HLA-F (major histocompatibility complex, class I, F)

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Keyword

Gene: HLA-F (major histocompatibility complex, class I, F) Homo sapiens

Symbol:

HLA-F

Name:

major histocompatibility complex, class I, F

Description:

This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

CDA12; HLA class I histocompatibility antigen, alpha chain F; HLA class I molecule; HLA F antigen; HLA-5.4; HLA-CDA12; HLAF; leukocyte antigen F; MHC class I antigen; MHC class I antigen F; MHC class Ib antigen; OTTHUMP00000109209; OTTHUMP00000109210; OTTHUMP00000109211

Orthologs:

Mus musculus : Gm11127 (predicted gene 11127) MGI

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	6	29,609,133 - 29,613,089	+	NCBI
Human Genome Assembly HuRef	6	29,494,781 - 29,498,733	+	NCBI
Human Genome Assembly GRCh37	6	29,691,117 - 29,695,073	+	NCBI
Human Genome Assembly Build 36	6	29,799,096 - 29,803,052	+	NCBI
Human Cytogenetic Map	6	p21.3		NCBI
Human Genome Assembly	6	29,799,219 - 29,802,262		NCBI