Gene:	Cd28 ( Rattus norvegicus ) Cd28 molecule
Description:	costimulatory molecule involved in induction of T cell proliferation and initiation of the Th2 response; may be important in maintanence of basal IgE production; binds to B7-1 or B7-2 on antigen presenting cells (APCs)
Synonyms:	CD28RNA; CD28 antigen;
ArrayIDs:	6046458; A_43_P11725; 5724798; 5721901; 1369865_at; A_44_P182276; 6682071; 6357359; X55288_at; GE20191; 5836649; 6085498;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Tspe1 - Trichinella spiralis expulsion QTL 1
primer pair:	635139
Homologs
Homo sapiens: CD28     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Cd28     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Cd28 genome assembly 3.1 9 59489254 - 59514725     RH 3.4 9 504.6     Rat Celera Assembly 9 59589124 - 59614592     RGSC genome assembly v3.4 9 59342273 - 59367743     Cytogenetic 9 q31 Mus musculus Cd28 Mouse genome assembly build 36.1 1 60803310 - 60830203     Cytogenetic 1 1 C1-C3 Homo sapiens CD28 human genome assembly 2 204396703 - 204428062     Human genome assembly build 36.2 2 204279443 - 204310801     Cytogenetic 2 q33   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Note Reference binds to B7-1 or B7-2 on Antigen Presenting Cells 634714 Gene Ontology coreceptor activity,  protein homodimerization activity (details...)
Biological Process	Note Reference involved in initiation of the Th2-response; may be required to maintain basal IgE production during mercuric chloride (HgCl2)-induced autoimmunity 634715 costimulatory molecule for T-cell proliferation, particularly during T-cell mediated allograft responses 634714 Gene Ontology positive regulation of isotype switching to IgG isotypes,  positive regulation of alpha-beta T cell proliferation,  immune response ...  (details...)
Cellular Component	Gene Ontology membrane raft,  membrane,  integral to membrane ...  (details...)
Disease	Ontology Diabetes Mellitus, Experimental,  Diabetic Angiopathies,  Lymphopenia ...  (details...)
External Links
Databases	DATABASE ID SOURCE SMART: IG IPI UNIPARC: UPI0000127345 IPI KEGG Report: rno:25660 ENTREZGENE HomoloGene Group ID: 4473 ENTREZGENE Germonline: 2299 Pfam: V-set IPI KEGG Pathway: 04514 ENTREZGENE KEGG Pathway: 05320 ENTREZGENE KEGG Pathway: 05330 ENTREZGENE KEGG Pathway: 05322 ENTREZGENE KEGG Pathway: 05332 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04940 ENTREZGENE InterPro: CD28. IPI InterPro: Ig_V-set. IPI InterPro: Ig_sub. IPI InterPro: Ig-like_fold. IPI IPI: IPI00208889 IPI Ensembl Protein: ENSRNOP00000013701 IPI Gene3D-CATH: Ig-like_fold IPI Entrez Gene: Cd28 ENTREZGENE UniProt: CD28_RAT IPI Ensembl Genes: ENSRNOG00000010283 IPI RatMap: 44397 ENTREZGENE PRINTS: CD28ANTIGEN. IPI
Sequences	Nucleotide: CH473965 Get FASTA Search GEO Profiles Nucleotide: NM_013121 Get FASTA Search GEO Profiles Nucleotide: X55288 Get FASTA Search GEO Profiles (View all 3 Nucleotide Accessions) Protein: NP_037253 Get FASTA Protein: CAA39003 Get FASTA Protein: P31042 Get FASTA Protein: EDL98926 Get FASTA (View all 4 Protein Accessions)
Clusters	UniGene: 10327
References
Curated References	20 references in RGD related to Cd28
Other References	13 other references at PubMed related to Cd28
Database Information
RGD ID	2299
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 27-JUN-08: Cd28 Cd28 molecule Cd28 CD28 antigen APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 10-JUN-02: Cd28 CD28 antigen APPROVED Symbol and Name status set to approved 70586