Advanced Search (OLGA)

Gene: Angptl8 (angiopoietin-like 8) Rattus norvegicus

Analyze

Symbol:

Angptl8

Name:

angiopoietin-like 8

RGD ID:

2320121

Description:

Predicted to be involved in lipid metabolic process; regulation of lipid metabolic process; and triglyceride homeostasis. Predicted to act upstream of or within cell maturation; fat cell differentiation; and regulation of protein metabolic process. Predicted to be active in extracellular region. Orthologous to human ANGPTL8 (angiopoietin like 8); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

angiopoietin-like protein 8; betatrophin; lipasin; LOC100361444; rCG31799-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ANGPTL8 (angiopoietin like 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Angptl8 (angiopoietin-like 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Angptl8 (angiopoietin like 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ANGPTL8 (angiopoietin like 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ANGPTL8 (angiopoietin like 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Angptl8 (angiopoietin like 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ANGPTL8 (angiopoietin like 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ANGPTL8 (angiopoietin like 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Angptl8 (angiopoietin like 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Angptl8 (angiopoietin like 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ANGPTL8 (angiopoietin like 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ANGPTL8 (angiopoietin like 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Angptl8 (angiopoietin-like 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Angptl8 (angiopoietin-like 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	angptl8	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	angptl8	Alliance	DIOPT (OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	LOC101732836	Alliance	DIOPT (OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	LOC101732836	Alliance	DIOPT (OrthoFinder\|PANTHER)

Allele / Splice:

Angptl8^em1Kyo

Genetic Models:

F344-Angptl8^em1Kyo-/- ; F344-Angptl8^em1Kyo+/-

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	28,652,555 - 28,654,581 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	28,652,555 - 28,654,581 (+)	Ensembl				GRCr8
mRatBN7.2	8	20,376,462 - 20,378,488 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	20,376,462 - 20,378,490 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	24,411,953 - 24,413,979 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	22,707,496 - 22,709,522 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	20,606,057 - 20,608,083 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	22,855,495 - 22,858,565 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	22,856,539 - 22,858,565 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	22,910,979 - 22,913,005 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	20,948,070 - 20,950,087 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	21,767,738 - 21,769,764 (+)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,3',5-triiodo-L-thyronine (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

chloroquine (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dioxygen (ISO)

diquat (ISO)

drometrizole (ISO)

endosulfan (EXP)

fulvestrant (ISO)

genistein (EXP)

gentamycin (EXP)

metformin (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosodiethylamine (ISO)

N-Nitrosopyrrolidine (ISO)

nitrofen (EXP)

O-methyleugenol (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

pentanal (ISO)

phenformin (EXP)

quercetin (ISO)

quinolin-8-ol (ISO)

sodium arsenite (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

tris(2-butoxyethyl) phosphate (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell maturation (ISO)

fat cell differentiation (ISO)

glucose metabolic process (ISO)

lipid metabolic process (ISO)

positive regulation of protein processing (ISO)

regulation of lipid metabolic process (IBA,IEA,ISO)

regulation of lipoprotein metabolic process (ISO)

triglyceride homeostasis (IBA,IEA,ISO)

type B pancreatic cell proliferation (ISO)

Cellular Component

extracellular region (IBA,ISO)

Molecular Function

protein binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased body weight (IMP)

decreased circulating triglyceride level (IMP)

decreased circulating VLDL triglyceride level (IMP)

decreased epididymal fat pad weight (IMP)

decreased fat cell size (IMP)

decreased susceptibility to diet-induced obesity (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	CRISPR/Cas9-mediated Angptl8 knockout suppresses plasma triglyceride concentrations and adiposity in rats.	Izumi R, etal., J Lipid Res. 2018 Sep;59(9):1575-1585. doi: 10.1194/jlr.M082099. Epub 2018 Jul 24.
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:22569073	PMID:22809513	PMID:23150577	PMID:24043787	PMID:24353178	PMID:25417115	PMID:25720603	PMID:31578075	PMID:31702044	PMID:37933453

Genomics

Comparative Map Data

Angptl8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	28,652,555 - 28,654,581 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	28,652,555 - 28,654,581 (+)	Ensembl				GRCr8
mRatBN7.2	8	20,376,462 - 20,378,488 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	20,376,462 - 20,378,490 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	24,411,953 - 24,413,979 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	22,707,496 - 22,709,522 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	20,606,057 - 20,608,083 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	22,855,495 - 22,858,565 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	22,856,539 - 22,858,565 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	22,910,979 - 22,913,005 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	20,948,070 - 20,950,087 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	21,767,738 - 21,769,764 (+)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

ANGPTL8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	11,239,619 - 11,241,943 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	11,237,502 - 11,241,943 (+)	Ensembl			hg38	GRCh38
GRCh37	19	11,350,295 - 11,352,619 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	11,209,817 - 11,213,619 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	19	11,245,140 - 11,247,464 (+)	NCBI		Celera
Cytogenetic Map	19	p13.2	NCBI
HuRef	19	10,926,369 - 10,928,693 (+)	NCBI		HuRef
CHM1_1	19	11,351,357 - 11,353,681 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	11,366,594 - 11,368,918 (+)	NCBI		T2T-CHM13v2.0

Angptl8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	21,746,806 - 21,748,643 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	21,746,806 - 21,748,643 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	21,835,510 - 21,837,347 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	21,835,510 - 21,837,347 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	21,639,954 - 21,641,791 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	21,585,740 - 21,587,757 (+)	NCBI		MGSCv36	mm8
Celera	9	19,105,101 - 19,106,938 (+)	NCBI		Celera
Cytogenetic Map	9	A3	NCBI
cM Map	9	7.9	NCBI

Angptl8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	2,205,485 - 2,207,376 (+)	Ensembl
ChiLan1.0	NW_004955495	2,205,424 - 2,207,611 (+)	NCBI	ChiLan1.0	ChiLan1.0

ANGPTL8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	16,142,133 - 16,156,840 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	15,140,826 - 15,155,531 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	10,787,457 - 10,790,090 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	11,498,069 - 11,500,400 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	11,498,069 - 11,500,400 (+)	Ensembl			panPan2	panpan1.1

ANGPTL8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	50,040,383 - 50,043,312 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	50,040,383 - 50,042,031 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	49,913,888 - 49,915,655 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	50,561,284 - 50,563,051 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	50,561,284 - 50,562,932 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	49,771,477 - 49,773,244 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	50,198,362 - 50,200,129 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	50,441,068 - 50,442,835 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Angptl8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	208,982,926 - 208,984,600 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936659	1,370,113 - 1,371,769 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936659	1,370,115 - 1,371,767 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ANGPTL8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	69,952,581 - 69,954,220 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	69,951,556 - 69,954,223 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ANGPTL8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	10,169,733 - 10,172,433 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	10,170,052 - 10,173,005 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666074	9,713,854 - 9,716,184 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Angptl8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	3,092,739 - 3,099,120 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624828	3,092,673 - 3,094,919 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Angptl8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	18,100,024 - 18,102,072 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Angptl8
9 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	121
Count of miRNA genes:	91
Interacting mature miRNAs:	103
Transcripts:	ENSRNOT00000015381
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	16994642	61994642	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	10382540	55382540	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	12964165	57964165	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	15952279	60952279	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	12964165	57964165	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	17993862	62252873	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	10382540	55382540	Rat
9590084	Insglur5	Insulin/glucose ratio QTL 5	18.54	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	8	1	32882639	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	10382540	55382540	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	16994642	61994642	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	12964165	57964165	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	10382540	55382540	Rat

Markers in Region

BI274505

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	20,378,226 - 20,378,386 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	22,858,304 - 22,858,463	NCBI	Rnor6.0
Rnor_5.0	8	22,912,744 - 22,912,903	UniSTS	Rnor5.0
RGSC_v3.4	8	20,949,826 - 20,949,985	UniSTS	RGSC3.4
Celera	8	21,769,503 - 21,769,662	UniSTS
RH 3.4 Map	1	962.71	UniSTS
Cytogenetic Map	8	q13	UniSTS

BI282731

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	20,376,710 - 20,377,030 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	22,856,788 - 22,857,107	NCBI	Rnor6.0
Rnor_5.0	8	22,911,228 - 22,911,547	UniSTS	Rnor5.0
RGSC_v3.4	8	20,948,310 - 20,948,629	UniSTS	RGSC3.4
Celera	8	21,767,987 - 21,768,306	UniSTS
Cytogenetic Map	8	q13	UniSTS

Genetic Models

This gene Angptl8 is modified in the following models/strains:

F344-Angptl8^em1Kyo-/- F344-Angptl8^em1Kyo+/-

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	37	81	91	90	59	29	59	6	259	95	6	59	81	90	31	1	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001271710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_593760	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC119556	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC160867	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015381 ⟹ ENSRNOP00000015381

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	28,652,555 - 28,654,581 (+)	Ensembl
mRatBN7.2 Ensembl	8	20,376,462 - 20,378,488 (+)	Ensembl
Rnor_6.0 Ensembl	8	22,856,539 - 22,858,565 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094372 ⟹ ENSRNOP00000085135

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	28,652,555 - 28,653,798 (+)	Ensembl
mRatBN7.2 Ensembl	8	20,376,462 - 20,378,490 (+)	Ensembl

RefSeq Acc Id:

NM_001271710 ⟹ NP_001258639

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	28,652,555 - 28,654,581 (+)	NCBI
mRatBN7.2	8	20,376,462 - 20,378,488 (+)	NCBI
Rnor_6.0	8	22,856,539 - 22,858,565 (+)	NCBI
Rnor_5.0	8	22,910,979 - 22,913,005 (+)	NCBI
Celera	8	21,767,738 - 21,769,764 (+)	NCBI

Sequence:

show sequence

ATACCCCCGAGACTGTCCACCATGGTTGTGCCTATTCTCTGCCTCCTATGGGCCATAGCAACAG
CAGTGCGACCTGCCCCAGTGGCCCCTCTCGGTGGTCCAGAGCCGGCCCAATATGAAGAGTTGAC
CCTGCTCTTTCACGGGGCCCTACAGCTAGGTCAGGCCCTCAATGGTGTGTACAAAGCCACGGAA
GCTCGCCTGACAGAAGCTGGGCGCAACCTGGGCCTTTTTGACCAAGCACTGGAATTTCTGGGAA
GAGAGGTCAATCAGGGCCGGGATGCAACACGGGAGCTTCGCACCAGCTTGTCGGAGATTCAGGC
AGAAGAGGACACTTTACACCTTCGAGCAGAAGCCACAGCCCGATCGCTGAGGGAAGTGGCCCGG
GCCCAGCATGCTCTGCGGAACAGTGTACGGAGACTACAAGTGCAGCTGAGAGGTGCCTGGCTAG
GCCAAGCCCACCAAGAATTTGAGAATTTAAAGGATCGAGCCGATAAGCAGAACCACCTCTTGTG
GGCTCTCACTGGCCACGTGCAGCGACAGCAGCGTGAGATGGCAGAGCAGCAACAGTGGCTGCGG
CAGATCCAGCAGAGACTCCACATGGCAGCCCTCCCAGCCTGAGACTACCTGGATGCCACTGAGG
ACCAGTTGTGCTGCAGGGAACACTGAATGCGCTCCACCGGGCCTATCTATGAGCAGGGCCGACA
GAGCTGGCTGCCCATCAGCTAGACTTGGCCGGTGCACCCCGCTTCCTGGCAGAGCAGAGACAGA
AGCAAGCAGGCGGGATGGAAGGCAGAAGACAGCCCCGTGGAGAAGGCTGGAGAAGGACATGAGC
TCCCTTATGCCCCACACCCCACAATAAAAAAGAGGCAATCTATAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001258639	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL78268	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015381
	ENSRNOP00000015381.6
	ENSRNOP00000085135.1

RefSeq Acc Id:	NP_001258639 ⟸ NM_001271710
- Peptide Label:	precursor
- UniProtKB:	D3ZMI0 (UniProtKB/TrEMBL), A6JNU9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVVPILCLLWAIATAVRPAPVAPLGGPEPAQYEELTLLFHGALQLGQALNGVYKATEARLTEAG RNLGLFDQALEFLGREVNQGRDATRELRTSLSEIQAEEDTLHLRAEATARSLREVARAQHALRN SVRRLQVQLRGAWLGQAHQEFENLKDRADKQNHLLWALTGHVQRQQREMAEQQQWLRQIQQRLH MAALPA hide sequence

Ensembl Acc Id:

ENSRNOP00000015381 ⟸ ENSRNOT00000015381

Ensembl Acc Id:

ENSRNOP00000085135 ⟸ ENSRNOT00000094372

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZMI0-F1-model_v2	AlphaFold	D3ZMI0	1-198	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695790

Promoter ID:

EPDNEW_R6314

Type:

single initiation site

Name:

Angptl8_1

Description:

angiopoietin-like 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	22,856,539 - 22,856,599	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2320121	AgrOrtholog
BioCyc Gene	G2FUF-31407	BioCyc
Ensembl Genes	ENSRNOG00000011490	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000015381	ENTREZGENE
	ENSRNOT00000015381.9	UniProtKB/TrEMBL
	ENSRNOT00000094372.2	UniProtKB/TrEMBL
InterPro	TD26	UniProtKB/TrEMBL
KEGG Report	rno:100361444	UniProtKB/TrEMBL
NCBI Gene	100361444	ENTREZGENE
PANTHER	ANGIOPOIETIN-LIKE PROTEIN 8	UniProtKB/TrEMBL
	PTHR21463	UniProtKB/TrEMBL
PhenoGen	Angptl8	PhenoGen
RatGTEx	ENSRNOG00000011490	RatGTEx
UniProt	A0A8I6A1K9_RAT	UniProtKB/TrEMBL
	A6JNU9	ENTREZGENE, UniProtKB/TrEMBL
	D3ZMI0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-05	Angptl8	angiopoietin-like 8	LOC100361444	rCG31799-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-05	LOC100361444	rCG31799-like			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Mammalian Phenotype