Atp2a3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3) - Rat Genome Database

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Gene: Atp2a3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3) Rattus norvegicus
Analyze
Symbol: Atp2a3
Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
RGD ID: 2175
Description: Enables P-type calcium transporter activity and calcium-dependent ATPase activity. Involved in calcium ion transmembrane transport; endoplasmic reticulum calcium ion homeostasis; and liver regeneration. Predicted to be located in organelle membrane and sarcoplasmic reticulum. Predicted to be active in membrane. Biomarker of hypertension. Orthologous to human ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; Alzheimer's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATPase, Ca++ transporting, ubiquitous; calcium pump 3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3; SERCA3; SR Ca(2+)-ATPase 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81058,079,710 - 58,111,279 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1058,079,852 - 58,111,278 (+)EnsemblGRCr8
mRatBN7.21057,581,742 - 57,612,758 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1057,582,128 - 57,612,748 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1062,242,465 - 62,273,108 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01061,730,937 - 61,761,578 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01057,230,020 - 57,260,653 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01059,528,849 - 59,560,440 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1059,529,785 - 59,560,433 (+)Ensemblrn6Rnor6.0
Rnor_5.01059,268,396 - 59,299,909 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41059,853,363 - 59,884,087 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1056,706,446 - 56,736,977 (+)NCBICelera
RGSC_v3.11059,866,985 - 59,897,710 (+)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-Hydroxybenzophenone  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
ampicillin  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP,ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
flavonoids  (EXP)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (EXP)
GSK-J4  (ISO)
haloperidol  (ISO)
ionomycin  (ISO)
lycopene  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mercaptopurine  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
metronidazole  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
neomycin  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
nitrates  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
purine-6-thiol  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Calcium pumps in health and disease. Brini M and Carafoli E, Physiol Rev. 2009 Oct;89(4):1341-78. doi: 10.1152/physrev.00032.2008.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Expression of intracellular calcium channels and pumps after partial hepatectomy in rat. Magnino F, etal., Mol Cell Biol Res Commun. 2000 Jun;3(6):374-9. doi: 10.1006/mcbr.2000.0242.
4. Three novel sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family. Martin V, etal., J Biol Chem 2002 Jul 5;277(27):24442-52.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Ca2+ uptake by the endoplasmic reticulum Ca2+-ATPase in rat microvascular endothelial cells. Moccia F, etal., Biochem J 2002 May 15;364(Pt 1):235-44.
7. Expression of Ca(2+) Transport Genes in Platelets and Endothelial Cells in Hypertension. Mountian I I, etal., Hypertension 2001 Jan;37(1):135-141.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Functional characterization of alternatively spliced human SERCA3 transcripts. Poch E, etal., Am J Physiol. 1998 Dec;275(6):C1449-58. doi: 10.1152/ajpcell.1998.275.6.C1449.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Thermal instability of rat muscle sarcoplasmic reticulum Ca(2+)-ATPase function. Schertzer JD, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E722-8.
16. Intracellular Ca2+ regulating proteins in vascular smooth muscle cells are altered with type 1 diabetes due to the direct effects of hyperglycemia. Searls YM, etal., Cardiovasc Diabetol. 2010 Feb 1;9:8. doi: 10.1186/1475-2840-9-8.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:2553713   PMID:8809064   PMID:10642281   PMID:11844792   PMID:12119294   PMID:15028735   PMID:16725111   PMID:18068335   PMID:21700703   PMID:24625528   PMID:25931508   PMID:27923914  


Genomics

Comparative Map Data
Atp2a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81058,079,710 - 58,111,279 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1058,079,852 - 58,111,278 (+)EnsemblGRCr8
mRatBN7.21057,581,742 - 57,612,758 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1057,582,128 - 57,612,748 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1062,242,465 - 62,273,108 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01061,730,937 - 61,761,578 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01057,230,020 - 57,260,653 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01059,528,849 - 59,560,440 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1059,529,785 - 59,560,433 (+)Ensemblrn6Rnor6.0
Rnor_5.01059,268,396 - 59,299,909 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41059,853,363 - 59,884,087 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1056,706,446 - 56,736,977 (+)NCBICelera
RGSC_v3.11059,866,985 - 59,897,710 (+)NCBI
Cytogenetic Map10q24NCBI
ATP2A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38173,923,873 - 3,964,437 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl173,923,866 - 3,964,491 (-)Ensemblhg38GRCh38
GRCh37173,827,167 - 3,867,731 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36173,773,918 - 3,814,485 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34173,773,917 - 3,814,485NCBI
Celera173,838,972 - 3,879,550 (-)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef173,716,986 - 3,757,589 (-)NCBIHuRef
CHM1_1173,835,929 - 3,876,526 (-)NCBICHM1_1
T2T-CHM13v2.0173,813,121 - 3,853,682 (-)NCBIT2T-CHM13v2.0
Atp2a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,851,995 - 72,883,869 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,851,995 - 72,883,870 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381172,961,169 - 72,993,043 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,961,169 - 72,993,044 (+)Ensemblmm10GRCm38
MGSCv371172,774,671 - 72,806,545 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361172,777,450 - 72,809,234 (+)NCBIMGSCv36mm8
Celera1180,489,834 - 80,521,726 (+)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1145.0NCBI
Atp2a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546712,911,679 - 12,941,924 (+)Ensembl
ChiLan1.0NW_00495546712,911,679 - 12,941,322 (+)NCBIChiLan1.0ChiLan1.0
ATP2A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21911,534,518 - 11,575,407 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11713,498,563 - 13,539,571 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0173,992,088 - 4,013,998 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1173,964,348 - 4,023,563 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl173,965,925 - 3,998,382 (-)EnsemblpanPan2panpan1.1
ATP2A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1947,694,494 - 47,727,017 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl947,695,809 - 47,727,778 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha946,856,404 - 46,888,927 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0948,539,697 - 48,572,225 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl948,539,694 - 48,572,226 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1947,317,039 - 47,349,552 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0947,606,054 - 47,638,604 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0947,662,326 - 47,694,837 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Atp2a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560255,315,881 - 55,350,665 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936677551,933 - 585,114 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936677552,066 - 585,093 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP2A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1249,980,497 - 50,025,171 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11249,980,488 - 50,014,006 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,031,809 - 52,042,263 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATP2A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,405,871 - 3,443,339 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl163,405,820 - 3,443,275 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605918,268,234 - 18,306,511 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp2a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247866,528,182 - 6,558,547 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247866,528,177 - 6,558,576 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Atp2a3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1942,518,578 - 42,548,788 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Atp2a3
247 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:705
Count of miRNA genes:265
Interacting mature miRNAs:335
Transcripts:ENSRNOT00000064840, ENSRNOT00000065181
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105429622758944345Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 159 91 90 59 92 59 6 356 192 11 136 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000064840   ⟹   ENSRNOP00000060512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1058,080,618 - 58,111,278 (+)Ensembl
mRatBN7.2 Ensembl1057,582,128 - 57,612,748 (+)Ensembl
Rnor_6.0 Ensembl1059,529,785 - 59,560,430 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000065181   ⟹   ENSRNOP00000060212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1058,080,640 - 58,107,937 (+)Ensembl
mRatBN7.2 Ensembl1057,582,128 - 57,609,567 (+)Ensembl
Rnor_6.0 Ensembl1059,529,916 - 59,557,098 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087723   ⟹   ENSRNOP00000075069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1058,081,842 - 58,111,278 (+)Ensembl
mRatBN7.2 Ensembl1057,584,352 - 57,612,748 (+)Ensembl
Rnor_6.0 Ensembl1059,533,480 - 59,560,433 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000146379   ⟹   ENSRNOP00000104630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1058,079,852 - 58,111,273 (+)Ensembl
RefSeq Acc Id: NM_012914   ⟹   NP_037046
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81058,080,652 - 58,111,269 (+)NCBI
mRatBN7.21057,582,128 - 57,612,748 (+)NCBI
Rnor_6.01059,529,785 - 59,560,430 (+)NCBI
Rnor_5.01059,268,396 - 59,299,909 (+)NCBI
RGSC_v3.41059,853,363 - 59,884,087 (+)RGD
Celera1056,706,446 - 56,736,977 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085272   ⟹   XP_038941200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81058,079,710 - 58,106,232 (+)NCBI
mRatBN7.21057,581,742 - 57,607,707 (+)NCBI
RefSeq Acc Id: XM_063268465   ⟹   XP_063124535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81058,079,710 - 58,111,279 (+)NCBI
RefSeq Acc Id: NP_037046   ⟸   NM_012914
- UniProtKB: Q8R5I9 (UniProtKB/Swiss-Prot),   P18596 (UniProtKB/Swiss-Prot),   A6HGH2 (UniProtKB/TrEMBL),   G3V9U7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060212   ⟸   ENSRNOT00000065181
Ensembl Acc Id: ENSRNOP00000075069   ⟸   ENSRNOT00000087723
Ensembl Acc Id: ENSRNOP00000060512   ⟸   ENSRNOT00000064840
RefSeq Acc Id: XP_038941200   ⟸   XM_039085272
- Peptide Label: isoform X2
- UniProtKB: A6HGH2 (UniProtKB/TrEMBL),   G3V9U7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124535   ⟸   XM_063268465
- Peptide Label: isoform X1
- UniProtKB: A6HGH2 (UniProtKB/TrEMBL),   G3V9U7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000104630   ⟸   ENSRNOT00000146379
Protein Domains
Cation-transporting P-type ATPase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18596-F1-model_v2 AlphaFold P18596 1-999 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697395
Promoter ID:EPDNEW_R7920
Type:initiation region
Name:Atp2a3_1
Description:ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7921  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01059,529,785 - 59,529,845EPDNEW
RGD ID:13697403
Promoter ID:EPDNEW_R7921
Type:single initiation site
Name:Atp2a3_2
Description:ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7920  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01059,533,384 - 59,533,444EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2175 AgrOrtholog
BioCyc Gene G2FUF-24344 BioCyc
Ensembl Genes ENSRNOG00000017912 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000064840 ENTREZGENE
  ENSRNOT00000146379 ENTREZGENE
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot
  3.40.50.1000 UniProtKB/Swiss-Prot
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/Swiss-Prot
  Calcium-transporting ATPase, transmembrane domain UniProtKB/Swiss-Prot
InterPro ATPase_P-typ_cation-transptr_C UniProtKB/Swiss-Prot
  ATPase_P-typ_cation-transptr_N UniProtKB/Swiss-Prot
  ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot
  HAD-like_sf UniProtKB/Swiss-Prot
  HAD_sf UniProtKB/Swiss-Prot
  P-type_ATPase_IIA UniProtKB/Swiss-Prot
  P_typ_ATPase UniProtKB/Swiss-Prot
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot
KEGG Report rno:25391 UniProtKB/Swiss-Prot
NCBI Gene 25391 ENTREZGENE
PANTHER CALCIUM-TRANSPORTING ATPASE UniProtKB/Swiss-Prot
Pfam Cation_ATPase UniProtKB/Swiss-Prot
  Cation_ATPase_C UniProtKB/Swiss-Prot
  Cation_ATPase_N UniProtKB/Swiss-Prot
  E1-E2_ATPase UniProtKB/Swiss-Prot
  Hydrolase UniProtKB/Swiss-Prot
PhenoGen Atp2a3 PhenoGen
PRINTS CATATPASE UniProtKB/Swiss-Prot
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017912 RatGTEx
SMART Cation_ATPase_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot
  SSF81653 UniProtKB/Swiss-Prot
  SSF81660 UniProtKB/Swiss-Prot
  SSF81665 UniProtKB/Swiss-Prot
TIGR TC209291
UniProt A0A0G2K9N9_RAT UniProtKB/TrEMBL
  A0ABK0LLV9_RAT UniProtKB/TrEMBL
  A6HGH1_RAT UniProtKB/TrEMBL
  A6HGH2 ENTREZGENE, UniProtKB/TrEMBL
  AT2A3_RAT UniProtKB/Swiss-Prot
  D3ZHJ6_RAT UniProtKB/TrEMBL
  G3V9U7 ENTREZGENE, UniProtKB/TrEMBL
  P18596 ENTREZGENE
  Q8R5I9 ENTREZGENE
UniProt Secondary Q8R5I9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp2a3  ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3  Atp2a3  ATPase, Ca++ transporting, ubiquitous  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Atp2a3  ATPase, Ca++ transporting, ubiquitous      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the endoplasmic reticulum 631751
gene_expression expressed in microvascular endothelial cells 631779
gene_function Ca2+ ATPase 631751
gene_process pumps Ca2+ into the endoplasmic reticulum 631751
gene_protein has multiple splicing variant forms 631751