Atp1b2 (ATPase Na+/K+ transporting subunit beta 2) - Rat Genome Database

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Gene: Atp1b2 (ATPase Na+/K+ transporting subunit beta 2) Rattus norvegicus
Analyze
Symbol: Atp1b2
Name: ATPase Na+/K+ transporting subunit beta 2
RGD ID: 2171
Description: Enables P-type sodium:potassium-exchanging transporter activity and protein heterodimerization activity. Predicted to be involved in several processes, including intracellular monoatomic cation homeostasis; monoatomic cation transmembrane transport; and positive regulation of cation transmembrane transport. Predicted to act upstream of or within several processes, including brain development; motor behavior; and photoreceptor cell maintenance. Located in apical plasma membrane. Part of sodium:potassium-exchanging ATPase complex. Orthologous to human ATP1B2 (ATPase Na+/K+ transporting subunit beta 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Amog; ATPase Na+K+ transporting beta polypeptide 2; ATPase, Na+/K+ transporting, beta 2 polypeptide; ATPase, Na+K+ transporting, beta polypeptide 2; ATPB2; ATPB2S; MGC93648; RATATPB2S; sodium/potassium-dependent ATPase subunit beta-2; sodium/potassium-transporting ATPase subunit beta-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   WKY.SHRSP-(Shbg-Atp1b2)/Bbb  
QTLs:   Bp106  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,817,473 - 54,823,708 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1054,817,476 - 54,823,708 (-)EnsemblGRCr8
mRatBN7.21054,318,698 - 54,324,933 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,318,701 - 54,324,933 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1058,981,123 - 58,987,375 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,469,668 - 58,475,921 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0PNS010001144.11,821 - 8,077 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,205,622 - 56,211,879 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,205,625 - 56,211,891 (-)Ensemblrn6Rnor6.0
Rnor_5.01055,951,260 - 55,957,510 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41056,418,323 - 56,424,465 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1053,472,960 - 53,479,196 (-)NCBICelera
RGSC_v3.11056,431,946 - 56,438,088 (-)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
astemizole  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
clobetasol  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
dexamethasone  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
gamma-tocopherol  (ISO)
gentamycin  (EXP)
haloperidol  (EXP)
indometacin  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (EXP)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
aldosterone signaling pathway  (IEA)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Prokaryotic expression, polyclonal antibody preparation, and sub-cellular localization analysis of Na+, K+-ATPase beta2 subunit. Chen TF, etal., Protein Expr Purif. 2004 Sep;37(1):47-52. doi: 10.1016/j.pep.2004.05.003.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Training-induced changes in skeletal muscle Na+-K+ pump number and isoform expression in rats with chronic heart failure. Helwig B, etal., J Appl Physiol 2003 Jun;94(6):2225-36.
5. Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression. Martin-Vasallo P, etal., J Biol Chem 1989 Mar 15;264(8):4613-8.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Expression and synthesis of the Na,K-ATPase beta 2 subunit in human retinal pigment epithelium. Ruiz A, etal., Gene 1996 Oct 17;176(1-2):237-42.
14. The α2β2 isoform combination dominates the astrocytic Na+ /K+ -ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation. Stoica A, etal., Glia. 2017 Nov;65(11):1777-1793. doi: 10.1002/glia.23194. Epub 2017 Aug 8.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:2170236   PMID:2438288   PMID:7504672   PMID:7525597   PMID:8305453   PMID:8793730   PMID:10636900   PMID:10859164   PMID:11193188   PMID:12477932   PMID:12887597   PMID:16624992  
PMID:19542013   PMID:21196491   PMID:21705333   PMID:27121029   PMID:28373281   PMID:29476059   PMID:34989308  


Genomics

Comparative Map Data
Atp1b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,817,473 - 54,823,708 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1054,817,476 - 54,823,708 (-)EnsemblGRCr8
mRatBN7.21054,318,698 - 54,324,933 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,318,701 - 54,324,933 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1058,981,123 - 58,987,375 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,469,668 - 58,475,921 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0PNS010001144.11,821 - 8,077 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,205,622 - 56,211,879 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,205,625 - 56,211,891 (-)Ensemblrn6Rnor6.0
Rnor_5.01055,951,260 - 55,957,510 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41056,418,323 - 56,424,465 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1053,472,960 - 53,479,196 (-)NCBICelera
RGSC_v3.11056,431,946 - 56,438,088 (-)NCBI
Cytogenetic Map10q24NCBI
ATP1B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,646,627 - 7,657,770 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,646,627 - 7,657,770 (+)Ensemblhg38GRCh38
GRCh37177,549,945 - 7,561,088 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,494,979 - 7,501,814 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34177,494,978 - 7,501,814NCBI
Celera177,580,634 - 7,587,472 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,448,147 - 7,454,987 (+)NCBIHuRef
CHM1_1177,563,405 - 7,570,244 (+)NCBICHM1_1
T2T-CHM13v2.0177,550,794 - 7,561,928 (+)NCBIT2T-CHM13v2.0
Atp1b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,490,554 - 69,496,786 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,490,562 - 69,496,768 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381169,599,728 - 69,605,978 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,599,736 - 69,605,942 (-)Ensemblmm10GRCm38
MGSCv371169,413,252 - 69,419,462 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361169,415,948 - 69,422,024 (-)NCBIMGSCv36mm8
Celera1176,563,216 - 76,569,425 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.86NCBI
Atp1b2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,261,775 - 9,268,743 (-)Ensembl
ChiLan1.0NW_0049554679,261,775 - 9,268,743 (-)NCBIChiLan1.0ChiLan1.0
ATP1B2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,244,925 - 15,251,810 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,210,989 - 17,217,867 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,681,831 - 7,688,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,669,997 - 7,675,730 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,669,626 - 7,673,834 (+)EnsemblpanPan2panpan1.1
ATP1B2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,548,591 - 32,553,911 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,549,167 - 32,553,504 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha532,687,510 - 32,694,048 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0532,653,348 - 32,659,884 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,653,362 - 32,662,492 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,621,044 - 32,627,582 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,577,297 - 32,583,829 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,756,419 - 32,762,956 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Atp1b2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,433,820 - 47,440,238 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595907,919 - 915,053 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936595908,019 - 914,426 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP1B2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,925,693 - 52,932,635 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11252,925,697 - 52,932,638 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,241,662 - 55,248,610 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATP1B2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,030,016 - 7,035,620 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,030,055 - 7,037,754 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605914,373,302 - 14,379,044 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp1b2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,234,492 - 10,262,367 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478610,254,979 - 10,261,508 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Atp1b2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1949,208,873 - 49,215,290 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Atp1b2
31 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:251
Count of miRNA genes:146
Interacting mature miRNAs:194
Transcripts:ENSRNOT00000015076
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105429622758944345Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631652Bp106Blood pressure QTL 106arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105482370854831716Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Related Rat Strains
The following Strains have been annotated to Atp1b2
WKY.SHRSP-(Shbg-Atp1b2)/Bbb    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 90 89 58 91 58 6 354 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015076   ⟹   ENSRNOP00000015076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,817,476 - 54,823,708 (-)Ensembl
mRatBN7.2 Ensembl1054,318,701 - 54,324,933 (-)Ensembl
Rnor_6.0 Ensembl1056,205,625 - 56,211,891 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000130881   ⟹   ENSRNOP00000107801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,817,476 - 54,823,708 (-)Ensembl
RefSeq Acc Id: NM_012507   ⟹   NP_036639
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,817,473 - 54,823,708 (-)NCBI
mRatBN7.21054,318,698 - 54,324,933 (-)NCBI
Rnor_6.01056,205,622 - 56,211,857 (-)NCBI
Rnor_5.01055,951,260 - 55,957,510 (-)NCBI
RGSC_v3.41056,418,323 - 56,424,465 (-)RGD
Celera1053,472,960 - 53,479,196 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036639 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40782 (Get FASTA)   NCBI Sequence Viewer  
  AAC52918 (Get FASTA)   NCBI Sequence Viewer  
  AAH87034 (Get FASTA)   NCBI Sequence Viewer  
  BAA14101 (Get FASTA)   NCBI Sequence Viewer  
  EDM04874 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015076
GenBank Protein P13638 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036639   ⟸   NM_012507
- UniProtKB: P13638 (UniProtKB/Swiss-Prot),   Q5M9H4 (UniProtKB/TrEMBL),   D3ZQE0 (UniProtKB/TrEMBL),   A6HFR9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015076   ⟸   ENSRNOT00000015076
Ensembl Acc Id: ENSRNOP00000107801   ⟸   ENSRNOT00000130881

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13638-F1-model_v2 AlphaFold P13638 1-290 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697315
Promoter ID:EPDNEW_R7840
Type:single initiation site
Name:Atp1b2_1
Description:ATPase Na+/K+ transporting subunit beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01056,211,877 - 56,211,937EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2171 AgrOrtholog
BioCyc Gene G2FUF-24539 BioCyc
Ensembl Genes ENSRNOG00000011227 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015076 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  2.60.40.1660 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7124310 IMAGE-MGC_LOAD
InterPro Na/K_ATPase_sub_beta UniProtKB/Swiss-Prot
  Na/K_ATPase_sub_beta_sf UniProtKB/Swiss-Prot
MGC_CLONE MGC:93648 IMAGE-MGC_LOAD
NCBI Gene 24214 ENTREZGENE
PANTHER PTHR11523 UniProtKB/Swiss-Prot
  SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-2 UniProtKB/Swiss-Prot
Pfam Na_K-ATPase UniProtKB/Swiss-Prot
PhenoGen Atp1b2 PhenoGen
PROSITE ATPASE_NA_K_BETA_1 UniProtKB/Swiss-Prot
  ATPASE_NA_K_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011227 RatGTEx
TIGR TC223975
UniProt A0ABK0LZ30_RAT UniProtKB/TrEMBL
  A6HFR9 ENTREZGENE, UniProtKB/TrEMBL
  AT1B2_RAT UniProtKB/Swiss-Prot
  D3ZQE0 ENTREZGENE
  P13638 ENTREZGENE
  Q5M9H4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp1b2  ATPase Na+/K+ transporting subunit beta 2  Atp1b2  ATPase, Na+/K+ transporting, beta 2 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Atp1b2  ATPase, Na+/K+ transporting, beta 2 polypeptide    ATPase, Na+K+ transporting, beta polypeptide 2  Name updated 629478 APPROVED
2002-06-10 Atp1b2  ATPase, Na+K+ transporting, beta polypeptide 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the apical membrane 631778
gene_expression expressed abundantly in brain and eye, with moderate levels in kidney, heart, spleen, adrenals, bladder, uterus and testis 631777
gene_expression expressed in retinal pigment epithelium 631778
gene_function Na+/K+ ATPase subunit 631758
gene_process Na+/K+ ATPase activity 631758
gene_transcript 3.4 kilobase 631777