Arsb (arylsulfatase B) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Arsb (arylsulfatase B) Rattus norvegicus
Analyze
Symbol: Arsb
Name: arylsulfatase B
RGD ID: 2158
Description: Enables sulfuric ester hydrolase activity. Involved in several processes, including positive regulation of neuron projection development; response to estrogen; and response to methylmercury. Located in cell surface. Used to study mucopolysaccharidosis VI. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to human ARSB (arylsulfatase B); PARTICIPATES IN glycosaminoglycan degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Arylsulfatase B (MPS VI); ASB; G4S; N-acetylgalactosamine-4-sulfatase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: ArsbMPR
Genetic Models: WIAR.MPR-Arsbabd/Ncchd
Is Marker For: Strains:   MPR/Iar ; WIAR.MPR-Arsbabd/Ncchd
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8226,736,395 - 26,895,682 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl226,736,957 - 26,897,611 (+)EnsemblGRCr8
mRatBN7.2225,002,210 - 25,162,675 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl225,002,346 - 25,162,671 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx232,029,775 - 32,188,228 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0230,130,038 - 30,288,496 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0224,954,935 - 25,113,379 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0223,385,154 - 23,543,028 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl223,385,183 - 23,544,963 (+)Ensemblrn6Rnor6.0
Rnor_5.0242,559,079 - 42,717,753 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4224,067,560 - 24,223,821 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera221,077,645 - 21,235,680 (+)NCBICelera
RGSC_v3.1223,988,194 - 24,144,190 (+)NCBI
Cytogenetic Map2q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chlordecone  (ISO)
chondroitin sulfate  (ISO)
cisplatin  (ISO)
DDT  (EXP)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (ISO)
naled  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
organophosphorus compound  (EXP)
ozone  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP)
poly(I:C)  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
theophylline  (ISO)
thiram  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IDA,IEA,ISO)
lysosome  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cytochemical localization of arylsulfatase B in rat basophils and mast cells. Bentfeld-Barker ME and Bainton DF, J Histochem Cytochem. 1980 Oct;28(10):1055-61.
2. Anti-TNF-alpha therapy enhances the effects of enzyme replacement therapy in rats with mucopolysaccharidosis type VI. Eliyahu E, etal., PLoS One. 2011;6(8):e22447. doi: 10.1371/journal.pone.0022447. Epub 2011 Aug 22.
3. Characterization of liver lysosomal enzyme activity in hepatocytes, Kupffer and endothelial cells during aging: effect of dietary restriction. Ferland G, etal., Mech Ageing Dev. 1990 Nov;56(2):143-54.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Mucopolysaccharidosis type VI: identification of three mutations in the arylsulfatase B gene of patients with the severe and mild phenotypes provides molecular evidence for genetic heterogeneity. Jin WD, etal., Am J Hum Genet. 1992 Apr;50(4):795-800.
6. Mucopolysaccharidosis type VI in rats: isolation of cDNAs encoding arylsulfatase B, chromosomal localization of the gene, and identification of the mutation. Kunieda T, etal., Genomics 1995 Oct 10;29(3):582-7.
7. Localization of arylsulphatase A and B activities in rat kidney. Leznicki AJ and Rozanska M, Acta Biochim Pol. 1991;38(1):151-6.
8. Ultrastructural localization of arylsulfatase B in mitochondria of epithelial cells of the proximal convoluted tubules of the rat kidney. Makita T and Sandborn EB, Experientia. 1971 Feb 15;27(2):187-9.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Cell-surface arylsulfatase A and B on sinusoidal endothelial cells, hepatocytes, and Kupffer cells in mammalian livers. Mitsunaga-Nakatsubo K, etal., Med Mol Morphol. 2009 Jun;42(2):63-9. doi: 10.1007/s00795-009-0447-x. Epub 2009 Jun 18.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. The effect of pH on the kinetics of arylsulphatases A and B. O'Fagain C, etal., Biochem J. 1983 Sep 1;213(3):603-7.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Autophagy-related changes of arylsulphatases A and B in rat liver lysosomes. Sanghavi P and Koenig H, Biochem J. 1976 Jun 1;155(3):725-8.
18. Isolation and characterization of rat hepatic ascorbic acid-2-sulfatases. Thompson DB and Daniel WL, Enzyme. 1987;37(3):134-40.
19. Developmental profiles of arylsulfatases A and B in rat cerebral cortex and spinal cord. van der Pal RH, etal., Biochim Biophys Acta. 1991 Feb 5;1081(3):315-20.
20. Inability of thiol compounds to restore CNS arylsulfatases inhibited by methyl mercury. Vinay SD and Sood PP, Pharmacol Toxicol. 1991 Jul;69(1):71-4.
21. Enzymic changes in the cervix of the rat and hamster during the oestrous cycle and the effect of steroids. Zachariah E and Moudgal NR, J Endocrinol. 1977 Feb;72(2):153-61.
22. Arylsulfatase B modulates neurite outgrowth via astrocyte chondroitin-4-sulfate: dysregulation by ethanol. Zhang X, etal., Glia. 2014 Feb;62(2):259-71. doi: 10.1002/glia.22604. Epub 2013 Dec 6.
Additional References at PubMed
PMID:7470017   PMID:8889548   PMID:12477932   PMID:12947022   PMID:16174644   PMID:19306108   PMID:23376485   PMID:23533145   PMID:25002582   PMID:26234751  


Genomics

Comparative Map Data
Arsb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8226,736,395 - 26,895,682 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl226,736,957 - 26,897,611 (+)EnsemblGRCr8
mRatBN7.2225,002,210 - 25,162,675 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl225,002,346 - 25,162,671 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx232,029,775 - 32,188,228 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0230,130,038 - 30,288,496 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0224,954,935 - 25,113,379 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0223,385,154 - 23,543,028 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl223,385,183 - 23,544,963 (+)Ensemblrn6Rnor6.0
Rnor_5.0242,559,079 - 42,717,753 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4224,067,560 - 24,223,821 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera221,077,645 - 21,235,680 (+)NCBICelera
RGSC_v3.1223,988,194 - 24,144,190 (+)NCBI
Cytogenetic Map2q12NCBI
ARSB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38578,777,209 - 78,985,958 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl578,777,209 - 78,986,087 (-)Ensemblhg38GRCh38
GRCh37578,073,032 - 78,281,781 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36578,108,788 - 78,318,113 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34578,147,295 - 78,317,522NCBI
Celera573,966,272 - 74,175,272 (-)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef573,279,833 - 73,488,328 (-)NCBIHuRef
CHM1_1577,506,051 - 77,714,858 (-)NCBICHM1_1
T2T-CHM13v2.0579,258,792 - 79,467,648 (-)NCBIT2T-CHM13v2.0
Arsb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391393,908,187 - 94,079,524 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1393,908,138 - 94,079,524 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381393,771,679 - 93,943,016 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1393,771,630 - 93,943,016 (+)Ensemblmm10GRCm38
MGSCv371394,541,634 - 94,712,971 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361394,872,512 - 95,041,668 (+)NCBIMGSCv36mm8
Celera1397,379,077 - 97,564,231 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.88NCBI
Arsb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542522,119,930 - 22,279,006 (+)Ensembl
ChiLan1.0NW_00495542522,120,507 - 22,281,221 (+)NCBIChiLan1.0ChiLan1.0
ARSB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2436,319,804 - 36,528,385 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1534,473,431 - 34,682,012 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0536,325,581 - 36,534,371 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1536,804,874 - 37,023,746 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl536,804,874 - 37,023,739 (+)EnsemblpanPan2panpan1.1
ARSB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1327,870,111 - 28,034,906 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl327,870,151 - 28,034,906 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha329,107,602 - 29,273,552 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0327,790,052 - 27,973,468 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl327,790,052 - 27,958,957 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1327,726,564 - 27,892,579 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0327,705,072 - 27,870,890 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0328,031,550 - 28,197,915 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arsb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213184,032,193 - 184,203,920 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365496,653,978 - 6,826,349 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365496,654,259 - 6,827,647 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARSB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl287,614,963 - 87,778,447 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1287,614,938 - 87,779,553 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2289,559,337 - 89,591,727 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARSB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1473,016,497 - 73,203,570 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl473,015,980 - 73,202,439 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604921,862,979 - 22,049,954 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arsb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248693,289,430 - 3,476,437 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248693,226,633 - 3,476,071 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Arsb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13202,392,453 - 202,567,227 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arsb
1761 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1100
Count of miRNA genes:332
Interacting mature miRNAs:439
Transcripts:ENSRNOT00000014860
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358144538110Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2142977529Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat

Markers in Region
RH144163  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2225,111,194 - 25,111,363 (+)MAPPERmRatBN7.2
Rnor_6.0223,494,026 - 23,494,194NCBIRnor6.0
Rnor_5.0242,668,726 - 42,668,894UniSTSRnor5.0
RGSC_v3.4224,176,427 - 24,176,595UniSTSRGSC3.4
Celera221,186,394 - 21,186,562UniSTS
RH 3.4 Map213.3UniSTS
Cytogenetic Map2q12UniSTS
RH127520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2225,001,638 - 25,001,830 (+)MAPPERmRatBN7.2
Rnor_6.0223,643,200 - 23,643,391NCBIRnor6.0
Rnor_6.0223,384,461 - 23,384,652NCBIRnor6.0
Rnor_5.0242,559,161 - 42,559,352UniSTSRnor5.0
Rnor_5.0242,815,872 - 42,816,063UniSTSRnor5.0
RGSC_v3.4224,066,867 - 24,067,058UniSTSRGSC3.4
Celera221,076,952 - 21,077,143UniSTS
Cytogenetic Map2q12UniSTS
RH130793  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2225,162,470 - 25,162,650 (+)MAPPERmRatBN7.2
Rnor_6.0223,544,760 - 23,544,939NCBIRnor6.0
Rnor_5.0242,719,485 - 42,719,664UniSTSRnor5.0
RGSC_v3.4224,225,553 - 24,225,732UniSTSRGSC3.4
Celera221,237,412 - 21,237,591UniSTS
Cytogenetic Map2q12UniSTS
BF413485  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8226,776,781 - 26,776,995 (+)Marker Load Pipeline
mRatBN7.2225,041,827 - 25,042,041 (+)MAPPERmRatBN7.2
Rnor_6.0223,424,646 - 23,424,859NCBIRnor6.0
Rnor_5.0242,599,346 - 42,599,559UniSTSRnor5.0
RGSC_v3.4224,107,052 - 24,107,265UniSTSRGSC3.4
Celera221,117,143 - 21,117,356UniSTS
Cytogenetic Map2q12UniSTS
AU049865  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2225,018,811 - 25,018,969 (+)MAPPERmRatBN7.2
Rnor_6.0223,401,632 - 23,401,787NCBIRnor6.0
Rnor_5.0242,576,332 - 42,576,487UniSTSRnor5.0
RGSC_v3.4224,084,038 - 24,084,193UniSTSRGSC3.4
Celera221,094,129 - 21,094,284UniSTS
Cytogenetic Map2q12UniSTS
D16S506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2225,070,752 - 25,072,105 (+)MAPPERmRatBN7.2
Rnor_6.0223,453,588 - 23,454,940NCBIRnor6.0
Rnor_5.0242,628,288 - 42,629,640UniSTSRnor5.0
RGSC_v3.4224,135,989 - 24,137,341UniSTSRGSC3.4
Celera221,145,940 - 21,147,292UniSTS
Cytogenetic Map2q12UniSTS


Related Rat Strains
The following Strains have been annotated to Arsb
MPR/Iar     WIAR.MPR-Arsbabd/Ncchd    


Genetic Models
This gene Arsb is modified in the following models/strains:
WIAR.MPR-Arsbabd/Ncchd    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014860   ⟹   ENSRNOP00000014860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl226,736,957 - 26,897,611 (+)Ensembl
mRatBN7.2 Ensembl225,002,346 - 25,162,671 (+)Ensembl
Rnor_6.0 Ensembl223,385,183 - 23,544,963 (+)Ensembl
RefSeq Acc Id: NM_033443   ⟹   NP_254278
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8226,737,290 - 26,895,682 (+)NCBI
mRatBN7.2225,002,332 - 25,160,739 (+)NCBI
Rnor_6.0223,385,154 - 23,543,028 (+)NCBI
Rnor_5.0242,559,079 - 42,717,753 (+)NCBI
RGSC_v3.4224,067,560 - 24,223,821 (+)RGD
Celera221,077,645 - 21,235,680 (+)RGD
Sequence:
RefSeq Acc Id: XR_005500242
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8226,736,395 - 26,895,262 (+)NCBI
mRatBN7.2225,002,255 - 25,160,429 (+)NCBI
RefSeq Acc Id: XR_005500243
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8226,736,395 - 26,895,262 (+)NCBI
mRatBN7.2225,002,210 - 25,162,675 (+)NCBI
Protein Sequences
Protein RefSeqs NP_254278 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI27451 (Get FASTA)   NCBI Sequence Viewer  
  AAI68241 (Get FASTA)   NCBI Sequence Viewer  
  BAA08412 (Get FASTA)   NCBI Sequence Viewer  
  CAI84982 (Get FASTA)   NCBI Sequence Viewer  
  EDM10069 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014860
  ENSRNOP00000014860.5
GenBank Protein P50430 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_254278   ⟸   NM_033443
- Peptide Label: precursor
- UniProtKB: Q32KK1 (UniProtKB/Swiss-Prot),   P50430 (UniProtKB/Swiss-Prot),   B4F7E2 (UniProtKB/TrEMBL),   A6I4W1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014860   ⟸   ENSRNOT00000014860
Protein Domains
Sulfatase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50430-F1-model_v2 AlphaFold P50430 1-528 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2158 AgrOrtholog
BioCyc Gene G2FUF-54841 BioCyc
Ensembl Genes ENSRNOG00000011150 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014860 ENTREZGENE
  ENSRNOT00000014860.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1120.10 UniProtKB/Swiss-Prot
  3.40.720.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7445706 IMAGE-MGC_LOAD
InterPro Alkaline_phosphatase_core_sf UniProtKB/Swiss-Prot
  ARSB UniProtKB/Swiss-Prot
  Sulfatase_CS UniProtKB/Swiss-Prot
  Sulfatase_N UniProtKB/Swiss-Prot
KEGG Report rno:25227 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156489 IMAGE-MGC_LOAD
NCBI Gene 25227 ENTREZGENE
PANTHER ARYLSULFATASE UniProtKB/Swiss-Prot
  ARYLSULFATASE B UniProtKB/Swiss-Prot
Pfam Sulfatase UniProtKB/Swiss-Prot
PhenoGen Arsb PhenoGen
PROSITE SULFATASE_1 UniProtKB/Swiss-Prot
  SULFATASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011150 RatGTEx
Superfamily-SCOP SSF53649 UniProtKB/Swiss-Prot
UniProt A0JPJ3_RAT UniProtKB/TrEMBL
  A6I4W1 ENTREZGENE, UniProtKB/TrEMBL
  ARSB_RAT UniProtKB/Swiss-Prot
  B4F7E2 ENTREZGENE, UniProtKB/TrEMBL
  P50430 ENTREZGENE
  Q32KK1 ENTREZGENE
UniProt Secondary Q32KK1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Arsb  arylsulfatase B    Arylsulfatase B (MPS VI)  Name updated 625702 APPROVED
2002-06-10 Arsb  Arylsulfatase B (MPS VI)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease insertion at nucleotide 507 is responsible for deficiency causing Mucopolysaccharidosis (MPS) type VI, the lysosomal storage disorder 631738
gene_expression expressed in liver 631738
gene_process hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate in lysosomal proteins 631738