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Gene: Bckdk (branched chain ketoacid dehydrogenase kinase) Rattus norvegicus

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Symbol:

Bckdk

Name:

branched chain ketoacid dehydrogenase kinase

RGD ID:

2198

Description:

Enables ATP binding activity and [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity. Involved in branched-chain amino acid catabolic process; phosphorylation; and spermatogenesis. Part of oxoglutarate dehydrogenase complex. Used to study branched-chain keto acid dehydrogenase kinase deficiency and oligospermia. Human ortholog(s) of this gene implicated in branched-chain keto acid dehydrogenase kinase deficiency. Orthologous to human BCKDK (branched chain keto acid dehydrogenase kinase); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; BCKD-kinase; BCKDH kinase; BCKDHKIN; BDK; branched chain keto acid dehydrogenase kinase; branched-chain alpha-ketoacid dehydrogenase kinase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	191,945,809 - 191,950,480 (+)	NCBI		GRCr8
mRatBN7.2	1	182,515,335 - 182,520,007 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	182,515,327 - 182,536,633 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	190,865,878 - 190,870,549 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	198,051,970 - 198,056,641 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	190,722,400 - 190,727,069 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	199,351,628 - 199,356,299 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	199,351,628 - 199,356,881 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	206,374,221 - 206,378,892 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	187,189,665 - 187,194,336 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	187,340,263 - 187,344,799 (+)	NCBI
Celera	1	180,166,156 - 180,170,827 (+)	NCBI		Celera
Cytogenetic Map	1	q37	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Bckdk	Rat	branched-chain keto acid dehydrogenase kinase deficiency		IAGP		39131293	DNA:missense mutation:cds:G369E (rat)	RGD
Bckdk	Rat	oligospermia		IAGP		39131293	DNA:missense mutation:cds:G369E (rat)	RGD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Bckdk	Rat	branched-chain keto acid dehydrogenase kinase deficiency		ISO	BCKDK (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:17576681 more ...
Bckdk	Rat	dilated cardiomyopathy		ISO	BCKDK (Homo sapiens)	8554872	ClinVar Annotator: match by term: Dilated Cardiomyopathy and Dominant	ClinVar	PMID:28492532
Bckdk	Rat	genetic disease		ISO	BCKDK (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:17576681 more ...
Bckdk	Rat	intellectual disability		ISO	BCKDK (Homo sapiens)	8554872	ClinVar Annotator: match by term: Intellectual disability	ClinVar	PMID:30167849
Bckdk	Rat	maple syrup urine disease		ISO	BCKDK (Homo sapiens)	8554872	ClinVar Annotator: match by term: Maple syrup urine disease and mild variant	ClinVar	PMID:25741868 and PMID:35205278

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Bckdk	Rat	autism spectrum disorder		ISS	Bckdk (Mus musculus)	13592920		MouseDO
Bckdk	Rat	branched-chain keto acid dehydrogenase kinase deficiency		ISS	Bckdk (Mus musculus)	13592920	OMIM:614923	MouseDO

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Bckdk	Rat	branched-chain keto acid dehydrogenase kinase deficiency		ISO	BCKDK (Homo sapiens)	7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Bckdk	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	Bckdk (Mus musculus)	6480464	[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of BCKDK mRNA	CTD	PMID:22206623
Bckdk	Rat	17alpha-ethynylestradiol	multiple interactions	ISO	Bckdk (Mus musculus)	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BCKDK mRNA	CTD	PMID:17942748
Bckdk	Rat	17alpha-ethynylestradiol	increases expression	ISO	Bckdk (Mus musculus)	6480464	Ethinyl Estradiol results in increased expression of BCKDK mRNA	CTD	PMID:17942748
Bckdk	Rat	17beta-estradiol	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of BCKDK mRNA	CTD	PMID:20823114
Bckdk	Rat	17beta-estradiol	increases expression	ISO	Bckdk (Mus musculus)	6480464	Estradiol results in increased expression of BCKDK mRNA	CTD	PMID:39298647
Bckdk	Rat	17beta-estradiol	increases expression	EXP		6480464	Estradiol results in increased expression of BCKDK mRNA	CTD	PMID:32145629
Bckdk	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	Bckdk (Mus musculus)	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BCKDK mRNA	CTD	PMID:17942748
Bckdk	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of BCKDK mRNA	CTD	PMID:33387578 and PMID:34747641
Bckdk	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of BCKDK mRNA	CTD	PMID:21215274
Bckdk	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of BCKDK mRNA	CTD	PMID:22298810
Bckdk	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	EXP		6480464	AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of BCKDK mRNA]	CTD	PMID:21215274
Bckdk	Rat	2-hydroxypropanoic acid	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	Lactic Acid results in decreased expression of BCKDK mRNA	CTD	PMID:30851411
Bckdk	Rat	4,4'-sulfonyldiphenol	affects expression	ISO	Bckdk (Mus musculus)	6480464	bisphenol S affects the expression of BCKDK mRNA	CTD	PMID:39298647
Bckdk	Rat	acrylamide	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	Acrylamide results in decreased expression of BCKDK mRNA	CTD	PMID:32763439
Bckdk	Rat	aflatoxin B1	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	Aflatoxin B1 results in decreased expression of BCKDK mRNA	CTD	PMID:27153756
Bckdk	Rat	ammonium chloride	affects expression	EXP		6480464	Ammonium Chloride affects the expression of BCKDK mRNA	CTD	PMID:16483693
Bckdk	Rat	aristolochic acid A	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	aristolochic acid I results in decreased expression of BCKDK mRNA and aristolochic acid I results in decreased expression of BCKDK protein	CTD	PMID:33212167
Bckdk	Rat	atrazine	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	Atrazine results in decreased expression of BCKDK mRNA	CTD	PMID:22378314
Bckdk	Rat	benzo[a]pyrene	decreases methylation	ISO	BCKDK (Homo sapiens)	6480464	Benzo(a)pyrene results in decreased methylation of BCKDK 5' UTR	CTD	PMID:27901495
Bckdk	Rat	benzo[a]pyrene	affects methylation	ISO	BCKDK (Homo sapiens)	6480464	Benzo(a)pyrene affects the methylation of BCKDK promoter	CTD	PMID:27901495
Bckdk	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	Bckdk (Mus musculus)	6480464	Diethylhexyl Phthalate results in decreased expression of BCKDK mRNA	CTD	PMID:34319233
Bckdk	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	Bckdk (Mus musculus)	6480464	Diethylhexyl Phthalate results in increased expression of BCKDK mRNA	CTD	PMID:33754040
Bckdk	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of BCKDK mRNA	CTD	PMID:33296240
Bckdk	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of BCKDK mRNA	CTD	PMID:32145629 and PMID:34947998
Bckdk	Rat	bucladesine	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of BCKDK mRNA	CTD	PMID:20823114
Bckdk	Rat	caffeine	decreases phosphorylation	ISO	BCKDK (Homo sapiens)	6480464	Caffeine results in decreased phosphorylation of BCKDK protein	CTD	PMID:35688186
Bckdk	Rat	chromium(6+)	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[zinc chromate results in increased abundance of chromium hexavalent ion] which results in decreased expression of BCKDK mRNA	CTD	PMID:38479592
Bckdk	Rat	cisplatin	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[Cisplatin co-treated with jinfukang] results in increased expression of BCKDK mRNA	CTD	PMID:27392435
Bckdk	Rat	clobetasol	increases expression	ISO	Bckdk (Mus musculus)	6480464	Clobetasol results in increased expression of BCKDK mRNA	CTD	PMID:27462272
Bckdk	Rat	clofibrate	decreases expression	ISO	Bckdk (Mus musculus)	6480464	Clofibrate results in decreased expression of BCKDK mRNA	CTD	PMID:17585979
Bckdk	Rat	clofibric acid	multiple interactions	EXP		6480464	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of BCKDK mRNA	CTD	PMID:17602206
Bckdk	Rat	cobalt dichloride	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	cobaltous chloride results in decreased expression of BCKDK mRNA	CTD	PMID:19320972
Bckdk	Rat	cobalt dichloride	decreases expression	EXP		6480464	cobaltous chloride results in decreased expression of BCKDK mRNA	CTD	PMID:24386269
Bckdk	Rat	copper atom	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[NSC 689534 binds to Copper] which results in decreased expression of BCKDK mRNA	CTD	PMID:20971185
Bckdk	Rat	copper(0)	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[NSC 689534 binds to Copper] which results in decreased expression of BCKDK mRNA	CTD	PMID:20971185
Bckdk	Rat	copper(II) sulfate	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	Copper Sulfate results in decreased expression of BCKDK mRNA	CTD	PMID:19549813
Bckdk	Rat	daidzein	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of BCKDK mRNA	CTD	PMID:27424125
Bckdk	Rat	daidzein 7-O-beta-D-glucoside	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of BCKDK mRNA	CTD	PMID:27424125
Bckdk	Rat	Dibutyl phosphate	affects expression	ISO	BCKDK (Homo sapiens)	6480464	di-n-butylphosphoric acid affects the expression of BCKDK mRNA	CTD	PMID:37042841
Bckdk	Rat	dibutyl phthalate	decreases expression	EXP		6480464	Dibutyl Phthalate results in decreased expression of BCKDK mRNA	CTD	PMID:21266533
Bckdk	Rat	dibutyl phthalate	decreases expression	ISO	Bckdk (Mus musculus)	6480464	Dibutyl Phthalate results in decreased expression of BCKDK mRNA	CTD	PMID:17361019 and PMID:21266533
Bckdk	Rat	dimethylarsinic acid	decreases expression	EXP		6480464	Cacodylic Acid results in decreased expression of BCKDK mRNA	CTD	PMID:16122865
Bckdk	Rat	doxorubicin	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	Doxorubicin results in decreased expression of BCKDK mRNA	CTD	PMID:29803840
Bckdk	Rat	fenofibrate	decreases activity	EXP		6480464	Fenofibrate results in decreased activity of BCKDK protein	CTD	PMID:19819289
Bckdk	Rat	folic acid	multiple interactions	ISO	Bckdk (Mus musculus)	6480464	[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of BCKDK mRNA	CTD	PMID:22206623
Bckdk	Rat	formaldehyde	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	Formaldehyde results in decreased expression of BCKDK mRNA	CTD	PMID:23649840
Bckdk	Rat	FR900359	increases phosphorylation	ISO	BCKDK (Homo sapiens)	6480464	FR900359 results in increased phosphorylation of BCKDK protein	CTD	PMID:37730182
Bckdk	Rat	genistein	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of BCKDK mRNA	CTD	PMID:27424125
Bckdk	Rat	genistein 7-O-beta-D-glucoside	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of BCKDK mRNA	CTD	PMID:27424125
Bckdk	Rat	gentamycin	decreases expression	EXP		6480464	Gentamicins results in decreased expression of BCKDK mRNA	CTD	PMID:33387578
Bckdk	Rat	glycitein	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of BCKDK mRNA	CTD	PMID:27424125
Bckdk	Rat	glycitin	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of BCKDK mRNA	CTD	PMID:27424125
Bckdk	Rat	hydralazine	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[Hydralazine co-treated with Valproic Acid] results in increased expression of BCKDK mRNA	CTD	PMID:17183730
Bckdk	Rat	hydrogen peroxide	affects expression	ISO	BCKDK (Homo sapiens)	6480464	Hydrogen Peroxide affects the expression of BCKDK mRNA	CTD	PMID:20044591
Bckdk	Rat	hydroquinone O-beta-D-glucopyranoside	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	Arbutin results in decreased expression of BCKDK mRNA	CTD	PMID:17103032
Bckdk	Rat	hypochlorous acid	decreases expression	ISO	Bckdk (Mus musculus)	6480464	Hypochlorous Acid results in decreased expression of BCKDK mRNA	CTD	PMID:19376150
Bckdk	Rat	isobutanol	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of BCKDK mRNA	CTD	PMID:29432896
Bckdk	Rat	ivermectin	increases expression	ISO	BCKDK (Homo sapiens)	6480464	Ivermectin results in increased expression of BCKDK protein	CTD	PMID:32959892
Bckdk	Rat	medroxyprogesterone acetate	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of BCKDK mRNA	CTD	PMID:20823114
Bckdk	Rat	methapyrilene	decreases expression	EXP		6480464	Methapyrilene results in decreased expression of BCKDK mRNA	CTD	PMID:30467583
Bckdk	Rat	methoxyacetic acid	affects expression	EXP		6480464	methoxyacetic acid affects the expression of BCKDK mRNA	CTD	PMID:20864626
Bckdk	Rat	N-nitrosodiethylamine	multiple interactions	EXP		6480464	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of BCKDK mRNA	CTD	PMID:17602206
Bckdk	Rat	nefazodone	decreases expression	EXP		6480464	nefazodone results in decreased expression of BCKDK mRNA	CTD	PMID:24136188
Bckdk	Rat	nitrates	multiple interactions	ISO	Bckdk (Mus musculus)	6480464	[Particulate Matter results in increased abundance of Nitrates] which results in increased expression of BCKDK mRNA	CTD	PMID:35964746
Bckdk	Rat	ochratoxin A	decreases expression	EXP		6480464	ochratoxin A results in decreased expression of BCKDK mRNA	CTD	PMID:22124623
Bckdk	Rat	oxaliplatin	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of BCKDK mRNA	CTD	PMID:25729387
Bckdk	Rat	ozone	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[Air Pollutants results in increased abundance of Ozone] which affects the expression of BCKDK mRNA	CTD	PMID:35430440
Bckdk	Rat	paracetamol	affects expression	ISO	Bckdk (Mus musculus)	6480464	Acetaminophen affects the expression of BCKDK mRNA	CTD	PMID:17562736
Bckdk	Rat	pirinixic acid	increases expression	ISO	Bckdk (Mus musculus)	6480464	pirinixic acid results in increased expression of BCKDK mRNA	CTD	PMID:18301758
Bckdk	Rat	procymidone	decreases expression	EXP		6480464	procymidone results in decreased expression of BCKDK mRNA	CTD	PMID:15686871
Bckdk	Rat	quercetin	increases expression	ISO	BCKDK (Homo sapiens)	6480464	Quercetin results in increased expression of BCKDK mRNA	CTD	PMID:21632981
Bckdk	Rat	rac-lactic acid	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	Lactic Acid results in decreased expression of BCKDK mRNA	CTD	PMID:30851411
Bckdk	Rat	rotenone	increases expression	EXP		6480464	Rotenone results in increased expression of BCKDK protein	CTD	PMID:35544339
Bckdk	Rat	sodium arsenite	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	sodium arsenite results in decreased expression of BCKDK mRNA	CTD	PMID:38568856
Bckdk	Rat	sodium dichromate	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	sodium bichromate results in decreased expression of BCKDK mRNA	CTD	PMID:17685462
Bckdk	Rat	sodium fluoride	decreases expression	ISO	Bckdk (Mus musculus)	6480464	Sodium Fluoride results in decreased expression of BCKDK protein	CTD	PMID:28918527
Bckdk	Rat	testosterone	decreases expression	ISO	Bckdk (Mus musculus)	6480464	Testosterone deficiency results in decreased expression of BCKDK mRNA	CTD	PMID:33848595
Bckdk	Rat	thapsigargin	decreases expression	ISO	Bckdk (Mus musculus)	6480464	Thapsigargin results in decreased expression of BCKDK protein	CTD	PMID:24648495
Bckdk	Rat	thapsigargin	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	Thapsigargin results in decreased expression of BCKDK mRNA	CTD	PMID:22378314
Bckdk	Rat	titanium dioxide	increases expression	ISO	Bckdk (Mus musculus)	6480464	titanium dioxide results in increased expression of BCKDK mRNA	CTD	PMID:29264374
Bckdk	Rat	titanium dioxide	increases methylation	ISO	Bckdk (Mus musculus)	6480464	titanium dioxide results in increased methylation of BCKDK gene	CTD	PMID:35295148
Bckdk	Rat	topotecan	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of BCKDK mRNA	CTD	PMID:25729387
Bckdk	Rat	triphenyl phosphate	affects expression	ISO	BCKDK (Homo sapiens)	6480464	triphenyl phosphate affects the expression of BCKDK mRNA	CTD	PMID:37042841
Bckdk	Rat	tunicamycin	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	Tunicamycin results in decreased expression of BCKDK mRNA	CTD	PMID:22378314
Bckdk	Rat	urethane	decreases expression	ISO	BCKDK (Homo sapiens)	6480464	Urethane results in decreased expression of BCKDK mRNA	CTD	PMID:28818685
Bckdk	Rat	valproic acid	increases methylation	ISO	BCKDK (Homo sapiens)	6480464	Valproic Acid results in increased methylation of BCKDK gene	CTD	PMID:29154799
Bckdk	Rat	valproic acid	multiple interactions	ISO	BCKDK (Homo sapiens)	6480464	[Hydralazine co-treated with Valproic Acid] results in increased expression of BCKDK mRNA	CTD	PMID:17183730
Bckdk	Rat	valproic acid	increases expression	ISO	BCKDK (Homo sapiens)	6480464	Valproic Acid results in increased expression of BCKDK mRNA	CTD	PMID:23179753
Bckdk	Rat	valproic acid	affects expression	ISO	BCKDK (Homo sapiens)	6480464	Valproic Acid affects the expression of BCKDK mRNA	CTD	PMID:25979313

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Bckdk	Rat	branched-chain amino acid catabolic process		TAS		68918		RGD
Bckdk	Rat	branched-chain amino acid catabolic process	involved_in	IDA		68712	PMID:1377677	HGNC-UCL
Bckdk	Rat	chromatin remodeling	involved_in	IEA	GO:0004402	1600115	GO_REF:0000108	GOC	GO_REF:0000108
Bckdk	Rat	dosage compensation by inactivation of X chromosome	involved_in	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	isoleucine catabolic process		IMP		39131293		RGD
Bckdk	Rat	L-leucine catabolic process		IMP		39131293		RGD
Bckdk	Rat	lipid biosynthetic process	involved_in	ISO	BCKDK (Homo sapiens)	1624291	PMID:29779826	RGD	PMID:29779826
Bckdk	Rat	lipid biosynthetic process	involved_in	IEA	UniProtKB:O14874 and ensembl:ENSP00000219794	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	myeloid cell differentiation	involved_in	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	negative regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	negative regulation of epithelial to mesenchymal transition	involved_in	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	negative regulation of type I interferon production	involved_in	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	neurogenesis	involved_in	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	neurogenesis	involved_in	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	oogenesis	involved_in	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	positive regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	positive regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	positive regulation of skeletal muscle satellite cell differentiation	involved_in	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	positive regulation of transcription initiation by RNA polymerase II	involved_in	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	post-embryonic hemopoiesis	involved_in	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	regulation of acetyl-CoA biosynthetic process from pyruvate	involved_in	IBA	MGI:1343087 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Bckdk	Rat	regulation of autophagy	acts_upstream_of_or_within	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	regulation of DNA-templated transcription	involved_in	IEA	InterPro:IPR002717	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Bckdk	Rat	regulation of glucose metabolic process	involved_in	IBA	MGI:1343087 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Bckdk	Rat	regulation of mitochondrial transcription	involved_in	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	regulation of mitochondrial transcription	involved_in	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	regulation of mRNA processing	involved_in	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	spermatogenesis		IMP		39131293		RGD
Bckdk	Rat	transcription initiation-coupled chromatin remodeling	involved_in	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	valine catabolic process		IMP		39131293		RGD

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Bckdk	Rat	chromatin	located_in	IEA	ARBA:ARBA00027601	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Bckdk	Rat	chromosome	is_active_in	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	chromosome	is_active_in	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	histone acetyltransferase complex	part_of	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	kinetochore	located_in	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	mitochondrial matrix	located_in	IEA	UniProtKB-SubCell:SL-0170	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Bckdk	Rat	mitochondrion	located_in	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	mitochondrion	located_in	IEA	UniProtKB-SubCell:SL-0173	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Bckdk	Rat	mitochondrion	located_in	IEA	UniProtKB-KW:KW-0496	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Bckdk	Rat	mitochondrion	located_in	IEA	UniProtKB:O14874 and ensembl:ENSP00000219794	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	mitochondrion	located_in	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	mitochondrion	located_in	ISO	BCKDK (Homo sapiens) more ...	1624291		RGD	GO_REF:0000052
Bckdk	Rat	mitochondrion	is_active_in	IBA	MGI:1343087 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Bckdk	Rat	MLL1 complex	part_of	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	MSL complex	part_of	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	MSL complex	part_of	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	NSL complex	part_of	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	NSL complex	part_of	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	nuclear lumen	located_in	IEA	ARBA:ARBA00026536	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Bckdk	Rat	nuclear matrix	located_in	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	nucleoplasm	located_in	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Bckdk	Rat	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Bckdk	Rat	nucleus	located_in	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	nucleus	is_active_in	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	oxoglutarate dehydrogenase complex	part_of	IDA		68712	PMID:1377677	HGNC-UCL
Bckdk	Rat	protein-containing complex	part_of	IEA	ARBA:ARBA00028902	1600115	GO_REF:0000117	UniProt	GO_REF:0000117

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Bckdk	Rat	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity		IMP		68712		RGD
Bckdk	Rat	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity	enables	IEA	EC:2.7.11.4	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Bckdk	Rat	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity	enables	IEA	RHEA:17301	1600115	GO_REF:0000116	RHEA	GO_REF:0000116
Bckdk	Rat	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity		TAS		68918		RGD
Bckdk	Rat	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity		IMP		69775		RGD
Bckdk	Rat	acetyltransferase activity	enables	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	acyltransferase activity	enables	IEA	UniProtKB-KW:KW-0012	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Bckdk	Rat	ATP binding	enables	IDA		68712	PMID:1377677	HGNC-UCL
Bckdk	Rat	ATP binding	enables	IEA	UniProtKB-KW:KW-0067	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Bckdk	Rat	chromatin binding	enables	IEA	ARBA:ARBA00027831	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Bckdk	Rat	enzyme binding	enables	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	histone acetyltransferase activity	enables	IEA	InterPro:IPR002717	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Bckdk	Rat	histone H4 acetyltransferase activity	enables	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	histone H4K16 acetyltransferase activity	enables	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	histone H4K16 acetyltransferase activity	enables	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	histone H4K5 acetyltransferase activity	contributes_to	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	histone H4K8 acetyltransferase activity	contributes_to	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	kinase activity	enables	IEA	UniProtKB-KW:KW-0418	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Bckdk	Rat	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Bckdk	Rat	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Bckdk	Rat	promoter-specific chromatin binding	enables	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	protein binding	enables	ISO	BCKDK (Homo sapiens)	1624291	UniProtKB:P02549 more ...	RGD	PMID:18985028 more ...
Bckdk	Rat	protein binding	enables	ISO	BCKDK (Homo sapiens) and UniProtKB:O14874-2	1624291	UniProtKB:Q8WUW1 and PMID:32814053	RGD	PMID:32814053
Bckdk	Rat	protein kinase activity	enables	ISO	Bckdk (Mus musculus)	1624291	PMID:9611264	RGD	PMID:9611264
Bckdk	Rat	protein kinase activity	enables	IEA	InterPro:IPR039028	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Bckdk	Rat	protein kinase activity	enables	IEA	UniProtKB:O55028 and ensembl:ENSMUSP00000070345	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	protein propionyltransferase activity	enables	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	protein serine kinase activity	enables	IEA	RHEA:17989	1600115	GO_REF:0000116	RHEA	GO_REF:0000116
Bckdk	Rat	protein serine/threonine kinase activity	enables	IDA		68712	PMID:1377677	HGNC-UCL
Bckdk	Rat	protein serine/threonine phosphatase activity	enables	ISO	BCKDK (Homo sapiens)	1624291	PMID:29779826	RGD	PMID:29779826
Bckdk	Rat	protein serine/threonine phosphatase activity	enables	IEA	UniProtKB:O14874 and ensembl:ENSP00000219794	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	protein-lysine-acetyltransferase activity	enables	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	protein-lysine-acetyltransferase activity	enables	IEA	RHEA:45948	1600115	GO_REF:0000116	RHEA	GO_REF:0000116
Bckdk	Rat	protein-lysine-acetyltransferase activity	enables	IEA	UniProtKB:Q9D1P2 and ensembl:ENSMUSP00000033070	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	pyruvate dehydrogenase (acetyl-transferring) kinase activity	enables	IBA	MGI:1343087 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Bckdk	Rat	RNA polymerase II-specific DNA-binding transcription factor binding	enables	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	transcription coactivator activity	enables	IEA	UniProtKB:Q9H7Z6 and ensembl:ENSP00000219797	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Bckdk	Rat	transferase activity	enables	IEA	UniProtKB-KW:KW-0808	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Bckdk	Rat	transferase activity, transferring phosphorus-containing groups	enables	IEA	InterPro:IPR004358	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Bckdk	Rat	zinc ion binding	enables	IEA	UniProtKB-KW:KW-0863	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Bckdk	Rat	abnormal foot pad morphology		IAGP		39131293	DNA:missense mutation:cds:G369E rat	RGD
Bckdk	Rat	abnormal hindlimb morphology		IAGP		39131293	DNA:missense mutation:cds:G369E rat	RGD
Bckdk	Rat	abnormal Schwann cell morphology		IAGP		39131293	DNA:missense mutation:cds:G369E rat	RGD
Bckdk	Rat	abnormal sciatic nerve morphology		IAGP		39131293	DNA:missense mutation:cds:G369E rat	RGD
Bckdk	Rat	abnormal soleus morphology		IAGP		39131293	DNA:missense mutation:cds:G369E rat	RGD
Bckdk	Rat	decreased body size		IAGP		39131293	DNA:missense mutation:cds:G369E rat	RGD
Bckdk	Rat	decreased brain weight		IAGP		39131293	DNA:missense mutation:cds:G369E rat	RGD
Bckdk	Rat	decreased circulating isoleucine level		IAGP		39131293	DNA:missense mutation:cds:G369E rat	RGD
Bckdk	Rat	decreased circulating leucine level		IAGP		39131293	DNA:missense mutation:cds:G369E rat	RGD
Bckdk	Rat	decreased circulating valine level		IAGP		39131293	DNA:missense mutation:cds:G369E rat	RGD
Bckdk	Rat	enlarged lateral ventricles		IAGP		39131293	DNA:missense mutation:cds:G369E rat	RGD
Bckdk	Rat	long toenails		IAGP		39131293	DNA:missense mutation:cds:G369E rat	RGD
Bckdk	Rat	reduced male fertility		IAGP		39131293	DNA:missense mutation:cds:G369E rat	RGD
Bckdk	Rat	testis hypoplasia		IAGP		39131293	DNA:missense mutation:cds:G369E rat	RGD

#	Reference Title	Reference Citation
1.	Expression and characterization of branched-chain alpha-ketoacid dehydrogenase kinase from the rat. Is it a histidine-protein kinase?	Davie JR, etal., J Biol Chem 1995 Aug 25;270(34):19861-7.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	From the Cover: Structure of rat BCKD kinase: Nucleotide-induced domain communication in a mitochondrial protein kinase.	Machius M, etal., Proc Natl Acad Sci U S A 2001 Sep 25;98(20):11218-23.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	Branched-chain alpha-ketoacid dehydrogenase kinase. Molecular cloning, expression, and sequence similarity with histidine protein kinases.	Popov KM, etal., J Biol Chem 1992 Jul 5;267(19):13127-30.
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13.	A Spontaneous Missense Mutation in Branched Chain Keto Acid Dehydrogenase Kinase in the Rat Affects Both the Central and Peripheral Nervous Systems.	Zigler JS, etal., PLoS One. 2016 Jul 29;11(7):e0160447. doi: 10.1371/journal.pone.0160447. eCollection 2016.

PMID:1496922	PMID:8889548	PMID:9611264	PMID:14651853	PMID:15302860	PMID:18614015	PMID:20833797

Bckdk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	191,945,809 - 191,950,480 (+)	NCBI		GRCr8
mRatBN7.2	1	182,515,335 - 182,520,007 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	182,515,327 - 182,536,633 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	190,865,878 - 190,870,549 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	198,051,970 - 198,056,641 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	190,722,400 - 190,727,069 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	199,351,628 - 199,356,299 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	199,351,628 - 199,356,881 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	206,374,221 - 206,378,892 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	187,189,665 - 187,194,336 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	187,340,263 - 187,344,799 (+)	NCBI
Celera	1	180,166,156 - 180,170,827 (+)	NCBI		Celera
Cytogenetic Map	1	q37	NCBI

BCKDK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	31,108,386 - 31,117,640 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	31,106,107 - 31,112,791 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	31,119,707 - 31,124,159 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	31,027,223 - 31,031,422 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	31,027,221 - 31,031,420	NCBI
Celera	16	29,173,915 - 29,178,365 (-)	NCBI		Celera
Cytogenetic Map	16	p11.2	NCBI
HuRef	16	28,680,789 - 28,685,286 (+)	NCBI		HuRef
CHM1_1	16	32,437,335 - 32,441,832 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	31,495,847 - 31,505,117 (+)	NCBI		T2T-CHM13v2.0

Bckdk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	127,503,245 - 127,508,836 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	127,503,254 - 127,509,393 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	127,904,073 - 127,909,664 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	127,904,082 - 127,910,221 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	135,047,587 - 135,053,178 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	127,695,221 - 127,700,812 (+)	NCBI		MGSCv36	mm8
Celera	7	127,739,285 - 127,744,876 (+)	NCBI		Celera
Cytogenetic Map	7	F3	NCBI
cM Map	7	69.82	NCBI

Bckdk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955493	7,940,315 - 7,946,317 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955493	7,940,358 - 7,946,317 (+)	NCBI	ChiLan1.0	ChiLan1.0

BCKDK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	34,314,330 - 34,318,566 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	39,115,733 - 39,119,970 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	23,856,349 - 23,860,586 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	31,476,917 - 31,481,193 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	31,476,917 - 31,483,639 (+)	Ensembl	panpan1.1		panPan2

BCKDK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	17,128,615 - 17,132,925 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	17,128,824 - 17,133,585 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	18,703,976 - 18,708,295 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	17,259,506 - 17,263,825 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	17,259,509 - 17,263,938 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	17,059,901 - 17,064,220 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	16,978,760 - 16,983,079 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	17,291,152 - 17,295,471 (-)	NCBI		UU_Cfam_GSD_1.0

Bckdk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	125,369,683 - 125,373,950 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	13,467,305 - 13,471,858 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	13,467,603 - 13,471,810 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BCKDK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	17,375,354 - 17,380,880 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	17,375,628 - 17,380,925 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	17,491,364 - 17,496,671 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BCKDK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	27,794,963 - 27,799,239 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	27,795,083 - 27,799,410 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	1,668,249 - 1,672,509 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bckdk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624782	14,150,024 - 14,154,124 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624782	14,150,019 - 14,154,124 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Bckdk
44 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	503
Count of miRNA genes:	249
Interacting mature miRNAs:	291
Transcripts:	ENSRNOT00000026466
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	167909849	212909849	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	171629477	216629477	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	171629477	216629477	Rat
1302787	Stl25	Serum triglyceride level QTL 25	2.7	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	180359209	210702199	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	144267353	196383668	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	172609619	217609619	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	174133260	219133260	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1558658	Bw59	Body weight QTL 59	3.5	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	1	178784622	223784622	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	151162512	201278233	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	171629477	216629477	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	123556856	242907031	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169537671	214537671	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	151162512	201278233	Rat
4889428	Stresp24	Stress response QTL 24		0.05	heart pumping trait (VT:2000009)	absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)	1	155866514	200866514	Rat
152025232	Bw192	Body weight QTL 192	3.93		body mass (VT:0001259)		1	117917486	196963478	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
61343	Bp28	Blood pressure QTL 28			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	151646613	196646613	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	171629477	216629477	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
61347	Bp197	Blood pressure QTL 197	4.2		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	1	158633083	203633083	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144017057	197814409	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	100357752	183970443	Rat
2303622	Vencon6	Ventilatory control QTL 6		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	1	154561505	199561505	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	173108781	218108781	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
1300158	Bp173	Blood pressure QTL 173	3.48		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	1	115540693	185145286	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	171629477	216629477	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	181133855	226133855	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	171629477	216629477	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	171310381	216310381	Rat
61378	Bp43	Blood pressure QTL 43	22.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	181746937	196383668	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	181759564	214537555	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	176869060	221869060	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
2312558	Glom17	Glomerulus QTL 17	3.9	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	166532971	191278129	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	164747424	209747424	Rat
619614	Bp78	Blood pressure QTL 78		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	169112897	197261052	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	169537671	214537671	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	213533942	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	176550523	221550523	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	201278233	Rat
1354618	Kidm15	Kidney mass QTL 15	5		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	1	156677124	201278233	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	180359209	218108781	Rat
152025212	Bw190	Body weight QTL 190	5.7		body mass (VT:0001259)		1	123556856	196963478	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	181829673	224569684	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	201278233	Rat
2325725	Eae31	Experimental allergic encephalomyelitis QTL 31			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	1	178810256	188377506	Rat
631670	Iddm10	Insulin dependent diabetes mellitus QTL 10	1.9		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	174133260	196383668	Rat

Bckdk

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	182,518,763 - 182,519,692 (+)	MAPPER	mRatBN7.2
mRatBN7.2	6	97,927,157 - 97,927,588 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	102,302,478 - 102,302,908	NCBI	Rnor6.0
Rnor_6.0	1	199,355,056 - 199,355,984	NCBI	Rnor6.0
Rnor_5.0	1	206,377,649 - 206,378,577	UniSTS	Rnor5.0
Rnor_5.0	6	114,990,191 - 114,990,621	UniSTS	Rnor5.0
RGSC_v3.4	1	187,193,093 - 187,194,021	UniSTS	RGSC3.4
Celera	6	96,312,640 - 96,313,070	UniSTS
Celera	1	180,169,584 - 180,170,512	UniSTS
Cytogenetic Map	1	q36	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_019244	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC111812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BM392152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK479351	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M93271	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U27456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026466 ⟹ ENSRNOP00000026466

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	182,515,349 - 182,536,633 (+)	Ensembl
Rnor_6.0 Ensembl	1	199,352,344 - 199,356,881 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000026527 ⟹ ENSRNOP00000026527

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	182,523,777 - 182,536,633 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000078578 ⟹ ENSRNOP00000069014

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	182,515,327 - 182,520,007 (+)	Ensembl
Rnor_6.0 Ensembl	1	199,351,628 - 199,356,296 (+)	Ensembl

RefSeq Acc Id:

NM_019244 ⟹ NP_062117

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	191,945,809 - 191,950,480 (+)	NCBI
mRatBN7.2	1	182,515,335 - 182,520,007 (+)	NCBI
Rnor_6.0	1	199,351,628 - 199,356,299 (+)	NCBI
Rnor_5.0	1	206,374,221 - 206,378,892 (+)	NCBI
RGSC_v3.4	1	187,189,665 - 187,194,336 (+)	RGD
Celera	1	180,166,156 - 180,170,827 (+)	RGD

Sequence:

show sequence

GCGAAGGCGGGCTCGGCCAGCCGGGCGGGTCGACTGCTCCCGCGGTTCCGCTCGGACCCCGGCCCAGCGTCTGGCCTCGCGATGGAAGCTGCTGTGGCGGCGCCGAGCATGTCAGCATCCTCGAGGGA
GCCACATCCCTGAAATCCGGAGAAAACCCTGTCCACTCACTCTCTCTCTACTCCTGCTTTGGGGTCACCGTTGCCTGTCGAGCCCTTAGTCCCATAGTATCACCCTAGTTCAACAAAGAAGCGGGACA
ATGATACTGACTTCAGTGCTGGGCAGCGGCCCTCGGAGCGGGTCTTCACTTTGGCCCCTCTTGGGGTCCTCACTGTCACTCCGGGTTCGCTCAACATCAGCCACCGATACACACCATGTAGAGCTGGC
CAGGGAACGCTCCAAGACTGTTACCTCCTTTTACAACCAGTCAGCTATTGACGTGGTAGCAGAGAAGCCCTCAGTCCGCCTCACTCCCACCATGATGCTCTATTCTGGTCGCTCACAGGATGGCAGCC
ACCTTCTGAAAAGTGGTCGCTACTTGCAGCAAGAGTTACCGGTGAGGATCGCTCACCGCATCAAGGGCTTCCGTAGTCTTCCTTTCATCATTGGTTGCAACCCTACCATACTGCATGTGCACGAGCTA
TACATCCGGGCCTTCCAGAAGTTGACAGACTTCCCTCCGATCAAGGACCAGGCAGACGAAGCCCAGTATTGCCAGCTGGTGCGACAGCTGCTAGATGACCACAAGGATGTGGTAACCCTGTTAGCTGA
GGGTCTGCGTGAGAGCCGGAAACACATAGAGGATGAAAAGCTGGTCCGCTACTTCCTGGATAAAACACTAACGTCCAGACTTGGGATCCGAATGCTGGCTACTCACCACTTGGCGCTACATGAAGACA
AGCCTGATTTTGTTGGCATCATCTGCACTCGTCTGTCACCCAAGAAGATTATTGAGAAGTGGGTGGATTTTGCCAGACGCCTGTGCGAGCACAAGTATGGCAATGCCCCTAGAGTCCGCATCAATGGG
CACGTGGCTGCCCGTTTCCCCTTCATTCCTATGCCGCTGGACTATATCCTGCCTGAGCTGCTCAAGAACGCCATGAGAGCCACAATGGAGAGTCACCTAGACACGCCCTACAATGTTCCTGATGTGGT
CATCACCATCGCCAATAACGATGTGGATCTCATCATCAGGATCTCAGACCGGGGTGGAGGAATCGCTCATAAGGACCTGGATCGGGTCATGGACTACCACTTCACCACAGCTGAGGCCAGCACCCAGG
ACCCCCGAATCAGCCCCCTCTTCGGCCACCTGGATATGCACAGTGGTGGCCAATCAGGACCTATGCATGGCTTTGGCTTCGGGTTGCCCACGTCCAGGGCCTATGCGGAGTATCTCGGTGGCTCCCTG
CAGCTGCAGTCCCTGCAGGGCATTGGCACAGATGTCTACCTACGGCTCCGCCACATTGATGGCCGGGAGGAAAGCTTCAGAATCTGATGGTGGATTTTGGCCAGCTAGCCTGCCACACTCCTCGTAGG
ACCTACTGGGCCTGGCAGGGGGCCGCTGTGCTCCATACACTGCTGCTTCGTGGAGCTTAGGGCCTCAGACAGGTGGACTTAGATGGAGCTGGGCACCACTCCTCCTCAACAGGGCTCATTGCTTTCTG
CCTCCTGGTCTCGGAGGGGAGGAAGCAGGAGCCTCTGAGGCCTCCAATACCAGCTGTGCTGTGCTTACTCTTGAGGAGTACTTATTTGACCTGCTGTTATTAAAGTTTGCATTTTGAATGCCCTCTTG
GGCCTCAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063287660 ⟹ XP_063143730

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	191,945,886 - 191,950,480 (+)	NCBI


Protein RefSeqs	NP_062117	(Get FASTA)	NCBI Sequence Viewer
	XP_063143730	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA40818	(Get FASTA)	NCBI Sequence Viewer
	AAB60498	(Get FASTA)	NCBI Sequence Viewer
	EDM17216	(Get FASTA)	NCBI Sequence Viewer
	EDM17217	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069014
	ENSRNOP00000069014.1
GenBank Protein	Q00972	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_062117 ⟸ NM_019244
- Peptide Label:	precursor
- UniProtKB:	Q64552 (UniProtKB/Swiss-Prot), Q00972 (UniProtKB/Swiss-Prot), A6I9W3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MILTSVLGSGPRSGSSLWPLLGSSLSLRVRSTSATDTHHVELARERSKTVTSFYNQSAIDVVAEKPSVRLTPTMMLYSGRSQDGSHLLKSGRYLQQELPVRIAHRIKGFRSLPFIIGCNPTILHVHEL YIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRING HVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGGQSGPMHGFGFGLPTSRAYAEYLGGSL QLQSLQGIGTDVYLRLRHIDGREESFRI hide sequence

Ensembl Acc Id:

ENSRNOP00000026466 ⟸ ENSRNOT00000026466

Ensembl Acc Id:

ENSRNOP00000069014 ⟸ ENSRNOT00000078578

Ensembl Acc Id:

ENSRNOP00000026527 ⟸ ENSRNOT00000026527

RefSeq Acc Id:	XP_063143730 ⟸ XM_063287660
- Peptide Label:	isoform X1
- UniProtKB:	Q64552 (UniProtKB/Swiss-Prot), Q00972 (UniProtKB/Swiss-Prot), A6I9W3 (UniProtKB/TrEMBL)

Protein Domains

Histidine kinase MYST-type HAT

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q00972-F1-model_v2	AlphaFold	Q00972	1-412	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13690445

Promoter ID:

EPDNEW_R970

Type:

initiation region

Name:

Bckdk_1

Description:

branched chain ketoacid dehydrogenase kinase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	199,351,654 - 199,351,714	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-57330	BioCyc
Ensembl Genes	ENSRNOG00000019485	Ensembl, UniProtKB/Swiss-Prot
	ENSRNOG00000077965	ENTREZGENE
Ensembl Transcript	ENSRNOT00000078578	ENTREZGENE
	ENSRNOT00000078578.2	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.140.20	UniProtKB/Swiss-Prot
	3.30.565.10	UniProtKB/Swiss-Prot
InterPro	AK/P_DHK_N_sf	UniProtKB/Swiss-Prot
	BCDHK/PDK_N	UniProtKB/Swiss-Prot
	BCKD/PDK	UniProtKB/Swiss-Prot
	HATPase_C	UniProtKB/Swiss-Prot
	HATPase_C_sf	UniProtKB/Swiss-Prot
	His_kinase_dom	UniProtKB/Swiss-Prot
	Sig_transdc_His_kin-like_C	UniProtKB/Swiss-Prot
KEGG Report	rno:29603	UniProtKB/Swiss-Prot
NCBI Gene	29603	ENTREZGENE
PANTHER	[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL	UniProtKB/Swiss-Prot
	PTHR11947	UniProtKB/Swiss-Prot
Pfam	BCDHK_Adom3	UniProtKB/Swiss-Prot
	HATPase_c	UniProtKB/Swiss-Prot
PhenoGen	Bckdk	PhenoGen
PRINTS	BCTRLSENSOR	UniProtKB/Swiss-Prot
PROSITE	HIS_KIN	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000019485	RatGTEx
	ENSRNOG00000077965	RatGTEx
SMART	HATPase_c	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF55874	UniProtKB/Swiss-Prot
	SSF69012	UniProtKB/Swiss-Prot
TIGR	TC216918
UniProt	A0A0H2UHR5_RAT	UniProtKB/TrEMBL
	A0A8L2QED5_RAT	UniProtKB/TrEMBL
	A6I9W3	ENTREZGENE, UniProtKB/TrEMBL
	BCKD_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q64552	ENTREZGENE
UniProt Secondary	Q64552	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Bckdk	branched chain ketoacid dehydrogenase kinase		branched chain keto acid dehydrogenase kinase	Name updated	1299863	APPROVED
2002-06-10	Bckdk	branched chain keto acid dehydrogenase kinase			Symbol and Name status set to approved	70586	APPROVED

Note Type	Note	Reference
gene_cellular_localization	localizes to the mitochondria	69775
gene_domains	contains a nucleotide-binding domain and a four-helix bundle domain	68918
gene_function	phosphorylates and inactivates the branched-chain alpha-ketoacid dehydrogenase complex	68712
gene_function	phosphorylates and inactivates the branched-chain alpha-ketoacid dehydrogenase complex	68918
gene_function	phosphorylates and inactivates the branched-chain alpha-ketoacid dehydrogenase complex	69775
gene_function	interaction with nucleotides is mediated by potassium and magnesium	68918
gene_process	rate-limiting step in the oxidative degradation of branched-chain amino acids, leading to lipogenesis and energy production	68712
gene_process	rate-limiting step in the oxidative degradation of branched-chain amino acids, leading to lipogenesis and energy production	68918
gene_process	rate-limiting step in the oxidative degradation of branched-chain amino acids, leading to lipogenesis and energy production	69775

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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