Prl3d1  Prolactin family 3, subfamily D, member 1  Prl3d1  Prolactin family 3, subfamily d, member 1  Name changed 629549 APPROVED
2007-05-04 Prl3d1  Prolactin family 3, subfamily d, member 1  Csh1  chorionic somatomammotropin hormone 1  Symbol and Name updated 1624237 APPROVED
2003-04-09 Csh1  chorionic somatomammotropin hormone 1      Symbol and Name updated 629477 APPROVED
2003-03-06 Csh1  chorionic somatomammotropin hormone 1  Pl1  placental lactogen 1  Data merged from RGD:619873 628472 PROVISIONAL
2002-11-06 Csh1  chorionic somatomammotropin hormone 1    Chorionic somatomammotropin hormone 1; Placental lactogen-1  Name updated 625702 APPROVED
2002-08-07 Pl1  placental lactogen 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Csh1  Chorionic somatomammotropin hormone 1; Placental lactogen-1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in placenta during late pregnancy; mainly expressed in cytotrophoblasts of the basal zone 1298820
gene_product member of prolactin growth hormone family 1298820