RGD Reference Report - Enhancement in cognitive function recovery by granulocyte-colony stimulating factor in a rodent model of traumatic brain injury. - Rat Genome Database

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Enhancement in cognitive function recovery by granulocyte-colony stimulating factor in a rodent model of traumatic brain injury.

Authors: Sikoglu, EM  Heffernan, ME  Tam, K  Sicard, KM  Bratane, BT  Quan, M  Fisher, M  King, JA 
Citation: Sikoglu EM, etal., Behav Brain Res. 2014 Feb 1;259:354-6. doi: 10.1016/j.bbr.2013.11.008. Epub 2013 Nov 14.
RGD ID: 11039431
Pubmed: PMID:24239694   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbr.2013.11.008   (Journal Full-text)

Traumatic brain injury (TBI) is characterized by neuronal damage and commonly, secondary cell death, leading to functional and neurological dysfunction. Despite the recent focus of TBI research on developing therapies, affective therapeutic strategies targeting neuronal death associated with TBI remain underexplored. This study explored the efficacy of granulocyte-colony stimulating factor (G-CSF) as an intervention for improving cognitive deficits commonly associated with TBI. Although G-CSF has been studied with histological techniques, to date, its effects on functional outcome remain unknown. To this end, we used a closed head injury (CHI) model in Wistar rats that were randomly assigned to one of four groups (untreated TBI, G-CSF treated TBI, G-CSF treated Control, Control). The treatment groups were administered subcutaneous injections of G-CSF 30 min (120 mug/kg) and 12 h (60 mug/kg) post-trauma. The Morris Water Maze test was used to measure any treatment-associated changes in cognitive deficits observed in TBI animals at days 2-6 post-injury. Our findings demonstrate a significant improvement in cognitive performance in the G-CSF treated TBI animals within a week of injury, compared to untreated TBI, indicative of immediate and beneficial effect of G-CSF on cognitive performance post CHI. Our model suggests that early G-CSF exposure may be a promising therapeutic approach in recovery of cognitive deficits due to TBI.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Brain Injuries treatmentIDA 11039431 RGD 
Brain Injuries treatmentISOCSF3 (Homo sapiens)11039431; 11039431 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Csf3  (colony stimulating factor 3)

Genes (Mus musculus)
Csf3  (colony stimulating factor 3 (granulocyte))

Genes (Homo sapiens)
CSF3  (colony stimulating factor 3)


Additional Information