Ca3 (carbonic anhydrase 3) - Rat Genome Database

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Gene: Ca3 (carbonic anhydrase 3) Rattus norvegicus
Analyze
Symbol: Ca3 (Ensembl: Car3)
Name: carbonic anhydrase 3
RGD ID: 2241
Description: Enables phosphatase activity. Involved in several processes, including liver regeneration; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide; and negative regulation of reactive oxygen species biosynthetic process. Located in cytosol; nucleus; and sarcomere. Biomarker of lesion of sciatic nerve; metabolic dysfunction and alcohol associated liver disease; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human CA3 (carbonic anhydrase 3); INTERACTS WITH (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CA-III; Car3; carbonate dehydratase III; carbonic anhydrase III
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8288,491,666 - 88,501,299 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl288,491,670 - 88,500,524 (-)EnsemblGRCr8
mRatBN7.2286,770,418 - 86,780,011 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl286,770,420 - 86,784,280 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx293,090,323 - 93,098,286 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0291,211,325 - 91,219,288 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0286,268,152 - 86,276,115 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0288,126,519 - 88,136,063 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,126,667 - 88,135,410 (-)Ensemblrn6Rnor6.0
Rnor_5.02107,900,433 - 107,909,977 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4288,106,727 - 88,114,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera282,369,065 - 82,377,024 (-)NCBICelera
RGSC_v3.1288,050,843 - 88,059,683 (-)NCBI
Cytogenetic Map2q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-aminobenzotriazole  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-Hydroxythalidomide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetazolamide  (ISO)
acrylamide  (ISO)
Actein  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
brinzolamide  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium silicate  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
clofibrate  (EXP)
clothianidin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumarin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichlorine  (EXP)
diclofenac  (EXP,ISO)
diclofenamide  (ISO)
dimethylarsinic acid  (EXP,ISO)
diuron  (EXP)
doramapimod  (ISO)
dorsomorphin  (ISO)
dorzolamide hydrochloride  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP)
endosulfan  (EXP)
erianin  (ISO)
ethanol  (EXP)
ethoxzolamide  (ISO)
eugenol  (EXP)
flavonoids  (EXP)
fonofos  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (ISO)
glafenine  (EXP)
glucose  (ISO)
glyphosate  (EXP,ISO)
graphite  (ISO)
herbicide  (ISO)
hyaluronic acid  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP)
hydrogencarbonate  (ISO)
hydroquinone  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
iodide salt  (EXP)
L-cysteine  (ISO)
L-ethionine  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
mancozeb  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metacetamol  (EXP)
methapyrilene  (EXP)
Methazolamide  (ISO)
methimazole  (EXP)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel subsulfide  (EXP)
nicotine  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP)
potassium bromate  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
prontosil  (ISO)
propiconazole  (ISO)
quercetin  (EXP)
rac-1,2-dichloropropane  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
saccharin  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sulpiride  (ISO)
tamoxifen  (EXP,ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topiramate  (ISO)
topotecan  (EXP)
trabectedin  (EXP)
triazines  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
triticonazole  (EXP)
valdecoxib  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
vorinostat  (ISO)
XL147  (ISO)
zonisamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IBA,IDA,IEA,ISO)
nucleus  (IDA)
sarcomere  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Effects of leptin and insulin on CA III expression in rat adipose tissue. Alver A, etal., J Enzyme Inhib Med Chem. 2004 Jun;19(3):279-81. doi: 10.1080/14756360410001720445.
2. Proteomic identification of cytosolic proteins that undergo arginine methylation during rat liver regeneration. An S, etal., Electrophoresis. 2009 Jul;30(14):2412-21. doi: 10.1002/elps.200800772.
3. A proteomic analysis of liver after ethanol binge in chronically ethanol treated rats. Aroor AR, etal., Proteome Sci. 2012 Apr 30;10(1):29. doi: 10.1186/1477-5956-10-29.
4. Leakage of carbonic anhydrase III from normal and denervated rat skeletal muscle following contractile activity. Askmark H and Wistrand PJ, Muscle Nerve. 1992 Jun;15(6):643-7. doi: 10.1002/mus.880150602.
5. The phosphatase activity of carbonic anhydrase III is reversibly regulated by glutathiolation. Cabiscol E and Levine RL, Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4170-4.
6. Androgen-linked control of carbonic anhydrase III expression occurs in rat perivenous hepatocytes; an immunocytochemical study. Carter N, etal., Ups J Med Sci 2001;106(1):67-76.
7. Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury. Carter WG, etal., Biochem Biophys Res Commun. 2015 Mar 13;458(3):626-631. doi: 10.1016/j.bbrc.2015.01.158. Epub 2015 Feb 13.
8. Carbonic anhydrase III in skeletal muscle fibers: an immunocytochemical and biochemical study. Frémont P, etal., J Histochem Cytochem. 1988 Jul;36(7):775-82. doi: 10.1177/36.7.3133407.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Region- and cell-specific differences in the distribution of carbonic anhydrases II, III, XII, and XIV in the adult rat epididymis. Hermo L, etal., J Histochem Cytochem. 2005 Jun;53(6):699-713. doi: 10.1369/jhc.4A6575.2005.
11. Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3, 3',4,4',5-pentachlorobiphenyl. Ikeda M, etal., Arch Biochem Biophys 2000 Aug 1;380(1):159-64.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. Characterisation of cDNA clones for rat muscle carbonic anhydrase III. Kelly CD, etal., Biosci Rep 1988 Oct;8(5):401-6.
14. Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats. Kharbanda KK, etal., Biochem Biophys Res Commun. 2009 Apr 17;381(4):523-7. doi: 10.1016/j.bbrc.2009.02.082. Epub 2009 Feb 23.
15. Carbonic anhydrase III in obese Zucker rats. Lynch CJ, etal., Am J Physiol. 1993 Apr;264(4 Pt 1):E621-30. doi: 10.1152/ajpendo.1993.264.4.E621.
16. Putative effects of nerve extract on carbonic anhydrase III expression in rat muscles. Milot J, etal., Muscle Nerve. 1994 Dec;17(12):1431-8. doi: 10.1002/mus.880171212.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Carbonic anhydrase III protects cells from hydrogen peroxide-induced apoptosis. Räisänen SR, etal., FASEB J. 1999 Mar;13(3):513-22. doi: 10.1096/fasebj.13.3.513.
22. Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death. Silagi ES, etal., Sci Rep. 2018 Mar 20;8(1):4856. doi: 10.1038/s41598-018-23196-7.
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. Combined proteomic analysis of liver tissue and serum in chronically alcohol-fed rats. Yamada M, etal., Alcohol Clin Exp Res. 2013 Jan;37 Suppl 1:E79-87. doi: 10.1111/j.1530-0277.2012.01883.x. Epub 2012 Oct 19.
25. Carbonic anhydrase 3 increases during liver adipogenesis even in pre-obesity, and its inhibitors reduce liver adipose accumulation. Yamamoto H, etal., FEBS Open Bio. 2022 Apr;12(4):827-834. doi: 10.1002/2211-5463.13376. Epub 2022 Feb 10.
Additional References at PubMed
PMID:1899179   PMID:9020864   PMID:11024467   PMID:12602780   PMID:15449734   PMID:15489334   PMID:15930751   PMID:15998239   PMID:18756007   PMID:20015077   PMID:21551946   PMID:23012479  
PMID:24789143   PMID:28983629   PMID:34387844  


Genomics

Comparative Map Data
Ca3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8288,491,666 - 88,501,299 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl288,491,670 - 88,500,524 (-)EnsemblGRCr8
mRatBN7.2286,770,418 - 86,780,011 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl286,770,420 - 86,784,280 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx293,090,323 - 93,098,286 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0291,211,325 - 91,219,288 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0286,268,152 - 86,276,115 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0288,126,519 - 88,136,063 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,126,667 - 88,135,410 (-)Ensemblrn6Rnor6.0
Rnor_5.02107,900,433 - 107,909,977 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4288,106,727 - 88,114,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera282,369,065 - 82,377,024 (-)NCBICelera
RGSC_v3.1288,050,843 - 88,059,683 (-)NCBI
Cytogenetic Map2q23NCBI
CA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38885,438,859 - 85,449,040 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl885,373,436 - 85,449,040 (+)Ensemblhg38GRCh38
GRCh37886,351,088 - 86,361,269 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36886,537,710 - 86,548,526 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34886,537,709 - 86,548,526NCBI
Celera882,356,136 - 82,366,348 (+)NCBICelera
Cytogenetic Map8q21.2NCBI
HuRef881,845,249 - 81,855,461 (+)NCBIHuRef
CHM1_1886,402,742 - 86,412,955 (+)NCBICHM1_1
T2T-CHM13v2.0885,877,589 - 85,887,769 (+)NCBIT2T-CHM13v2.0
Car3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39314,928,598 - 14,937,441 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl314,928,572 - 14,937,583 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38314,863,538 - 14,872,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl314,863,512 - 14,872,523 (+)Ensemblmm10GRCm38
MGSCv37314,863,538 - 14,872,381 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36314,840,282 - 14,849,125 (+)NCBIMGSCv36mm8
Celera314,876,182 - 14,885,071 (+)NCBICelera
Cytogenetic Map3A1NCBI
cM Map33.22NCBI
Ca3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554173,362,492 - 3,372,932 (+)Ensembl
ChiLan1.0NW_0049554173,362,091 - 3,372,270 (+)NCBIChiLan1.0ChiLan1.0
CA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27101,105,573 - 101,186,789 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1876,738,248 - 76,819,477 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0881,965,041 - 81,976,133 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1883,574,931 - 83,585,737 (+)NCBIPanPan1.1PanPan1.1panPan2
CA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12931,935,192 - 31,945,585 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2931,935,172 - 31,980,579 (+)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.02932,083,862 - 32,094,321 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2932,083,849 - 32,094,327 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12932,135,278 - 32,145,713 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02932,156,474 - 32,166,928 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02932,543,269 - 32,553,756 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ca3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530347,444,945 - 47,454,991 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936544337,382 - 348,462 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936544337,437 - 347,760 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl451,227,485 - 51,237,844 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1451,227,485 - 51,237,861 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2456,190,405 - 56,200,779 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1880,805,296 - 80,816,127 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl880,805,134 - 80,816,190 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603960,283,705 - 60,322,506 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ca3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247446,199,382 - 6,212,163 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247446,202,151 - 6,211,662 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ca3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13157,388,752 - 157,398,163 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ca3
55 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:69
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000014180
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)261556902106556902Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)278269809104744824Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)261051541105724065Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)261051883104684275Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)261051541105724065Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260861391105861391Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
RH127589  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8288,491,729 - 88,491,912 (+)Marker Load Pipeline
mRatBN7.2286,770,483 - 86,770,666 (+)MAPPERmRatBN7.2
Rnor_6.0288,126,583 - 88,126,765NCBIRnor6.0
Rnor_5.02107,900,497 - 107,900,679UniSTSRnor5.0
RGSC_v3.4288,105,942 - 88,106,124UniSTSRGSC3.4
Celera282,368,280 - 82,368,462UniSTS
RH 3.4 Map2533.9UniSTS
Cytogenetic Map2q23UniSTS
RH129349  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8288,491,695 - 88,491,907 (+)Marker Load Pipeline
mRatBN7.2286,770,449 - 86,770,661 (+)MAPPERmRatBN7.2
Rnor_6.0288,126,549 - 88,126,760NCBIRnor6.0
Rnor_5.02107,900,463 - 107,900,674UniSTSRnor5.0
RGSC_v3.4288,105,908 - 88,106,119UniSTSRGSC3.4
Celera282,368,246 - 82,368,457UniSTS
RH 3.4 Map2533.1UniSTS
Cytogenetic Map2q23UniSTS
UniSTS:498421  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2286,780,677 - 86,780,760 (+)MAPPERmRatBN7.2
Rnor_6.0288,136,778 - 88,136,860NCBIRnor6.0
Rnor_5.02107,910,692 - 107,910,774UniSTSRnor5.0
RGSC_v3.4288,116,137 - 88,116,219UniSTSRGSC3.4
Celera282,378,475 - 82,378,557UniSTS
Cytogenetic Map2q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 63 122 91 90 59 46 59 6 305 142 11 100 80 88 31 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB030829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB030830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB170009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF037072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M22413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000014180   ⟹   ENSRNOP00000014177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl288,491,670 - 88,500,509 (-)Ensembl
mRatBN7.2 Ensembl286,770,420 - 86,779,274 (-)Ensembl
Rnor_6.0 Ensembl288,126,667 - 88,135,410 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105296   ⟹   ENSRNOP00000083954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl288,492,399 - 88,500,524 (-)Ensembl
mRatBN7.2 Ensembl286,770,420 - 86,784,280 (-)Ensembl
RefSeq Acc Id: NM_019292   ⟹   NP_062165
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8288,492,515 - 88,500,474 (-)NCBI
mRatBN7.2286,771,269 - 86,779,227 (-)NCBI
Rnor_6.0288,127,368 - 88,135,327 (-)NCBI
Rnor_5.02107,900,433 - 107,909,977 (-)NCBI
RGSC_v3.4288,106,727 - 88,114,686 (-)RGD
Celera282,369,065 - 82,377,024 (-)RGD
Sequence:
RefSeq Acc Id: XM_006232116   ⟹   XP_006232178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8288,491,666 - 88,501,299 (-)NCBI
mRatBN7.2286,770,418 - 86,780,011 (-)NCBI
Rnor_6.0288,126,519 - 88,136,063 (-)NCBI
Rnor_5.02107,900,433 - 107,909,977 (-)NCBI
Sequence:
RefSeq Acc Id: NP_062165   ⟸   NM_019292
- UniProtKB: O54961 (UniProtKB/Swiss-Prot),   Q9QV77 (UniProtKB/Swiss-Prot),   P14141 (UniProtKB/Swiss-Prot),   A6IH11 (UniProtKB/TrEMBL),   A0A8L2Q6S9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232178   ⟸   XM_006232116
- Peptide Label: isoform X1
- UniProtKB: O54961 (UniProtKB/Swiss-Prot),   Q9QV77 (UniProtKB/Swiss-Prot),   P14141 (UniProtKB/Swiss-Prot),   A6IH11 (UniProtKB/TrEMBL),   A0A8L2Q6S9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014177   ⟸   ENSRNOT00000014180
Ensembl Acc Id: ENSRNOP00000083954   ⟸   ENSRNOT00000105296
Protein Domains
Alpha-carbonic anhydrase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14141-F1-model_v2 AlphaFold P14141 1-260 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691220
Promoter ID:EPDNEW_R1745
Type:multiple initiation site
Name:Car3_1
Description:carbonic anhydrase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0288,135,374 - 88,135,434EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2241 AgrOrtholog
BioCyc Gene G2FUF-53808 BioCyc
Ensembl Genes ENSRNOG00000010079 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014180 ENTREZGENE
  ENSRNOT00000105296.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5597975 IMAGE-MGC_LOAD
InterPro CA_dom UniProtKB/Swiss-Prot
  CA_dom_sf UniProtKB/Swiss-Prot
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot
  Carbonic_anhydrase_a-class_CS UniProtKB/Swiss-Prot
KEGG Report rno:54232 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72261 IMAGE-MGC_LOAD
NCBI Gene 54232 ENTREZGENE
PANTHER PTHR18952 UniProtKB/Swiss-Prot
  PTHR18952:SF127 UniProtKB/Swiss-Prot
Pfam Carb_anhydrase UniProtKB/Swiss-Prot
PharmGKB CA3 RGD
PhenoGen Ca3 PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/Swiss-Prot
  ALPHA_CA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010079 RatGTEx
SMART Carb_anhydrase UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot
UniProt A0A8L2Q6S9 ENTREZGENE, UniProtKB/TrEMBL
  A6IH11 ENTREZGENE, UniProtKB/TrEMBL
  A6IH12_RAT UniProtKB/TrEMBL
  CAH3_RAT UniProtKB/Swiss-Prot
  O54961 ENTREZGENE
  P14141 ENTREZGENE
  Q9QV77 ENTREZGENE
UniProt Secondary O54961 UniProtKB/Swiss-Prot
  Q9QV77 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-04-28 Ca3  carbonic anhydrase 3  Car3  carbonic anhydrase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-04-18 Car3  carbonic anhydrase 3  Ca3  carbonic anhydrase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-16 Ca3  carbonic anhydrase 3  Car3  carbonic anhydrase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Car3  carbonic anhydrase 3  Ca3  carbonic anhydrase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ca3  carbonic anhydrase 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 634676
gene_process may play a role in a defense system for oxidative stress 634677
gene_regulation expression is regulated by testosterone in the male 634676