Btn3a2 (butyrophilin, subfamily 3, member A2) - Rat Genome Database

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Gene: Btn3a2 (butyrophilin, subfamily 3, member A2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Btn3a2 (Ensembl: AABR07044388.4)
Name: butyrophilin, subfamily 3, member A2
RGD ID: 1598538
Description: Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in cytoplasm and membrane. Predicted to be active in external side of plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Btnl4; butyrophilin subfamily 3 member A2; butyrophilin-like 4; LOC294268; RGD1562488; similar to butyrophilin-like 8
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,397,659 - 4,410,150 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl204,400,176 - 4,407,603 (+)EnsemblGRCr8
mRatBN7.2204,398,254 - 4,405,681 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,398,254 - 4,405,681 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx205,158,446 - 5,165,907 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,520,186 - 4,527,647 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,993,478 - 5,000,948 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,240,270 - 4,247,115 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0206,319,626 - 6,326,471 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4204,471,149 - 4,528,035 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera206,000,866 - 6,008,294 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15060004  


Genomics

Variants

.
Variants in Btn3a2
418 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015332005306452Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2016693431Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2016693431Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036263239244918Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
D20Yum69  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,343,228 - 4,343,417 (-)MAPPERmRatBN7.2
Rnor_6.0202,879,334 - 2,879,522NCBIRnor6.0
Rnor_5.0204,977,074 - 4,977,262UniSTSRnor5.0
RGSC_v3.4204,477,476 - 4,477,664UniSTSRGSC3.4
Cytogenetic Map20p12UniSTS
RH134883  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera205,979,708 - 5,979,925UniSTS
Celera206,007,981 - 6,008,315UniSTS
RH 3.4 Map2053.73UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
sensory system
visual system
7 2 1 38 48 40 1 1 12 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000029451   ⟹   ENSRNOP00000034717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,398,254 - 4,405,681 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085662   ⟹   ENSRNOP00000070494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,398,254 - 4,405,681 (+)Ensembl
RefSeq Acc Id: NM_001166344   ⟹   NP_001159816
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,400,176 - 4,407,603 (+)NCBI
mRatBN7.2204,398,254 - 4,405,681 (+)NCBI
Rnor_6.0204,240,270 - 4,247,115 (-)NCBI
Rnor_5.0206,319,626 - 6,326,471 (-)NCBI
RGSC_v3.4204,471,149 - 4,528,035 (+)RGD
Celera206,000,866 - 6,008,294 (+)RGD
Sequence:
RefSeq Acc Id: XM_063279013   ⟹   XP_063135083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,397,659 - 4,410,150 (+)NCBI
RefSeq Acc Id: XM_063279014   ⟹   XP_063135084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,397,659 - 4,410,144 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001159816 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135083 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135084 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE83951 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000109002
  ENSRNOP00000109002.1
  ENSRNOP00000111219
  ENSRNOP00000111219.1
RefSeq Acc Id: NP_001159816   ⟸   NM_001166344
- UniProtKB: A0A0G2JY27 (UniProtKB/TrEMBL),   F7F1D5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070494   ⟸   ENSRNOT00000085662
Ensembl Acc Id: ENSRNOP00000034717   ⟸   ENSRNOT00000029451
RefSeq Acc Id: XP_063135083   ⟸   XM_063279013
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063135084   ⟸   XM_063279014
- Peptide Label: isoform X2
- UniProtKB: F7F1D5 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7F1D5-F1-model_v2 AlphaFold F7F1D5 1-589 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598538 AgrOrtholog
BioCyc Gene G2FUF-4572 BioCyc
Ensembl Genes ENSRNOG00000052710 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000068592 Ensembl
Ensembl Transcript ENSRNOT00000089737 ENTREZGENE
  ENSRNOT00000089737.4 UniProtKB/TrEMBL
  ENSRNOT00000120585 ENTREZGENE
  ENSRNOT00000120585.2 UniProtKB/TrEMBL
NCBI Gene Btn3a2 ENTREZGENE
PhenoGen Btn3a2 PhenoGen
RatGTEx ENSRNOG00000052710 RatGTEx
  ENSRNOG00000068592 RatGTEx
UniProt A0A0G2JY27 ENTREZGENE
  A0ABK0M2F6_RAT UniProtKB/TrEMBL
  A0ABK0M534_RAT UniProtKB/TrEMBL
  F7F1D5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-13 Btn3a2  butyrophilin, subfamily 3, member A2  Btnl4  butyrophilin-like 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-13 Btnl4  butyrophilin-like 4  RGD1562488  similar to butyrophilin-like 8  Data merged from RGD:1562488 737654 APPROVED
2008-04-30 RGD1562488  similar to butyrophilin-like 8   RGD1562488_predicted  similar to butyrophilin-like 8 (predicted)  'predicted' is removed 2292626 APPROVED
2006-12-03 Btnl4  butyrophilin-like 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1562488_predicted  similar to butyrophilin-like 8 (predicted)  LOC294268  similar to butyrophilin-like 8  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC294268  similar to butyrophilin-like 8      Symbol and Name status set to provisional 70820 PROVISIONAL