C5 (complement C5) - Rat Genome Database

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Gene: C5 (complement C5) Rattus norvegicus
Analyze
Symbol: C5
Name: complement C5
RGD ID: 2237
Description: Enables C5a anaphylatoxin chemotactic receptor binding activity. Involved in several processes, including intracellular calcium ion homeostasis; leukocyte migration involved in inflammatory response; and negative regulation of catecholamine secretion. Located in extracellular space. Used to study adult respiratory distress syndrome; asthma; and neutropenia. Biomarker of brain edema and fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in several diseases, including complement component 5 deficiency; liver cirrhosis; neutropenia; paroxysmal nocturnal hemoglobinuria; and pneumonia. Orthologous to human C5 (complement C5); PARTICIPATES IN coagulation cascade pathway; complement system pathway; prion disease pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: anaphylatoxin; C5a; complement component 5; Hc; RGD1561905
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Cia11
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8338,668,174 - 38,759,468 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl338,668,174 - 38,759,468 (-)EnsemblGRCr8
mRatBN7.2318,270,696 - 18,361,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,270,696 - 18,361,994 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx321,338,177 - 21,436,625 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0329,923,207 - 30,021,653 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0328,177,076 - 28,275,525 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0314,049,993 - 14,113,931 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0314,206,466 - 14,229,141 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,049,995 - 14,229,080 (-)Ensemblrn6Rnor6.0
Rnor_5.0319,525,468 - 19,547,636 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0319,369,981 - 19,432,948 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4314,011,115 - 14,102,744 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera312,987,748 - 13,080,508 (-)NCBICelera
RGSC_v3.1313,962,273 - 13,963,756 (-)NCBI
Cytogenetic Map3p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
Actein  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chondroitin sulfate  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cytochalasin B  (ISO)
D-glucose  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dithionite(2-)  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylene glycol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenthion  (ISO)
flutamide  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
glafenine  (EXP)
glucose  (ISO)
glutathione  (EXP)
GSK-J4  (ISO)
heparin  (ISO)
herbicide  (ISO)
hexadecanoic acid  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
leukotriene B4  (ISO)
levofloxacin  (EXP)
manganese(II) chloride  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N,N-dimethylsphingosine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parthenolide  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
picoxystrobin  (ISO)
pifithrin-alpha hydrobromide  (EXP)
pirinixic acid  (ISO)
poly(styrene)  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
tributylstannane  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Contribution of anaphylatoxin C5a to late airway responses after repeated exposure of antigen to allergic rats. Abe M, etal., J Immunol. 2001 Oct 15;167(8):4651-60.
2. cDNA cloning and characterization of rat C5a anaphylatoxin receptor. Akatsu H, etal., Microbiol Immunol 1997;41(7):575-80.
3. Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Arumugam TV, etal., J Hepatol. 2004 Jun;40(6):934-41.
4. Complement factor C5a exerts an anti-inflammatory effect in acute pancreatitis and associated lung injury. Bhatia M, etal., Am J Physiol Gastrointest Liver Physiol. 2001 May;280(5):G974-8.
5. Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H. Bora NS, etal., J Immunol. 2006 Aug 1;177(3):1872-8.
6. Correlation of plasma complement split product levels with allergic respiratory disease activity and relation to allergen immunotherapy. Bowser C, etal., Ann Allergy Asthma Immunol. 2010 Jan;104(1):42-9.
7. Increased activation of the alternative complement pathway in sickle cell disease. Chudwin DS, etal., Clin Immunol Immunopathol. 1985 Oct;37(1):93-7.
8. Complement activation in patients with COVID-19: A novel therapeutic target. Cugno M, etal., J Allergy Clin Immunol. 2020 May 14. pii: S0091-6749(20)30650-3. doi: 10.1016/j.jaci.2020.05.006.
9. Primary structure and functional characterization of rat C5a: an anaphylatoxin with unusually high potency. Cui L, etal., Protein Sci. 1994 Aug;3(8):1169-77.
10. Expression of a functional C5a receptor in regenerating hepatocytes and its involvement in a proliferative signaling pathway in rat. Daveau M, etal., J Immunol. 2004 Sep 1;173(5):3418-24.
11. Role of IgG and complement component C5 in the initial course of experimental cryptococcosis. Dromer F, etal., Clin Exp Immunol. 1989 Dec;78(3):412-7.
12. Complement activation in cystic fibrosis respiratory fluids: in vivo and in vitro generation of C5a and chemotactic activity. Fick RB Jr, etal., Pediatr Res. 1986 Dec;20(12):1258-68.
13. The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. Flierl MA, etal., PLoS One. 2008 Jul 2;3(7):e2560.
14. Induction of acute pulmonary inflammation. A differential effect of C5 and the 200,000 molecular weight form of trypsin-activated C5 (C5'). Fowler SR, etal., Am Rev Respir Dis. 1987 Sep;136(3):691-7.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
17. Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. Hasegawa K, etal., Hum Genet. 2004 Sep;115(4):295-301.
18. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Hillebrandt S, etal., Nat Genet. 2005 Aug;37(8):835-43. Epub 2005 Jul 3.
19. Oxidative stress in lymphoid tissues and complement activation in alcoholic mother rats and their newborns. Ince E, etal., Gen Physiol Biophys. 2019 Jan;38(1):91-100. doi: 10.4149/gpb_2018018. Epub 2019 Jan 18.
20. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Karp CL, etal., Nat Immunol. 2000 Sep;1(3):221-6.
21. Renal C3 complement component: feed forward to diabetic kidney disease. Kelly KJ, etal., Am J Nephrol. 2015;41(1):48-56. doi: 10.1159/000371426. Epub 2015 Jan 30.
22. The role of C5a in the development of thrombotic glomerulonephritis in rats. Kondo C, etal., Clin Exp Immunol. 2001 May;124(2):323-9.
23. Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Lajoie S, etal., Nat Immunol. 2010 Oct;11(10):928-35. Epub 2010 Aug 29.
24. Accentuated formation of the terminal C5b-9 complement complex in patient plasma precedes development of the adult respiratory distress syndrome. Langlois PF and Gawryl MS, Am Rev Respir Dis. 1988 Aug;138(2):368-75.
25. Complement factor C5a in acute exacerbation of Chronic Obstructive Pulmonary Disease. Marc MM, etal., Scand J Immunol. 2010 May;71(5):386-91.
26. C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression. Melendi GA, etal., J Virol. 2007 Jan;81(2):991-9. Epub 2006 Nov 1.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Requirement and role of C5a in acute lung inflammatory injury in rats. Mulligan MS, etal., J Clin Invest. 1996 Jul 15;98(2):503-12.
29. A recombinant vaccine effectively induces c5a-specific neutralizing antibodies and prevents arthritis. Nandakumar KS, etal., PLoS One. 2010 Oct 20;5(10):e13511.
30. The membrane attack complex of complement induces caspase activation and apoptosis. Nauta AJ, etal., Eur J Immunol 2002 Mar;32(3):783-92.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
33. Chemotactic mediator requirements in lung injury following skin burns in rats. Piccolo MT, etal., Exp Mol Pathol. 1999 Aug;66(3):220-6.
34. Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia. Pierangeli SS, etal., Arthritis Rheum. 2005 Jul;52(7):2120-4.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. GOA pipeline RGD automated data pipeline
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. FcgammaRIII is protective against Pseudomonas aeruginosa pneumonia. Rhein LM, etal., Am J Respir Cell Mol Biol. 2008 Apr;38(4):401-6. Epub 2007 Nov 1.
40. Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. Riedemann NC, etal., FASEB J. 2004 Feb;18(2):370-2. Epub 2003 Dec 19.
41. Expression and function of the C5a receptor in rat alveolar epithelial cells. Riedemann NC, etal., J Immunol 2002 Feb 15;168(4):1919-25.
42. Activation of the complement system in the adult respiratory distress syndrome. Robbins RA, etal., Am Rev Respir Dis. 1987 Mar;135(3):651-8.
43. Nucleotide and corrected amino acid sequence of the functional recombinant rat anaphylatoxin C5a. Rothermel E, etal., Biochim Biophys Acta 1997 Mar 20;1351(1-2):9-12.
44. Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia. Rubins JB, etal., J Clin Invest. 1995 Jan;95(1):142-50.
45. Increase by anaphylatoxin C5a of glucose output in perfused rat liver via prostanoids derived from nonparenchymal cells: direct action of prostaglandins and indirect action of thromboxane A(2) on hepatocytes. Schieferdecker HL, etal., Hepatology. 1999 Aug;30(2):454-61.
46. Differential expression of the C5a receptor on the main cell types of rat liver as demonstrated with a novel monoclonal antibody and by C5a anaphylatoxin-induced Ca2+ release. Schlaf G, etal., Lab Invest. 1999 Oct;79(10):1287-97.
47. Neutrophil chemotactic activity and C5a following systemic activation of complement in rats. Schmid E, etal., Inflammation. 1997 Jun;21(3):325-33.
48. Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat. Short A, etal., Br J Pharmacol. 1999 Feb;126(3):551-4.
49. Response-selective C5a agonists: differential effects on neutropenia and hypotension in the rat. Short AJ, etal., Br J Pharmacol. 1999 Oct;128(3):511-4.
50. A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats. Strachan AJ, etal., J Immunol. 2000 Jun 15;164(12):6560-5.
51. Protective effect of C5 shRNA on myocardial ischemia-reperfusion injury in rats. Tang K, etal., Can J Physiol Pharmacol. 2012 Oct;90(10):1394-402. doi: 10.1139/y2012-114. Epub 2012 Oct 15.
52. Mediators of lung injury in mice following systemic activation of complement. Tvedten HW, etal., Am J Pathol. 1985 Apr;119(1):92-100.
53. Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti-C5 therapy. Vakeva AP, etal., Circulation. 1998 Jun 9;97(22):2259-67.
54. Circulating immune complexes and complement levels in hemophilic children. Verroust F, etal., J Clin Lab Immunol. 1981 Sep;6(2):127-30.
55. Physical mapping of the major histocompatibility complex class II and class III regions of the rat. Walter L, etal., Immunogenetics 2002 Jul;54(4):268-75. Epub 2002 Jun 14.
56. Specific detection by flow cytometry of histidine-tagged ligands bound to their receptors using a tag-specific monoclonal antibody. Wilken HC, etal., J Immunol Methods. 1999 Jun 24;226(1-2):139-45.
57. Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat. Woodruff TM, etal., Arthritis Rheum. 2002 Sep;46(9):2476-85.
58. Systemic complement depletion diminishes perihematomal brain edema in rats. Xi G, etal., Stroke. 2001 Jan;32(1):162-7.
Additional References at PubMed
PMID:11877299   PMID:12218141   PMID:12637249   PMID:14566334   PMID:14732352   PMID:16452172   PMID:16769899   PMID:16780818   PMID:17068344   PMID:17389734   PMID:17621257   PMID:17703884  
PMID:18084313   PMID:18178252   PMID:18947875   PMID:19056867   PMID:19196477   PMID:19285573   PMID:21148255   PMID:22537900   PMID:22832194   PMID:23237573   PMID:23533145   PMID:24344329  
PMID:25385326   PMID:27437704   PMID:29956782   PMID:30092352   PMID:31624141   PMID:32567007   PMID:36251578   PMID:38326494  


Genomics

Comparative Map Data
C5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8338,668,174 - 38,759,468 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl338,668,174 - 38,759,468 (-)EnsemblGRCr8
mRatBN7.2318,270,696 - 18,361,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,270,696 - 18,361,994 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx321,338,177 - 21,436,625 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0329,923,207 - 30,021,653 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0328,177,076 - 28,275,525 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0314,049,993 - 14,113,931 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0314,206,466 - 14,229,141 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,049,995 - 14,229,080 (-)Ensemblrn6Rnor6.0
Rnor_5.0319,525,468 - 19,547,636 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0319,369,981 - 19,432,948 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4314,011,115 - 14,102,744 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera312,987,748 - 13,080,508 (-)NCBICelera
RGSC_v3.1313,962,273 - 13,963,756 (-)NCBI
Cytogenetic Map3p11NCBI
C5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389120,952,335 - 121,074,865 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9120,932,987 - 121,075,195 (-)Ensemblhg38GRCh38
GRCh379123,714,613 - 123,837,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369122,754,434 - 122,852,375 (-)NCBIBuild 36Build 36hg18NCBI36
Build 349120,794,168 - 120,892,108NCBI
Celera994,363,035 - 94,461,011 (-)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef993,332,095 - 93,430,452 (-)NCBIHuRef
CHM1_19123,861,740 - 123,959,592 (-)NCBICHM1_1
T2T-CHM13v2.09133,148,474 - 133,270,972 (-)NCBIT2T-CHM13v2.0
Hc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39234,873,341 - 34,958,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl234,873,343 - 34,951,450 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38234,983,329 - 35,068,506 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl234,983,331 - 35,061,438 (-)Ensemblmm10GRCm38
MGSCv37234,838,851 - 34,916,961 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36234,805,340 - 34,883,405 (-)NCBIMGSCv36mm8
Celera234,677,654 - 34,755,968 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map223.22NCBI
C5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21118,270,718 - 18,393,732 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1918,273,303 - 18,396,082 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0992,069,574 - 92,202,513 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19120,416,256 - 120,548,366 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9120,426,354 - 120,523,856 (-)EnsemblpanPan2panpan1.1
C5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11173,953,727 - 74,029,919 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1173,953,727 - 74,029,851 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1172,364,536 - 72,439,848 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01175,089,862 - 75,165,511 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1175,089,988 - 75,165,437 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11173,598,023 - 73,673,494 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01173,629,460 - 73,704,118 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01174,367,743 - 74,443,207 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
C5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947189,622,879 - 189,804,753 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364879,391,804 - 9,474,159 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364879,391,774 - 9,474,168 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,995,668 - 261,133,483 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11260,995,662 - 261,088,868 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21293,077,418 - 293,163,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q2.13NCBI
C5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11218,525,855 - 18,624,048 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1218,525,880 - 18,623,636 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603524,390,627 - 24,506,352 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15586,299 - 670,215 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in C5
709 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:47
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000025534
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
11528620Bss113Bone structure and strength QTL 1139.752e-10femur morphology trait (VT:0000559)femoral neck width (CMO:0001695)33688834239639105Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)33777225855937853Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)33779691953640235Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33870893167641995Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33870893167641995Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33870893167641995Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)33870893167641995Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33870893167641995Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33870893167641995Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893167641995Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)33779691947904329Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)33779691959119581Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
D3Rat52  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8338,708,931 - 38,709,087 (+)Marker Load Pipeline
mRatBN7.2318,311,454 - 18,311,610 (+)MAPPERmRatBN7.2
Rnor_6.0314,090,411 - 14,090,566NCBIRnor6.0
Rnor_5.0319,410,399 - 19,410,554UniSTSRnor5.0
RGSC_v3.4314,051,873 - 14,052,028UniSTSRGSC3.4
RGSC_v3.4314,051,872 - 14,052,028RGDRGSC3.4
Celera313,028,531 - 13,028,700UniSTS
RGSC_v3.1313,948,245 - 13,948,400RGD
RH 3.4 Map3157.8RGD
RH 3.4 Map3157.8UniSTS
RH 2.0 Map347.5RGD
SHRSP x BN Map34.6298RGD
Cytogenetic Map3p11UniSTS
D3Cebr7  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8338,675,635 - 38,675,846 (+)Marker Load Pipeline
mRatBN7.2318,278,158 - 18,278,369 (+)MAPPERmRatBN7.2
Rnor_6.0314,057,455 - 14,057,665NCBIRnor6.0
Rnor_5.0319,377,443 - 19,377,653UniSTSRnor5.0
RGSC_v3.4314,018,577 - 14,018,787UniSTSRGSC3.4
Celera312,995,210 - 12,995,413UniSTS
Cytogenetic Map3p11UniSTS
RH143462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,357,646 - 18,357,794 (+)MAPPERmRatBN7.2
Rnor_6.0314,224,793 - 14,224,940NCBIRnor6.0
Rnor_5.0319,543,310 - 19,543,457UniSTSRnor5.0
RGSC_v3.4314,098,470 - 14,098,617UniSTSRGSC3.4
Celera313,076,161 - 13,076,308UniSTS
RH 3.4 Map3164.3UniSTS
Cytogenetic Map3p11UniSTS
RH131515  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,326,070 - 18,326,264 (+)MAPPERmRatBN7.2
Rnor_6.0314,105,149 - 14,105,342NCBIRnor6.0
Rnor_5.0319,425,137 - 19,425,330UniSTSRnor5.0
RGSC_v3.4314,067,044 - 14,067,237UniSTSRGSC3.4
Celera313,044,868 - 13,045,061UniSTS
RH 3.4 Map3161.8UniSTS
Cytogenetic Map3p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 10 37 144 91 90 59 75 59 6 302 141 11 117 81 84 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000025534   ⟹   ENSRNOP00000025534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl338,668,174 - 38,759,468 (-)Ensembl
mRatBN7.2 Ensembl318,270,696 - 18,361,994 (-)Ensembl
Rnor_6.0 Ensembl314,050,357 - 14,229,067 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092736   ⟹   ENSRNOP00000076004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl314,049,995 - 14,112,851 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092865   ⟹   ENSRNOP00000075982
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl314,207,044 - 14,229,080 (-)Ensembl
RefSeq Acc Id: NM_053020   ⟹   NP_444179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8338,668,174 - 38,759,468 (-)NCBI
mRatBN7.2318,270,696 - 18,361,994 (-)NCBI
Protein Sequences
Protein RefSeqs NP_444179 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA62994 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025534
GenBank Protein P08650 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000076004   ⟸   ENSRNOT00000092736
Ensembl Acc Id: ENSRNOP00000075982   ⟸   ENSRNOT00000092865
Ensembl Acc Id: ENSRNOP00000025534   ⟸   ENSRNOT00000025534
RefSeq Acc Id: NP_444179   ⟸   NM_053020
- Peptide Label: precursor
- UniProtKB: Q63078 (UniProtKB/Swiss-Prot),   P08650 (UniProtKB/Swiss-Prot),   A0A096P6L9 (UniProtKB/Swiss-Prot),   A0A8I5ZDN9 (UniProtKB/TrEMBL)
Protein Domains
Anaphylatoxin-like   NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08650-F1-model_v2 AlphaFold P08650 1-1681 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692014
Promoter ID:EPDNEW_R2538
Type:initiation region
Name:C5_1
Description:complement C5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0314,229,122 - 14,229,182EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2237 AgrOrtholog
BioCyc Gene G2FUF-50067 BioCyc
Ensembl Genes ENSRNOG00000018899 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000025534 ENTREZGENE
Gene3D-CATH 1.50.10.20 UniProtKB/Swiss-Prot
  2.20.130.20 UniProtKB/Swiss-Prot
  2.40.50.120 UniProtKB/Swiss-Prot
  2.60.120.1540 UniProtKB/Swiss-Prot
  2.60.40.10 UniProtKB/Swiss-Prot
  2.60.40.1930 UniProtKB/Swiss-Prot
  2.60.40.1940 UniProtKB/Swiss-Prot
  2.60.40.690 UniProtKB/Swiss-Prot
  6.20.50.160 UniProtKB/Swiss-Prot
  Anaphylotoxins (complement system) UniProtKB/Swiss-Prot
InterPro A-macroglobulin_rcpt-bd UniProtKB/Swiss-Prot
  A-macroglobulin_rcpt-bd_sf UniProtKB/Swiss-Prot
  A2M/Complement_sys UniProtKB/Swiss-Prot
  A2M_N_BRD UniProtKB/Swiss-Prot
  Alpha-macroglobulin_TED UniProtKB/Swiss-Prot
  Anaphylatoxin/fibulin UniProtKB/Swiss-Prot
  Anaphylatoxin_comp_syst UniProtKB/Swiss-Prot
  C3/4/5_MG1 UniProtKB/Swiss-Prot
  C5_CUB UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Macroglobln_a2 UniProtKB/Swiss-Prot
  MG2 UniProtKB/Swiss-Prot
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  Netrin_domain UniProtKB/Swiss-Prot
  Netrin_module_non-TIMP UniProtKB/Swiss-Prot
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot
  TIMP-like_OB-fold UniProtKB/Swiss-Prot
NCBI Gene C5 ENTREZGENE
PANTHER MACROGLOBULIN / COMPLEMENT UniProtKB/Swiss-Prot
  PTHR11412:SF83 UniProtKB/Swiss-Prot
Pfam A2M UniProtKB/Swiss-Prot
  A2M_BRD UniProtKB/Swiss-Prot
  A2M_recep UniProtKB/Swiss-Prot
  ANATO UniProtKB/Swiss-Prot
  C5_CUB UniProtKB/Swiss-Prot
  MG1 UniProtKB/Swiss-Prot
  MG2 UniProtKB/Swiss-Prot
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  NTR UniProtKB/Swiss-Prot
  TED_complement UniProtKB/Swiss-Prot
PhenoGen C5 PhenoGen
PROSITE ANAPHYLATOXIN_1 UniProtKB/Swiss-Prot
  ANAPHYLATOXIN_2 UniProtKB/Swiss-Prot
  NTR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018899 RatGTEx
SMART A2M UniProtKB/Swiss-Prot
  A2M_N_2 UniProtKB/Swiss-Prot
  A2M_recep UniProtKB/Swiss-Prot
  ANATO UniProtKB/Swiss-Prot
  C345C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47686 UniProtKB/Swiss-Prot
  SSF48239 UniProtKB/Swiss-Prot
  SSF49410 UniProtKB/Swiss-Prot
  SSF50242 UniProtKB/Swiss-Prot
UniProt A0A096P6L9 ENTREZGENE
  A0A8I5ZDN9 ENTREZGENE, UniProtKB/TrEMBL
  CO5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63078 ENTREZGENE
UniProt Secondary A0A096P6L9 UniProtKB/Swiss-Prot
  Q63078 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 C5  complement C5  C5  complement component 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 C5  Complement component 5      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds to alveolar epithelial cells 61066
gene_function binds to alveolar epithelial cells 70320
gene_process enhances inflamatory response in lung by increasing expression of C5a receptor and pro-inflamatory mediators 61066
gene_process enhances inflamatory response in lung by increasing expression of C5a receptor and pro-inflamatory mediators 70320
gene_regulation binding to alveolar epithelial cells is increased by LPS, Il-6, and Tnf 61066
gene_regulation binding to alveolar epithelial cells is increased by LPS, Il-6, and Tnf 70320