Areg (amphiregulin) - Rat Genome Database

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Gene: Areg (amphiregulin) Rattus norvegicus
Analyze
Symbol: Areg
Name: amphiregulin
RGD ID: 2149
Description: Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in several processes, including negative regulation of osteoblast differentiation; neurogenesis; and response to hydrogen peroxide. Located in extracellular space. Used to study high grade glioma. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human AREG (amphiregulin); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AR; schwannoma-derived growth factor; SDGF
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,256,384 - 17,265,641 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1417,256,384 - 17,265,641 (-)EnsemblGRCr8
mRatBN7.21416,972,185 - 16,981,443 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1416,972,187 - 16,981,535 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1416,971,509 - 16,980,539 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,290,441 - 18,299,471 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01416,982,558 - 16,991,588 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,521,921 - 18,531,179 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,521,930 - 18,531,179 (-)Ensemblrn6Rnor6.0
Rnor_5.01418,431,477 - 18,440,735 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41418,466,313 - 18,475,571 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1416,350,045 - 16,359,315 (-)NCBICelera
RGSC_v3.11418,466,313 - 18,475,571 (-)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (ISO)
1,1-dichloroethene  (ISO)
1,2,3,7,8-Pentachlorodibenzodioxin  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-Hydroxybenzo[a]pyrene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-Nitrobenzanthrone  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrolein  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
atrazine  (EXP,ISO)
batimastat  (ISO)
bazedoxifene  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzofurans  (ISO)
beta-lapachone  (ISO)
bifenthrin  (EXP)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
brequinar  (ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
cholesterol  (ISO)
choline  (ISO)
Chorionic gonadotropin  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cumene  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
drometrizole  (ISO)
erlotinib hydrochloride  (ISO)
estrone  (ISO)
etoposide  (ISO)
exemestane  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
griseofulvin  (ISO)
Heliotrine  (ISO)
herbicide  (EXP,ISO)
hexane  (EXP)
hexestrol  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lasofoxifene  (ISO)
lipopolysaccharide  (ISO)
loxtidine  (ISO)
manganese(II) chloride  (EXP)
marimastat  (ISO)
menadione  (ISO)
mestranol  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
monoethyl phthalate  (ISO)
Muraglitazar  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
naphthalene  (EXP,ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (ISO)
okadaic acid  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
Pervanadate  (ISO)
Pf-06840003  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
promegestone  (ISO)
propanal  (ISO)
propylparaben  (ISO)
prostaglandin E2  (EXP,ISO)
protoporphyrins  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rolipram  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
SU6656  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetradecane  (EXP)
tetraphene  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tyrphostin AG 1478  (ISO)
undecane  (EXP)
valproic acid  (ISO)
wortmannin  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IEA,ISO)
cytoplasm  (IEA,ISO)
extracellular space  (IBA,IDA,IEA,ISO)
membrane  (IEA)
nucleus  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Gene expression profiling of ERBB receptors and ligands in human transitional cell carcinoma of the bladder. Amsellem-Ouazana D, etal., J Urol. 2006 Mar;175(3 Pt 1):1127-32.
2. Amphiregulin expression in prostatic intraepithelial neoplasia and adenocarcinoma: a study of 93 cases. Bostwick DG, etal., Prostate. 2004 Feb 1;58(2):164-8.
3. Amphiregulin causes functional downregulation of adherens junctions in psoriasis. Chung E, etal., J Invest Dermatol. 2005 Jun;124(6):1134-40.
4. Transforming growth factor alpha, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas. D'Antonio A, etal., Int J Oncol. 2002 Nov;21(5):941-8.
5. Expression of the epidermal growth factor system in endometrioid endometrial cancer. Ejskjaer K, etal., Gynecol Oncol. 2007 Jan;104(1):158-67. Epub 2006 Sep 7.
6. Involvement of epidermal growth factor receptor in chemically induced mouse bladder tumour progression. el-Marjou A, etal., Carcinogenesis. 2000 Dec;21(12):2211-8.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Gene Expression Profiling Distinguishes Between Spontaneous and Radiation-induced Rat Mammary Carcinomas. Imaoka T, etal., J Radiat Res (Tokyo). 2008 Apr 16;.
9. Schwannoma-derived growth factor promotes the neuronal differentiation and survival of PC12 cells. Kimura H and Schubert D, J Cell Biol. 1992 Feb;116(3):777-83.
10. Structure, expression and function of a schwannoma-derived growth factor. Kimura H, etal., Nature 1990 Nov 15;348(6298):257-60.
11. Expression of amphiregulin and epidermal growth factor receptor in human breast cancer: analysis of autocriny and stromal-epithelial interactions. Ma L, etal., J Pathol. 2001 Aug;194(4):413-9.
12. Zhonghua zhong liu za zhi [Chinese journal of oncology] Ma L, etal., Zhonghua Zhong Liu Za Zhi. 2005 Sep;27(9):521-3.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Increased expression of schwannoma-derived growth factor (SDGF) mRNA in rat tumor cells: involvement of SDGF in the growth promotion of rat gliomas. Mishima K, etal., Int J Cancer. 1996 May 3;66(3):352-7.
15. Oxidative stress increases gene expression of heparin-binding EGF-like growth factor and amphiregulin in cultured rat gastric epithelial cells. Miyazaki Y, etal., Biochem Biophys Res Commun. 1996 Sep 13;226(2):542-6.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Preneoplastic mammary tumor markers: Cripto and Amphiregulin are overexpressed in hyperplastic stages of tumor progression in transgenic mice. Niemeyer CC, etal., Int J Cancer. 1999 May 17;81(4):588-91.
18. Differential immunohistochemical detection of transforming growth factor alpha, amphiregulin and CRIPTO in human normal and malignant breast tissues. Panico L, etal., Int J Cancer. 1996 Jan 3;65(1):51-6.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. Stimulation of amphiregulin expression in osteoblastic cells by parathyroid hormone requires the protein kinase A and cAMP response element-binding protein signaling pathway. Qin L and Partridge NC, J Cell Biochem. 2005 Oct 15;96(3):632-40.
22. Amphiregulin is a novel growth factor involved in normal bone development and in the cellular response to parathyroid hormone stimulation. Qin L, etal., J Biol Chem. 2005 Feb 4;280(5):3974-81. Epub 2004 Oct 27.
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93.
26. A subclass of HER1 ligands are prognostic markers for survival in bladder cancer patients. Thogersen VB, etal., Cancer Res. 2001 Aug 15;61(16):6227-33.
Additional References at PubMed
PMID:8588926   PMID:8702723   PMID:10331984   PMID:12743035   PMID:15291759   PMID:17369357   PMID:19229996   PMID:21258428   PMID:22184114   PMID:24816162   PMID:30773606   PMID:35996142  


Genomics

Comparative Map Data
Areg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,256,384 - 17,265,641 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1417,256,384 - 17,265,641 (-)EnsemblGRCr8
mRatBN7.21416,972,185 - 16,981,443 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1416,972,187 - 16,981,535 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1416,971,509 - 16,980,539 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,290,441 - 18,299,471 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01416,982,558 - 16,991,588 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,521,921 - 18,531,179 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,521,930 - 18,531,179 (-)Ensemblrn6Rnor6.0
Rnor_5.01418,431,477 - 18,440,735 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41418,466,313 - 18,475,571 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1416,350,045 - 16,359,315 (-)NCBICelera
RGSC_v3.11418,466,313 - 18,475,571 (-)NCBI
Cytogenetic Map14p22NCBI
AREG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38474,445,136 - 74,455,005 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl474,444,999 - 74,455,005 (+)Ensemblhg38GRCh38
GRCh37475,310,853 - 75,320,722 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,529,717 - 75,539,590 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34475,675,887 - 75,685,760NCBI
Celera472,671,109 - 72,680,980 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef471,121,847 - 71,131,718 (+)NCBIHuRef
CHM1_1475,346,752 - 75,356,715 (+)NCBICHM1_1
T2T-CHM13v2.0477,788,795 - 77,798,664 (+)NCBIT2T-CHM13v2.0
Areg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39591,287,458 - 91,296,291 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl591,287,458 - 91,296,291 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38591,139,599 - 91,148,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl591,139,599 - 91,148,432 (+)Ensemblmm10GRCm38
MGSCv37591,568,641 - 91,577,458 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36592,214,815 - 92,223,632 (+)NCBIMGSCv36mm8
Celera589,277,608 - 89,286,422 (+)NCBICelera
Cytogenetic Map5E2NCBI
cM Map544.78NCBI
Areg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955474680,204 - 689,088 (+)Ensembl
ChiLan1.0NW_004955474680,212 - 689,021 (+)NCBIChiLan1.0ChiLan1.0
AREG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2355,604,814 - 55,617,056 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1455,794,221 - 55,806,459 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0449,737,191 - 49,747,013 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1455,570,299 - 55,580,142 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl455,570,299 - 55,580,142 (-)EnsemblpanPan2panpan1.1
AREG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,925,761 - 62,936,753 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,926,301 - 62,936,738 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1362,614,442 - 62,625,448 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01363,756,606 - 63,767,617 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,757,757 - 63,767,594 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11363,371,389 - 63,382,383 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,853,171 - 62,864,176 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,996,005 - 64,007,006 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Areg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528512,822,538 - 12,834,155 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365981,274,565 - 1,283,746 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365981,276,599 - 1,283,612 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AREG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl870,417,923 - 70,428,102 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1870,417,935 - 70,428,106 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,568,826 - 74,579,003 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AREG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,979,574 - 22,990,179 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl722,980,249 - 22,990,162 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660371,272,704 - 1,282,711 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Areg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247301,290,655 - 1,299,410 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247301,290,692 - 1,299,365 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Areg
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1114,535,263 - 4,542,455 (+)NCBIRrattus_CSIRO_v1

Variants

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Variants in Areg
122 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:131
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000003703
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 4 52 88 53 60 32 35 32 6 228 110 11 75 68 78 28 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000003703   ⟹   ENSRNOP00000003703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1417,256,384 - 17,265,641 (-)Ensembl
mRatBN7.2 Ensembl1416,972,187 - 16,981,535 (-)Ensembl
Rnor_6.0 Ensembl1418,521,930 - 18,531,179 (-)Ensembl
RefSeq Acc Id: NM_017123   ⟹   NP_058819
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,256,384 - 17,265,641 (-)NCBI
mRatBN7.21416,972,185 - 16,981,443 (-)NCBI
Rnor_6.01418,521,921 - 18,531,179 (-)NCBI
Rnor_5.01418,431,477 - 18,440,735 (-)NCBI
RGSC_v3.41418,466,313 - 18,475,571 (-)RGD
Celera1416,350,045 - 16,359,315 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058819 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA38967 (Get FASTA)   NCBI Sequence Viewer  
  EDL88581 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003703
  ENSRNOP00000003703.2
GenBank Protein P24338 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058819   ⟸   NM_017123
- Peptide Label: preproprotein
- UniProtKB: P24338 (UniProtKB/Swiss-Prot),   A6KKC9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003703   ⟸   ENSRNOT00000003703
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24338-F1-model_v2 AlphaFold P24338 1-243 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699222
Promoter ID:EPDNEW_R9746
Type:single initiation site
Name:Areg_1
Description:amphiregulin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01418,531,208 - 18,531,268EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2149 AgrOrtholog
BioCyc Gene G2FUF-16216 BioCyc
Ensembl Genes ENSRNOG00000002754 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003703 ENTREZGENE
  ENSRNOT00000003703.5 UniProtKB/Swiss-Prot
Gene3D-CATH Laminin UniProtKB/Swiss-Prot
InterPro EGF-like_dom UniProtKB/Swiss-Prot
KEGG Report rno:29183 UniProtKB/Swiss-Prot
NCBI Gene 29183 ENTREZGENE
PANTHER AMPHIREGULIN UniProtKB/Swiss-Prot
  PTHR10740 UniProtKB/Swiss-Prot
PhenoGen Areg PhenoGen
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002754 RatGTEx
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
UniProt A6KKC9 ENTREZGENE, UniProtKB/TrEMBL
  AREG_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Areg  amphiregulin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function has mitogenic activity 69755
gene_process may act as a growth factor during nervous system development 69755
gene_product member of the epidermal growth factor family 69755