Rbbp4 (RB binding protein 4, chromatin remodeling factor) - Rat Genome Database

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Gene: Rbbp4 (RB binding protein 4, chromatin remodeling factor) Rattus norvegicus
Analyze
Symbol: Rbbp4
Name: RB binding protein 4, chromatin remodeling factor
RGD ID: 1593768
Description: Predicted to enable histone binding activity. Predicted to be involved in chromatin remodeling and regulation of DNA-templated transcription. Predicted to be part of ESC/E(Z) complex and NuRD complex. Predicted to be active in nucleus. Orthologous to human RBBP4 (RB binding protein 4, chromatin remodeling factor); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; Hedgehog signaling pathway; histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: histone-binding protein RBBP4; LOC313048; LOC685491; retinoblastoma binding protein 4; retinoblastoma-binding protein 4 pseudogene; similar to retinoblastoma binding protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Rbbp4-ps2  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,940,207 - 146,959,501 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5146,922,611 - 146,959,501 (-)EnsemblGRCr8
mRatBN7.25141,655,863 - 141,675,157 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,638,421 - 141,675,284 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl2153,958,955 - 153,960,757 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5144,355,099 - 144,374,375 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05146,124,917 - 146,144,193 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,123,458 - 146,142,805 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,499,880 - 147,535,240 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,499,882 - 147,535,240 (-)Ensemblrn6Rnor6.0
Rnor_5.05151,232,120 - 151,256,539 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45148,472,397 - 148,492,172 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5140,134,357 - 140,153,816 (-)NCBICelera
RGSC_v3.15148,482,431 - 148,502,298 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsenous acid  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
capecitabine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
menadione  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (ISO)
miconazole  (ISO)
N-nitrosodiethylamine  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
succimer  (ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The nucleosome remodeling and deacetylase complex in development and disease. Basta J and Rauchman M, Transl Res. 2014 May 10. pii: S1931-5244(14)00166-2. doi: 10.1016/j.trsl.2014.05.003.
2. Growth hormone (GH) action in the developing lung: changes in lung proteins after adenoviral GH overexpression. Beyea JA, etal., Dev Dyn. 2005 Oct;234(2):404-12.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Hargreaves DC and Crabtree GR, Cell Res. 2011 Mar;21(3):396-420. doi: 10.1038/cr.2011.32. Epub 2011 Mar 1.
5. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Herz HM, etal., Trends Biochem Sci. 2013 Dec;38(12):621-39. doi: 10.1016/j.tibs.2013.09.004. Epub 2013 Oct 20.
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex. Roche AE, etal., J Mol Cell Cardiol. 2008 Feb;44(2):352-60. Epub 2007 Nov 12.
10. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013.
Additional References at PubMed
PMID:8858152   PMID:12477932   PMID:14609955   PMID:14645126   PMID:14718166   PMID:16217013   PMID:17827154   PMID:19644445   PMID:20064376   PMID:20075857   PMID:20720167   PMID:20850016  
PMID:22720776   PMID:22770845   PMID:22926524   PMID:23104054   PMID:23273982   PMID:28053041   PMID:31451685   PMID:35352799  


Genomics

Comparative Map Data
Rbbp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,940,207 - 146,959,501 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5146,922,611 - 146,959,501 (-)EnsemblGRCr8
mRatBN7.25141,655,863 - 141,675,157 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,638,421 - 141,675,284 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl2153,958,955 - 153,960,757 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5144,355,099 - 144,374,375 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05146,124,917 - 146,144,193 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,123,458 - 146,142,805 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,499,880 - 147,535,240 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,499,882 - 147,535,240 (-)Ensemblrn6Rnor6.0
Rnor_5.05151,232,120 - 151,256,539 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45148,472,397 - 148,492,172 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5140,134,357 - 140,153,816 (-)NCBICelera
RGSC_v3.15148,482,431 - 148,502,298 (-)NCBI
Cytogenetic Map5q36NCBI
RBBP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38132,651,208 - 32,686,211 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl132,651,142 - 32,686,211 (+)Ensemblhg38GRCh38
GRCh37133,116,809 - 33,151,812 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36132,889,411 - 32,918,841 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34132,785,916 - 32,815,345NCBI
Celera131,385,428 - 31,420,582 (+)NCBICelera
Cytogenetic Map1p35.1NCBI
HuRef131,231,934 - 31,267,005 (+)NCBIHuRef
CHM1_1133,232,162 - 33,267,239 (+)NCBICHM1_1
T2T-CHM13v2.0132,510,988 - 32,546,003 (+)NCBIT2T-CHM13v2.0
Rbbp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394129,200,893 - 129,229,163 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4129,200,893 - 129,229,163 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384129,307,100 - 129,335,370 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4129,307,100 - 129,335,370 (-)Ensemblmm10GRCm38
MGSCv374128,984,344 - 129,012,614 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364128,809,404 - 128,837,674 (-)NCBIMGSCv36mm8
Celera4127,647,840 - 127,676,109 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map463.26NCBI
Rbbp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545210,955,399 - 10,975,036 (+)Ensembl
ChiLan1.0NW_00495545210,955,399 - 10,975,036 (+)NCBIChiLan1.0ChiLan1.0
RBBP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21194,138,913 - 194,168,532 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11193,261,113 - 193,290,737 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0131,944,257 - 31,974,763 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1133,111,234 - 33,146,184 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl133,111,234 - 33,140,518 (+)EnsemblpanPan2panpan1.1
RBBP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,638,459 - 68,660,942 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,638,498 - 68,660,910 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha265,220,721 - 65,243,237 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0269,205,850 - 69,228,372 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,205,858 - 69,228,373 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1266,042,918 - 66,065,306 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0267,038,390 - 67,060,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,032,020 - 68,054,562 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rbbp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505849,767,432 - 49,786,599 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647415,592,240 - 15,611,381 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647415,592,226 - 15,611,381 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBBP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1688,987,092 - 89,006,815 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2682,938,419 - 83,033,099 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RBBP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120100,191,259 - 100,220,608 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603316,468,914 - 16,498,674 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbbp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476415,800,143 - 15,823,319 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rbbp4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1128,813,792 - 28,833,107 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rbbp4
142 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:52
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000029177
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
AI029854  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85146,939,789 - 146,939,969 (+)Marker Load Pipeline
mRatBN7.25141,655,445 - 141,655,625 (+)MAPPERmRatBN7.2
Rnor_6.05147,499,463 - 147,499,642NCBIRnor6.0
Rnor_5.05151,231,703 - 151,231,882UniSTSRnor5.0
RGSC_v3.45148,471,980 - 148,472,159UniSTSRGSC3.4
Celera5140,133,940 - 140,134,119UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000029177   ⟹   ENSRNOP00000036568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5146,940,209 - 146,959,501 (-)Ensembl
mRatBN7.2 Ensembl5141,655,732 - 141,675,284 (-)Ensembl
Rnor_6.0 Ensembl5147,499,882 - 147,535,240 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096112   ⟹   ENSRNOP00000096372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5146,922,611 - 146,959,501 (-)Ensembl
mRatBN7.2 Ensembl5141,638,421 - 141,675,284 (-)Ensembl
RefSeq Acc Id: NM_001107912   ⟹   NP_001101382
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85146,940,207 - 146,959,501 (-)NCBI
mRatBN7.25141,655,863 - 141,675,157 (-)NCBI
Rnor_6.05147,499,880 - 147,535,240 (-)NCBI
Rnor_5.05151,232,120 - 151,256,539 (-)NCBI
RGSC_v3.45148,472,397 - 148,492,172 (-)RGD
Celera5140,134,357 - 140,153,816 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101382 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68994 (Get FASTA)   NCBI Sequence Viewer  
  EDL80533 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000033725.4
  ENSRNOP00000036568
  ENSRNOP00000036568.4
RefSeq Acc Id: NP_001101382   ⟸   NM_001107912
- UniProtKB: A6ISI2 (UniProtKB/TrEMBL),   B5DFB2 (UniProtKB/TrEMBL),   D4A250 (UniProtKB/TrEMBL),   F7EQ75 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000036568   ⟸   ENSRNOT00000029177
Ensembl Acc Id: ENSRNOP00000096372   ⟸   ENSRNOT00000096112
Protein Domains
Histone-binding protein RBBP4-like N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DFB2-F1-model_v2 AlphaFold B5DFB2 1-425 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694059
Promoter ID:EPDNEW_R4584
Type:initiation region
Name:Rbbp4_1
Description:RB binding protein 4, chromatin remodeling factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05147,535,331 - 147,535,391EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593768 AgrOrtholog
BioCyc Gene G2FUF-39811 BioCyc
Ensembl Genes ENSRNOG00000021492 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000028052 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029177 ENTREZGENE
  ENSRNOT00000029177.6 UniProtKB/TrEMBL
  ENSRNOT00000033132.5 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro G-protein_beta_WD-40_rep_reg UniProtKB/TrEMBL
  Histone-bd_RBBP4 UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
  WD_repeat_RBAP46/RBAP48/MSI1 UniProtKB/TrEMBL
KEGG Report rno:313048 UniProtKB/TrEMBL
NCBI Gene Rbbp4 ENTREZGENE
PANTHER WD40 REPEAT FAMILY UniProtKB/TrEMBL
Pfam CAF1C_H4-bd UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PhenoGen Rbbp4 PhenoGen
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021492 RatGTEx
  ENSRNOG00000028052 RatGTEx
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP WD40_like UniProtKB/TrEMBL
UniProt A6ISI2 ENTREZGENE, UniProtKB/TrEMBL
  A6J5N5_RAT UniProtKB/TrEMBL
  B5DFB2 ENTREZGENE
  D4A250 ENTREZGENE, UniProtKB/TrEMBL
  F7EQ75 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B5DFB2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-03 Rbbp4  RB binding protein 4, chromatin remodeling factor  Rbbp4  retinoblastoma binding protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Rbbp4  retinoblastoma binding protein 4  Rbbp4_predicted  retinoblastoma binding protein 4 (predicted)  Data merged from RGD:1311737 737654 APPROVED
2008-03-05 Rbbp4  retinoblastoma binding protein 4  LOC685491  similar to retinoblastoma binding protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC685491  similar to retinoblastoma binding protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Rbbp4_predicted  retinoblastoma binding protein 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED