Add3 (adducin 3) - Rat Genome Database

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Gene: Add3 (adducin 3) Rattus norvegicus
Analyze
Symbol: Add3
Name: adducin 3
RGD ID: 2043
Description: Enables protein kinase C binding activity. Involved in positive regulation of cytoskeleton organization; positive regulation of vasoconstriction; and response to xenobiotic stimulus. Predicted to be located in several cellular components, including brush border; cell-cell junction; and condensed nuclear chromosome. Predicted to be active in cytoskeleton; plasma membrane; and postsynaptic density. Used to study hypertension and proteinuria. Human ortholog(s) of this gene implicated in spastic quadriplegic cerebral palsy 3. Orthologous to human ADD3 (adducin 3); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adducin 3 (gamma); adducin 3, gamma; adducin-like protein 70; gamma-adducin; potein kinase C binding protein 35H; protein kinase C-binding protein 35H
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Add3em1Mcwi ; Add3em2Mcwi
Genetic Models: FHH-Chr 1BN-Add3em2Mcwi /Roman ; SD-Add3em1Mcwi/ Roman
Is Marker For: Strains:   FHH-Tg(CAG-Add3)McwiRoman  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81262,152,722 - 262,260,504 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1262,154,996 - 262,260,504 (+)EnsemblGRCr8
mRatBN7.21252,147,341 - 252,255,126 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1252,147,386 - 252,255,124 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1260,336,161 - 260,443,763 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01267,042,224 - 267,149,829 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01259,697,436 - 259,805,286 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01273,854,195 - 273,961,982 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1273,854,248 - 273,961,982 (+)Ensemblrn6Rnor6.0
Rnor_5.01281,267,424 - 281,375,203 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41259,347,673 - 259,455,407 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1247,872,140 - 247,979,623 (+)NCBICelera
RGSC_v3.11259,560,471 - 259,923,891 (-)NCBI
Cytogenetic Map1q55NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
flusilazole  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
malathion  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
Mesaconitine  (EXP)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodimethylamine  (EXP)
nickel sulfate  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
parathion  (EXP)
parathion-methyl  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
brush border  (IEA,ISO)
cell cortex  (IEA,ISO)
cell-cell junction  (IEA,ISO)
condensed nuclear chromosome  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytoskeleton  (IBA,IEA,ISO)
membrane  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
postsynaptic density  (IBA,IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interaction cloning of protein kinase C substrates. Chapline C, etal., J Biol Chem 1993 Apr 5;268(10):6858-61.
2. Microarray analysis of changes in renal phenotype in the ethylene glycol rat model of urolithiasis: potential and pitfalls. Chen DH, etal., BJU Int. 2004 Sep;94(4):637-50.
3. 35H, a sequence isolated as a protein kinase C binding protein, is a novel member of the adducin family. Dong L, etal., J Biol Chem 1995 Oct 27;270(43):25534-40.
4. Knockdown of Add3 impairs the myogenic response of renal afferent arterioles and middle cerebral arteries. Fan F, etal., Am J Physiol Renal Physiol. 2017 Jun 1;312(6):F971-F981. doi: 10.1152/ajprenal.00529.2016. Epub 2016 Dec 7.
5. A Mutation in γ-Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease. Fan F, etal., J Am Soc Nephrol. 2020 Apr;31(4):687-700. doi: 10.1681/ASN.2019080784. Epub 2020 Feb 6.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Targeted disruption of the beta adducin gene (Add2) causes red blood cell spherocytosis in mice. Gilligan DM, etal., Proc Natl Acad Sci U S A 1999 Sep 14;96(19):10717-22.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. NUP98 is fused to adducin 3 in a patient with T-cell acute lymphoblastic leukemia and myeloid markers, with a new translocation t(10;11)(q25;p15). Lahortiga I, etal., Cancer Res 2003 Jun 15;63(12):3079-83.
10. Regulation of the mitochondrial ATP synthase/ATPase complex: cDNA cloning, sequence, overexpression, and secondary structural characterization of a functional protein inhibitor. Lebowitz MS and Pedersen PL, Arch Biochem Biophys 1993 Feb 15;301(1):64-70.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells. van de Water B, etal., J Biol Chem. 2000 Aug 18;275(33):25805-13.
16. Hypertension-linked decrease in the expression of brain gamma-adducin. Yang H, etal., Circ Res 2002 Oct 4;91(7):633-9.
Additional References at PubMed
PMID:1864459   PMID:8889548   PMID:9299427   PMID:12947022   PMID:17114649   PMID:22114352   PMID:31505169   PMID:33308016   PMID:33414130  


Genomics

Comparative Map Data
Add3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81262,152,722 - 262,260,504 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1262,154,996 - 262,260,504 (+)EnsemblGRCr8
mRatBN7.21252,147,341 - 252,255,126 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1252,147,386 - 252,255,124 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1260,336,161 - 260,443,763 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01267,042,224 - 267,149,829 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01259,697,436 - 259,805,286 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01273,854,195 - 273,961,982 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1273,854,248 - 273,961,982 (+)Ensemblrn6Rnor6.0
Rnor_5.01281,267,424 - 281,375,203 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41259,347,673 - 259,455,407 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1247,872,140 - 247,979,623 (+)NCBICelera
RGSC_v3.11259,560,471 - 259,923,891 (-)NCBI
Cytogenetic Map1q55NCBI
ADD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810109,996,373 - 110,135,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10109,996,356 - 110,135,565 (+)Ensemblhg38GRCh38
GRCh3710111,756,131 - 111,895,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610111,755,716 - 111,885,313 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3410111,755,793 - 111,885,313NCBI
Celera10105,497,404 - 105,626,995 (+)NCBICelera
Cytogenetic Map10q25.1-q25.2NCBI
HuRef10105,396,619 - 105,526,176 (+)NCBIHuRef
CHM1_110112,047,392 - 112,177,067 (+)NCBICHM1_1
T2T-CHM13v2.010110,880,187 - 111,019,428 (+)NCBIT2T-CHM13v2.0
Add3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391953,128,874 - 53,235,518 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1953,128,874 - 53,235,830 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381953,140,443 - 53,247,326 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1953,140,443 - 53,247,399 (+)Ensemblmm10GRCm38
MGSCv371953,214,935 - 53,321,889 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361953,256,726 - 53,300,399 (+)NCBIMGSCv36mm8
Celera1955,321,358 - 55,428,774 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1947.18NCBI
Add3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554851,216,435 - 1,353,953 (-)Ensembl
ChiLan1.0NW_0049554851,216,435 - 1,273,275 (-)NCBIChiLan1.0ChiLan1.0
ADD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28121,884,928 - 122,014,764 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110121,890,333 - 122,020,100 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010106,597,693 - 106,727,494 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110110,048,680 - 110,178,671 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10110,123,270 - 110,178,671 (+)EnsemblpanPan2panpan1.1
ADD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12821,402,068 - 21,527,006 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2821,403,680 - 21,525,063 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2821,545,130 - 21,669,800 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02821,916,580 - 22,041,306 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2821,875,987 - 22,041,302 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12821,477,401 - 21,602,290 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02821,481,987 - 21,606,180 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02821,617,201 - 21,742,113 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Add3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721324,519,105 - 24,632,420 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936486928,522 - 1,043,084 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936486928,956 - 1,042,168 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14120,451,575 - 120,583,722 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114120,451,421 - 120,583,725 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214131,288,509 - 131,420,807 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19102,930,270 - 103,056,558 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9103,010,713 - 103,057,101 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604864,133,099 - 64,259,617 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Add3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473736,091,671 - 36,256,398 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Add3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1252,648,779 - 52,680,078 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:964
Count of miRNA genes:301
Interacting mature miRNAs:394
Transcripts:ENSRNOT00000017600, ENSRNOT00000044827
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1257624997270518180Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat

Markers in Region
D1Got253  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21252,223,685 - 252,223,828 (+)MAPPERmRatBN7.2
Rnor_6.01273,930,544 - 273,930,686NCBIRnor6.0
Rnor_5.01281,343,765 - 281,343,907UniSTSRnor5.0
RGSC_v3.41259,378,968 - 259,379,111RGDRGSC3.4
RGSC_v3.41259,378,969 - 259,379,111UniSTSRGSC3.4
Celera1247,948,325 - 247,948,467UniSTS
RGSC_v3.11259,590,014 - 259,590,156RGD
RH 3.4 Map11665.0UniSTS
RH 3.4 Map11665.0RGD
RH 2.0 Map11286.0999RGD
Cytogenetic Map1q55UniSTS
RH127841  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21252,254,804 - 252,255,023 (+)MAPPERmRatBN7.2
Rnor_6.01273,961,661 - 273,961,879NCBIRnor6.0
Rnor_5.01281,374,882 - 281,375,100UniSTSRnor5.0
RGSC_v3.41259,347,776 - 259,347,994UniSTSRGSC3.4
Celera1247,979,302 - 247,979,520UniSTS
RH 3.4 Map11664.5UniSTS
Cytogenetic Map1q55UniSTS


Related Rat Strains
The following Strains have been annotated to Add3
FHH-Tg(CAG-Add3)McwiRoman    


Genetic Models
This gene Add3 is modified in the following models/strains:
FHH-Chr 1BN-Add3em2Mcwi /Roman     SD-Add3em1Mcwi/ Roman    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001164103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA899625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC106606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC119371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW141606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB725075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB757924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF111029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK596161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO402732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM038946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM059497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM072500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U35775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000017600   ⟹   ENSRNOP00000017600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1262,193,829 - 262,260,497 (+)Ensembl
mRatBN7.2 Ensembl1252,147,386 - 252,255,124 (+)Ensembl
Rnor_6.0 Ensembl1273,854,248 - 273,961,982 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000044827   ⟹   ENSRNOP00000043399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1262,206,796 - 262,260,504 (+)Ensembl
mRatBN7.2 Ensembl1252,147,386 - 252,255,124 (+)Ensembl
Rnor_6.0 Ensembl1273,854,248 - 273,961,982 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086496   ⟹   ENSRNOP00000069717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1273,854,342 - 273,960,228 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128366   ⟹   ENSRNOP00000109495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1262,206,234 - 262,260,504 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000132974   ⟹   ENSRNOP00000110239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1262,155,012 - 262,260,479 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000171420   ⟹   ENSRNOP00000112493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1262,154,996 - 262,260,479 (+)Ensembl
RefSeq Acc Id: NM_001164103   ⟹   NP_001157575
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,152,768 - 262,260,504 (+)NCBI
mRatBN7.21252,147,386 - 252,255,126 (+)NCBI
Rnor_6.01273,854,248 - 273,961,982 (+)NCBI
Rnor_5.01281,267,424 - 281,375,203 (+)NCBI
RGSC_v3.41259,347,673 - 259,455,407 (-)RGD
Celera1247,872,140 - 247,979,623 (+)RGD
Sequence:
RefSeq Acc Id: NM_031552   ⟹   NP_113740
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,152,768 - 262,260,504 (+)NCBI
mRatBN7.21252,147,386 - 252,255,126 (+)NCBI
Rnor_6.01273,854,248 - 273,961,982 (+)NCBI
Rnor_5.01281,267,424 - 281,375,203 (+)NCBI
RGSC_v3.41259,347,673 - 259,455,407 (-)RGD
Celera1247,872,140 - 247,979,623 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231599   ⟹   XP_006231661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,155,171 - 262,260,486 (+)NCBI
mRatBN7.21252,149,574 - 252,255,108 (+)NCBI
Rnor_6.01273,856,706 - 273,961,964 (+)NCBI
Rnor_5.01281,267,424 - 281,375,203 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231600   ⟹   XP_006231662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,152,722 - 262,260,486 (+)NCBI
mRatBN7.21252,147,341 - 252,255,108 (+)NCBI
Rnor_6.01273,854,195 - 273,961,964 (+)NCBI
Rnor_5.01281,267,424 - 281,375,203 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231601   ⟹   XP_006231663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,206,113 - 262,260,486 (+)NCBI
mRatBN7.21252,200,750 - 252,255,108 (+)NCBI
Rnor_6.01273,906,949 - 273,961,964 (+)NCBI
Rnor_5.01281,267,424 - 281,375,203 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008760510   ⟹   XP_008758732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,155,165 - 262,260,486 (+)NCBI
mRatBN7.21252,149,602 - 252,255,108 (+)NCBI
Rnor_6.01273,856,695 - 273,961,964 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101448   ⟹   XP_038957376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,153,813 - 262,260,486 (+)NCBI
mRatBN7.21252,148,037 - 252,255,108 (+)NCBI
RefSeq Acc Id: XM_063281377   ⟹   XP_063137447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,206,794 - 262,260,486 (+)NCBI
RefSeq Acc Id: XM_063281396   ⟹   XP_063137466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,206,414 - 262,260,486 (+)NCBI
RefSeq Acc Id: XM_063281404   ⟹   XP_063137474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,206,756 - 262,260,486 (+)NCBI
RefSeq Acc Id: XM_063281414   ⟹   XP_063137484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,155,171 - 262,260,486 (+)NCBI
RefSeq Acc Id: XM_063281425   ⟹   XP_063137495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,153,824 - 262,260,486 (+)NCBI
RefSeq Acc Id: NP_113740   ⟸   NM_031552
- Peptide Label: isoform 2
- UniProtKB: Q62847 (UniProtKB/Swiss-Prot),   D3ZCH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157575   ⟸   NM_001164103
- Peptide Label: isoform 1
- UniProtKB: D3ZCH7 (UniProtKB/Swiss-Prot),   Q62847 (UniProtKB/Swiss-Prot),   G3V9D7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231662   ⟸   XM_006231600
- Peptide Label: isoform X2
- UniProtKB: Q62847 (UniProtKB/Swiss-Prot),   D3ZCH7 (UniProtKB/Swiss-Prot),   G3V9D7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231661   ⟸   XM_006231599
- Peptide Label: isoform X2
- UniProtKB: Q62847 (UniProtKB/Swiss-Prot),   D3ZCH7 (UniProtKB/Swiss-Prot),   G3V9D7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231663   ⟸   XM_006231601
- Peptide Label: isoform X2
- UniProtKB: Q62847 (UniProtKB/Swiss-Prot),   D3ZCH7 (UniProtKB/Swiss-Prot),   G3V9D7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758732   ⟸   XM_008760510
- Peptide Label: isoform X2
- UniProtKB: Q62847 (UniProtKB/Swiss-Prot),   D3ZCH7 (UniProtKB/Swiss-Prot),   G3V9D7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043399   ⟸   ENSRNOT00000044827
Ensembl Acc Id: ENSRNOP00000069717   ⟸   ENSRNOT00000086496
Ensembl Acc Id: ENSRNOP00000017600   ⟸   ENSRNOT00000017600
RefSeq Acc Id: XP_038957376   ⟸   XM_039101448
- Peptide Label: isoform X2
- UniProtKB: Q62847 (UniProtKB/Swiss-Prot),   D3ZCH7 (UniProtKB/Swiss-Prot),   G3V9D7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137495   ⟸   XM_063281425
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063137484   ⟸   XM_063281414
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063137466   ⟸   XM_063281396
- Peptide Label: isoform X2
- UniProtKB: Q62847 (UniProtKB/Swiss-Prot),   G3V9D7 (UniProtKB/Swiss-Prot),   D3ZCH7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137474   ⟸   XM_063281404
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063137447   ⟸   XM_063281377
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000112493   ⟸   ENSRNOT00000171420
Ensembl Acc Id: ENSRNOP00000110239   ⟸   ENSRNOT00000132974
Ensembl Acc Id: ENSRNOP00000109495   ⟸   ENSRNOT00000128366

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62847-F1-model_v2 AlphaFold Q62847 1-705 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690988
Promoter ID:EPDNEW_R1513
Type:initiation region
Name:Add3_1
Description:adducin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01273,854,244 - 273,854,304EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2043 AgrOrtholog
BioCyc Gene G2FUF-55400 BioCyc
Ensembl Genes ENSRNOG00000012820 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017600 ENTREZGENE
  ENSRNOT00000017600.7 UniProtKB/Swiss-Prot
  ENSRNOT00000044827 ENTREZGENE
  ENSRNOT00000044827.7 UniProtKB/Swiss-Prot
  ENSRNOT00000128366 ENTREZGENE
  ENSRNOT00000132974 ENTREZGENE
  ENSRNOT00000171420 ENTREZGENE
Gene3D-CATH 3.40.225.10 UniProtKB/Swiss-Prot
InterPro Aldolase-II_Adducin_sf UniProtKB/Swiss-Prot
  Aldolase_II/adducin_N UniProtKB/Swiss-Prot
  Aldolase_II/adducin_N_sf UniProtKB/Swiss-Prot
KEGG Report rno:25230 UniProtKB/Swiss-Prot
NCBI Gene 25230 ENTREZGENE
PANTHER ADDUCIN UniProtKB/Swiss-Prot
  PTHR10672:SF5 UniProtKB/Swiss-Prot
Pfam Aldolase_II UniProtKB/Swiss-Prot
PhenoGen Add3 PhenoGen
RatGTEx ENSRNOG00000012820 RatGTEx
SMART Aldolase_II UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53639 UniProtKB/Swiss-Prot
UniProt A0ABK0M2Y0_RAT UniProtKB/TrEMBL
  ADDG_RAT UniProtKB/Swiss-Prot
  D3ZCH7 ENTREZGENE
  G3V9D7 ENTREZGENE
  Q62847 ENTREZGENE
UniProt Secondary D3ZCH7 UniProtKB/Swiss-Prot
  G3V9D7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Add3  adducin 3  Add3  adducin 3 (gamma)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Add3  adducin 3 (gamma)    adducin 3, gamma  Name updated 1299863 APPROVED
2002-11-06 Add3  adducin 3, gamma    Adducin 3, gamma  Name updated 625702 APPROVED
2002-06-10 Add3  Adducin 3, gamma      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cytoskeleton 631726
gene_expression mRNA is detected in kidney 631734
gene_expression protein detected in renal proximal tubule epithelial cells 631726
gene_function binds phosphatidylserine 631734
gene_function binds and is a substrate for protein kinase C 631734
gene_homology has high similarity to the 3' end of beta adducin (Add2) 631734
gene_physical_interaction may form a heterodimer with alpha adducin (Add1) 631726
gene_product member of the adducin family 631726
gene_protein 80 and 90 kDa 631726