ANGPTL8 (angiopoietin like 8) - Rat Genome Database

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Gene: ANGPTL8 (angiopoietin like 8) Canis lupus familiaris
Analyze
Symbol: ANGPTL8
Name: angiopoietin like 8
RGD ID: 12423561
Description: INVOLVED IN cell maturation (ortholog); fat cell differentiation (ortholog); glucose metabolic process (ortholog); ASSOCIATED WITH alpha-mannosidosis (ortholog); Charcot-Marie-Tooth disease dominant intermediate B (ortholog); episodic ataxia type 2 (ortholog); FOUND IN extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: angiopoietin-like protein 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,040,383 - 50,043,312 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,040,383 - 50,042,031 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,913,888 - 49,915,655 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02050,561,284 - 50,563,051 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,561,284 - 50,562,932 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,771,477 - 49,773,244 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,198,362 - 50,200,129 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,441,068 - 50,442,835 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
ANGPTL8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,040,383 - 50,043,312 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,040,383 - 50,042,031 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,913,888 - 49,915,655 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02050,561,284 - 50,563,051 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,561,284 - 50,562,932 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,771,477 - 49,773,244 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,198,362 - 50,200,129 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,441,068 - 50,442,835 (-)NCBIUU_Cfam_GSD_1.0
ANGPTL8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,239,619 - 11,241,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,237,502 - 11,241,943 (+)EnsemblGRCh38hg38GRCh38
GRCh371911,350,295 - 11,352,619 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,209,817 - 11,213,619 (+)NCBINCBI36Build 36hg18NCBI36
Celera1911,245,140 - 11,247,464 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,926,369 - 10,928,693 (+)NCBIHuRef
CHM1_11911,351,357 - 11,353,681 (+)NCBICHM1_1
T2T-CHM13v2.01911,366,594 - 11,368,918 (+)NCBIT2T-CHM13v2.0
Angptl8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,746,806 - 21,748,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,746,806 - 21,748,643 (+)EnsemblGRCm39 Ensembl
GRCm38921,835,510 - 21,837,347 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,835,510 - 21,837,347 (+)EnsemblGRCm38mm10GRCm38
MGSCv37921,639,954 - 21,641,791 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36921,585,740 - 21,587,757 (+)NCBIMGSCv36mm8
Celera919,105,101 - 19,106,938 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.9NCBI
Angptl8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,652,555 - 28,654,581 (+)NCBIGRCr8
mRatBN7.2820,376,462 - 20,378,488 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,376,462 - 20,378,490 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,411,953 - 24,413,979 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,707,496 - 22,709,522 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,606,057 - 20,608,083 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,855,495 - 22,858,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,856,539 - 22,858,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,910,979 - 22,913,005 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,948,070 - 20,950,087 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera821,767,738 - 21,769,764 (+)NCBICelera
Cytogenetic Map8q13NCBI
Angptl8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,205,485 - 2,207,376 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554952,205,424 - 2,207,611 (+)NCBIChiLan1.0ChiLan1.0
ANGPTL8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22016,142,133 - 16,156,840 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11915,140,826 - 15,155,531 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,787,457 - 10,790,090 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11911,498,069 - 11,500,400 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,498,069 - 11,500,400 (+)Ensemblpanpan1.1panPan2
Angptl8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,982,926 - 208,984,600 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,370,113 - 1,371,769 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,370,115 - 1,371,767 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANGPTL8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,952,581 - 69,954,220 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,951,556 - 69,954,223 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ANGPTL8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,169,733 - 10,172,433 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl610,170,052 - 10,173,005 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660749,713,854 - 9,716,184 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Angptl8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,092,739 - 3,099,120 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,092,673 - 3,094,919 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ANGPTL8
23 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 3 3
Low 5 3 1 3 1 2 3 6
Below cutoff 5 5 14 5 5 4 9 6 7

Sequence


RefSeq Acc Id: ENSCAFT00000027782   ⟹   ENSCAFP00000025832
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2050,040,383 - 50,042,031 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845037896   ⟹   ENSCAFP00845029695
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2050,561,284 - 50,562,932 (-)Ensembl
RefSeq Acc Id: XM_005632866   ⟹   XP_005632923
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12050,040,383 - 50,043,312 (-)NCBI
Dog10K_Boxer_Tasha2049,913,888 - 49,915,655 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038428584   ⟹   XP_038284512
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02050,561,284 - 50,563,051 (-)NCBI
RefSeq Acc Id: XM_038504223   ⟹   XP_038360151
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12049,771,477 - 49,773,244 (-)NCBI
RefSeq Acc Id: XM_038567250   ⟹   XP_038423178
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02050,441,068 - 50,442,835 (-)NCBI
RefSeq Acc Id: XM_038631400   ⟹   XP_038487328
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02050,198,362 - 50,200,129 (-)NCBI
RefSeq Acc Id: XP_005632923   ⟸   XM_005632866
- UniProtKB: A0A8C0JSB4 (UniProtKB/TrEMBL),   A0A8C0SV32 (UniProtKB/TrEMBL),   A0A8I3PGU9 (UniProtKB/TrEMBL),   A0A8C0P8M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000025832   ⟸   ENSCAFT00000027782
RefSeq Acc Id: XP_038360151   ⟸   XM_038504223
RefSeq Acc Id: XP_038487328   ⟸   XM_038631400
RefSeq Acc Id: XP_038284512   ⟸   XM_038428584
- UniProtKB: A0A8C0JSB4 (UniProtKB/TrEMBL),   A0A8C0SV32 (UniProtKB/TrEMBL),   A0A8I3PGU9 (UniProtKB/TrEMBL),   A0A8C0P8M0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038423178   ⟸   XM_038567250
- UniProtKB: A0A8C0JSB4 (UniProtKB/TrEMBL),   A0A8C0P8M0 (UniProtKB/TrEMBL),   A0A8C0SV32 (UniProtKB/TrEMBL),   A0A8I3PGU9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845029695   ⟸   ENSCAFT00845037896

Promoters
RGD ID:13687025
Promoter ID:EPDNEW_C5093
Type:single initiation site
Name:ANGPTL8_1
Description:angiopoietin like 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12050,042,048 - 50,042,108EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017534 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022122 UniProtKB/TrEMBL
  ENSCAFG00040016869 UniProtKB/TrEMBL
  ENSCAFG00845021478 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000027782.5 UniProtKB/TrEMBL
  ENSCAFT00030040628.1 UniProtKB/TrEMBL
  ENSCAFT00040031156.1 UniProtKB/TrEMBL
  ENSCAFT00845037896 ENTREZGENE
  ENSCAFT00845037896.1 UniProtKB/TrEMBL
InterPro ANGPTL8 UniProtKB/TrEMBL
KEGG Report cfa:102155149 UniProtKB/TrEMBL
NCBI Gene ANGPTL8 ENTREZGENE
PANTHER ANGIOPOIETIN-LIKE PROTEIN 8 UniProtKB/TrEMBL
  PTHR21463 UniProtKB/TrEMBL
UniProt A0A8C0JSB4 ENTREZGENE
  A0A8C0P8M0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SV32 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PGU9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:37864 ENTREZGENE