Acp3 (acid phosphatase 3) - Rat Genome Database

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Gene: Acp3 (acid phosphatase 3) Rattus norvegicus
Analyze
Symbol: Acp3
Name: acid phosphatase 3
RGD ID: 2023
Description: Enables acid phosphatase activity; choline binding activity; and protein homodimerization activity. Involved in dephosphorylation. Located in Golgi cisterna; apical part of cell; and cytoplasmic vesicle. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human ACP3 (acid phosphatase 3); PARTICIPATES IN riboflavin metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5'-NT; 5'-nucleotidase; acid phosphatase prostate; acid phosphatase, prostate; Acpp; Acpp11; ecto-5'-nucleotidase; fluoride-resistant acid phosphatase; FRAP; pap; Ppal; prostatic acid phosphatase; prostatic acid phosphatase (rPAP); RNACPP11; thiamine monophosphatase; TMPase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Coreg1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88113,784,372 - 113,833,033 (-)NCBIGRCr8
mRatBN7.28104,905,570 - 104,956,146 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8104,905,586 - 104,954,236 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8110,555,965 - 110,601,143 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08108,755,152 - 108,800,326 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08106,597,855 - 106,643,027 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08112,838,574 - 112,884,062 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8112,834,707 - 112,884,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08112,224,707 - 112,272,400 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48109,354,381 - 109,400,296 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18109,382,705 - 109,419,751 (-)NCBI
Celera8104,274,154 - 104,317,190 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Acp3Ratprostate cancer  ISOACP3 (Homo sapiens)2301055 RGD 
Acp3Ratprostate cancer disease_progressionISOACP3 (Homo sapiens)2301054 RGD 
Acp3RatProstatic Neoplasms  ISOACP3 (Homo sapiens)2301052 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Acp3Ratalkaptonuria  ISOACP3 (Homo sapiens)8554872ClinVar Annotator: match by term: AlkaptonuriaClinVarPMID:12501223 more ...
Acp3RatPrimary Lymphedema with Myelodysplasia  ISOACP3 (Homo sapiens)8554872ClinVar Annotator: match by term: Emberger syndromeClinVarPMID:22147895 and PMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Original Reference(s)
Acp3Ratjuvenile rheumatoid arthritis  ISOACP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504
Object Symbol
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Term
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Original Reference(s)
Acp3Ratprostate cancer  ISSAcp3 (Mus musculus)13592920OMIM:176807 more ...MouseDO 

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Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Acp3Rat1,2-dimethylhydrazine decreases expressionISOAcp3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of ACP3 mRNACTDPMID:22206623
Acp3Rat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of ACP3 mRNACTDPMID:30723492
Acp3Rat17alpha-ethynylestradiol increases expressionISOAcp3 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of ACP3 mRNACTDPMID:17942748
Acp3Rat17alpha-ethynylestradiol multiple interactionsISOAcp3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACP3 mRNACTDPMID:17942748
Acp3Rat17beta-estradiol multiple interactionsISOACP3 (Homo sapiens)6480464[Estradiol co-treated with Norethindrone Acetate] results in increased expression of ACP3 mRNA more ...CTDPMID:17404688 more ...
Acp3Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of ACP3 mRNACTDPMID:32145629
Acp3Rat17beta-estradiol increases expressionISOACP3 (Homo sapiens)6480464Estradiol results in increased expression of ACP3 mRNACTDPMID:21795739
Acp3Rat17beta-estradiol decreases expressionISOACP3 (Homo sapiens)6480464Estradiol results in decreased expression of ACP3 mRNACTDPMID:12391264 more ...
Acp3Rat17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expressionISOACP3 (Homo sapiens)6480464Metribolone results in increased expression of ACP3 proteinCTDPMID:17541959
Acp3Rat17beta-hydroxy-5alpha-androstan-3-one decreases expressionISOACP3 (Homo sapiens)6480464Dihydrotestosterone results in decreased expression of ACP3 mRNACTDPMID:12391264
Acp3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOAcp3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ACP3 mRNACTDPMID:20702594 and PMID:26377647
Acp3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOAcp3 (Mus musculus)6480464[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of ACP3 mRNA more ...CTDPMID:16214954 more ...
Acp3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOAcp3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of ACP3 mRNACTDPMID:17337447 more ...
Acp3Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expressionISOACP3 (Homo sapiens)64804642 more ...CTDPMID:26705709
Acp3Rat2-hydroxypropanoic acid decreases expressionISOACP3 (Homo sapiens)6480464Lactic Acid results in decreased expression of ACP3 mRNACTDPMID:30851411
Acp3Rat2-palmitoylglycerol increases expressionISOACP3 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of ACP3 mRNACTDPMID:37199045
Acp3Rat3,3',4,4',5-pentachlorobiphenyl affects expressionISOAcp3 (Mus musculus)64804643 more ...CTDPMID:20702594
Acp3Rat4,4'-diaminodiphenylmethane increases expressionISOAcp3 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in increased expression of ACP3 mRNACTDPMID:18648102
Acp3Rat4,4'-sulfonyldiphenol decreases methylationISOAcp3 (Mus musculus)6480464bisphenol S results in decreased methylation of ACP3 exonCTDPMID:33297965
Acp3Rat4-hydroxyphenyl retinamide increases expressionISOAcp3 (Mus musculus)6480464Fenretinide results in increased expression of ACP3 mRNACTDPMID:28973697

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Biological Process
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Original Reference(s)
Acp3Ratadenosine metabolic process involved_inISOAcp3 (Mus musculus)1624291 PMID:18940592RGDPMID:18940592
Acp3Ratadenosine metabolic process involved_inISOACP3 (Homo sapiens)1624291 PMID:18940592RGDPMID:18940592
Acp3Ratadenosine metabolic process involved_inIEAUniProtKB:Q8CE08 and ensembl:ENSMUSP000000598891600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3Ratadenosine metabolic process involved_inIEAUniProtKB:P15309 and ensembl:ENSP000003374711600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3Ratdephosphorylation involved_inISOACP3 (Homo sapiens)1624291 PMID:8132635RGDPMID:8132635
Acp3Ratdephosphorylation  IDA 2299977phosphorylcholine substrateRGD 
Acp3Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Acp3Ratnucleotide metabolic process involved_inIEAUniProtKB:Q8CE08 and ensembl:ENSMUSP000000598891600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3Ratnucleotide metabolic process involved_inISOAcp3 (Mus musculus)1624291 PMID:18940592RGDPMID:18940592
Acp3Ratpositive regulation of adenosine receptor signaling pathway involved_inIEAUniProtKB:P15309 and ensembl:ENSP000003374711600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3Ratpositive regulation of adenosine receptor signaling pathway involved_inIBAPANTHER:PTN002480352 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Acp3Ratpositive regulation of adenosine receptor signaling pathway involved_inISOACP3 (Homo sapiens)1624291 PMID:18940592 and PMID:22389722RGDPMID:18940592 and PMID:22389722
Acp3Ratpurine nucleobase metabolic process involved_inIEAUniProtKB:Q8CE08 and ensembl:ENSMUSP000000598891600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3Ratpurine nucleobase metabolic process involved_inISOAcp3 (Mus musculus)1624291 PMID:18940592RGDPMID:18940592
Acp3Ratregulation of sensory perception of pain involved_inISOACP3 (Homo sapiens)1624291 PMID:18940592 and PMID:22389722RGDPMID:18940592 and PMID:22389722
Acp3Ratregulation of sensory perception of pain involved_inISOAcp3 (Mus musculus)1624291 PMID:18940592RGDPMID:18940592
Acp3Ratregulation of sensory perception of pain involved_inIEAUniProtKB:Q8CE08 and ensembl:ENSMUSP000000598891600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3Ratregulation of sensory perception of pain involved_inIEAUniProtKB:P15309 and ensembl:ENSP000003374711600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3Ratregulation of sensory perception of pain involved_inIBAMGI:1928480 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Acp3Ratthiamine metabolic process involved_inISOAcp3 (Mus musculus)1624291 PMID:18940592RGDPMID:18940592
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Cellular Component
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Object Symbol
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Original Reference(s)
Acp3Ratapical part of cell  IDA 2299977 RGD 
Acp3Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Acp3Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Acp3Ratextracellular space located_inIEAUniProtKB:P15309 and ensembl:ENSP000003374711600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3Ratextracellular space located_inISOACP3 (Homo sapiens)1624291 PMID:10639192 more ...RGDPMID:10639192 more ...
Acp3Ratfilopodium located_inISOAcp3 (Mus musculus)1624291 PMID:17658863RGDPMID:17658863
Acp3Ratfilopodium located_inIEAUniProtKB:Q8CE08 and ensembl:ENSMUSP000000598891600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3RatGolgi cisterna  IDA 2299977 RGD 
Acp3Ratlysosomal membrane located_inIEAUniProtKB-SubCell:SL-01571600115GO_REF:0000044UniProtGO_REF:0000044
Acp3Ratlysosome located_inIEAUniProtKB-KW:KW-04581600115GO_REF:0000043UniProtGO_REF:0000043
Acp3Ratmembrane located_inISOAcp3 (Mus musculus)1624291 PMID:17658863RGDPMID:17658863
Acp3Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Acp3Ratmembrane located_inIEAUniProtKB:Q8CE08 and ensembl:ENSMUSP000000598891600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3Ratmultivesicular body  IDA 2299977 RGD 
Acp3Ratplasma membrane located_inISOACP3 (Homo sapiens)1624291 PMID:17658863RGDPMID:17658863
Acp3Ratplasma membrane is_active_inIBAMGI:1928480 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Acp3Ratplasma membrane located_inISOAcp3 (Mus musculus)1624291 PMID:17658863 and PMID:18940592RGDPMID:17658863 and PMID:18940592
Acp3Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Acp3Ratplasma membrane located_inIEAUniProtKB:P15309 and ensembl:ENSP000003374711600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Original Reference(s)
Acp3Rat5'-nucleotidase activity enablesIEAUniProtKB:P15309 and ensembl:ENSP000003374711600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3Rat5'-nucleotidase activity enablesIEARHEA:124841600115GO_REF:0000116RHEAGO_REF:0000116
Acp3Rat5'-nucleotidase activity enablesIEAEC:3.1.3.51600115GO_REF:0000003UniProtGO_REF:0000003
Acp3Rat5'-nucleotidase activity enablesISOACP3 (Homo sapiens) and UniProtKB:P15309-21624291 PMID:18940592RGDPMID:18940592
Acp3Ratacid phosphatase activity enablesIEAUniProtKB:P15309 and ensembl:ENSP000003374711600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3Ratacid phosphatase activity  IDA 2299977phosphorylcholine substrateRGD 
Acp3Ratacid phosphatase activity enablesIEAEC:3.1.3.21600115GO_REF:0000003UniProtGO_REF:0000003
Acp3Ratacid phosphatase activity enablesISOACP3 (Homo sapiens)1624291 PMID:10506173 and PMID:8132635RGDPMID:10506173 and PMID:8132635
Acp3Ratcholine binding  IDA 2299977phosphorylcholine substrateRGD 
Acp3Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Acp3Ratidentical protein binding enablesISOACP3 (Homo sapiens)1624291UniProtKB:P15309 more ...RGDPMID:18083097 and PMID:24657436
Acp3Ratidentical protein binding enablesIEAUniProtKB:P15309 and ensembl:ENSP000003374711600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3Ratlysophosphatidic acid phosphatase activity enablesISOACP3 (Homo sapiens)1624291 PMID:15280042RGDPMID:15280042
Acp3Ratlysophosphatidic acid phosphatase activity enablesIEAUniProtKB:P15309 and ensembl:ENSP000003374711600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3Ratmolecular adaptor activity enablesISOACP3 (Homo sapiens)1624291 PMID:19995078RGDPMID:19995078
Acp3Ratphosphatase activity enablesISOACP3 (Homo sapiens)1624291 PMID:18940592 and PMID:22389722RGDPMID:18940592 and PMID:22389722
Acp3Ratphosphatase activity enablesIEAUniProtKB:P15309 and ensembl:ENSP000003374711600115GO_REF:0000107EnsemblGO_REF:0000107
Acp3Ratphosphatase activity enablesIBAFB:FBgn0000032 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Acp3Ratprotein binding enablesISOACP3 (Homo sapiens)1624291UniProtKB:P04626 and PMID:9705354RGDPMID:9705354
Acp3Ratprotein homodimerization activity enablesIDA 8554747PMID:8077215UniProt 
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Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Acp3Ratriboflavin metabolic pathway  IEA 6907045 KEGGrno:00740

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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Gene Data File Integration of LocusLink data, October 12, 2001
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Human CTL epitopes prostatic acid phosphatase-3 and six-transmembrane epithelial antigen of prostate-3 as candidates for prostate cancer immunotherapy. Machlenkin A, etal., Cancer Res. 2005 Jul 15;65(14):6435-42.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. [Acute Meckel's diverticulitis in a patient with a pseudomucinous cyst of the appendix] Modzelewski B and Wasiak J, Pol Tyg Lek 1978 Aug 7;33(32):1257-8.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. [Osteosynthesis of the tubular bones using a polymeric pin]. Plakhotin MV, etal., Veterinariia. 1978 Dec;(12):89-90.
11. Site-directed mutagenesis of prostatic acid phosphatase. Catalytically important aspartic acid 258, substrate specificity, and oligomerization. Porvari KS, etal., J Biol Chem. 1994 Sep 9;269(36):22642-6.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Primary structure of rat secretory acid phosphatase and comparison to other acid phosphatases. Roiko K, etal., Gene 1990 May 14;89(2):223-9.
16. Prostate-specific antigen/prostatic acid phosphatase ratio is significant prognostic factor in patients with stage IV prostate cancer. Saito T, etal., Urology. 2007 Oct;70(4):702-5.
17. The cytochemical demonstration of prostatic acid phosphatase using a new substrate, phosphorylcholine. Serrano JA, etal., J Histochem Cytochem. 1976 Oct;24(10):1046-56.
18. Structural comparison of human and rat prostate-specific acid phosphatase genes and their promoters: identification of putative androgen response elements. Virkkunen P, etal., Biochem Biophys Res Commun 1994 Jul 15;202(1):49-57.
19. Transcriptional activation of the human prostatic acid phosphatase gene by NF-kappaB via a novel hexanucleotide-binding site. Zelivianski S, etal., Nucleic Acids Res. 2004 Jul 7;32(12):3566-80. Print 2004.
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PMID:8132635   PMID:8334986   PMID:8407898   PMID:10639192   PMID:15280042   PMID:15578709   PMID:17638863   PMID:17658863   PMID:17897319   PMID:18083097   PMID:18940592   PMID:19056867  
PMID:20084276   PMID:21630459   PMID:22389722   PMID:23376485   PMID:23533145   PMID:24657436   PMID:25482440   PMID:25674224   PMID:27348306  



Acp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88113,784,372 - 113,833,033 (-)NCBIGRCr8
mRatBN7.28104,905,570 - 104,956,146 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8104,905,586 - 104,954,236 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8110,555,965 - 110,601,143 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08108,755,152 - 108,800,326 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08106,597,855 - 106,643,027 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08112,838,574 - 112,884,062 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8112,834,707 - 112,884,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08112,224,707 - 112,272,400 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48109,354,381 - 109,400,296 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18109,382,705 - 109,419,751 (-)NCBI
Celera8104,274,154 - 104,317,190 (-)NCBICelera
Cytogenetic Map8q32NCBI
ACP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383132,317,407 - 132,368,302 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3132,317,369 - 132,368,302 (+)EnsemblGRCh38hg38GRCh38
GRCh373132,036,251 - 132,087,146 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363133,518,949 - 133,560,294 (+)NCBINCBI36Build 36hg18NCBI36
Build 343133,518,956 - 133,560,298NCBI
Celera3130,462,489 - 130,513,425 (+)NCBICelera
Cytogenetic Map3q22.1ENTREZGENE
HuRef3129,415,425 - 129,466,393 (+)NCBIHuRef
CHM1_13131,999,235 - 132,050,170 (+)NCBICHM1_1
T2T-CHM13v2.03135,061,847 - 135,112,776 (+)NCBIT2T-CHM13v2.0
Acp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399104,165,439 - 104,214,921 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9104,165,450 - 104,214,947 (-)EnsemblGRCm39 Ensembl
GRCm389104,288,240 - 104,337,722 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9104,288,251 - 104,337,748 (-)EnsemblGRCm38mm10GRCm38
MGSCv379104,190,570 - 104,240,052 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369104,146,585 - 104,196,067 (-)NCBIMGSCv36mm8
Celera9103,840,497 - 103,890,048 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map956.61NCBI
Acp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555016,164,152 - 6,218,967 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555016,168,083 - 6,218,934 (-)NCBIChiLan1.0ChiLan1.0
ACP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22130,267,935 - 130,324,616 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13130,272,663 - 130,330,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03129,392,396 - 129,465,962 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13136,713,816 - 136,764,655 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3136,713,816 - 136,764,655 (+)Ensemblpanpan1.1panPan2
ACP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12329,294,641 - 29,353,970 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2329,294,843 - 29,343,499 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2329,269,310 - 29,328,452 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02329,807,873 - 29,866,994 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2329,807,934 - 29,849,928 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12329,500,099 - 29,559,146 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02329,558,604 - 29,617,766 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02329,808,824 - 29,868,045 (+)NCBIUU_Cfam_GSD_1.0
Acp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560268,901,255 - 68,964,887 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365295,661,702 - 5,725,363 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365295,661,772 - 5,723,108 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1373,471,889 - 73,530,011 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11373,471,837 - 73,530,778 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21381,003,170 - 81,028,400 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11557,887,528 - 57,934,851 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1557,887,365 - 57,934,707 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604130,876,931 - 30,930,054 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247308,375,258 - 8,432,302 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247308,375,429 - 8,441,375 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Acp3
408 total Variants

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:52
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000016222
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 26 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)888612425107550209Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat

1 to 10 of 26 rows
D8Wox15  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr88113,796,300 - 113,796,465 (+)Marker Load Pipeline
mRatBN7.28104,917,506 - 104,917,671 (+)MAPPERmRatBN7.2
Rnor_6.08112,847,165 - 112,847,329NCBIRnor6.0
Rnor_5.08112,233,298 - 112,233,462UniSTSRnor5.0
RGSC_v3.48109,362,917 - 109,363,081UniSTSRGSC3.4
Celera8104,282,671 - 104,282,821UniSTS
Cytogenetic Map8q32UniSTS
BI283253  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr88113,795,923 - 113,796,041 (+)Marker Load Pipeline
mRatBN7.28104,917,129 - 104,917,247 (+)MAPPERmRatBN7.2
Rnor_6.08112,846,788 - 112,846,905NCBIRnor6.0
Rnor_5.08112,232,921 - 112,233,038UniSTSRnor5.0
RGSC_v3.48109,362,540 - 109,362,657UniSTSRGSC3.4
Celera8104,282,295 - 104,282,411UniSTS
RH 3.4 Map81155.3UniSTS
Cytogenetic Map8q32UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 48 103 91 90 59 25 59 6 216 95 83 45 60 31



Ensembl Acc Id: ENSRNOT00000016222   ⟹   ENSRNOP00000016222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8104,917,841 - 104,954,236 (-)Ensembl
Rnor_6.0 Ensembl8112,847,499 - 112,884,062 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085585   ⟹   ENSRNOP00000072975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8104,905,586 - 104,954,236 (-)Ensembl
Rnor_6.0 Ensembl8112,834,707 - 112,884,077 (-)Ensembl
RefSeq Acc Id: NM_001134901   ⟹   NP_001128373
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88113,785,032 - 113,833,033 (-)NCBI
mRatBN7.28104,906,244 - 104,954,245 (-)NCBI
Rnor_6.08112,838,629 - 112,884,022 (-)NCBI
Rnor_5.08112,224,707 - 112,272,400 (-)NCBI
RGSC_v3.48109,354,381 - 109,400,296 (-)RGD
Celera8104,274,154 - 104,317,150 (-)NCBI
Sequence:
RefSeq Acc Id: NM_020072   ⟹   NP_064457
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88113,796,634 - 113,833,033 (-)NCBI
mRatBN7.28104,917,840 - 104,954,245 (-)NCBI
Rnor_6.08112,847,499 - 112,884,062 (-)NCBI
Rnor_5.08112,224,707 - 112,272,400 (-)NCBI
RGSC_v3.48109,354,381 - 109,400,296 (-)RGD
Celera8104,282,991 - 104,317,190 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039082022   ⟹   XP_038937950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88113,784,372 - 113,830,073 (-)NCBI
mRatBN7.28104,905,570 - 104,954,207 (-)NCBI
RefSeq Acc Id: XM_039082023   ⟹   XP_038937951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88113,784,372 - 113,829,010 (-)NCBI
mRatBN7.28104,905,570 - 104,949,213 (-)NCBI
RefSeq Acc Id: NP_064457   ⟸   NM_020072
- Peptide Label: short isoform precursor
- UniProtKB: P20646 (UniProtKB/Swiss-Prot),   A6XJQ5 (UniProtKB/Swiss-Prot),   A0A0G2JSL5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001128373   ⟸   NM_001134901
- Peptide Label: long isoform precursor
- UniProtKB: A0A0G2K4B4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016222   ⟸   ENSRNOT00000016222
Ensembl Acc Id: ENSRNOP00000072975   ⟸   ENSRNOT00000085585
RefSeq Acc Id: XP_038937950   ⟸   XM_039082022
- Peptide Label: isoform X1

Name Modeler Protein Id AA Range Protein Structure
AF-P20646-F1-model_v2 AlphaFold P20646 1-381 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696238
Promoter ID:EPDNEW_R6762
Type:multiple initiation site
Name:Acpp_1
Description:acid phosphatase, prostate
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08112,884,071 - 112,884,131EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-29288 BioCyc
Ensembl Genes ENSRNOG00000011820 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016222 ENTREZGENE
  ENSRNOT00000016222.6 UniProtKB/Swiss-Prot
  ENSRNOT00000085585 ENTREZGENE
  ENSRNOT00000085585.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1240 UniProtKB/Swiss-Prot
InterPro Acid_Pase_AS UniProtKB/Swiss-Prot
  His_Pase_clade-2 UniProtKB/Swiss-Prot
  His_PPase_superfam UniProtKB/Swiss-Prot
  Histidine_acid_phosphatase UniProtKB/Swiss-Prot
KEGG Report rno:56780 UniProtKB/Swiss-Prot
NCBI Gene Acp3 ENTREZGENE
PANTHER ACID PHOSPHATASE-RELATED UniProtKB/Swiss-Prot
  PROSTATIC ACID PHOSPHATASE UniProtKB/Swiss-Prot
Pfam His_Phos_2 UniProtKB/Swiss-Prot
PhenoGen Acp3 PhenoGen
PROSITE HIS_ACID_PHOSPHAT_1 UniProtKB/Swiss-Prot
  HIS_ACID_PHOSPHAT_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011820 RatGTEx
Superfamily-SCOP SSF53254 UniProtKB/Swiss-Prot
UniProt A0A0G2JSL5 ENTREZGENE
  A0A0G2K4B4 ENTREZGENE, UniProtKB/TrEMBL
  A6XJQ5 ENTREZGENE
  P20646 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A0G2JSL5 UniProtKB/Swiss-Prot
  A6XJQ5 UniProtKB/Swiss-Prot
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-30 Acp3  acid phosphatase 3  Acpp  acid phosphatase, prostate  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Acpp  acid phosphatase, prostate      Symbol and Name updated 629477 APPROVED
2003-03-06 Acpp  acid phosphatase, prostate  Ppal  prostatic acid phosphatase (rPAP)  Data merged from RGD:620235 628472 PROVISIONAL
2002-08-07 Ppal  prostatic acid phosphatase (rPAP)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Acpp  acid phosphatase, prostate      Symbol and Name status set to approved 70586 APPROVED
2001-06-12 Acpp  acid phosphatase, prostate      Symbol and Name updated to reflect Human and Mouse nomenclature 62408 APPROVED
2001-06-12 Acpp11  Prostatic acid phosphatase      Symbol and Name withdrawn 62408 WITHDRAWN

Note Type Note Reference
gene_expression synthesized in prostate epithelial cells, released into prostatic fluid 69941
gene_expression synthesized in prostate epithelial cells, released into prostatic fluid 70323
gene_function hydrolyzes phosphomonoesters under acidic condition 69941
gene_function hydrolyzes phosphomonoesters under acidic condition 70323
gene_physical_interaction androgen receptor binds to two conserved regions, one in the proximal promoter and another in intron 1 69941
gene_physical_interaction androgen receptor binds to two conserved regions, one in the proximal promoter and another in intron 1 70323
gene_product cDNA 1626 nt long 69941
gene_product cDNA 1626 nt long 70323
gene_product contains 11 exons 69941
gene_product contains 11 exons 70323
gene_regulation regulated by androgen 69941
gene_regulation regulated by androgen 70323
gene_transcript three mRNA species (4.9, 2.3 and 1.5 kb) in prostate 69941
gene_transcript three mRNA species (4.9, 2.3 and 1.5 kb) in prostate 70323