Bckdk (branched chain keto acid dehydrogenase kinase) - Rat Genome Database

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Gene: Bckdk (branched chain keto acid dehydrogenase kinase) Ictidomys tridecemlineatus
Analyze
Symbol: Bckdk
Name: branched chain keto acid dehydrogenase kinase
RGD ID: 12662249
Description: ENCODES a protein that exhibits [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN branched-chain amino acid catabolic process (ortholog); isoleucine catabolic process (ortholog); L-leucine catabolic process (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); branched-chain keto acid dehydrogenase kinase deficiency (ortholog); epilepsy (ortholog); FOUND IN obsolete mitochondrial oxoglutarate dehydrogenase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 3-methyl-2-oxobutanoate dehydrogenase [lipoamide] kinase, mitochondrial; branched chain ketoacid dehydrogenase kinase; branched chain ketoacid dehydrogenase kinase, transcript variant X1; branched chain ketoacid dehydrogenase kinase, transcript variant X2; branched chain ketoacid dehydrogenase kinase, transcript variant X3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,369,683 - 125,373,950 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,467,305 - 13,471,858 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,467,603 - 13,471,810 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Bckdk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,369,683 - 125,373,950 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,467,305 - 13,471,858 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,467,603 - 13,471,810 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCKDK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,108,386 - 31,117,640 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,106,107 - 31,112,791 (+)EnsemblGRCh38hg38GRCh38
GRCh371631,119,707 - 31,124,159 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,027,223 - 31,031,422 (+)NCBINCBI36Build 36hg18NCBI36
Build 341631,027,221 - 31,031,420NCBI
Celera1629,173,915 - 29,178,365 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,680,789 - 28,685,286 (+)NCBIHuRef
CHM1_11632,437,335 - 32,441,832 (+)NCBICHM1_1
T2T-CHM13v2.01631,495,847 - 31,505,117 (+)NCBIT2T-CHM13v2.0
Bckdk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,503,245 - 127,508,836 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,503,254 - 127,509,393 (+)EnsemblGRCm39 Ensembl
GRCm387127,904,073 - 127,909,664 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,904,082 - 127,910,221 (+)EnsemblGRCm38mm10GRCm38
MGSCv377135,047,587 - 135,053,178 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,695,221 - 127,700,812 (+)NCBIMGSCv36mm8
Celera7127,739,285 - 127,744,876 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.82NCBI
Bckdk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,945,809 - 191,950,480 (+)NCBIGRCr8
mRatBN7.21182,515,335 - 182,520,007 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,515,327 - 182,536,633 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,865,878 - 190,870,549 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,051,970 - 198,056,641 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,722,400 - 190,727,069 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,351,628 - 199,356,299 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,351,628 - 199,356,881 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,374,221 - 206,378,892 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,189,665 - 187,194,336 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,340,263 - 187,344,799 (+)NCBI
Celera1180,166,156 - 180,170,827 (+)NCBICelera
Cytogenetic Map1q37NCBI
Bckdk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554937,940,315 - 7,946,317 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554937,940,358 - 7,946,317 (+)NCBIChiLan1.0ChiLan1.0
BCKDK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,314,330 - 34,318,566 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,115,733 - 39,119,970 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,856,349 - 23,860,586 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,476,917 - 31,481,193 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,476,917 - 31,483,639 (+)Ensemblpanpan1.1panPan2
BCKDK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,128,615 - 17,132,925 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,128,824 - 17,133,585 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,703,976 - 18,708,295 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,259,506 - 17,263,825 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,259,509 - 17,263,938 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,059,901 - 17,064,220 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,978,760 - 16,983,079 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,291,152 - 17,295,471 (-)NCBIUU_Cfam_GSD_1.0
BCKDK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,375,354 - 17,380,880 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,375,628 - 17,380,925 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,491,364 - 17,496,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BCKDK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,794,963 - 27,799,239 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,795,083 - 27,799,410 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,668,249 - 1,672,509 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bckdk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,150,024 - 14,154,124 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,150,019 - 14,154,124 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000000633   ⟹   ENSSTOP00000000576
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493650113,468,419 - 13,471,256 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000034621   ⟹   ENSSTOP00000031905
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493650113,467,305 - 13,471,858 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000040023   ⟹   ENSSTOP00000026689
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493650113,467,745 - 13,471,858 (+)Ensembl
RefSeq Acc Id: XM_005323881   ⟹   XP_005323938
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024409344125,369,683 - 125,373,950 (+)NCBI
SpeTri2.0NW_00493650113,467,603 - 13,471,810 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013357959   ⟹   XP_013213413
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024409344125,369,855 - 125,373,950 (+)NCBI
SpeTri2.0NW_00493650113,467,728 - 13,471,810 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021725525   ⟹   XP_021581200
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024409344125,369,683 - 125,373,950 (+)NCBI
SpeTri2.0NW_00493650113,467,603 - 13,471,810 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040277116   ⟹   XP_040133050
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024409344125,369,683 - 125,373,950 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005323938   ⟸   XM_005323881
- Peptide Label: isoform X1
- UniProtKB: A0A287CZK9 (UniProtKB/TrEMBL),   I3LX29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013213413   ⟸   XM_013357959
- Peptide Label: isoform X1
- UniProtKB: A0A287CZK9 (UniProtKB/TrEMBL),   I3LX29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021581200   ⟸   XM_021725525
- Peptide Label: isoform X2
- UniProtKB: I3LX29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040133050   ⟸   XM_040277116
- Peptide Label: isoform X3
- UniProtKB: I3LX29 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000031905   ⟸   ENSSTOT00000034621
RefSeq Acc Id: ENSSTOP00000026689   ⟸   ENSSTOT00000040023
RefSeq Acc Id: ENSSTOP00000000576   ⟸   ENSSTOT00000000633
Protein Domains
Branched-chain alpha-ketoacid dehydrogenase   Histidine kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000632 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000633.3 UniProtKB/TrEMBL
  ENSSTOT00000034621.1 UniProtKB/TrEMBL
  ENSSTOT00000040023.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.20 UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/TrEMBL
InterPro AK/P_DHK_N_sf UniProtKB/TrEMBL
  BCDHK/PDK_N UniProtKB/TrEMBL
  BCKD/PDK UniProtKB/TrEMBL
  HATPase_C UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/TrEMBL
  His_kinase_dom UniProtKB/TrEMBL
  Sig_transdc_His_kin-like_C UniProtKB/TrEMBL
NCBI Gene Bckdk ENTREZGENE
PANTHER [3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR11947 UniProtKB/TrEMBL
Pfam BCDHK_Adom3 UniProtKB/TrEMBL
  HATPase_c UniProtKB/TrEMBL
PRINTS BCTRLSENSOR UniProtKB/TrEMBL
PROSITE HIS_KIN UniProtKB/TrEMBL
SMART HATPase_c UniProtKB/TrEMBL
Superfamily-SCOP SSF55874 UniProtKB/TrEMBL
  SSF69012 UniProtKB/TrEMBL
UniProt A0A287CZK9 ENTREZGENE, UniProtKB/TrEMBL
  I3LX29 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-30 Bckdk  branched chain keto acid dehydrogenase kinase    branched chain ketoacid dehydrogenase kinase  Symbol and/or name change 5135510 APPROVED