Csf3 (colony stimulating factor 3) - Rat Genome Database

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Gene: Csf3 (colony stimulating factor 3) Rattus norvegicus
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Symbol: Csf3
Name: colony stimulating factor 3
RGD ID: 2426
Description: Enables growth factor activity. Involved in cellular response to lipopolysaccharide; positive regulation of cell population proliferation; and response to ethanol. Located in extracellular space. Biomarker of cystitis; lung disease; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human CSF3 (colony stimulating factor 3); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; malaria pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: colony stimulating factor 3 (granulocyte); Gcsf; granulocyte colony-stimulating factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,157,485 - 84,159,860 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1084,157,211 - 84,159,860 (+)EnsemblGRCr8
mRatBN7.21083,660,787 - 83,664,569 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,661,207 - 83,663,603 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1088,605,117 - 88,607,492 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,103,193 - 88,105,568 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,495,892 - 83,498,267 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,616,785 - 86,619,160 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,616,785 - 86,619,157 (+)Ensemblrn6Rnor6.0
Rnor_5.01086,413,088 - 86,415,478 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41087,473,990 - 87,476,365 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1082,409,331 - 82,411,709 (+)NCBICelera
RGSC_v3.11087,488,359 - 87,490,732 (+)NCBI
RH 3.4 Map10850.39RGD
Cytogenetic Map10q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
agranulocytosis  (ISO)
allergic cutaneous vasculitis  (ISO)
anemia  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
anterior ischemic optic neuropathy  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aplastic anemia  (ISO)
Arthralgia  (ISO)
asthma  (ISO)
B-cell lymphoma  (ISO)
bacterial pneumonia  (ISO)
bilirubin metabolic disorder  (ISO)
Bone Marrow Neoplasms  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiac Fibrosis  (ISO)
Carotid Artery Injuries  (IEP)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (ISO)
COVID-19  (ISO)
cystitis  (IEP)
depressive disorder  (ISO)
diarrhea  (ISO)
dilated cardiomyopathy  (ISO)
Disease Susceptibility  (ISO)
Drug-Induced Agranulocytosis  (ISO)
Drug-induced Neutropenia  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Endotoxemia  (ISO)
Enterobacteriaceae Infections  (IEP)
Esophageal Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
gastrointestinal system disease  (ISO)
Head and Neck Neoplasms  (ISO)
Headache  (ISO)
heart disease  (ISO)
hepatic veno-occlusive disease  (ISO)
Hodgkin's lymphoma  (ISO)
Hyperalgesia  (ISO)
Hypertrophy  (ISO)
Infarction  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
left ventricular failure  (ISO)
leiomyosarcoma  (ISO)
Leukocytosis  (ISO)
leukopenia  (ISO)
limb ischemia  (ISO)
liver disease  (ISO)
Liver Injury  (ISO)
Liver Neoplasms  (ISO)
localized scleroderma  (ISO)
lung disease  (IEP,ISO)
Lung Injury  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
Lymphoma, AIDS-Related  (ISO)
melanoma  (ISO)
middle cerebral artery infarction  (IEP,ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
Muscle Weakness  (ISO)
muscular disease  (ISO)
myeloid leukemia  (ISO)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasms, Second Primary  (ISO)
nervous system disease  (ISO)
neutropenia  (ISO)
Neutrophilia  (ISO)
non-Hodgkin lymphoma  (ISO)
Optic Nerve Injuries  (ISO)
Pain  (ISO)
pancytopenia  (ISO)
peripheral nervous system disease  (ISO)
pleurisy  (ISO)
Poisoning  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Sepsis  (ISO)
Septic Peritonitis  (ISO)
Skin Neoplasms  (ISO)
Soft Tissue Neoplasms  (ISO)
Somatosensory Disorders  (ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (ISO)
Staphylococcal Infections  (ISO)
Staphylococcal Pneumonia  (ISO)
Stevens-Johnson syndrome  (ISO)
stomatitis  (ISO)
stroke  (ISO)
Systemic Vasculitis  (ISO)
thrombocytopenia  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
urinary bladder cancer  (ISO)
Uterine Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,5-dichlorophenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-acetyldeoxynivalenol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (ISO)
acrylamide  (ISO)
agomelatine  (EXP)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
apigenin  (ISO)
aripiprazole  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
boric acid  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
choline  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
creatine  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
Cuprizon  (EXP)
DDE  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP,ISO)
dinitrogen  (ISO)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
Erionite  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furosemide  (EXP)
gemcitabine  (ISO)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
heparin  (EXP)
hesperetin  (ISO)
hydrogen peroxide  (ISO)
inositol  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
malathion  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
mercury dichloride  (ISO)
methotrexate  (EXP,ISO)
methylparaben  (ISO)
mirex  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel dichloride  (ISO)
o-anisidine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenylarsine oxide  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
polymyxin B2  (ISO)
pomalidomide  (ISO)
progesterone  (ISO)
propanal  (ISO)
propylparaben  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sodium tungstate  (ISO)
sotorasib  (ISO)
succimer  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
taurocholic acid  (ISO)
terameprocol  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
theophylline  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
verteporfin  (ISO)
XL147  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Effects of granulocyte colony-stimulating factor (G-CSF) on bleomycin-induced lung injury of varying severity. Adachi K, etal., Toxicol Pathol. 2003 Nov-Dec;31(6):665-73.
2. Granulocyte colony-stimulating factor enhances host defenses against bacterial pneumonia following peritonitis in nonneutropenic rats. Attalah HL, etal., Crit Care Med. 2002 Sep;30(9):2107-14.
3. Granulocyte colony-stimulating factor enhances alpha-naphthylthiourea-induced pulmonary hypertension. Azoulay E, etal., J Appl Physiol (1985). 2003 May;94(5):2027-33. Epub 2003 Jan 10.
4. Suppression of the granulocyte colony-stimulating factor response to Escherichia coli challenge by alcohol intoxication. Bagby GJ, etal., Alcohol Clin Exp Res. 1998 Nov;22(8):1740-5.
5. Treatment of adjuvant arthritis with granulocyte-colony stimulating factor and peptide derived from heat shock protein 65. Brendolan A, etal., Cell Immunol. 2003 Jan;221(1):6-14.
6. Granulocyte colony-stimulating factor serum and urine concentrations in neutropenic neonates before and after intravenous administration of recombinant granulocyte colony-stimulating factor. Calhoun DA, etal., Pediatrics. 2000 Feb;105(2):392-7.
7. Neuroprotective effects of recombinant human granulocyte colony-stimulating factor (G-CSF) in a rat model of anterior ischemic optic neuropathy (rAION). Chang CH, etal., Exp Eye Res. 2014 Jan;118:109-16. doi: 10.1016/j.exer.2013.11.012. Epub 2013 Dec 5.
8. Co-delivery of G-CSF and EPO released from fibrin gel for therapeutic neovascularization in rat hindlimb ischemia model. Chen F, etal., Microcirculation. 2013 Jul;20(5):416-24. doi: 10.1111/micc.12037.
9. Expression of granulocyte colony-stimulating factor is induced in injured rat carotid arteries and mediates vascular smooth muscle cell migration. Chen X, etal., Am J Physiol Cell Physiol. 2005 Jan;288(1):C81-8. Epub 2004 Sep 22.
10. Granulocyte colony-stimulating factor exacerbates cardiac fibrosis after myocardial infarction in a rat model of permanent occlusion. Cheng Z, etal., Cardiovasc Res. 2008 Dec 1;80(3):425-34. doi: 10.1093/cvr/cvn202. Epub 2008 Jul 31.
11. Granulocyte colony stimulating factor neuroprotective effects on spinal motoneurons after ventral root avulsion. De Freria CM, etal., Synapse. 2012 Feb;66(2):128-41. doi: 10.1002/syn.20993. Epub 2011 Nov 3.
12. Effects of granulocyte colony stimulating factor in a nonneutropenic rodent model of Escherichia coli peritonitis. Dunne JR, etal., J Surg Res. 1996 Mar;61(2):348-54.
13. Granulocyte colony stimulating factor exacerbates antineutrophil cytoplasmic antibody vasculitis. Freeley SJ, etal., Ann Rheum Dis. 2013 Jun;72(6):1053-8. doi: 10.1136/annrheumdis-2012-202160. Epub 2012 Oct 19.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Therapy for neutropenia in hairy cell leukemia with recombinant human granulocyte colony-stimulating factor. Glaspy JA, etal., Ann Intern Med. 1988 Nov 15;109(10):789-95.
16. Cloning and expression of the cDNA encoding rat granulocyte colony-stimulating factor. Han SW, etal., Gene 1996 Oct 10;175(1-2):101-4.
17. Granulocyte colony-stimulating factor after intensive consolidation chemotherapy in acute myeloid leukemia: results of a randomized trial of the Groupe Ouest-Est Leucemies Aigues Myeloblastiques. Harousseau JL, etal., J Clin Oncol. 2000 Feb;18(4):780-7.
18. Hemorrhagic shock induces G-CSF expression in bronchial epithelium. Hierholzer C, etal., Am J Physiol. 1997 Nov;273(5 Pt 1):L1058-64.
19. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
20. Granulocyte colony stimulating factor attenuates hyperoxia-induced lung injury by down-modulating inflammatory responses in neonatal rats. Jeon GW, etal., Yonsei Med J. 2011 Jan 1;52(1):65-73.
21. [Effects of granulocyte colony-stimulating factor on hepatocyte apoptosis in acute liver failure: experiment with rats]. Kang W, etal., Zhonghua Yi Xue Za Zhi. 2008 Apr 8;88(14):980-4.
22. G-CSF during Escherichia coli versus Staphylococcus aureus pneumonia in rats has fundamentally different and opposite effects. Karzai W, etal., Am J Respir Crit Care Med. 1999 May;159(5 Pt 1):1377-82.
23. Leukocytoclastic vasculitis in patients with severe congenital neutropenia. Kilic SS, etal., J Trop Pediatr. 2010 Oct;56(5):359-62. doi: 10.1093/tropej/fmp140. Epub 2010 Jan 25.
24. Induction of granulocyte colony-stimulating factor mRNA by focal cerebral ischemia and cortical spreading depression. Kleinschnitz C, etal., Brain Res Mol Brain Res. 2004 Nov 24;131(1-2):73-8.
25. Delayed granulocyte colony-stimulating factor treatment in rats attenuates mechanical allodynia induced by chronic constriction injury of the sciatic nerve. Koda M, etal., Spine (Phila Pa 1976). 2014 Feb 1;39(3):192-7. doi: 10.1097/BRS.0000000000000108.
26. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
27. Granulocyte-colony stimulating factor inhibits neuronal apoptosis in a rat model of diabetic cerebral ischemia. Lan X, etal., Tohoku J Exp Med. 2008 Oct;216(2):117-26.
28. Therapeutic angiogenesis with intramuscular injection of low-dose recombinant granulocyte-colony stimulating factor. Lee M, etal., Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2535-41. Epub 2005 Oct 13.
29. Granulocyte-colony stimulating factor is involved in low-dose LPS-induced neuroprotection. Li ZX, etal., Neurosci Lett. 2009 Nov 13;465(2):128-32. Epub 2009 Sep 2.
30. Improvement of heart allograft acceptability associated with recruitment of CD4+CD25+ T cells in peripheral blood by recipient treatment with granulocyte colony-stimulating factor. Liang HL, etal., Transplant Proc. 2008 Jun;40(5):1604-11. doi: 10.1016/j.transproceed.2008.02.078.
31. Granulocyte colony-stimulating factor improves survival rate and reduces concentrations of bacteria, endotoxin, tumor necrosis factor, and endothelin-1 in fulminant intra-abdominal sepsis in rats. Lundblad R, etal., Crit Care Med. 1996 May;24(5):820-6.
32. In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse. Luo X, etal., PLoS One. 2010 Apr 13;5(4):e10149.
33. Granulocyte colony-stimulating factor prevents progression of monocrotaline-induced pulmonary arterial hypertension in rats. Maruyama H, etal., Circ J. 2007 Jan;71(1):138-43.
34. Relationship between the cAMP levels in leukocytes and the cytokine balance in patients surviving gram negative bacterial pneumonia. Matsumoto T, etal., J Clin Biochem Nutr. 2011 Mar;48(2):134-41. Epub 2011 Feb 26.
35. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
36. Treatment of relapsed adult acute lymphoblastic leukemia with fludarabine and cytosine arabinoside followed by granulocyte colony-stimulating factor (FLAG-GCSF). Montillo M, etal., Leuk Lymphoma. 1997 May;25(5-6):579-83.
37. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
38. Increased migration of neutrophils to granulocyte-colony stimulating factor in rat carrageenin-induced pleurisy: roles of complement, bradykinin, and inducible cyclooxygenase-2. Ogino M, etal., Inflamm Res. 1996 Jul;45(7):335-46.
39. The immunohistochemical localization of the interferon-gamma and granulocyte colony-stimulating factor receptors during early amelogenesis in rat molars. Otsuji W, etal., Arch Oral Biol. 1999 Feb;44(2):173-81.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. Effect of recombinant human granulocyte colony stimulating factor on granulocytopenia induced by cytotoxic chemotherapy in patients with multiple myeloma. Poglod R, etal., Mater Med Pol. 1995 Jul-Sep;27(3):83-9.
42. G-CSF suppresses allergic pulmonary inflammation, downmodulating cytokine, chemokine and eosinophil production. Queto T, etal., Life Sci. 2011 May 9;88(19-20):830-8. Epub 2011 Mar 21.
43. GOA pipeline RGD automated data pipeline
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Levels of serum granulocyte colony-stimulating factor in patients with chronic myeloid leukemia. Saitoh H and Shibata A, Leuk Lymphoma. 1993 Nov;11(5-6):443-6.
46. Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Schabitz WR, etal., Stroke. 2003 Mar;34(3):745-51. Epub 2003 Feb 13.
47. IFN/RBV treatment induced neutropenia and its correction with neupogen in patients with hepatitis C. Sharvadze L, etal., Georgian Med News. 2007 Jun;(147):52-5.
48. Enhancement in cognitive function recovery by granulocyte-colony stimulating factor in a rodent model of traumatic brain injury. Sikoglu EM, etal., Behav Brain Res. 2014 Feb 1;259:354-6. doi: 10.1016/j.bbr.2013.11.008. Epub 2013 Nov 14.
49. Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. Smaldone MC, etal., Urology. 2009 Feb;73(2):421-6. Epub 2008 Oct 9.
50. Granulocyte colony-stimulating factor protects the brain against experimental stroke via inhibition of apoptosis and inflammation. Solaroglu I, etal., Neurol Res. 2009 Mar;31(2):167-72. doi: 10.1179/174313209X393582.
51. The effects of recombinant human granulocyte-colony stimulating factor on vascular dysfunction and splanchnic ischaemia-reperfusion injury. Squadrito F, etal., Br J Pharmacol. 1997 Jan;120(2):333-9.
52. Granulocyte colony-stimulating factor attenuates early ventricular expansion after experimental myocardial infarction. Sugano Y, etal., Cardiovasc Res. 2005 Feb 1;65(2):446-56.
53. Antithyroid drug-induced agranulocytosis: how has granulocyte colony-stimulating factor changed therapy? Tajiri J and Noguchi S, Thyroid. 2005 Mar;15(3):292-7.
54. Implantation of fibroblasts transfected with human granulocyte colony-stimulating factor cDNA into mice as a model of cytokine-supplement gene therapy. Tani K, etal., Blood. 1989 Sep;74(4):1274-80.
55. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
56. Granulocyte colony-stimulating factor administration reverses cadmium-associated inhibition of hepatocyte regeneration. Theocharis SE, etal., Eur J Gastroenterol Hepatol. 1996 Aug;8(8):805-9.
57. Anti-apoptotic effects of human granulocyte colony-stimulating factor (G-CSF) on retinal ganglion cells after optic nerve crush are PI3K/AKT-dependent. Tsai RK, etal., Exp Eye Res. 2010 May;90(5):537-45. doi: 10.1016/j.exer.2010.01.004. Epub 2010 Feb 6.
58. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
59. Effect of nartograstim, a recombinant human granulocyte colony-stimulating factor on elastase-induced emphysema in rats. Yoshimatsu A, etal., Arzneimittelforschung. 2009;59(5):248-53. doi: 10.1055/s-0031-1296393.
60. The neutrophil/Th1 lymphocyte balance and the therapeutic effect of granulocyte colony-stimulating factor in TNBS-induced colitis of rat strains. Yoshimitsu M, etal., J Interferon Cytokine Res. 2006 May;26(5):291-300.
61. Protective effect of granulocyte colony-stimulating factor on intracerebral hemorrhage in rat. Zhang L, etal., Neurochem Res. 2009 Jul;34(7):1317-23. doi: 10.1007/s11064-008-9911-6. Epub 2009 Jan 24.
62. Granulocyte colony-stimulating factor treatment ameliorates liver injury and improves survival in rats with D-galactosamine-induced acute liver failure. Zhang L, etal., Toxicol Lett. 2011 Jul 4;204(1):92-9. doi: 10.1016/j.toxlet.2011.04.016. Epub 2011 Apr 27.
63. Acute ethanol intoxication inhibits neutrophil beta2-integrin expression in rats during endotoxemia. Zhang P, etal., Alcohol Clin Exp Res. 1998 Feb;22(1):135-41.
64. Granulocyte colony-stimulating factor treatment prevents cognitive impairment following status epilepticus in rats. Zhang Y, etal., Biol Pharm Bull. 2010;33(4):572-9.
65. Brain repair by hematopoietic growth factors in a rat model of stroke. Zhao LR, etal., Stroke. 2007 Sep;38(9):2584-91. Epub 2007 Jul 26.
Additional References at PubMed
PMID:2158861   PMID:12393522   PMID:17681181   PMID:21292035   PMID:21461559   PMID:22099173   PMID:23001182   PMID:23209732   PMID:23437199   PMID:24167558   PMID:24216483   PMID:25144367  
PMID:25425079   PMID:28176642  


Genomics

Comparative Map Data
Csf3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,157,485 - 84,159,860 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1084,157,211 - 84,159,860 (+)EnsemblGRCr8
mRatBN7.21083,660,787 - 83,664,569 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,661,207 - 83,663,603 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1088,605,117 - 88,607,492 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,103,193 - 88,105,568 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,495,892 - 83,498,267 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,616,785 - 86,619,160 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,616,785 - 86,619,157 (+)Ensemblrn6Rnor6.0
Rnor_5.01086,413,088 - 86,415,478 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41087,473,990 - 87,476,365 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1082,409,331 - 82,411,709 (+)NCBICelera
RGSC_v3.11087,488,359 - 87,490,732 (+)NCBI
RH 3.4 Map10850.39RGD
Cytogenetic Map10q31NCBI
CSF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,015,440 - 40,017,813 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,015,361 - 40,017,816 (+)Ensemblhg38GRCh38
GRCh371738,171,693 - 38,174,066 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,425,214 - 35,427,592 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341735,425,213 - 35,427,591NCBI
Celera1734,831,674 - 34,834,127 (+)NCBICelera
Cytogenetic Map17q21.1NCBI
HuRef1733,965,611 - 33,968,064 (+)NCBIHuRef
CHM1_11738,407,306 - 38,409,759 (+)NCBICHM1_1
T2T-CHM13v2.01740,879,315 - 40,881,689 (+)NCBIT2T-CHM13v2.0
Csf3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,591,287 - 98,594,457 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,592,089 - 98,594,455 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381198,700,183 - 98,703,631 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,701,263 - 98,703,629 (+)Ensemblmm10GRCm38
MGSCv371198,562,627 - 98,564,943 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361198,517,403 - 98,519,719 (+)NCBIMGSCv36mm8
Celera11108,355,655 - 108,357,971 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.45NCBI
Csf3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,688,181 - 14,690,126 (+)Ensembl
ChiLan1.0NW_00495545114,688,181 - 14,690,126 (+)NCBIChiLan1.0ChiLan1.0
CSF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,936,910 - 24,939,329 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,831,703 - 26,834,122 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,271,074 - 17,273,493 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,491,272 - 17,493,729 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,491,276 - 17,493,729 (-)EnsemblpanPan2panpan1.1
CSF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,529,643 - 22,532,326 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,530,698 - 22,533,108 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha922,001,811 - 22,004,573 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0923,322,490 - 23,325,252 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,323,327 - 23,325,322 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,095,850 - 22,098,611 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,355,055 - 22,357,817 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,479,613 - 22,482,375 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Csf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,929,893 - 21,934,092 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,142,808 - 15,144,487 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,142,526 - 15,146,375 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,333,449 - 22,338,753 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11222,333,445 - 22,335,949 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,732,713 - 22,734,736 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,162,814 - 66,166,192 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,163,681 - 66,165,172 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607737,070,211 - 37,072,804 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csf3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,163,009 - 3,166,594 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247953,162,999 - 3,167,248 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Csf3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1955,732,650 - 55,735,170 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Csf3
16 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:73
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000011509
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107870758585720738Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313384503487Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH94653  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81084,159,659 - 84,159,818 (+)Marker Load Pipeline
mRatBN7.21083,663,402 - 83,663,561 (+)MAPPERmRatBN7.2
Rnor_6.01086,618,960 - 86,619,118NCBIRnor6.0
Rnor_5.01086,415,278 - 86,415,436UniSTSRnor5.0
RGSC_v3.41087,476,165 - 87,476,323UniSTSRGSC3.4
Celera1082,411,509 - 82,411,667UniSTS
RH 3.4 Map10850.39UniSTS
Cytogenetic Map10q31UniSTS
PMC316809P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,662,492 - 83,663,166 (+)MAPPERmRatBN7.2
Rnor_6.01086,618,050 - 86,618,723NCBIRnor6.0
Rnor_5.01086,414,368 - 86,415,041UniSTSRnor5.0
RGSC_v3.41087,475,255 - 87,475,928UniSTSRGSC3.4
Celera1082,410,599 - 82,411,272UniSTS
Cytogenetic Map10q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 1 13 23 20 27 4 44 4 6 130 61 19 55 77 23 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000011509   ⟹   ENSRNOP00000011509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1084,157,211 - 84,159,860 (+)Ensembl
mRatBN7.2 Ensembl1083,661,207 - 83,663,603 (+)Ensembl
Rnor_6.0 Ensembl1086,616,785 - 86,619,157 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112863   ⟹   ENSRNOP00000089962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1084,157,383 - 84,159,231 (+)Ensembl
mRatBN7.2 Ensembl1083,661,228 - 83,662,974 (+)Ensembl
RefSeq Acc Id: NM_017104   ⟹   NP_058800
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81084,157,485 - 84,159,860 (+)NCBI
mRatBN7.21083,661,228 - 83,663,603 (+)NCBI
Rnor_6.01086,616,785 - 86,619,160 (+)NCBI
Rnor_5.01086,413,088 - 86,415,478 (+)NCBI
RGSC_v3.41087,473,990 - 87,476,365 (+)RGD
Celera1082,409,331 - 82,411,709 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058800 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52915 (Get FASTA)   NCBI Sequence Viewer  
  EDM05943 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011509
  ENSRNOP00000011509.5
  ENSRNOP00000089962.2
RefSeq Acc Id: NP_058800   ⟸   NM_017104
- Peptide Label: precursor
- UniProtKB: A6HIT8 (UniProtKB/TrEMBL),   F7FGY7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011509   ⟸   ENSRNOT00000011509
Ensembl Acc Id: ENSRNOP00000089962   ⟸   ENSRNOT00000112863

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97712-F1-model_v2 AlphaFold P97712 1-214 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697667
Promoter ID:EPDNEW_R8192
Type:single initiation site
Name:Csf3_1
Description:colony stimulating factor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01086,616,743 - 86,616,803EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2426 AgrOrtholog
BioCyc Gene G2FUF-23349 BioCyc
Ensembl Genes ENSRNOG00000008525 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011509 ENTREZGENE
  ENSRNOT00000011509.5 UniProtKB/TrEMBL
  ENSRNOT00000112863.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  GCSF/MGF UniProtKB/TrEMBL
  IL-6/GCSF/MGF UniProtKB/TrEMBL
  IL6/GCSF/MGF_CS UniProtKB/TrEMBL
NCBI Gene 25610 ENTREZGENE
PANTHER GRANULOCYTE COLONY-STIMULATING FACTOR UniProtKB/TrEMBL
  PTHR10511 UniProtKB/TrEMBL
Pfam GCSF UniProtKB/TrEMBL
PhenoGen Csf3 PhenoGen
PIRSF IL6_MGF_GCSF UniProtKB/TrEMBL
PRINTS IL6GCSFMGF UniProtKB/TrEMBL
PROSITE INTERLEUKIN_6 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008525 RatGTEx
SMART IL6 UniProtKB/TrEMBL
Superfamily-SCOP 4_helix_cytokine UniProtKB/TrEMBL
TIGR TC226551
UniProt A0A8I6AAV9_RAT UniProtKB/TrEMBL
  A6HIT8 ENTREZGENE, UniProtKB/TrEMBL
  F7FGY7 ENTREZGENE, UniProtKB/TrEMBL
  P97712_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-12 Csf3  colony stimulating factor 3  Csf3  colony stimulating factor 3 (granulocyte)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Csf3  colony stimulating factor 3 (granulocyte)    colony stimulating factor 3   Name updated 1299863 APPROVED
2002-11-06 Csf3  colony stimulating factor 3     Colony stimulating factor 3 (granulocyte)  Name updated 625702 APPROVED
2002-06-10 Csf3  Colony stimulating factor 3 (granulocyte)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs used as a treatment for cyclic hematopoiesis, a severe recurrent neutropenia, in man and dogs 1298819
gene_process controls production and maintenance of neutrophils by acting on hematopoetic precursor cells 1298819