Hspa1l (heat shock protein family A (Hsp70) member 1 like) - Rat Genome Database

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Gene: Hspa1l (heat shock protein family A (Hsp70) member 1 like) Rattus norvegicus
Analyze
Symbol: Hspa1l
Name: heat shock protein family A (Hsp70) member 1 like
RGD ID: 1595925
Description: Predicted to enable several functions, including ATP hydrolysis activity; ubiquitin protein ligase binding activity; and unfolded protein binding activity. Predicted to be involved in positive regulation of protein targeting to mitochondrion and protein refolding. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in Kawasaki disease; major depressive disorder; schizophrenia; systemic lupus erythematosus; and uveitis. Orthologous to human HSPA1L (heat shock protein family A (Hsp70) member 1 like); PARTICIPATES IN antigen processing and presentation pathway; endocytosis pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: heat shock 70 kDa protein 1-like; heat shock 70 kDa protein 1L; heat shock 70 kDa protein 3; heat shock 70kD protein 1-like; heat shock 70kD protein 1-like (mapped); heat shock protein 1-like; heat shock protein 70; Heat shock protein 70-1l; Hsp70-3; HSP70.3; Hspa1l_mapped; MGC112562; MGC114222
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SHR-Hspa1em1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,853,496 - 3,860,223 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl203,853,331 - 3,876,877 (-)EnsemblGRCr8
mRatBN7.2203,848,843 - 3,855,571 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,848,843 - 3,855,571 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx204,548,331 - 4,555,029 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,910,388 - 3,917,087 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,448,330 - 4,454,924 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,879,998 - 4,965,191 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,959,294 - 4,964,963 (+)Ensemblrn6Rnor6.0
Rnor_5.0207,032,557 - 7,038,454 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera204,171,282 - 4,177,670 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
acrolein  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alpha-Zearalanol  (EXP)
amphibole asbestos  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
Aurin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromoacetate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
CGP 52608  (ISO)
choline  (EXP)
clofibrate  (ISO)
cobalt atom  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocin-1  (EXP)
crotonaldehyde  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP)
ferric ammonium citrate  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fructose  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
glucose  (ISO)
GSK-J4  (ISO)
hemin  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
L-methionine  (EXP)
L-serine  (ISO)
Licochalcone B  (ISO)
linalool  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
monocrotaline  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nitroprusside  (ISO)
omeprazole  (EXP)
organoselenium compound  (ISO)
oxidopamine  (EXP)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenytoin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
quercitrin  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
styrene  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
thiostrepton  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Heat shock protein 70 gene polymorphisms in sudden sensorineural hearing loss. Chien CY, etal., Audiol Neurootol. 2012;17(6):381-5. doi: 10.1159/000341815. Epub 2012 Aug 22.
2. Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus. Furnrohr BG, etal., Ann Rheum Dis. 2010 Nov;69(11):1983-9. Epub 2010 May 24.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia. Kim JJ, etal., Eur Arch Psychiatry Clin Neurosci. 2008 Jun;258(4):239-44.
5. HLA class III genes involvement in Kawasaki disease: a case-control study in Caucasian population. Maggioli E, etal., Int J Immunogenet. 2014 Feb;41(1):44-53. doi: 10.1111/iji.12077. Epub 2013 Jul 22.
6. Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant. Martin AM, etal., Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4180-5. Epub 2004 Mar 15.
7. Heat-shock protein-70 genes and response to antidepressants in major depression. Pae CU, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1006-11. Epub 2007 Feb 27.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. Rardin MJ, etal., J Biol Chem. 2008 May 30;283(22):15440-50. doi: 10.1074/jbc.M709547200. Epub 2008 Apr 2.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Association between heat shock protein 70/Hom genetic polymorphisms and uveitis in patients with sarcoidosis. Spagnolo P, etal., Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3019-25.
15. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Wiley SE, etal., Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5318-23. Epub 2007 Mar 21.
16. Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers. Yang M, etal., Cell Stress Chaperones. 2006 Autumn;11(3):233-9.
Additional References at PubMed
PMID:7927536   PMID:12477932   PMID:15060004   PMID:15489334   PMID:17182002   PMID:18850735   PMID:21231916   PMID:21880732   PMID:22516433   PMID:24270810   PMID:26316108   PMID:28259758  
PMID:29476059   PMID:31904090  


Genomics

Comparative Map Data
Hspa1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,853,496 - 3,860,223 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl203,853,331 - 3,876,877 (-)EnsemblGRCr8
mRatBN7.2203,848,843 - 3,855,571 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,848,843 - 3,855,571 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx204,548,331 - 4,555,029 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,910,388 - 3,917,087 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,448,330 - 4,454,924 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,879,998 - 4,965,191 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,959,294 - 4,964,963 (+)Ensemblrn6Rnor6.0
Rnor_5.0207,032,557 - 7,038,454 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera204,171,282 - 4,177,670 (+)NCBICelera
Cytogenetic Map20p12NCBI
HSPA1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,809,619 - 31,815,283 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,809,619 - 31,815,788 (-)Ensemblhg38GRCh38
GRCh37631,777,396 - 31,783,060 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,885,375 - 31,890,814 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34631,885,374 - 31,890,786NCBI
Celera633,375,646 - 33,381,084 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,563,804 - 31,569,242 (-)NCBIHuRef
CHM1_1631,779,530 - 31,784,969 (-)NCBICHM1_1
T2T-CHM13v2.0631,662,676 - 31,668,340 (-)NCBIT2T-CHM13v2.0
Hspa1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,191,679 - 35,198,204 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,191,679 - 35,198,261 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381734,972,703 - 34,979,228 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,972,703 - 34,979,285 (+)Ensemblmm10GRCm38
MGSCv371735,109,648 - 35,116,173 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361734,580,788 - 34,587,281 (+)NCBIMGSCv36mm8
Celera1738,068,927 - 38,075,454 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.51NCBI
LOC102029440
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437328,193 - 335,959 (-)Ensembl
ChiLan1.0NW_004955437328,193 - 335,852 (-)NCBIChiLan1.0ChiLan1.0
HSPA1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,286,601 - 46,299,239 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,248,104 - 42,260,544 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,470,745 - 31,483,615 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,357,626 - 32,370,055 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,358,054 - 32,359,979 (-)EnsemblpanPan2panpan1.1
LOC474850
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,281,164 - 1,285,010 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,281,472 - 1,285,440 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha121,416,835 - 1,420,649 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0121,424,019 - 1,427,833 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,423,961 - 1,428,295 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,283,032 - 1,286,847 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,350,176 - 1,353,991 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,414,602 - 1,418,416 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101956412
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,816,113 - 35,825,083 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,736,243 - 1,745,231 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,735,880 - 1,745,231 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,910,079 - 23,914,517 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1723,909,960 - 23,938,678 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HSPA1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,206,365 - 40,211,996 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,209,754 - 40,211,676 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604431,724,065 - 31,729,529 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspa1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,416,738 - 24,424,613 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475424,403,438 - 24,423,477 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hspa1l
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1187,572,706 - 7,575,027 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hspa1l
132 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:190
Count of miRNA genes:150
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000074223
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015332005306452Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2016693431Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2016693431Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036263239244918Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
PMC117401P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map20p12UniSTS
PMC314357P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,871,310 - 3,871,800 (-)MAPPERmRatBN7.2
mRatBN7.2203,856,718 - 3,857,207 (-)MAPPERmRatBN7.2
Rnor_6.0204,878,745 - 4,879,233NCBIRnor6.0
Rnor_6.0202,700,781 - 2,701,269NCBIRnor6.0
Rnor_5.0204,803,650 - 4,804,138UniSTSRnor5.0
Rnor_5.0206,959,145 - 6,959,633UniSTSRnor5.0
RGSC_v3.4203,956,153 - 3,956,641UniSTSRGSC3.4
Celera204,155,481 - 4,155,969UniSTS
Celera204,169,646 - 4,170,134UniSTS
Cytogenetic Map20p12UniSTS


Related Rat Strains
The following Strains have been annotated to Hspa1l
SHR-Hspa1em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 67 158 65 64 33 34 33 6 262 134 10 137 72 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000074223   ⟹   ENSRNOP00000063974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl203,853,805 - 3,875,256 (-)Ensembl
mRatBN7.2 Ensembl203,848,843 - 3,855,571 (-)Ensembl
Rnor_6.0 Ensembl204,959,294 - 4,964,963 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126760   ⟹   ENSRNOP00000106918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl203,853,776 - 3,857,704 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000129064   ⟹   ENSRNOP00000110920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl203,853,331 - 3,860,261 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144895   ⟹   ENSRNOP00000110573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl203,853,331 - 3,876,877 (-)Ensembl
RefSeq Acc Id: NM_212546   ⟹   NP_997711
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,853,496 - 3,860,223 (-)NCBI
mRatBN7.2203,848,843 - 3,855,571 (-)NCBI
Rnor_6.0204,959,294 - 4,965,191 (+)NCBI
Rnor_5.0207,032,557 - 7,038,454 (+)NCBI
Celera204,171,282 - 4,177,670 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_997711 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI08295 (Get FASTA)   NCBI Sequence Viewer  
  AAI08298 (Get FASTA)   NCBI Sequence Viewer  
  CAE83979 (Get FASTA)   NCBI Sequence Viewer  
  EDL83474 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063974.1
  ENSRNOP00000110573
GenBank Protein P55063 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_997711   ⟸   NM_212546
- UniProtKB: Q32P36 (UniProtKB/Swiss-Prot),   Q6MG67 (UniProtKB/Swiss-Prot),   P55063 (UniProtKB/Swiss-Prot),   A6KTP4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063974   ⟸   ENSRNOT00000074223
Ensembl Acc Id: ENSRNOP00000110920   ⟸   ENSRNOT00000129064
Ensembl Acc Id: ENSRNOP00000106918   ⟸   ENSRNOT00000126760
Ensembl Acc Id: ENSRNOP00000110573   ⟸   ENSRNOT00000144895

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55063-F1-model_v2 AlphaFold P55063 1-641 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701377
Promoter ID:EPDNEW_R11901
Type:multiple initiation site
Name:Hspa1l_1
Description:heat shock protein family A member 1 like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,959,295 - 4,959,355EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595925 AgrOrtholog
BioCyc Gene G2FUF-4622 BioCyc
Ensembl Genes ENSRNOG00000047966 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000074223.3 UniProtKB/Swiss-Prot
  ENSRNOT00000144895 ENTREZGENE
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot
  3.30.30.30 UniProtKB/Swiss-Prot
  3.30.420.40 UniProtKB/Swiss-Prot
  Actin, Chain A, domain 4 UniProtKB/Swiss-Prot
  Substrate Binding Domain Of DNAk, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7111250 IMAGE-MGC_LOAD
  IMAGE:7115041 IMAGE-MGC_LOAD
InterPro ATPase_NBD UniProtKB/Swiss-Prot
  Heat_shock_70_CS UniProtKB/Swiss-Prot
  HSP70_C_sf UniProtKB/Swiss-Prot
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot
  Hsp_70_fam UniProtKB/Swiss-Prot
KEGG Report rno:24963 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112562 IMAGE-MGC_LOAD
  MGC:114222 IMAGE-MGC_LOAD
NCBI Gene 24963 ENTREZGENE
PANTHER PTHR19375 UniProtKB/Swiss-Prot
Pfam HSP70 UniProtKB/Swiss-Prot
PhenoGen Hspa1l PhenoGen
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot
PROSITE HSP70_1 UniProtKB/Swiss-Prot
  HSP70_2 UniProtKB/Swiss-Prot
  HSP70_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047966 RatGTEx
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot
  SSF100934 UniProtKB/Swiss-Prot
  SSF53067 UniProtKB/Swiss-Prot
UniProt A0ABK0M236_RAT UniProtKB/TrEMBL
  A6KTP4 ENTREZGENE, UniProtKB/TrEMBL
  HS71L_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q32P36 ENTREZGENE
  Q6MG67 ENTREZGENE
UniProt Secondary Q32P36 UniProtKB/Swiss-Prot
  Q6MG67 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-25 Hspa1l  heat shock protein family A (Hsp70) member 1 like  Hspa1l  heat shock protein 1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Hspa1l  heat shock protein 1-like  Hspa1l  heat shock 70kD protein 1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   heat shock 70kD protein 1-like  Hspa1l  heat shock 70kD protein 1-like (mapped)  Name updated 737654 APPROVED
2007-04-11 Hspa1l  heat shock 70kD protein 1-like (mapped)  Hspa1l_mapped  heat shock 70kD protein 1-like (mapped)  Data merged from RGD:2842 737654 APPROVED
2006-11-20 Hspa1l  heat shock 70kD protein 1-like (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Hspa1l_mapped  heat shock 70kD protein 1-like (mapped)      Symbol and Name updated 1556543 APPROVED
2002-11-06 Hspa1l  heat shock 70kD protein 1-like    Heat shock protein 70-1l  Name updated 625702 APPROVED
2002-06-10 Hspa1l  Heat shock protein 70-1l      Symbol and Name status set to approved 70586 APPROVED