Zfp141 (zinc finger protein 141) - Rat Genome Database

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Gene: Zfp141 (zinc finger protein 141) Rattus norvegicus
Analyze
Symbol: Zfp141
Name: zinc finger protein 141
RGD ID: 1597345
Description: Predicted to enable metal ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human ZNF816 (zinc finger protein 816); INTERACTS WITH acrylamide (ortholog); aflatoxin B1 (ortholog); aflatoxin M1 (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: putative protein ZNF720; similar to zinc finger protein 420; zinc finger protein 2-like
RGD Orthologs
Human
Bonobo
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81102,267,194 - 102,300,911 (+)NCBIGRCr8
mRatBN7.2193,130,574 - 93,164,293 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl193,130,598 - 93,163,404 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0198,168,457 - 98,201,189 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0199,248,701 - 99,286,645 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4193,011,706 - 93,026,296 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera187,429,924 - 87,463,216 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zfp141
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81102,267,194 - 102,300,911 (+)NCBIGRCr8
mRatBN7.2193,130,574 - 93,164,293 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl193,130,598 - 93,163,404 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0198,168,457 - 98,201,189 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0199,248,701 - 99,286,645 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4193,011,706 - 93,026,296 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera187,429,924 - 87,463,216 (+)NCBICelera
Cytogenetic Map1q22NCBI
ZNF816
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381952,949,385 - 52,962,881 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1952,949,379 - 52,962,911 (-)EnsemblGRCh38hg38GRCh38
GRCh371953,452,638 - 53,466,134 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361958,144,444 - 58,157,926 (-)NCBINCBI36Build 36hg18NCBI36
Celera1950,500,194 - 50,513,676 (-)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1949,778,813 - 49,792,345 (-)NCBIHuRef
CHM1_11953,454,437 - 53,467,969 (-)NCBICHM1_1
T2T-CHM13v2.01956,031,917 - 56,045,413 (-)NCBIT2T-CHM13v2.0
LOC100977156
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22058,995,399 - 59,067,558 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11960,911,652 - 60,986,005 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01949,888,155 - 49,960,753 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11958,760,189 - 58,773,655 (-)NCBIpanpan1.1PanPan1.1panPan2
LOC100627241
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1657,008,838 - 57,052,907 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Zfp141
441 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat

Markers in Region
RH140556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2193,197,315 - 93,197,531 (+)MAPPERmRatBN7.2
Rnor_6.0198,231,506 - 98,231,721NCBIRnor6.0
Rnor_5.0199,313,892 - 99,314,107UniSTSRnor5.0
RGSC_v3.4193,062,918 - 93,063,133UniSTSRGSC3.4
Celera187,495,997 - 87,496,212UniSTS
RH 3.4 Map1883.99UniSTS
Cytogenetic Map1q22UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000112878   ⟹   ENSRNOP00000094350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl193,130,598 - 93,163,404 (+)Ensembl
RefSeq Acc Id: NM_001408793   ⟹   NP_001395722
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81102,267,194 - 102,300,911 (+)NCBI
mRatBN7.2193,130,574 - 93,164,293 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395722 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000094350
  ENSRNOP00000094350.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000094350   ⟸   ENSRNOT00000112878
RefSeq Acc Id: NP_001395722   ⟸   NM_001408793
- UniProtKB: A0A8I6GL47 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type   KRAB

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597345 AgrOrtholog
BioCyc Gene G2FUF-59872 BioCyc
Ensembl Genes ENSRNOG00000070234 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000112878 ENTREZGENE
  ENSRNOT00000112878.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
KEGG Report rno:690343 UniProtKB/TrEMBL
NCBI Gene 690343 ENTREZGENE
PANTHER HISTONE-LYSINE N-METHYLTRANSFERASE PRDM9 UniProtKB/TrEMBL
  PR DOMAIN ZINC FINGER PROTEIN UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp141 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000070234 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6GL47 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Zfp141  zinc finger protein 141  Zfp141  zinc finger protein 141  Data merged from RGD:149736296 737654 PROVISIONAL
2021-08-09 Zfp141  zinc finger protein 141      Symbol and Name status set to provisional 45752 PROVISIONAL
2006-11-20 LOC690343  similar to zinc finger protein 420      Symbol and Name status set to provisional 70820 PROVISIONAL