Zfp141 (zinc finger protein 141) - Rat Genome Database

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Gene: Zfp141 (zinc finger protein 141) Rattus norvegicus
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Symbol: Zfp141
Name: zinc finger protein 141
RGD ID: 1597345
Description: Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human ZNF816 (zinc finger protein 816); INTERACTS WITH acrylamide (ortholog); aflatoxin B1 (ortholog); aflatoxin M1 (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: putative protein ZNF720; similar to zinc finger protein 420; zinc finger protein 2-like
RGD Orthologs
Human
Bonobo
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81102,267,194 - 102,300,911 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1102,267,194 - 102,300,911 (+)EnsemblGRCr8
mRatBN7.2193,130,574 - 93,164,293 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl193,130,598 - 93,163,404 (+)EnsemblmRatBN7.2
Rnor_6.0198,168,457 - 98,201,189 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0199,248,701 - 99,286,645 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4193,011,706 - 93,026,296 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera187,429,924 - 87,463,216 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
psoriasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zfp141
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81102,267,194 - 102,300,911 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1102,267,194 - 102,300,911 (+)EnsemblGRCr8
mRatBN7.2193,130,574 - 93,164,293 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl193,130,598 - 93,163,404 (+)EnsemblmRatBN7.2
Rnor_6.0198,168,457 - 98,201,189 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0199,248,701 - 99,286,645 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4193,011,706 - 93,026,296 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera187,429,924 - 87,463,216 (+)NCBICelera
Cytogenetic Map1q22NCBI
ZNF816
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381952,949,385 - 52,962,881 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1952,949,377 - 52,962,911 (-)Ensemblhg38GRCh38
GRCh371953,452,638 - 53,466,134 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361958,144,444 - 58,157,926 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1950,500,194 - 50,513,676 (-)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1949,778,813 - 49,792,345 (-)NCBIHuRef
CHM1_11953,454,437 - 53,467,969 (-)NCBICHM1_1
T2T-CHM13v2.01956,031,917 - 56,045,413 (-)NCBIT2T-CHM13v2.0
LOC100977156
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22058,995,399 - 59,067,558 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11960,911,652 - 60,986,005 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01949,888,155 - 49,960,753 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11958,760,189 - 58,773,655 (-)NCBIPanPan1.1PanPan1.1panPan2
LOC100627241
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1657,008,838 - 57,052,907 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Zfp141
482 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
RH140556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2193,197,315 - 93,197,531 (+)MAPPERmRatBN7.2
Rnor_6.0198,231,506 - 98,231,721NCBIRnor6.0
Rnor_5.0199,313,892 - 99,314,107UniSTSRnor5.0
RGSC_v3.4193,062,918 - 93,063,133UniSTSRGSC3.4
Celera187,495,997 - 87,496,212UniSTS
RH 3.4 Map1883.99UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 52 66 135 94 11 51 34 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000112878   ⟹   ENSRNOP00000094350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1102,267,194 - 102,300,911 (+)Ensembl
mRatBN7.2 Ensembl193,130,598 - 93,163,404 (+)Ensembl
RefSeq Acc Id: NM_001408793   ⟹   NP_001395722
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81102,267,194 - 102,300,911 (+)NCBI
mRatBN7.2193,130,574 - 93,164,293 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395722 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000094350
  ENSRNOP00000094350.1
Ensembl Acc Id: ENSRNOP00000094350   ⟸   ENSRNOT00000112878
RefSeq Acc Id: NP_001395722   ⟸   NM_001408793
- UniProtKB: A0A8I6GL47 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type   KRAB

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597345 AgrOrtholog
BioCyc Gene G2FUF-59872 BioCyc
Ensembl Genes ENSRNOG00000070234 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000112878 ENTREZGENE
  ENSRNOT00000112878.2 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Zinc_finger UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene 690343 ENTREZGENE
PANTHER PR DOMAIN ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 154-LIKE UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-H2C2_2 UniProtKB/TrEMBL
PhenoGen Zfp141 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000070234 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6GL47 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Zfp141  zinc finger protein 141  Zfp141  zinc finger protein 141  Data merged from RGD:149736296 737654 PROVISIONAL
2021-08-09 Zfp141  zinc finger protein 141      Symbol and Name status set to provisional 45752 PROVISIONAL
2006-11-20 LOC690343  similar to zinc finger protein 420      Symbol and Name status set to provisional 70820 PROVISIONAL