Idh2 (isocitrate dehydrogenase (NADP(+)) 2) - Rat Genome Database

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Gene: Idh2 (isocitrate dehydrogenase (NADP(+)) 2) Rattus norvegicus
Analyze
Symbol: Idh2
Name: isocitrate dehydrogenase (NADP(+)) 2
RGD ID: 1597139
Description: Enables isocitrate dehydrogenase (NADP+) activity. Involved in several processes, including NADP+ biosynthetic process; negative regulation of glial cell proliferation; and negative regulation of matrix metallopeptidase secretion. Predicted to be located in cytosol and peroxisome. Predicted to be active in mitochondrion. Used to study status epilepticus. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2); PARTICIPATES IN citric acid cycle pathway; glutathione metabolic pathway; INTERACTS WITH (+)-schisandrin B; (R)-adrenaline; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ICD-M; IDH; IDP; isocitrate dehydrogenase (NADP(+)) 2, mitochondrial; isocitrate dehydrogenase 2 (NADP+), mitochondrial; isocitrate dehydrogenase [NADP], mitochondrial; LOC361596; NADP(+)-specific ICDH; oxalosuccinate decarboxylase; similar to NADP+-specific isocitrate dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,447,925 - 143,467,248 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1143,439,323 - 143,467,248 (-)EnsemblGRCr8
mRatBN7.21134,038,644 - 134,057,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,029,772 - 134,058,025 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1141,947,731 - 141,967,051 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,117,130 - 149,136,466 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,034,887 - 142,054,220 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,874,354 - 141,893,674 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,866,283 - 141,893,705 (-)Ensemblrn6Rnor6.0
Rnor_5.01142,830,040 - 142,849,360 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41135,876,052 - 135,895,373 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1126,099,085 - 126,118,402 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(N(omega)-L-arginino)succinic acid  (ISO)
(R)-adrenaline  (EXP)
(R)-carnitine  (ISO)
(R)-pantothenic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2'-deoxycytosine 5'-monophosphate  (ISO)
2'-deoxyguanosine 5'-monophosphate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-bromohexadecanoic acid  (ISO)
2-hydroxyglutaric acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-dehydrocarnitine  (ISO)
3-methylcholanthrene  (ISO)
3-phosphoglyceric acid  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(trimethylammonio)butanoate  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
8-Epidiosbulbin E acetate  (ISO)
9H-xanthine  (EXP)
acetamide  (EXP)
aconitic acid  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine 6-phosphate  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-glucose 1-phosphate  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
amiodarone  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-fructofuranose 1,6-bisphosphate  (ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
creatinine  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cytidine  (ISO)
D-erythrose 4-phosphate  (ISO)
D-fructofuranose 1,6-bisphosphate  (ISO)
D-glyceric acid  (ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dihydroxyacetone phosphate  (ISO)
Diosbulbin B  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
dTMP  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
FMN  (ISO)
folic acid  (ISO)
furfural  (ISO)
GDP-alpha-D-glucose  (ISO)
glutathione  (ISO)
glyceric acid  (ISO)
glycerol 1-phosphate  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
guanine  (ISO)
Honokiol  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP,ISO)
indometacin  (EXP)
inulin  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
keto-D-fructose 1,6-bisphosphate  (ISO)
L-alanine  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lithocholic acid  (ISO)
malic acid  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylisothiazolinone  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methylnicotinamide  (ISO)
N-nitrosodiethylamine  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nickel dichloride  (ISO)
O-acetyl-L-carnitine  (ISO)
O-butanoyl-L-carnitine  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
phlorizin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prostaglandin A1  (ISO)
pyruvic acid  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sedoheptulose 1,7-bisphosphate  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sodium sulfide (anhydrous)  (EXP)
Soman  (EXP)
spermine  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triazines  (ISO)
trilobatin  (EXP)
triptonide  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
UDP  (ISO)
UDP-N-acetyl-alpha-D-glucosamine  (ISO)
uridine  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vosaroxin  (ISO)
VX nerve agent  (EXP)
XL147  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
mitochondrion  (IBA,IEA,ISO)
peroxisome  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Difference in driver gene expression patterns between perihilar and peripheral intrahepatic cholangiocarcinoma in an experimental mouse model. Adachi T, etal., J Hepatobiliary Pancreat Sci. 2020 Aug;27(8):477-486. doi: 10.1002/jhbp.772. Epub 2020 Jul 13.
2. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Chen X, etal., Br J Cancer. 2020 Jul;123(1):126-136. doi: 10.1038/s41416-020-0852-4. Epub 2020 May 5.
3. Robust quantitative assessments of cytosine modifications and changes in the expressions of related enzymes in gastric cancer. Du C, etal., Gastric Cancer. 2015 Jul;18(3):516-25. doi: 10.1007/s10120-014-0409-4. Epub 2014 Aug 7.
4. Glioma-derived mutations in isocitrate dehydrogenase 2 beneficial to traditional chemotherapy. Fu Y, etal., Biochem Biophys Res Commun. 2011 Jul 1;410(2):218-23. doi: 10.1016/j.bbrc.2011.05.108. Epub 2011 May 27.
5. Mutations in isocitrate dehydrogenase 2 accelerate glioma cell migration via matrix metalloproteinase-2 and 9. Fu Y, etal., Biotechnol Lett. 2012 Mar;34(3):441-6. doi: 10.1007/s10529-011-0800-8. Epub 2011 Nov 22.
6. Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy. Gano LB, etal., Free Radic Biol Med. 2018 Aug 1;123:116-124. doi: 10.1016/j.freeradbiomed.2018.05.063. Epub 2018 May 17.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. IDH2 protects against nonalcoholic steatohepatitis by alleviating dyslipidemia regulated by oxidative stress. Gong F, etal., Biochem Biophys Res Commun. 2019 Jun 30;514(3):593-600. doi: 10.1016/j.bbrc.2019.04.069. Epub 2019 May 4.
9. Genetic variants in genes of tricarboxylic acid cycle key enzymes are associated with prognosis of patients with non-small cell lung cancer. Guo X, etal., Lung Cancer. 2015 Feb;87(2):162-8. doi: 10.1016/j.lungcan.2014.12.005. Epub 2014 Dec 18.
10. IDH2 deficiency increases the liver susceptibility to ischemia-reperfusion injury via increased mitochondrial oxidative injury. Han SJ, etal., Redox Biol. 2018 Apr;14:142-153. doi: 10.1016/j.redox.2017.09.003. Epub 2017 Sep 8.
11. Expression and mutagenesis of mammalian cytosolic NADP+-specific isocitrate dehydrogenase. Jennings GT, etal., Biochemistry. 1997 Nov 4;36(44):13743-7.
12. IDH2 deficiency exacerbates acetaminophen hepatotoxicity in mice via mitochondrial dysfunction-induced apoptosis. Kim H, etal., Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2333-2341. doi: 10.1016/j.bbadis.2019.05.012. Epub 2019 May 20.
13. Amelioration of late-onset hepatic steatosis in IDH2-deficient mice. Lee SJ, etal., Free Radic Res. 2017 Apr;51(4):368-374. doi: 10.1080/10715762.2017.1320554. Epub 2017 May 5.
14. A new functional IDH2 genetic variant is associated with the risk of lung cancer. Li J, etal., Mol Carcinog. 2017 Mar;56(3):1082-1087. doi: 10.1002/mc.22573. Epub 2016 Oct 24.
15. Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer. Li J, etal., Theranostics. 2018 Jul 16;8(15):4050-4061. doi: 10.7150/thno.21524. eCollection 2018.
16. IDH2 is a novel diagnostic and prognostic serum biomarker for non-small-cell lung cancer. Li JJ, etal., Mol Oncol. 2018 May;12(5):602-610. doi: 10.1002/1878-0261.12182. Epub 2018 Mar 25.
17. High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma. Liu WR, etal., J Exp Clin Cancer Res. 2014 Apr 10;33:32. doi: 10.1186/1756-9966-33-32.
18. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. Marcucci G, etal., J Clin Oncol. 2010 May 10;28(14):2348-55. doi: 10.1200/JCO.2009.27.3730. Epub 2010 Apr 5.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. IDH2 Deficiency Aggravates Fructose-Induced NAFLD by Modulating Hepatic Fatty Acid Metabolism and Activating Inflammatory Signaling in Female Mice. Pan JH, etal., Nutrients. 2018 May 27;10(6). pii: nu10060679. doi: 10.3390/nu10060679.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Comprehensive gene review and curation RGD comprehensive gene curation
26. A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model. Wang F, etal., J Inherit Metab Dis. 2016 Nov;39(6):807-820. doi: 10.1007/s10545-016-9960-y. Epub 2016 Jul 28.
27. Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Wang P, etal., Oncogene. 2013 Jun 20;32(25):3091-100. doi: 10.1038/onc.2012.315. Epub 2012 Jul 23.
28. Mutations in the isocitrate dehydrogenase 2 gene and IDH1 SNP 105C > T have a prognostic value in acute myeloid leukemia. Willander K, etal., Biomark Res. 2014 Oct 8;2:18. doi: 10.1186/2050-7771-2-18. eCollection 2014.
29. Genetic variations in IDH gene as prognosis predictors in TACE-treated hepatocellular carcinoma patients. Zhang H, etal., Med Oncol. 2014 Nov;31(11):278. doi: 10.1007/s12032-014-0278-z. Epub 2014 Oct 22.
Additional References at PubMed
PMID:7323947   PMID:8867815   PMID:12477932   PMID:12865426   PMID:14651853   PMID:15489334   PMID:18275837   PMID:18614015   PMID:18806796   PMID:20833797   PMID:22082260   PMID:22309944  
PMID:23226729   PMID:23533145   PMID:24296260   PMID:24625528   PMID:25931508   PMID:26316108   PMID:29476059   PMID:33450132  


Genomics

Comparative Map Data
Idh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,447,925 - 143,467,248 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1143,439,323 - 143,467,248 (-)EnsemblGRCr8
mRatBN7.21134,038,644 - 134,057,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,029,772 - 134,058,025 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1141,947,731 - 141,967,051 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,117,130 - 149,136,466 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,034,887 - 142,054,220 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,874,354 - 141,893,674 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,866,283 - 141,893,705 (-)Ensemblrn6Rnor6.0
Rnor_5.01142,830,040 - 142,849,360 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41135,876,052 - 135,895,373 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1126,099,085 - 126,118,402 (-)NCBICelera
Cytogenetic Map1q31NCBI
IDH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,083,045 - 90,102,468 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,083,045 - 90,102,490 (-)Ensemblhg38GRCh38
GRCh371590,626,277 - 90,645,700 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,428,214 - 88,446,712 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341588,428,217 - 88,446,712NCBI
Celera1567,031,136 - 67,049,657 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1566,738,326 - 66,745,989 (-)NCBIHuRef
CHM1_11590,468,783 - 90,487,283 (-)NCBICHM1_1
T2T-CHM13v2.01587,839,072 - 87,858,500 (-)NCBIT2T-CHM13v2.0
Idh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,744,594 - 79,768,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,744,594 - 79,765,140 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38780,094,845 - 80,118,608 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,094,846 - 80,115,392 (-)Ensemblmm10GRCm38
MGSCv37787,239,732 - 87,260,236 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36779,968,359 - 79,988,834 (-)NCBIMGSCv36mm8
Celera777,493,303 - 77,513,823 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.43NCBI
Idh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,197,366 - 15,223,363 (+)Ensembl
ChiLan1.0NW_00495541615,197,611 - 15,212,919 (+)NCBIChiLan1.0ChiLan1.0
IDH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21679,630,229 - 79,649,755 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11583,330,550 - 83,349,140 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01568,771,050 - 68,790,523 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11587,972,883 - 87,991,270 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1587,972,889 - 87,991,276 (-)EnsemblpanPan2panpan1.1
IDH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,070,462 - 53,077,566 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,070,695 - 53,087,496 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha355,708,523 - 55,724,976 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0353,486,432 - 53,502,992 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,486,432 - 53,503,494 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,006,922 - 53,023,434 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,217,752 - 53,234,294 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,558,279 - 53,574,816 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Idh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,470,218 - 130,488,711 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,845,792 - 15,864,341 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,845,777 - 15,864,341 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,651,609 - 55,675,554 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1755,654,298 - 55,675,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,539,333 - 60,549,480 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IDH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,633,429 - 8,650,744 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,633,715 - 8,650,657 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605938,130,227 - 38,147,558 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Idh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,094,655 - 17,111,397 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476817,094,649 - 17,111,333 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Idh2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12120,143,000 - 120,162,929 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Idh2
272 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:209
Count of miRNA genes:157
Interacting mature miRNAs:169
Transcripts:ENSRNOT00000019059
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132889797152403053Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1142582180153680016Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429152404087Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
Idh2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,038,739 - 134,038,943 (+)MAPPERmRatBN7.2
Rnor_6.01141,874,450 - 141,874,653NCBIRnor6.0
Rnor_5.01142,830,136 - 142,830,339UniSTSRnor5.0
RGSC_v3.41135,876,148 - 135,876,351UniSTSRGSC3.4
Celera1126,099,181 - 126,099,384UniSTS
Cytogenetic Map1q31UniSTS
RH133902  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,038,757 - 134,038,977 (+)MAPPERmRatBN7.2
Rnor_6.01141,874,468 - 141,874,687NCBIRnor6.0
Rnor_5.01142,830,154 - 142,830,373UniSTSRnor5.0
RGSC_v3.41135,876,166 - 135,876,385UniSTSRGSC3.4
Celera1126,099,199 - 126,099,418UniSTS
RH 3.4 Map11068.9UniSTS
Cytogenetic Map1q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019059   ⟹   ENSRNOP00000019059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,447,931 - 143,467,248 (-)Ensembl
mRatBN7.2 Ensembl1134,037,572 - 134,057,975 (-)Ensembl
Rnor_6.0 Ensembl1141,874,358 - 141,893,674 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085988   ⟹   ENSRNOP00000069080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,439,323 - 143,467,248 (-)Ensembl
mRatBN7.2 Ensembl1134,029,772 - 134,058,025 (-)Ensembl
Rnor_6.0 Ensembl1141,866,283 - 141,893,705 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109065   ⟹   ENSRNOP00000080037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,036,753 - 134,058,025 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114588   ⟹   ENSRNOP00000084214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,448,243 - 143,467,248 (-)Ensembl
mRatBN7.2 Ensembl1134,038,962 - 134,058,025 (-)Ensembl
RefSeq Acc Id: NM_001014161   ⟹   NP_001014183
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,447,925 - 143,467,248 (-)NCBI
mRatBN7.21134,038,644 - 134,057,969 (-)NCBI
Rnor_6.01141,874,354 - 141,893,674 (-)NCBI
Rnor_5.01142,830,040 - 142,849,360 (-)NCBI
RGSC_v3.41135,876,052 - 135,895,373 (-)RGD
Celera1126,099,085 - 126,118,402 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001014183 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH76398 (Get FASTA)   NCBI Sequence Viewer  
  EDM08607 (Get FASTA)   NCBI Sequence Viewer  
  EDM08608 (Get FASTA)   NCBI Sequence Viewer  
  EDM08609 (Get FASTA)   NCBI Sequence Viewer  
  EDM08610 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019059
GenBank Protein P56574 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001014183   ⟸   NM_001014161
- Peptide Label: precursor
- UniProtKB: Q6DGF1 (UniProtKB/Swiss-Prot),   P56574 (UniProtKB/Swiss-Prot),   A6JC81 (UniProtKB/TrEMBL),   A0A0G2JUF6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069080   ⟸   ENSRNOT00000085988
Ensembl Acc Id: ENSRNOP00000019059   ⟸   ENSRNOT00000019059
Ensembl Acc Id: ENSRNOP00000080037   ⟸   ENSRNOT00000109065
Ensembl Acc Id: ENSRNOP00000084214   ⟸   ENSRNOT00000114588
Protein Domains
Isopropylmalate dehydrogenase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56574-F1-model_v2 AlphaFold P56574 1-452 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690140
Promoter ID:EPDNEW_R661
Type:initiation region
Name:Idh2_1
Description:isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01141,893,687 - 141,893,747EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597139 AgrOrtholog
BioCyc Gene G2FUF-58763 BioCyc
Ensembl Genes ENSRNOG00000013949 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000019059 ENTREZGENE
Gene3D-CATH Isopropylmalate Dehydrogenase UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110062 IMAGE-MGC_LOAD
InterPro IsoCit/isopropylmalate_DH_CS UniProtKB/Swiss-Prot
  Isocitrate_DH_NADP UniProtKB/Swiss-Prot
  IsoPropMal-DH-like_dom UniProtKB/Swiss-Prot
KEGG Report rno:361596 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94864 IMAGE-MGC_LOAD
NCBI Gene 361596 ENTREZGENE
PANTHER ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR11822 UniProtKB/Swiss-Prot
Pfam Iso_dh UniProtKB/Swiss-Prot
PhenoGen Idh2 PhenoGen
PIRSF IDH_NADP UniProtKB/Swiss-Prot
PROSITE IDH_IMDH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013949 RatGTEx
SMART Iso_dh UniProtKB/Swiss-Prot
Superfamily-SCOP Isocitrate/Isopropylmalate dehydrogenase-like UniProtKB/Swiss-Prot
UniProt A0A0G2JUF6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXJ8_RAT UniProtKB/TrEMBL
  A0A8L2UJA4_RAT UniProtKB/TrEMBL
  A6JC81 ENTREZGENE, UniProtKB/TrEMBL
  IDHP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6DGF1 ENTREZGENE
UniProt Secondary Q6DGF1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Idh2  isocitrate dehydrogenase (NADP(+)) 2  Idh2  isocitrate dehydrogenase (NADP(+)) 2, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-04 Idh2  isocitrate dehydrogenase (NADP(+)) 2, mitochondrial  Idh2  isocitrate dehydrogenase 2 (NADP+), mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Idh2  isocitrate dehydrogenase 2 (NADP+), mitochondrial  LOC361596  similar to NADP+-specific isocitrate dehydrogenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC361596  similar to NADP+-specific isocitrate dehydrogenase      Symbol and Name status set to provisional 70820 PROVISIONAL