Gene: RT1-M5 (RT1 class Ib, locus M5) Rattus norvegicus
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Symbol:
RT1-M5
Name:
RT1 class Ib, locus M5
RGD ID:
1595816
Description:
Predicted to enable peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-E (major histocompatibility complex, class I, E); INTERACTS WITH 6-propyl-2-thiouracil; aflatoxin B1; ammonium chloride.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
Hla-f; LOC499400; major histocompatibility complex, class I, F; MHC class Ib antigen RT1.M5 long isoform; MHC class Ib antigen RT1.M5 short isoform; RGD1560260; RT1 class Ib gene, locus M5; RT1 class Ib, locus M5 (mapped); RT1-M5_mapped; RT1.M5; similar to RT1 class I, M5
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
H2-M5 (histocompatibility 2, M region locus 5)
RGD
RGD
Other homologs 2
Homo sapiens (human):
HLA-C (major histocompatibility complex, class I, C)
HGNC
OrthoDB, Panther
Homo sapiens (human):
HLA-G (major histocompatibility complex, class I, G)
HGNC
OrthoDB, Panther
Homo sapiens (human):
HLA-B (major histocompatibility complex, class I, B)
HGNC
OrthoDB, Panther
Homo sapiens (human):
HLA-F (major histocompatibility complex, class I, F)
HGNC
Panther
Homo sapiens (human):
HLA-H (major histocompatibility complex, class I, H (pseudogene))
HGNC
Panther
Homo sapiens (human):
HLA-A (major histocompatibility complex, class I, A)
HGNC
OrthoDB
Homo sapiens (human):
HLA-E (major histocompatibility complex, class I, E)
HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
HLA-C (major histocompatibility complex, class I, C)
Alliance
DIOPT (Ensembl Compara|OrthoFinder|PANTHER)
Homo sapiens (human):
HLA-F (major histocompatibility complex, class I, F)
Alliance
DIOPT (Ensembl Compara|OrthoFinder|PANTHER)
Homo sapiens (human):
HLA-G (major histocompatibility complex, class I, G)
Alliance
DIOPT (Ensembl Compara|OrthoFinder|PANTHER)
Homo sapiens (human):
HLA-B (major histocompatibility complex, class I, B)
Alliance
DIOPT (Ensembl Compara|OrthoFinder|PANTHER)
Homo sapiens (human):
HLA-E (major histocompatibility complex, class I, E)
Alliance
DIOPT (Ensembl Compara|OrthoFinder|PANTHER)
Mus musculus (house mouse):
H2-M5 (histocompatibility 2, M region locus 5)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
mhc1zja (major histocompatibility complex class I ZJA)
Alliance
DIOPT (Ensembl Compara|InParanoid|OMA|PANTHER|SonicParanoid)
Danio rerio (zebrafish):
mhc1zka (major histocompatibility complex class I ZKA)
Alliance
DIOPT (Ensembl Compara|InParanoid|OMA|PANTHER|SonicParanoid)
Danio rerio (zebrafish):
mhc1zca (major histocompatibility complex class I ZCA)
Alliance
DIOPT (Ensembl Compara|InParanoid|OMA|PANTHER|SonicParanoid)
Danio rerio (zebrafish):
mhc1zea (major histocompatibility complex class I ZEA)
Alliance
DIOPT (Ensembl Compara|InParanoid|OMA|PANTHER|SonicParanoid)
Danio rerio (zebrafish):
mhc1lfa (major histocompatibility complex class I LFA)
Alliance
DIOPT (Ensembl Compara|PANTHER|PhylomeDB)
Danio rerio (zebrafish):
mhc1zba (major histocompatibility complex class I ZBA)
Alliance
DIOPT (Ensembl Compara|InParanoid|OMA|PANTHER|SonicParanoid)
Danio rerio (zebrafish):
mhc1zfa (major histocompatibility complex class I ZFA)
Alliance
DIOPT (Ensembl Compara|InParanoid|OMA|PANTHER|SonicParanoid)
Danio rerio (zebrafish):
mhc1zaa
Alliance
DIOPT (Ensembl Compara|InParanoid|OMA|PANTHER|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
cox16
Alliance
DIOPT (InParanoid|OMA|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
mhc1b2
Alliance
DIOPT (OMA|PANTHER|PhylomeDB)
Latest Assembly:
mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 20 1,551,751 - 1,554,015 (-) NCBI GRCr8 mRatBN7.2 20 1,546,496 - 1,548,948 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 20 1,546,511 - 1,548,775 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 20 1,599,901 - 1,602,165 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 20 1,603,397 - 1,605,661 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 20 1,544,793 - 1,547,057 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 20 2,038,158 - 2,040,422 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 20 2,038,158 - 2,040,422 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 20 4,078,537 - 4,080,801 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 20 1,638,276 - 1,640,540 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 Celera 20 2,254,856 - 2,257,120 (-) NCBI Celera Cytogenetic Map 20 p12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO H2-M5 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO H2-M5 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO H2-M5 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of H2-M5 gene CTD PMID:21212295 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of RT1-M5 mRNA CTD PMID:24780913 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of RT1-M5 mRNA CTD PMID:23630614 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of RT1-M5 mRNA CTD PMID:16483693 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of RT1-M5 mRNA CTD PMID:30816183 and PMID:32528016 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of RT1-M5 mRNA CTD PMID:34947998 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of RT1-M5 mRNA CTD PMID:19167457 copper atom multiple interactions EXP 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of RT1-M5 mRNA CTD PMID:26033743 copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of RT1-M5 mRNA CTD PMID:26033743 copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of RT1-M5 mRNA CTD PMID:26033743 copper(0) multiple interactions EXP 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of RT1-M5 mRNA CTD PMID:26033743 furan increases expression EXP 6480464 furan results in increased expression of RT1-M5 mRNA CTD PMID:25539665 lipopolysaccharide multiple interactions ISO H2-M5 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of H2-M5 gene CTD PMID:21212295 PCB138 multiple interactions ISO H2-M5 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870