Ak2 (adenylate kinase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ak2 (adenylate kinase 2) Rattus norvegicus
Analyze
Symbol: Ak2
Name: adenylate kinase 2
RGD ID: 2077
Description: Enables AMP kinase activity. Contributes to nucleobase-containing compound kinase activity. Involved in several processes, including liver development; purine nucleotide metabolic process; and response to thyroid hormone. Predicted to be located in sperm mitochondrial sheath. Predicted to be active in mitochondrion. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2); PARTICIPATES IN adefovir pharmacokinetics pathway; tenofovir pharmacokinetics pathway; de novo purine biosynthetic pathway; INTERACTS WITH (R)-adrenaline; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenylate kinase 2, mitochondrial; adenylate monophosphate kinase; AK 2; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Ak2-ps3  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,609,469 - 146,649,008 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5146,630,445 - 146,650,610 (+)EnsemblGRCr8
mRatBN7.25141,308,650 - 141,364,633 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,346,063 - 141,364,632 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5144,044,192 - 144,062,698 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05145,814,021 - 145,832,527 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05145,813,302 - 145,831,915 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,185,474 - 147,204,050 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,185,474 - 147,204,050 (+)Ensemblrn6Rnor6.0
Rnor_5.05150,910,910 - 150,929,525 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45148,156,751 - 148,176,195 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5139,827,913 - 139,846,149 (+)NCBICelera
RGSC_v3.15148,166,789 - 148,183,198 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
genistein  (EXP,ISO)
irinotecan  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
piroxicam  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thiram  (ISO)
tolcapone  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes. Eimre M, etal., Biochim Biophys Acta. 2008 Jun;1777(6):514-24. Epub 2008 Mar 29.
2. Development of adenylate kinase isoenzymes in rat liver. Filler R and Criss WE, Biochem J. 1971 May;122(4):553-5.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Distribution and developmental changes of adenylate kinase isozymes in the rat brain: localization of adenylate kinase 1 in the olfactory bulb. Inouye S, etal., Biochem Biophys Res Commun 1999 Jan 27;254(3):618-22.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Lagresle-Peyrou C, etal., Nat Genet. 2009 Jan;41(1):106-11. doi: 10.1038/ng.278. Epub 2008 Nov 30.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Mechanism of mitochondrial import of adenylate kinase isozymes. Nobumoto M, etal., J Biochem. 1998 Jan;123(1):128-35.
10. Dynamics of nucleotide metabolism as a supporter of life phenomena. Noma T J Med Invest. 2005 Aug;52(3-4):127-36.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Dynamic expression of adenylate kinase 2 in the hippocampus of pilocarpine model rats. Peng X, etal., J Mol Neurosci. 2012 May;47(1):150-7. doi: 10.1007/s12031-011-9703-3. Epub 2012 Jan 14.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Purification of rat liver adenylate kinase isozyme II and comparison with isozyme 3. Sapico V, etal., Biochim Biophys Acta. 1972 Feb 28;258(2):436-45.
19. Proteomic characterization of early changes induced by triiodothyronine in rat liver. Severino V, etal., J Proteome Res. 2011 Jul 1;10(7):3212-24. Epub 2011 Jun 1.
20. Tissue-specific and developmentally regulated expression of the genes encoding adenylate kinase isozymes. Tanabe T, etal., J Biochem. 1993 Feb;113(2):200-7.
21. Evidence of a new phosphoryl transfer system in nucleotide metabolism. Vannoni D, etal., FEBS J. 2009 Jan;276(1):271-85. Epub 2008 Nov 27.
22. Distinct behaviors of adenylate kinase and cytochrome c observed following induction of mitochondrial permeability transition by Ca(2+) in the absence of respiratory substrate. Yamamoto T, etal., J Bioenerg Biomembr. 2008 Dec;40(6):619-23. Epub 2009 Jan 13.
Additional References at PubMed
PMID:6182143   PMID:8889548   PMID:12477932   PMID:12865426   PMID:14651853   PMID:15632090   PMID:16790685   PMID:18614015   PMID:20458337   PMID:34800366  


Genomics

Comparative Map Data
Ak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,609,469 - 146,649,008 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5146,630,445 - 146,650,610 (+)EnsemblGRCr8
mRatBN7.25141,308,650 - 141,364,633 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,346,063 - 141,364,632 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5144,044,192 - 144,062,698 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05145,814,021 - 145,832,527 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05145,813,302 - 145,831,915 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,185,474 - 147,204,050 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,185,474 - 147,204,050 (+)Ensemblrn6Rnor6.0
Rnor_5.05150,910,910 - 150,929,525 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45148,156,751 - 148,176,195 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5139,827,913 - 139,846,149 (+)NCBICelera
RGSC_v3.15148,166,789 - 148,183,198 (+)NCBI
Cytogenetic Map5q36NCBI
AK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38133,007,940 - 33,036,883 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl133,007,986 - 33,080,996 (-)Ensemblhg38GRCh38
GRCh37133,473,541 - 33,502,484 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36133,246,173 - 33,275,079 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34133,147,675 - 33,171,564NCBI
Celera131,743,797 - 31,772,701 (-)NCBICelera
Cytogenetic Map1p35.1NCBI
HuRef131,590,115 - 31,619,093 (-)NCBIHuRef
CHM1_1133,589,052 - 33,618,018 (-)NCBICHM1_1
T2T-CHM13v2.0132,867,728 - 32,896,675 (-)NCBIT2T-CHM13v2.0
Ak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394128,887,017 - 128,905,322 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4128,885,751 - 128,905,322 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384128,993,224 - 129,011,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4128,991,958 - 129,011,529 (+)Ensemblmm10GRCm38
MGSCv374128,670,509 - 128,688,773 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364128,495,569 - 128,513,833 (+)NCBIMGSCv36mm8
Celera4127,337,482 - 127,350,601 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map462.62NCBI
Ak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545211,254,334 - 11,275,632 (-)Ensembl
ChiLan1.0NW_00495545211,254,853 - 11,275,587 (-)NCBIChiLan1.0ChiLan1.0
AK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21193,789,141 - 193,817,156 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11192,911,293 - 192,939,311 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0132,295,668 - 32,323,681 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1133,480,074 - 33,508,697 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl133,480,947 - 33,508,621 (-)EnsemblpanPan2panpan1.1
AK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,342,769 - 68,371,769 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,350,057 - 68,371,090 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha264,922,664 - 64,951,721 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0268,906,961 - 68,936,418 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,914,650 - 68,936,416 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,719,275 - 65,748,337 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0266,741,685 - 66,770,757 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0267,733,734 - 67,762,814 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505850,062,232 - 50,083,751 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647415,886,412 - 15,908,560 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647415,887,014 - 15,908,522 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1689,295,164 - 89,318,169 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12099,834,286 - 99,863,071 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2099,834,334 - 99,858,781 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603316,834,347 - 16,863,178 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ak2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476416,089,357 - 16,113,275 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ak2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1129,119,757 - 29,138,078 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ak2
198 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
Ak2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25141,361,345 - 141,361,511 (+)MAPPERmRatBN7.2
Rnor_6.05147,200,763 - 147,200,928NCBIRnor6.0
Rnor_5.05150,926,238 - 150,926,403UniSTSRnor5.0
RGSC_v3.45148,172,908 - 148,173,073UniSTSRGSC3.4
Celera5139,842,862 - 139,843,027UniSTS
Cytogenetic Map5q36UniSTS
RH134035  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2444,967,927 - 44,968,117 (+)MAPPERmRatBN7.2
mRatBN7.25141,364,313 - 141,364,510 (+)MAPPERmRatBN7.2
Rnor_6.05147,203,731 - 147,203,927NCBIRnor6.0
Rnor_6.0443,916,634 - 43,916,823NCBIRnor6.0
Rnor_5.05150,929,206 - 150,929,402UniSTSRnor5.0
Rnor_5.0444,523,232 - 44,523,421UniSTSRnor5.0
RGSC_v3.4442,278,501 - 42,278,690UniSTSRGSC3.4
RGSC_v3.45148,175,876 - 148,176,072UniSTSRGSC3.4
Celera5139,845,830 - 139,846,026UniSTS
Celera440,259,514 - 40,259,703UniSTS
Cytogenetic Map5q36UniSTS
RH134503  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25141,361,306 - 141,361,512 (+)MAPPERmRatBN7.2
Rnor_6.05147,200,724 - 147,200,929NCBIRnor6.0
Rnor_5.05150,926,199 - 150,926,404UniSTSRnor5.0
RGSC_v3.45148,172,869 - 148,173,074UniSTSRGSC3.4
Celera5139,842,823 - 139,843,028UniSTS
RH 3.4 Map5957.2UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000134   ⟹   ENSRNOP00000000134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5146,630,445 - 146,650,610 (+)Ensembl
mRatBN7.2 Ensembl5141,346,063 - 141,364,632 (+)Ensembl
Rnor_6.0 Ensembl5147,185,474 - 147,204,050 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093801   ⟹   ENSRNOP00000095127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5141,346,063 - 141,357,320 (+)Ensembl
RefSeq Acc Id: NM_001033967   ⟹   NP_001029139
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85146,630,494 - 146,649,008 (+)NCBI
mRatBN7.25141,346,119 - 141,364,633 (+)NCBI
Rnor_6.05147,185,474 - 147,204,050 (+)NCBI
Rnor_5.05150,910,910 - 150,929,525 (+)NCBI
RGSC_v3.45148,156,751 - 148,176,195 (+)RGD
Celera5139,827,913 - 139,846,149 (+)NCBI
Sequence:
RefSeq Acc Id: NM_030986   ⟹   NP_112248
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85146,630,494 - 146,645,972 (+)NCBI
mRatBN7.25141,346,119 - 141,361,597 (+)NCBI
Rnor_6.05147,185,474 - 147,201,014 (+)NCBI
Rnor_5.05150,910,910 - 150,929,525 (+)NCBI
RGSC_v3.45148,156,751 - 148,176,195 (+)RGD
Celera5139,827,913 - 139,843,113 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109253   ⟹   XP_038965181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85146,609,469 - 146,645,973 (+)NCBI
mRatBN7.25141,325,153 - 141,361,603 (+)NCBI
RefSeq Acc Id: NP_112248   ⟸   NM_030986
- Peptide Label: isoform a
- UniProtKB: Q6P7C6 (UniProtKB/Swiss-Prot),   P29410 (UniProtKB/Swiss-Prot),   A6ISG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029139   ⟸   NM_001033967
- Peptide Label: isoform b
- UniProtKB: Q6P7C6 (UniProtKB/Swiss-Prot),   P29410 (UniProtKB/Swiss-Prot),   A0A0G2JSG6 (UniProtKB/TrEMBL),   A6ISG7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000134   ⟸   ENSRNOT00000000134
RefSeq Acc Id: XP_038965181   ⟸   XM_039109253
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000095127   ⟸   ENSRNOT00000093801
Protein Domains
Adenylate kinase active site lid

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29410-F1-model_v2 AlphaFold P29410 1-239 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694053
Promoter ID:EPDNEW_R4578
Type:initiation region
Name:Ak2_1
Description:adenylate kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05147,185,497 - 147,185,557EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2077 AgrOrtholog
BioCyc Gene G2FUF-39829 BioCyc
BioCyc Pathway PWY-7219 [adenosine ribonucleotides de novo biosynthesis] BioCyc
BioCyc Pathway Image PWY-7219 BioCyc
Ensembl Genes ENSRNOG00000000122 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000000134 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598607 IMAGE-MGC_LOAD
InterPro Adenyl_kin_sub UniProtKB/Swiss-Prot
  Adenylat/UMP-CMP_kin UniProtKB/Swiss-Prot
  Adenylat_kinase_CS UniProtKB/Swiss-Prot
  Adenylate_kinase_lid-dom UniProtKB/Swiss-Prot
  AK2 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:24184 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72419 IMAGE-MGC_LOAD
NCBI Gene 24184 ENTREZGENE
PANTHER PTHR23359 UniProtKB/Swiss-Prot
Pfam ADK UniProtKB/Swiss-Prot
  ADK_lid UniProtKB/Swiss-Prot
PhenoGen Ak2 PhenoGen
PRINTS ADENYLTKNASE UniProtKB/Swiss-Prot
PROSITE ADENYLATE_KINASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000122 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2JSG6 ENTREZGENE, UniProtKB/TrEMBL
  A6ISG7 ENTREZGENE, UniProtKB/TrEMBL
  A6ISG8 ENTREZGENE, UniProtKB/TrEMBL
  KAD2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P7C6 ENTREZGENE
UniProt Secondary Q6P7C6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ak2  Adenylate kinase 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression in liver is maintained at high levels throughout development; activity in liver increases after birth and was further elevated during growth 631735
gene_process functions in adenine nucleotide metabolism homeostasis 631735