Cacna1c Rat Gene (calcium channel, voltage-dependent, L type, alpha 1C subunit)

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Keyword

Gene:
Cacna1c ( Rattus norvegicus )
calcium channel, voltage-dependent, L type, alpha 1C subunit
Description: subunit of an L-type calcium channel that may be involved in bone metabolism and compensatory renal growth
Synonyms: RATIVS302; Ca channel, voltage-dependent, L type, alpha 1c subunit; Ca channel voltage-dependent L type alpha 1c subunit; calcium channel, voltage-dependent, alpha 1C subunit;
ArrayIDs: 6422213; 1370451_a_at; 1370452_at; A_44_P132903; 6436581; 6303595; 6698809; M59786_at; U31815_s_at; 6460567; 6045398; 5954810; 6295460; 5946971; 5660396; 6231912; 5712911; 6437447; 5929983; 5974084; 6684796; 6157646; 5973537; 6042719; 6144174; 5905763; 6562559; 6291173; 6180955; 6353282; 6601562; M89924cds_s_at; 6162332; 5849884; 6149601; 6627210; 5984321; 6425719; 6489618; 6562217; 6105397; 6274881; 5696351; 6282398; 5718443; 6358786; 5956043; 6533747; 5619182; 6575154; 6746326; 6023993; 6090330; 6046115; 5972243; 6173865; 6312455; 5907539; 5863045; 6650441; 6398997; 6534834; 6712759; 6640986; 6253007;  (details...)
Gene Type: protein-coding

Additional Data

Candidate gene for: Coreg2 - Compensatory renal growth QTL 2

Markers: D4Arb4 D4Mgh30

Homologs
Homo sapiens: CACNA1C     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Cacna1c     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Cacna1c Rat Celera Assembly 4 140633057 - 141244304
RGSC genome assembly v3.4 4 154895691 - 155517389
Cytogenetic 4 q42
genome assembly 3.1 4 155140531 - 155762230
Mus musculus Cacna1c Mouse genome assembly build 36.1 6 118543910 - 119146249
Cytogenetic 6 6 F1
Homo sapiens CACNA1C human genome assembly 12 2032724 - 2672368
Human genome assembly build 36.2 12 2032725 - 2672369
Cytogenetic 12 p13.3

View comparative maps:      NCBI MapViewer

Genome
View:

Browsers:

Other Map Data:
Associated SSLP Map Locations
STS D4Arb4 Rat cytogenetic map 4
RGSC genome assembly v3.4 4 154937067 - 154937227
genome assembly 3.1 4 155181908 - 155182068
STS D4Mgh30 genome assembly 3.1 4 155181901 - 155182026
RH 3.4 4 971
Rat cytogenetic map 4
RGSC genome assembly v3.4 4 154937060 - 154937185
RH 2.0 4 962.7

Annotation
Molecular Function

Note Reference

subunit of an L-type Ca2+ channel 625474

Gene Ontology

voltage-gated calcium channel activity,  calmodulin binding,  protein domain specific binding ... (details...)
Biological Process

Note Reference

may mediate compensatory renal growth 61074

may be involved in the transduction of extracellular signals regulating bone metabolism 634679

Gene Ontology

cellular calcium ion homeostasis,  regulation of organ growth,  calcium ion-dependent exocytosis ... (details...)
Cellular Component

Gene Ontology

dendritic shaft,  cytoplasm,  integral to membrane ... (details...)
Disease

Ontology

Death, Sudden,  Syncope,  Arrhythmia (details...)
Expression

Note Reference

expressed in kidney proximal tubule epithelial cells 61074

expressed in osteoblasts 634679

Pathway

Ontology

insulin secretion pathway (details...)
Transcript structure

Note Reference

8.6 kb mRNA 634679

promoter region contains putative response elements for MEF-2, Nkx2.5, NFAT and CRE binding protein 1 625537

External Links
Databases
DATABASE ID SOURCE
UNIPARC: UPI000002A5A6 IPI
UNIPARC: UPI0001B7B890 IPI
UNIPARC: UPI00000E746D IPI
UNIPARC: UPI0001B7B892 IPI
UNIPARC: UPI0001B7BA1D IPI
UNIPARC: UPI0001B7B893 IPI
UNIPARC: UPI0000503352 IPI
UNIPARC: UPI000002A5A7 IPI
UNIPARC: UPI0001B7B891 IPI
UNIPARC: UPI000002A5A5 IPI
KEGG Report: rno:24239 ENTREZGENE
HomoloGene Group ID: 55484 ENTREZGENE
Germonline: 2245
Pfam: Ion_trans IPI
Pfam: Ca_chan_IQ IPI
KEGG Pathway: 04270 ENTREZGENE
KEGG Pathway: 04930 ENTREZGENE
KEGG Pathway: 04010 ENTREZGENE
KEGG Pathway: 04720 ENTREZGENE
KEGG Pathway: 05410 ENTREZGENE
KEGG Pathway: 04912 ENTREZGENE
KEGG Pathway: 04260 ENTREZGENE
KEGG Pathway: 04020 ENTREZGENE
KEGG Pathway: 05412 ENTREZGENE
KEGG Pathway: 05010 ENTREZGENE
InterPro: VDCCAlpha1. IPI
InterPro: VDCC_L_a1su. IPI
InterPro: VDCC_L_a1csu. IPI
InterPro: VDCC_a1su_IQ. IPI
InterPro: Ion_trans. IPI
IPI: IPI00948183 IPI
IPI: IPI00948521 IPI
IPI: IPI00392650 IPI
IPI: IPI00476009 IPI
IPI: IPI00558680 IPI
IPI: IPI00369400 IPI
IPI: IPI00551614 IPI
IPI: IPI00231323 IPI
IPI: IPI00950778 IPI
IPI: IPI00949968 IPI
Ensembl Protein: ENSRNOP00000063196 IPI
Ensembl Protein: ENSRNOP00000051397 IPI
Ensembl Protein: ENSRNOP00000048580 IPI
Ensembl Protein: ENSRNOP00000009268 IPI
Ensembl Protein: ENSRNOP00000048790 IPI
Ensembl Protein: ENSRNOP00000009343 IPI
Ensembl Protein: ENSRNOP00000040042 IPI
Entrez Gene: Cacna1c ENTREZGENE
UniProt: CAC1C_RAT IPI
UniProt: Q8VHT2_RAT IPI
UniProt: CAC1C_RAT IPI
UniProt: Q8VHT3_RAT IPI
UniProt: Q71QJ6_RAT IPI
UniProt: Q6PMH9_RAT IPI
UniProt: A0SLC4_RAT IPI
UniProt: A0PJ39_RAT IPI
UniProt: CAC1C_RAT IPI
UniProt: Q7TQ09_RAT IPI
UniProt: CAC1C_RAT IPI
UniProt: CAC1C_RAT IPI
Ensembl Genes: ENSRNOG00000007090 IPI
RatMap: 127 ENTREZGENE
PANTHER: LVDCCAlpha1C IPI
BIND: 130593
BIND: 128229
PRINTS: LVDCCALPHA1C. IPI
PRINTS: LVDCCALPHA1. IPI
PRINTS: CACHANNEL. IPI
Sequences
Nucleotide: U31815 Get FASTA Search GEO Profiles
Nucleotide: S80558 Get FASTA Search GEO Profiles
Nucleotide: M67516 Get FASTA Search GEO Profiles
Nucleotide: M67515 Get FASTA Search GEO Profiles
Nucleotide: M59786 Get FASTA Search GEO Profiles
Nucleotide: DQ538522 Get FASTA Search GEO Profiles
Nucleotide: AY974797 Get FASTA Search GEO Profiles
Nucleotide: AY323810 Get FASTA Search GEO Profiles
Nucleotide: AF394940 Get FASTA Search GEO Profiles
Nucleotide: AF394939 Get FASTA Search GEO Profiles
Nucleotide: AF394938 Get FASTA Search GEO Profiles
Nucleotide: M91242 Get FASTA Search GEO Profiles
Nucleotide: M91240 Get FASTA Search GEO Profiles
Nucleotide: M89924 Get FASTA Search GEO Profiles
Nucleotide: CH473964 Get FASTA Search GEO Profiles
Nucleotide: AY594691 Get FASTA Search GEO Profiles
Nucleotide: NM_012517 Get FASTA Search GEO Profiles
(View all 17 Nucleotide Accessions)
Protein: Q71QJ6 Get FASTA
Protein: Q8VHT3 Get FASTA
Protein: Q8VHT2 Get FASTA
Protein: Q7TQ09 Get FASTA
Protein: Q6PMH9 Get FASTA
Protein: P22002 Get FASTA
Protein: AAA89157 Get FASTA
Protein: AAB35528 Get FASTA
Protein: AAA42016 Get FASTA
Protein: AAA18905 Get FASTA
Protein: AAA85463 Get FASTA
Protein: ABF85689 Get FASTA
Protein: AAY42392 Get FASTA
Protein: AAP85532 Get FASTA
Protein: AAL47073 Get FASTA
Protein: AAL47072 Get FASTA
Protein: AAL47071 Get FASTA
Protein: AAA41460 Get FASTA
Protein: EDM02070 Get FASTA
Protein: EDM02069 Get FASTA
Protein: EDM02068 Get FASTA
Protein: EDM02067 Get FASTA
Protein: EDM02066 Get FASTA
Protein: EDM02065 Get FASTA
Protein: EDM02064 Get FASTA
Protein: EDM02063 Get FASTA
Protein: EDM02062 Get FASTA
Protein: AAT06090 Get FASTA
Protein: NP_036649 Get FASTA
(View all 29 Protein Accessions)
Clusters
UniGene: 9827

References
Curated References
23 references in RGD related to Cacna1c

Other References
61 other references at PubMed related to Cacna1c

Database Information
RGD ID 2245
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

10-SEP-04: Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit calcium channel, voltage-dependent, alpha 1C subunit APPROVED Name updated 1299863

06-NOV-02: Cacna1c calcium channel, voltage-dependent, alpha 1C subunit Ca channel, voltage-dependent, L type, alpha 1c subunit APPROVED Name updated 625702

10-JUN-02: Cacna1c Ca channel, voltage-dependent, L type, alpha 1c subunit APPROVED Symbol and Name status set to approved 70586