Btnl5 (butyrophilin-like 5) - Rat Genome Database

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Gene: Btnl5 (butyrophilin-like 5) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Btnl5
Name: butyrophilin-like 5
RGD ID: 1598537
Description: Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Orthologous to human BTN3A2 (butyrophilin subfamily 3 member A2); INTERACTS WITH Cuprizon; gentamycin; lidocaine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: butyrophilin-like protein 1; butyrophilin-like protein 1-like; LOC100912021; LOC686048; similar to butyrophilin-like 7
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,348,162 - 4,378,309 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl204,368,704 - 4,372,446 (+)EnsemblGRCr8
mRatBN7.2204,366,780 - 4,376,385 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,365,793 - 4,376,385 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx205,126,909 - 5,136,539 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,488,657 - 4,498,279 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,961,947 - 4,971,562 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0202,723,576 - 2,733,181 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,723,572 - 2,734,296 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl202,938,417 - 2,942,136 (-)Ensemblrn6Rnor6.0
Rnor_5.0204,821,316 - 4,830,921 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4204,371,620 - 4,381,225 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera205,970,473 - 5,980,078 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15060004  


Genomics

Variants

.
Variants in Btnl5
1024 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:24
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000060394
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015332005306452Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2016693431Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2016693431Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036263239244918Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
RH134883  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera205,979,708 - 5,979,925UniSTS
Celera206,007,981 - 6,008,315UniSTS
RH 3.4 Map2053.73UniSTS
Cytogenetic Map20p12UniSTS
D17S802  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.03155,184,712 - 155,185,467UniSTSRnor5.0
RGSC_v3.4204,369,896 - 4,370,394UniSTSRGSC3.4
RGSC_v3.42227,893,021 - 227,893,896UniSTSRGSC3.4
Celera205,968,749 - 5,969,247UniSTS
Celera2211,247,899 - 211,248,773UniSTS
Cytogenetic Map3q41UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
16 15 21 15 8 33 8 5 73 45 1 1 4 32 7

Sequence


Ensembl Acc Id: ENSRNOT00000060394   ⟹   ENSRNOP00000057138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,365,793 - 4,376,385 (+)Ensembl
Rnor_6.0 Ensembl202,723,576 - 2,733,181 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082285   ⟹   ENSRNOP00000070044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,366,780 - 4,370,522 (+)Ensembl
Rnor_6.0 Ensembl202,729,213 - 2,734,296 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088972   ⟹   ENSRNOP00000075133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl202,938,417 - 2,942,136 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091797   ⟹   ENSRNOP00000072114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl202,723,572 - 2,727,527 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120525   ⟹   ENSRNOP00000098178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl204,368,704 - 4,372,446 (+)Ensembl
RefSeq Acc Id: NM_001166351   ⟹   NP_001159823
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,368,704 - 4,378,309 (+)NCBI
mRatBN7.2204,366,780 - 4,376,385 (+)NCBI
Rnor_6.0202,723,576 - 2,733,181 (-)NCBI
Rnor_5.0204,821,316 - 4,830,921 (-)NCBI
RGSC_v3.4204,371,620 - 4,381,225 (+)ENTREZGENE
Celera205,970,473 - 5,980,078 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: XM_063279509   ⟹   XP_063135579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,348,162 - 4,378,309 (+)NCBI
RefSeq Acc Id: XM_063279510   ⟹   XP_063135580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,348,162 - 4,378,309 (+)NCBI
RefSeq Acc Id: XM_063279511   ⟹   XP_063135581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,349,792 - 4,378,309 (+)NCBI
RefSeq Acc Id: XM_063279512   ⟹   XP_063135582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,367,342 - 4,378,309 (+)NCBI
RefSeq Acc Id: XM_063279513   ⟹   XP_063135583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,368,704 - 4,378,309 (+)NCBI
RefSeq Acc Id: XM_063279514   ⟹   XP_063135584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,348,162 - 4,378,309 (+)NCBI
RefSeq Acc Id: XM_063279515   ⟹   XP_063135585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,348,162 - 4,378,309 (+)NCBI
RefSeq Acc Id: XM_063279516   ⟹   XP_063135586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,348,162 - 4,378,309 (+)NCBI
RefSeq Acc Id: XM_063279517   ⟹   XP_063135587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,367,342 - 4,378,309 (+)NCBI
RefSeq Acc Id: NP_001159823   ⟸   NM_001166351
- Peptide Label: precursor
- UniProtKB: F1M8A0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070044   ⟸   ENSRNOT00000082285
Ensembl Acc Id: ENSRNOP00000057138   ⟸   ENSRNOT00000060394
Ensembl Acc Id: ENSRNOP00000072114   ⟸   ENSRNOT00000091797
Ensembl Acc Id: ENSRNOP00000075133   ⟸   ENSRNOT00000088972
RefSeq Acc Id: XP_063135579   ⟸   XM_063279509
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063135584   ⟸   XM_063279514
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063135586   ⟸   XM_063279516
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063135580   ⟸   XM_063279510
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063135585   ⟸   XM_063279515
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063135581   ⟸   XM_063279511
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063135582   ⟸   XM_063279512
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135587   ⟸   XM_063279517
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063135583   ⟸   XM_063279513
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000098178   ⟸   ENSRNOT00000120525
Protein Domains
B30.2/SPRY   Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K9U4-F1-model_v2 AlphaFold A0A0G2K9U4 1-303 view protein structure
AF-F1M8A0-F1-model_v2 AlphaFold F1M8A0 1-589 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598537 AgrOrtholog
BioCyc Gene G2FUF-4573 BioCyc
Ensembl Genes ENSRNOG00000047304 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000049946 Ensembl
Ensembl Transcript ENSRNOT00000120525.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
InterPro B30.2/SPRY_sf UniProtKB/TrEMBL
  B302 UniProtKB/TrEMBL
  BTN3A2-like_Ig-C UniProtKB/TrEMBL
  Butyrophylin UniProtKB/TrEMBL
  ConA-like_dom UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  IgSF_BTN/MOG UniProtKB/TrEMBL
NCBI Gene Btnl5 ENTREZGENE
PANTHER BUTYROPHILIN UniProtKB/TrEMBL
  BUTYROPHILIN, SUBFAMILY 3, MEMBER A3-RELATED UniProtKB/TrEMBL
Pfam C2-set_3 UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PhenoGen Btnl5 PhenoGen
PRINTS BUTYPHLNCDUF UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047304 RatGTEx
  ENSRNOG00000049946 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0ABK0KVX1_RAT UniProtKB/TrEMBL
  F1M8A0 ENTREZGENE
  Q6MG94_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Btnl5  butyrophilin-like 5  LOC100912021  butyrophilin-like protein 1-like  Data merged from RGD:6489407 737654 PROVISIONAL
2012-07-05 LOC100912021  butyrophilin-like protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-09-08 Btnl5  butyrophilin-like 5  LOC686048  similar to butyrophilin-like 7  Data merged from RGD:1586648 737654 APPROVED
2006-12-03 Btnl5  butyrophilin-like 5      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC686048  similar to butyrophilin-like 7      Symbol and Name status set to provisional 70820 PROVISIONAL